CN101573338B - 环烷基胺取代的异喹诺酮和异喹啉酮衍生物 - Google Patents

环烷基胺取代的异喹诺酮和异喹啉酮衍生物 Download PDF

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CN101573338B
CN101573338B CN2007800485212A CN200780048521A CN101573338B CN 101573338 B CN101573338 B CN 101573338B CN 2007800485212 A CN2007800485212 A CN 2007800485212A CN 200780048521 A CN200780048521 A CN 200780048521A CN 101573338 B CN101573338 B CN 101573338B
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alkyl
alkylene
aryl
formula
cycloalkyl
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CN101573338A (zh
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O·普来登伯格
A·霍夫迈斯特
J·格利策
M·勒恩
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Sanofi SRL
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
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CN2007800485212A 2006-12-27 2007-12-19 环烷基胺取代的异喹诺酮和异喹啉酮衍生物 Expired - Fee Related CN101573338B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP06026895 2006-12-27
EP06026895.0 2006-12-27
PCT/EP2007/011166 WO2008077553A1 (en) 2006-12-27 2007-12-19 Cycloalkylamine substituted isoquinolone and isoquinolinone derivatives

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CN101573338A CN101573338A (zh) 2009-11-04
CN101573338B true CN101573338B (zh) 2013-03-20

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US (1) US20100056568A1 (enExample)
EP (1) EP2125744B1 (enExample)
JP (1) JP5318778B2 (enExample)
KR (1) KR20090103903A (enExample)
CN (1) CN101573338B (enExample)
AT (1) ATE505458T1 (enExample)
AU (1) AU2007338409B2 (enExample)
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PT3811943T (pt) 2013-03-15 2023-03-15 Aerie Pharmaceuticals Inc Composto para uso no tratamento de distúrbios oculares
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US10308650B2 (en) 2014-12-11 2019-06-04 Syngenta Participations Ag Pesticidally active tetracyclic derivatives with sulfur containing substituents
TW202237569A (zh) 2014-12-24 2022-10-01 美商基利科學股份有限公司 喹唑啉化合物
EA032430B1 (ru) 2014-12-24 2019-05-31 Джилид Сайэнс, Инк. Конденсированные пиримидины для лечения вич
BR112017013440A2 (pt) 2014-12-24 2018-01-09 Gilead Sciences, Inc. compostos de isoquinolina para o tratamento de hiv
US9643927B1 (en) 2015-11-17 2017-05-09 Aerie Pharmaceuticals, Inc. Process for the preparation of kinase inhibitors and intermediates thereof
JP6832946B2 (ja) 2015-11-17 2021-02-24 アエリエ ファーマシューティカルズ インコーポレイテッド キナーゼ阻害剤およびその中間体の調製方法
CN109640966A (zh) 2016-08-31 2019-04-16 爱瑞制药公司 眼用组合物
SG11201908179UA (en) 2017-03-31 2019-10-30 Aerie Pharmaceuticals Inc Aryl cyclopropyl-amino-isoquinolinyl amide compounds
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US12398118B2 (en) 2018-11-09 2025-08-26 Beijing Tide Pharmaceutical Co., Ltd. Rho-associated protein kinase inhibitor, pharmaceutical composition comprising same, and use thereof
CN110670090B (zh) * 2019-11-13 2021-06-29 广西师范大学 一种基于电化学合成异喹啉酮类化合物的方法

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WO2008077553A1 (en) 2008-07-03
CA2673919A1 (en) 2008-07-03
JP2010514718A (ja) 2010-05-06
AU2007338409A1 (en) 2008-07-03
AU2007338409B2 (en) 2012-12-13
IL199536A (en) 2014-07-31
NO20092431L (no) 2009-09-21
MA31023B1 (fr) 2009-12-01
ATE505458T1 (de) 2011-04-15
ES2364511T3 (es) 2011-09-05
US20100056568A1 (en) 2010-03-04
CN101573338A (zh) 2009-11-04
EP2125744A1 (en) 2009-12-02
KR20090103903A (ko) 2009-10-01
ZA200903553B (en) 2010-04-28
MX2009005828A (es) 2009-06-16
MY148514A (en) 2013-04-30
EP2125744B1 (en) 2011-04-13
PT2125744E (pt) 2011-07-01
HK1138583A1 (en) 2010-08-27
BRPI0720710A2 (pt) 2014-12-23
RU2009128688A (ru) 2011-02-10
DK2125744T3 (da) 2011-08-01

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