CN101559036A - 一种阴道用避孕凝胶组合物及其制备方法和应用 - Google Patents
一种阴道用避孕凝胶组合物及其制备方法和应用 Download PDFInfo
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- CN101559036A CN101559036A CNA2008100362168A CN200810036216A CN101559036A CN 101559036 A CN101559036 A CN 101559036A CN A2008100362168 A CNA2008100362168 A CN A2008100362168A CN 200810036216 A CN200810036216 A CN 200810036216A CN 101559036 A CN101559036 A CN 101559036A
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Description
泊洛沙姆型号 | 物理状态 | a | b | 平均分子量 |
124 | 液态 | 12 | 20 | 2090-2360 |
188 | 固态 | 80 | 27 | 7680-9510 |
237 | 固态 | 64 | 37 | 6840-8830 |
338 | 固态 | 141 | 44 | 12700-17400 |
407 | 固态 | 101 | 56 | 9840-14600 |
P407wt% | P188wt% | T(℃) | P407wt% | P188wt% | T(℃) |
8 | 25 | 40 | 14 | 18 | 37 |
9 | 23 | 40 | 15 | 14 | 38 |
9 | 25 | 36 | 15 | 15 | 38 |
10 | 25 | 35 | 15 | 16 | 35 |
12 | 18 | 41 | 15 | 20 | 32 |
12 | 20 | 38 | 16 | 15 | 32 |
12 | 25 | 32 | 16 | 20 | 30 |
13 | 18 | 42 | 21 | 10 | 39 |
14 | 15 | 40 | \ | \ | \ |
组别 | 相变温度(℃) | 组别 | 相变温度(℃) |
对比实施例2 | 41 | 实施例8 | 31 |
实施例1 | 31 | 实施例9 | 38 |
实施例2 | 36 | 实施例10 | 34 |
实施例3 | 38 | 实施例11 | 38 |
实施例4 | 32 | 实施例12 | 38 |
实施例5 | 38 | 实施例13 | 37 |
实施例6 | 32 | 实施例14 | 35 |
实施例7 | 37 | \ | \ |
P407wt% | P188wt% | T(℃) | P407wt% | P188wt% | T(℃) |
8 | 25 | - | 14 | 18 | - |
9 | 23 | - | 15 | 14 | >50 |
9 | 25 | - | 15 | 15 | 48 |
10 | 25 | - | 15 | 16 | - |
12 | 18 | >50 | 15 | 20 | - |
12 | 20 | - | 16 | 15 | - |
12 | 25 | - | 16 | 20 | - |
13 | 18 | - | 21 | 10 | 45 |
14 | 15 | 48 |
组别 | meq NaOH | 组别 | meq NaOH |
对比实施例1 | 0.320 | 对比实施例2 | 0.040 |
实施例1 | 0.440 | 实施例8 | 0.240 |
实施例2 | 0.380 | 实施例9 | 0.340 |
实施例3 | 0.240 | 实施例10 | 0.320 |
实施例4 | 0.280 | 实施例11 | 0.260 |
实施例5 | 0.380 | 实施例12 | 0.280 |
实施例6 | 0.280 | 实施例13 | 0.300 |
实施例7 | 0.380 | 实施例14 | 0.260 |
组别 | 切向黏附力(g) | 垂直黏附力(g) | 组别 | 切向黏附力(g) | 垂直黏附力(g) |
对比实施例1 | 53.73 | 472.5 | 对比实施例2 | 12.47 | 99.1 |
实施例1 | 74.34 | 544.2 | 实施例8 | 40.41 | 459.8 |
实施例2 | 76.74 | 528.9 | 实施例9 | 72.37 | 543.1 |
实施例3 | 69.37 | 501.4 | 实施例10 | 39.43 | 436.8 |
实施例4 | 50.52 | 492.9 | 实施例11 | 57.76 | 501.5 |
实施例5 | 76.92 | 510.7 | 实施例12 | 38.93 | 430.7 |
实施例6 | 59.74 | 501.4 | 实施例13 | 40.14 | 460.2 |
实施例7 | 75.46 | 511.6 | 实施例14 | 50.30 | 476.5 |
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CN2008100362168A CN101559036B (zh) | 2008-04-18 | 2008-04-18 | 一种阴道用避孕凝胶组合物及其制备方法和应用 |
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CN2008100362168A CN101559036B (zh) | 2008-04-18 | 2008-04-18 | 一种阴道用避孕凝胶组合物及其制备方法和应用 |
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CN101559036A true CN101559036A (zh) | 2009-10-21 |
CN101559036B CN101559036B (zh) | 2012-02-08 |
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Cited By (12)
Publication number | Priority date | Publication date | Assignee | Title |
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CN102475675A (zh) * | 2010-11-26 | 2012-05-30 | 上海现代药物制剂工程研究中心有限公司 | 一种硝酸益康唑阴道避孕温敏凝胶剂及其制备方法 |
CN102895256A (zh) * | 2012-09-29 | 2013-01-30 | 广东同德药业有限公司 | 一种适用于女性屏障杀精双重避孕作用的壳聚糖复合凝胶泡沫剂及其制备方法 |
CN103315952A (zh) * | 2012-03-20 | 2013-09-25 | 上海市计划生育科学研究所 | 一种水难溶性药物的微乳载体系统及其制备方法和用途 |
CN103520091A (zh) * | 2013-10-15 | 2014-01-22 | 山东赛克赛斯药业科技有限公司 | 一种阴道用酸缓冲温敏凝胶制剂及其制备方法与应用 |
CN103655457A (zh) * | 2013-09-24 | 2014-03-26 | 杨莉 | 用于调节女性阴道pH值的温敏凝胶及其制备方法 |
CN104606212A (zh) * | 2015-01-29 | 2015-05-13 | 张维芬 | 一种避孕及杀微生物双功能阴道复合温敏水凝胶制剂及其制备方法 |
US9470676B2 (en) | 2014-12-19 | 2016-10-18 | Good Clean Love, Inc. | Systems and methods for bio-matching gels, creams and lotions |
CN106265486A (zh) * | 2016-08-18 | 2017-01-04 | 滨州医学院附属医院 | 一种硝酸咪康唑缓释凝胶及其制备方法 |
US10195169B2 (en) | 2014-12-19 | 2019-02-05 | Good Clean Love, Inc. | Systems and methods for bio-matching gels, creams and lotions |
CN110693812A (zh) * | 2012-06-13 | 2020-01-17 | 伊沃菲姆股份有限公司 | 用于增强避孕杀微生物剂有效性的组合物和方法 |
CN112274480A (zh) * | 2020-11-06 | 2021-01-29 | 山东莱商商贸有限公司 | 一种女用避孕抗菌的凝胶润滑剂的制备方法 |
US10952979B2 (en) | 2014-12-19 | 2021-03-23 | Good Clean Love, Inc. | Topical fertility promoting product and manufacturing method |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EA012205B1 (ru) * | 2004-05-17 | 2009-08-28 | Арес Трейдинг С.А. | Гидрогелевые препараты интерферона |
CN1311873C (zh) * | 2004-06-30 | 2007-04-25 | 上海复康医药科技发展有限公司 | 一种温度敏感的阴道用原位凝胶制剂 |
CN1872026A (zh) * | 2005-05-30 | 2006-12-06 | 张东军 | 阴道用新型药物制剂 |
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Cited By (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102475675A (zh) * | 2010-11-26 | 2012-05-30 | 上海现代药物制剂工程研究中心有限公司 | 一种硝酸益康唑阴道避孕温敏凝胶剂及其制备方法 |
CN103315952A (zh) * | 2012-03-20 | 2013-09-25 | 上海市计划生育科学研究所 | 一种水难溶性药物的微乳载体系统及其制备方法和用途 |
CN110693812A (zh) * | 2012-06-13 | 2020-01-17 | 伊沃菲姆股份有限公司 | 用于增强避孕杀微生物剂有效性的组合物和方法 |
CN102895256A (zh) * | 2012-09-29 | 2013-01-30 | 广东同德药业有限公司 | 一种适用于女性屏障杀精双重避孕作用的壳聚糖复合凝胶泡沫剂及其制备方法 |
CN102895256B (zh) * | 2012-09-29 | 2014-10-22 | 广东同德药业有限公司 | 一种适用于女性屏障杀精双重避孕作用的壳聚糖复合凝胶泡沫剂及其制备方法 |
CN103655457A (zh) * | 2013-09-24 | 2014-03-26 | 杨莉 | 用于调节女性阴道pH值的温敏凝胶及其制备方法 |
CN103520091A (zh) * | 2013-10-15 | 2014-01-22 | 山东赛克赛斯药业科技有限公司 | 一种阴道用酸缓冲温敏凝胶制剂及其制备方法与应用 |
US9470676B2 (en) | 2014-12-19 | 2016-10-18 | Good Clean Love, Inc. | Systems and methods for bio-matching gels, creams and lotions |
US11806325B2 (en) | 2014-12-19 | 2023-11-07 | Vaginal Biome Science, Inc. | Topical fertility promoting product and manufacturing method |
US10952979B2 (en) | 2014-12-19 | 2021-03-23 | Good Clean Love, Inc. | Topical fertility promoting product and manufacturing method |
US10195169B2 (en) | 2014-12-19 | 2019-02-05 | Good Clean Love, Inc. | Systems and methods for bio-matching gels, creams and lotions |
CN104606212A (zh) * | 2015-01-29 | 2015-05-13 | 张维芬 | 一种避孕及杀微生物双功能阴道复合温敏水凝胶制剂及其制备方法 |
CN104606212B (zh) * | 2015-01-29 | 2018-02-06 | 潍坊医学院 | 一种避孕及杀微生物双功能阴道复合温敏水凝胶制剂及其制备方法 |
CN106265486A (zh) * | 2016-08-18 | 2017-01-04 | 滨州医学院附属医院 | 一种硝酸咪康唑缓释凝胶及其制备方法 |
CN112274480A (zh) * | 2020-11-06 | 2021-01-29 | 山东莱商商贸有限公司 | 一种女用避孕抗菌的凝胶润滑剂的制备方法 |
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Inventor after: Wu Ying Inventor after: Chen Qinghua Inventor after: Bao Yongchu Inventor after: Pan Feng Inventor after: Ji Ting Inventor after: Zhao Yanlong Inventor after: Li Kun Inventor after: Xiao Lili Inventor after: He Wen Inventor before: Wu Ying Inventor before: Chen Qinghua Inventor before: Bao Yongchu Inventor before: Pan Feng Inventor before: Ji Ting Inventor before: Zhao Yanlong Inventor before: Li Kun Inventor before: Xiao Lili |
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Free format text: CORRECT: INVENTOR; FROM: WU YING CHEN QINGHUA BAO YONGCHU PAN FENG QU TING ZHAO YANLONG LI KUN XIAO LILI TO: WU YING CHEN QINGHUA BAO YONGCHU PAN FENG QU TING ZHAO YANLONG LI KUN XIAO LILI HE WEN |
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