CN101554338A - Cold and hot ablation apparatus with cold and heat accumulation devices - Google Patents
Cold and hot ablation apparatus with cold and heat accumulation devices Download PDFInfo
- Publication number
- CN101554338A CN101554338A CNA2008100432264A CN200810043226A CN101554338A CN 101554338 A CN101554338 A CN 101554338A CN A2008100432264 A CNA2008100432264 A CN A2008100432264A CN 200810043226 A CN200810043226 A CN 200810043226A CN 101554338 A CN101554338 A CN 101554338A
- Authority
- CN
- China
- Prior art keywords
- cold
- heat
- storage
- hot
- exchanger
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Abstract
The invention discloses a cold and hot ablation apparatus with cold and heat accumulation devices, the apparatus comprises a refrigerant container, a gas main and a cold/heat probe or a conduit, wherein the refrigerant container is connected with the gas main which is divided into two pipelines, one pipeline is connected with a gas inlet cold pipe, the other pipeline is connected with a gas inlet hot pipe, and the gas inlet cold pipe passing through a cold-accumulating heat exchanger is jointed with the gas inlet hot pipe passing through a heat-accumulating heat exchanger into one gas inlet pipe which is then is connected with the cold/heat probe or the conduit. One way of refrigerant in the refrigerant container used by the apparatus is pre-cooled firstly by the cold-accumulating heat exchanger, and then the refrigerant is used for cooling and freezing pathologically changed tissues through the cold/heat probe or the conduit.. The other way of refrigerant passes through the heat-accumulating heat exchanger and then heats the cold/heat probe or the head part of the conduit so that the temperature of the pathologically changed tissues is quickly reduced or the frozen pathologically changed tissues are molten, and then a series of inreversible injuries can be generated so as to achieve the aim of eliminating pathological changes.
Description
Technical field
The present invention is the cold and hot therapeutic equipment of a kind of novel pathological tissues, relates in particular to a kind of cold and hot ablation equipment with the cold-storage and thermal storage device.
Background technology
Cryosurgery claims cold therapy again, is meant and utilizes cryosurgery tool, thereby making lesion tissue experience cooling, freezing and rewarming causes irreversible damage so that a downright bad clinical medicine of control arranged.It can replace operation, and not only wound is small, and has the analgesia, reduces hemorrhage, response light and prevent advantage such as tumor diffusion.The cold therapy of tumor is that the cold-hot probe that thermocouple is installed that can control separately or conduit insert tumor tissues, imposes low temperature at cold-hot probe or catheter head then tumor is killed.The ultimate principle of cold therapy tumor is the mechanical injuries of ice crystal formation and ice crystal in the cell, cell dehydration and shrinkage, the concentrated and pH value change of cell electrolyte toxicity, cell membrane lipid protein ingredient degeneration, blood stagnation and microthrombusis.In addition, refrigerated effect also may be relevant with immunity.To the melting process of freezing tumor tissues in addition ACTIVE CONTROL just can reach goodish tumor-killing effect, so, clinically by tumor being implemented be aided with again to heat up after the cryogenic refrigeration to melt destroyed tumor tissue to greatest extent.Yet the curative effect of this respect is subjected to certain limitation, and mainly because of due to the difficulty aspect freezing and the thawing control, the cooling of tumor and heating be not if carry out the strict quality assurance, and be normal seldom to satisfied treatment for this.So seeking ideal cold therapy method and developing corresponding Medical Instruments is one of the top priority in current hypothermal medicine engineering field.Be applied to cold therapy at present and mainly contain two kinds of systems: liquid nitrogen system and argon helium system.Liquid nitrogen system is that the principle that need absorb a large amount of gasification latent heats when utilizing material to become gas by liquid reduces tissue temperature rapidly.In the operation liquid nitrogen is fed in the cryoprobe, gasification heat absorption when its contact tissue can make the temperature of treatment probe reduce rapidly, makes and organizes fast cooling, freezes, the air that passes to room temperature or heating then in probe makes organizes rewarming, through freeze-thaw cycle repeatedly tumor is killed.Argon helium knife is to utilize the adiabatic throttling effect of gas to finish the therapeutic process of cooling and rewarming, when the higher gas of pressure is flowed through the aperture adiabatic throttling, along with the decline temperature of pressure tends to change, some gas temperature descends, and some gas temperature rises, and the adiabatic throttling effect is also referred to as Joule-Thomson effect.When cryoprobe internal recycle argon, argon is in the point of a knife rapid expansion, and freezing in a short period of time pathological tissues is to subzero 140 degree, during rewarming, helium is in the point of a knife rapid expansion, and heating is in the pathological tissues of ultralow temperature state rapidly, colds and heat succeed each other to make the tumor cell death of breaking.
Argon helium knife has excellent quick freezing performance, but also has certain deficiency, as: (1) lowers the temperature and heats up and only depend on gas differential pressure, and along with the consumption of gas, refrigeration performance reduces.(2) the operating pressure height of argon, therefore to the security requirement height of whole system, and transportation trouble.(3) argon is a rare gas, and cost is higher. (4) high pressure argon bottle (40MPa) is difficult for obtaining, and only is confined to few city, has limited the popularization of argon helium system.
And do not say for liquid nitrogen system, its biggest advantage is the cryogenic temperature that can provide lower, but its shortcoming is: (1) need carry out vacuum thermal insulator to the cryoprobe back segment because the temperature (196 ℃) of liquid nitrogen is lower, to avoid the cold injury health tissues, cause the diameter of cryoprobe bigger; (2) the liquid nitrogen transfer pipeline is owing to will design thermal insulation layer, and diameter is big, and in operation process because low temperature has to a certain degree stiff, be unfavorable for that the doctor uses.(3) temperature is lower in the cryoprobe handle operation process, and the doctor grips inconvenience.
Summary of the invention
Technical problem to be solved by this invention is at the above-mentioned deficiency of existing liquid nitrogen system and nitrogen helium cutter two big cold therapy equipment, proposes a kind of cold and hot ablation equipment with the cold-storage and thermal storage device.
In order to solve technical problem of the present invention, a kind of cold and hot ablation equipment that the present invention proposes with the cold-storage and thermal storage device, comprise cryogen vessel, gas main and cold-hot probe or conduit, its innovative point is, cryogen vessel links to each other with the gas main, the gas main is divided into two pipelines, article one, with advance air cooled lamp and link to each other, article one, link to each other with the air inlet heat pipe, link to each other with cold-hot probe or conduit after two pipelines of air cooled lamp and the air inlet heat pipe that passes from regenerative heat exchanger accumulate an air inlet pipe from advancing of passing of cold-storage heat-exchanger.
Among the present invention, above-mentioned cold-storage heat-exchanger is preferably the closed cavity of shell insulation, and comprising the refrigeration plant vaporizer being arranged and advancing air cooled lamp, intracavity also is filled with cool storage material, and cool storage material fully is surrounded on the refrigeration plant vaporizer and advances around the air cooled lamp; The two ends of refrigeration plant vaporizer link to each other with refrigeration plant; Refrigeration plant is for cooling to the equipment of 300K to 0K.Cool storage material can be and is sensible heat, latent heat, magnetic, macromolecule cold accumulation material.
Among the present invention, above-mentioned regenerative heat exchanger is preferably the closed cavity of shell insulation, and comprising heating tube and air inlet heat pipe are arranged, intracavity also is filled with heat-storing material, and heat-storing material fully is surrounded on around heating tube and the air inlet heat pipe; The heating tube two ends link to each other with firing equipment; Firing equipment is for being heated to the equipment of 300K to 500K.
Among the present invention, cold-producing medium has guaranteed the reliable and stable of refrigeration and heating properties by cold-storage heat-exchanger pre-cooling, regenerative heat exchanger heating.The adiabator insulation is preferably adopted in cold-storage heat-exchanger and regenerative heat exchanger outside, as polyurethane foam, asbestos cloth insulation.When refrigeration plant was worked, the refrigeration working medium of refrigeration plant carried out heat exchange by vaporizer and cool storage material, and then cool storage material has absorbed a large amount of colds, by refrigerant line the cold release that stores was taken out of with the pre-cooling cold-producing medium during operation.
The principle of present device is that by using refrigeration plant be the cold-storage heat-exchanger cold-storage, by application of heat equipment is the regenerative heat exchanger accumulation of heat, make the cold-producing medium one road in the container pass through the cold-storage heat-exchanger pre-cooling earlier, again through the technology of the throttling fast-refrigerating of cold-hot probe or catheter head, impel the pathological tissues fast cooling, freeze, and another road cold-producing medium is by thermal probe of regenerative heat exchanger heats cold or catheter head, make pathological tissues intensification damage or make and freeze the pathological tissues thawing, produce a series of irreversible damages, thereby reach the purpose of eliminating pathological changes.Present device has the cold-storage and thermal storage device, has avoided the instability of equipment performance.Present device is used the room temperature cold-producing medium of lower pressure, has avoided expensive, the difficulty of high pressure argon (40MPa) to obtain, transport problems such as difficulty.Present device has also been avoided problems such as the cold-hot probe diameter that conveying caused of low temperature liquid nitrogen is big, transfer pipeline is thick.
Adopt cold-storage heat-exchanger that following advantage is arranged: 1, cold storage capacity is big, and the cold of pre-cooling is guaranteed and temperature fluctuation is little, and the cold-producing medium pre-cooling is more abundant, freezing stable performance.2, after pre-cooling was finished, refrigeration plant was shut down and is not worked, and can finish the cold-producing medium precooling process equally, reduced the noise in ward, guaranteed the continual smooth implementation of operation simultaneously.3, the use of cool storage material descends the vaporizer refrigeration duty peak value of refrigeration plant, and the moisture in the soil that reduces refrigeration system increases, and has guaranteed the reliable and stable of refrigeration system operation.4, Jia Gong technological requirement is lower.5, can set the cold-storage heat-exchanger temperature fluctuation range, lean on the start-stop of refrigeration plant that cold-storage heat-exchanger is ready for a long time, operation can be carried out at any time.When firing equipment was worked, the heat of its generation was stored in the heat-storing material, by refrigerant line the heat release that stores was taken out of with the heating and cooling agent during operation.
With respect to prior art, after the present invention used cold-storage heat-exchanger that the cold-producing medium of certain pressure is pre-chilled to uniform temperature, the low temperature by cold-hot probe or catheter head killed the pathological tissues cell.During operation cold-hot probe or conduit percutaneous or open surgery under the ultrasonic image guiding are inserted into the pathological tissues position.Can be used for urology department, oncology, department of dermatologry, gynecological, thoracic surgery, rectum section, department of general surgery, neurosurgery, department of otorhinolaryngology.Present device band cold-storage device, avoided the instability of refrigeration performance, use the room temperature cold-producing medium of certain pressure, avoided high pressure argon (40MPa) expensively, difficult obtain, problem such as transportation difficulty, problems such as the cryoprobe footpath that present device has also been avoided low temperature liquid nitrogen to carry and caused is thick, operation inconvenience.
Description of drawings
Fig. 1 is the system diagram of the cold and hot ablation equipment of band cold-storage and thermal storage device of the present invention.
Wherein: 1 is cryogen vessel; 2 is refrigeration plant; 3 is the refrigeration plant vaporizer; 4 is cold-storage heat-exchanger; 5 is cool storage material; 6 is firing equipment; 7 is heating tube; 8 is regenerative heat exchanger; 9 is heat-storing material; 10 is cold-hot probe or conduit; 11 for advancing air cooled lamp; 12 are the air inlet heat pipe.
The specific embodiment
For clearlyer understanding purpose, characteristics and the advantage of this patent, preferred embodiment of the present invention is described in detail below with reference to accompanying drawing.
Be a kind of cold and hot ablation equipment that a preferred embodiment of the present invention proposes as shown in Figure 1 with the cold-storage and thermal storage device, comprise cryogen vessel 1, gas main and cold-hot probe or conduit 10, cryogen vessel 1 links to each other with the gas main, the gas main is divided into two pipelines, article one, with advance air cooled lamp 11 and link to each other, article one, link to each other with air inlet heat pipe 12, link to each other with cold-hot probe or conduit 10 after 12 two pipelines of air cooled lamp 11 and the air inlet heat pipe that passes from regenerative heat exchanger 8 accumulate an air inlet pipe from advancing of passing of cold-storage heat-exchanger 4.
As shown in Figure 1, cold-storage heat-exchanger 4 is the closed cavity of shell insulation, and comprising refrigeration plant vaporizer 3 being arranged and advancing air cooled lamp 11, intracavity also is filled with cool storage material 5, and cool storage material 5 fully is surrounded on refrigeration plant vaporizer 3 and advances around the air cooled lamp 11; The two ends of refrigeration plant vaporizer 3 link to each other with refrigeration plant 2.
As shown in Figure 1, regenerative heat exchanger 8 is the closed cavity of shell insulation, and comprising heating tube 7 and air inlet heat pipe 12 are arranged, intracavity also is filled with heat-storing material 9, and heat-storing material 9 fully is surrounded on around heating tube 7 and the air inlet heat pipe 12; Heating tube 7 two ends link to each other with firing equipment 6.
Work process below in conjunction with the description of drawings present device.
As shown in Figure 1, the cold-producing medium of certain pressure, as argon, nitrogen, carbon dioxide or nitrous oxide, or the mist of above-mentioned two kinds or multiple gases, draw after the gas main is divided into two pipelines from cryogen vessel 1: one after cold-storage heat-exchanger 4 pre-coolings again to cold-hot probe or conduit 10 heads; Another pipeline is heating or rewarming pipeline, arrives cold-hot probe or conduit 10 front ends through regenerative heat exchanger 8.
When the process of cold-storage is refrigeration plant 2 work, the refrigeration working medium of refrigeration plant 2 cools off cool storage material 5 (can adopt commercially available common sensible heat, latent heat, magnetic or macromolecule cold accumulation material) by refrigeration plant vaporizer 3, cool storage material 5 produces sensible heat or latent heat changes, this moment, cool storage material 5 absorbed a large amount of colds, advanced air cooled lamp 11 by the cold that discharges cool storage material 5 with pre-cooling during operation.
When the process of accumulation of heat is firing equipment 6 work, the heat that heating tube 7 is produced is stored in heat-storing material 9 (can adopt commercially available common sensible heat, latent heat, magnetic or macromolecule heat-storing material) lining, by heat-storing material 9 the heat release that stores is taken out of with heating air inlet heat pipe 12 during operation.In cold-storage heat-exchanger 4, regenerative heat exchanger 8 and cold-hot probe or the conduit 10 the thermometric temperature sensor is housed all.
In the present embodiment, refrigeration plant 2 is the equipment of commercially available common cooled to 300K to 0K, the ultra cold storage freezer of the model Ultima-IITM that produces as U.S. REVCO company.By the cooling of refrigeration plant 2, can make cool storage material 5 temperature be reduced to 300K to 0K.Because the external world is an adiabatic environment, cool storage material 5 can keep this temperature range long period.When needs cooled off into air cooled lamp 11, cool storage material 5 can advance air cooled lamp 11 by the mode pre-cooling of heat exchange with the cold that stores, and made that gas cooled is to 300K to 0K in the pipe.
In the present embodiment, firing equipment 6 is the equipment of commercially available common be warmed up to 300K to 500K, and the model of producing as the rich farsighted omeprazole in Wuxi Electric Applicance Co., Ltd is the electric heater of ECH2.5/2-0.3.By the intensification of firing equipment 6, can make heat-storing material 9 temperature be increased to 300K to 500K.Because the external world is an adiabatic environment, heat-storing material 9 can keep this temperature range long period.When needs heating air inlet heat pipe 12, heat-storing material 9 can make the interior gas heating of pipe to 300K to 500K the heat that the stores mode pre-heating intaking heat pipe 12 by heat exchange.
Be input to cold-hot probe or conduit 10 coolings or intensification behind the cold-producing medium process cold-storage heat-exchanger 4 of certain pressure or the regenerative heat exchanger 8, reach the purpose of treatment pathological tissues.The means of pre-cooling be with cold-storage heat-exchanger in cool storage material carry out heat exchange.During operation cold-hot probe or conduit 10 percutaneous or open surgery under the ultrasonic image guiding are inserted into the pathological tissues position, pathological tissues is killed.
Below the present invention is specified, but the present invention is not limited to described embodiment, those of ordinary skill in the art also can make all modification that is equal to or replacement under the prerequisite of spirit of the present invention, modification that these are equal to or replacement all are included in the application's claim institute restricted portion.
Claims (10)
1, a kind of cold and hot ablation equipment with the cold-storage and thermal storage device, comprise cryogen vessel, gas main and cold-hot probe or conduit, it is characterized in that, cryogen vessel links to each other with the gas main, the gas main is divided into two pipelines, article one, with advance air cooled lamp and link to each other, one links to each other with the air inlet heat pipe, links to each other with cold-hot probe or conduit after two pipelines of air cooled lamp and the air inlet heat pipe that passes from regenerative heat exchanger accumulate an air inlet pipe from advancing of passing of cold-storage heat-exchanger.
2, the cold and hot ablation equipment of band cold-storage and thermal storage device according to claim 1 is characterized in that, the cold-producing medium of depositing in the cryogen vessel is argon, nitrogen, carbon dioxide or nitrous oxide, or the mist of above-mentioned two kinds or multiple gases.
3, the cold and hot ablation equipment of band cold-storage and thermal storage device according to claim 1, it is characterized in that, cold-storage heat-exchanger is the closed cavity of shell insulation, comprising the refrigeration plant vaporizer being arranged and advancing air cooled lamp, intracavity also is filled with cool storage material, and cool storage material fully is surrounded on the refrigeration plant vaporizer and advances around the air cooled lamp; The two ends of refrigeration plant vaporizer link to each other with refrigeration plant; Refrigeration plant is for cooling to the equipment of 300K to 0K.
4, the cold and hot ablation equipment of band cold-storage and thermal storage device according to claim 3 is characterized in that, cool storage material is sensible heat, latent heat, magnetic or macromolecule cold accumulation material.
5, the cold and hot ablation equipment of band cold-storage and thermal storage device according to claim 3 is characterized in that, the refrigeration plant vaporizer in the cold-storage heat-exchanger and advance the air cooled lamp staggered floor and alternately lay.
6, the cold and hot ablation equipment of band cold-storage and thermal storage device according to claim 1 is characterized in that, temperature sensor all is housed in cold-storage heat-exchanger, regenerative heat exchanger and cold-hot probe or the conduit.
7, the cold and hot ablation equipment of band cold-storage and thermal storage device according to claim 1, it is characterized in that regenerative heat exchanger is the closed cavity of shell insulation, comprising heating tube and air inlet heat pipe are arranged, intracavity also is filled with heat-storing material, and heat-storing material fully is surrounded on around heating tube and the air inlet heat pipe; The heating tube two ends link to each other with firing equipment; Firing equipment is for being heated to the equipment of 300K to 500K.
8, the cold and hot ablation equipment of band cold-storage and thermal storage device according to claim 7 is characterized in that, heat-storing material is sensible heat, latent heat, magnetic or macromolecule heat-storing material.
9, the cold and hot ablation equipment of band cold-storage and thermal storage device according to claim 7 is characterized in that, heating tube and air inlet heat pipe staggered floor are alternately laid.
According to the cold and hot ablation equipment of claim 1 or 3 or 7 described band cold-storage and thermal storage devices, it is characterized in that 10, polyurethane foam or asbestos cloth insulation are all adopted in cold-storage heat-exchanger outside and regenerative heat exchanger outside.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008100432264A CN101554338A (en) | 2008-04-08 | 2008-04-08 | Cold and hot ablation apparatus with cold and heat accumulation devices |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008100432264A CN101554338A (en) | 2008-04-08 | 2008-04-08 | Cold and hot ablation apparatus with cold and heat accumulation devices |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101554338A true CN101554338A (en) | 2009-10-14 |
Family
ID=41172723
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2008100432264A Pending CN101554338A (en) | 2008-04-08 | 2008-04-08 | Cold and hot ablation apparatus with cold and heat accumulation devices |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101554338A (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102274072A (en) * | 2011-05-03 | 2011-12-14 | 张子生 | Breast tumor treatment instrument based on gas injection method |
| CN103549992A (en) * | 2013-11-22 | 2014-02-05 | 上海导向医疗系统有限公司 | Mixed gas feeder of target knife and method for controlling cooling capacity output |
| CN104302255A (en) * | 2012-03-12 | 2015-01-21 | Djo有限责任公司 | Systems and methods for providing temperature-controlled therapy |
| CN105852960A (en) * | 2016-04-11 | 2016-08-17 | 赵国江 | Gas throttle type cryosurgical device and method for controlling same |
| CN107576124A (en) * | 2017-08-16 | 2018-01-12 | 中国科学院理化技术研究所 | A kind of low-temperature circulating system |
| CN110411118A (en) * | 2019-07-31 | 2019-11-05 | 上海交通大学 | A kind of ultra-low temperature cold source material and preparation method thereof |
-
2008
- 2008-04-08 CN CNA2008100432264A patent/CN101554338A/en active Pending
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102274072A (en) * | 2011-05-03 | 2011-12-14 | 张子生 | Breast tumor treatment instrument based on gas injection method |
| CN104302255A (en) * | 2012-03-12 | 2015-01-21 | Djo有限责任公司 | Systems and methods for providing temperature-controlled therapy |
| CN103549992A (en) * | 2013-11-22 | 2014-02-05 | 上海导向医疗系统有限公司 | Mixed gas feeder of target knife and method for controlling cooling capacity output |
| CN103549992B (en) * | 2013-11-22 | 2015-07-29 | 上海导向医疗系统有限公司 | The method that targeting cutter mist feeder and control cold export |
| CN105852960A (en) * | 2016-04-11 | 2016-08-17 | 赵国江 | Gas throttle type cryosurgical device and method for controlling same |
| CN105852960B (en) * | 2016-04-11 | 2018-07-06 | 天津美电医疗科技有限公司 | Gas throttling type cryosurgical device and control method thereof |
| CN107576124A (en) * | 2017-08-16 | 2018-01-12 | 中国科学院理化技术研究所 | A kind of low-temperature circulating system |
| CN110411118A (en) * | 2019-07-31 | 2019-11-05 | 上海交通大学 | A kind of ultra-low temperature cold source material and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US9345527B2 (en) | Method and system for cryoablation treatment | |
| CN1935096A (en) | Nitrogen precooled throttling tumour ultra low temperature therapeutical system | |
| CN102596119B (en) | Cryotreatment device using a supercritical gas | |
| US5254116A (en) | Cryosurgical instrument with vent holes and method using same | |
| ES2357878T3 (en) | CRIOQUIRURGICAL SYSTEM. | |
| US5520682A (en) | Cryosurgical instrument with vent means and method using same | |
| CN101584602A (en) | Multi-stage precooling cryoablation method and equipment | |
| CN101554338A (en) | Cold and hot ablation apparatus with cold and heat accumulation devices | |
| CN109009406B (en) | Cryoablation device and cryoablation method | |
| CN1935097A (en) | Nitrogen precooled throttling tumour ultra low temperature therapeutical system | |
| CN103079487A (en) | Heating and cooling of cryosurgical instrument using a single cryogen | |
| CN101292897A (en) | Cold-hot probe therapy system | |
| CN107951558B (en) | Multifunctional gas pipeline controlled cryoablation system | |
| JP7085255B2 (en) | Refrigeration equipment | |
| CN202044338U (en) | Self-sustained integral device of cold knife and hot knife for oncotherapy | |
| CN201519191U (en) | Freeze melting device with independent pre-cooling device | |
| CN201631375U (en) | Precooling device for ultralow temperature cryotherapy system | |
| CN109480999B (en) | Double-stage cryoablation system | |
| CN105902310A (en) | Cryosurgery device capable of achieving freezing and rewarming by adjusting gas pressure | |
| CN1212103C (en) | Circumferentia weld throttling type cryoprobe | |
| CN201085682Y (en) | Low-temperature precooling device of cold therapy instrument | |
| CN2726546Y (en) | Cryoprobe for target treatment for human tumor | |
| CN105852960B (en) | Gas throttling type cryosurgical device and control method thereof | |
| US8298220B2 (en) | Cryoprobe with coaxial chambers | |
| CN204618397U (en) | A kind of cryotherapy probe |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Open date: 20091014 |