CN101568331A - 减少或缓解消化道炎症的方法 - Google Patents

减少或缓解消化道炎症的方法 Download PDF

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Publication number
CN101568331A
CN101568331A CNA2007800394181A CN200780039418A CN101568331A CN 101568331 A CN101568331 A CN 101568331A CN A2007800394181 A CNA2007800394181 A CN A2007800394181A CN 200780039418 A CN200780039418 A CN 200780039418A CN 101568331 A CN101568331 A CN 101568331A
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CN
China
Prior art keywords
purposes
acid
ethylamino
carboxyl
imidazol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2007800394181A
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English (en)
Chinese (zh)
Inventor
路易斯·安东尼·塔尔塔利亚
托马斯·迈克尔·巴尔内斯
罗伯特·马克·库珀史密斯
斯克特·爱德华·莫尔斯特伦
大卫·威廉·怀特
多米尼克·皮卡雷拉
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Ore Pharmaceuticals Inc
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Ore Pharmaceuticals Inc
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Publication date
Application filed by Ore Pharmaceuticals Inc filed Critical Ore Pharmaceuticals Inc
Publication of CN101568331A publication Critical patent/CN101568331A/zh
Pending legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
CNA2007800394181A 2006-09-08 2007-09-07 减少或缓解消化道炎症的方法 Pending CN101568331A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US82507506P 2006-09-08 2006-09-08
US60/825,075 2006-09-08
US82780706P 2006-10-02 2006-10-02
US60/827,807 2006-10-02

Publications (1)

Publication Number Publication Date
CN101568331A true CN101568331A (zh) 2009-10-28

Family

ID=38670723

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2007800394181A Pending CN101568331A (zh) 2006-09-08 2007-09-07 减少或缓解消化道炎症的方法

Country Status (11)

Country Link
US (1) US20080234345A1 (enExample)
EP (1) EP2059234B1 (enExample)
JP (1) JP2010502736A (enExample)
CN (1) CN101568331A (enExample)
AT (1) ATE531362T1 (enExample)
AU (1) AU2007292247A1 (enExample)
CA (1) CA2662535A1 (enExample)
DK (1) DK2059234T3 (enExample)
ES (1) ES2376493T3 (enExample)
IL (1) IL197362A0 (enExample)
WO (1) WO2008031014A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2095819A1 (en) * 2008-02-28 2009-09-02 Maastricht University N-benzyl imidazole derivatives and their use as aldosterone synthase inhibitors
EP2262491A1 (en) * 2008-03-10 2010-12-22 Ore Pharmaceuticals Inc. Therapy for disorders of the proximal digestive tract
WO2010093804A1 (en) * 2009-02-12 2010-08-19 Ore Pharmaceuticals, Inc. Ace2 inhibitors for reducing gastrointestinal adverse effects of cytotoxic agents
EP2543388A4 (en) * 2010-03-04 2013-11-27 Dainippon Sumitomo Pharma Co MEDICINAL PRODUCT FOR INFLAMMATORY ENDURANCE
KR101713453B1 (ko) 2010-03-12 2017-03-07 오메로스 코포레이션 Pde10 억제제 및 관련 조성물 및 방법
NZ716462A (en) 2014-04-28 2017-11-24 Omeros Corp Optically active pde10 inhibitor
NZ630810A (en) 2014-04-28 2016-03-31 Omeros Corp Processes and intermediates for the preparation of a pde10 inhibitor
MA41271A (fr) * 2014-12-26 2017-10-31 Celgene Alpine Invest Company Ii Llc Méthodes d'utilisation d'oligonucléotides antisens ciblant smad7
CA2980801A1 (en) 2015-04-24 2016-10-27 Omeros Corporation Pde10 inhibitors and related compositions and methods
CA3003611C (en) 2015-11-04 2022-11-01 Omeros Corporation Solid state forms of a pde10 inhibitor
GB202116266D0 (en) * 2021-11-11 2021-12-29 Bicycletx Ltd Novel use

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6194556B1 (en) * 1997-12-11 2001-02-27 Millennium Pharmaceuticals, Inc. Angiotensin converting enzyme homolog and therapeutic and diagnostic uses therfor
US7045532B2 (en) 1999-04-30 2006-05-16 Millennium Pharmaceuticals, Inc. ACE-2 modulating compounds and methods of use thereof
US6632830B1 (en) * 1999-04-30 2003-10-14 Millennium Pharmaceuticals, Inc. ACE-2 inhibiting compounds and methods of use thereof
WO2002098448A1 (en) 2001-06-04 2002-12-12 Human Genome Sciences, Inc. Methods and compositions for modulating ace-2 activity
GB0203061D0 (en) 2002-02-08 2002-03-27 Novartis Ag Organic compounds
JP2006503905A (ja) * 2002-09-24 2006-02-02 コンビナトアールエックス インコーポレーティッド 炎症性サイトカインのレベルの増大と関連する病気および障害の治療のための方法および試薬
TW200902047A (en) * 2003-02-14 2009-01-16 Combinatorx Inc Methods and reagents for the treatment of diseases and disorders associated with increased levels of proinflammatory cytokines
US20050203168A1 (en) * 2004-03-11 2005-09-15 The Regents Of The University Of Michigan Angiotensin converting enzyme inhibitor use for treatment and prevention of gastrointestinal disorders
US7842709B2 (en) * 2006-09-08 2010-11-30 Ore Pharmaceuticals Inc. Method for treating inflammatory diseases of the digestive tract

Also Published As

Publication number Publication date
ES2376493T3 (es) 2012-03-14
AU2007292247A2 (en) 2009-03-26
DK2059234T3 (da) 2011-11-28
EP2059234B1 (en) 2011-11-02
WO2008031014A1 (en) 2008-03-13
AU2007292247A1 (en) 2008-03-13
ATE531362T1 (de) 2011-11-15
IL197362A0 (en) 2009-12-24
US20080234345A1 (en) 2008-09-25
CA2662535A1 (en) 2008-03-13
EP2059234A1 (en) 2009-05-20
JP2010502736A (ja) 2010-01-28

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Application publication date: 20091028