CN1212103C - Circumferentia weld throttling type cryoprobe - Google Patents
Circumferentia weld throttling type cryoprobe Download PDFInfo
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- CN1212103C CN1212103C CN 02149355 CN02149355A CN1212103C CN 1212103 C CN1212103 C CN 1212103C CN 02149355 CN02149355 CN 02149355 CN 02149355 A CN02149355 A CN 02149355A CN 1212103 C CN1212103 C CN 1212103C
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Abstract
The present invention relates to a circumferential seam throttling type freezing probe. A connecting joint communicated with a high-pressure gas source is led out from a host machine of a cryosurgery treatment machine, and enters an inner cavity of a handle by a connecting conduit, and the connecting joint is communicated with a probe communicated with the handle. The probe comprises a probe rod, a return pipe and a heat insulation sleeve pipe, wherein the return pipe and the heat insulation sleeve pipe are arranged in the probe rod and are orderly placed in a concentric mode from a shaft center point to outside, the heat insulation sleeve pipe is shorter than the return pipe, an annular seam which has a high-pressure gas throttling function and a gas regeneration function is formed between the heat insulation sleeve pipe and the return pipe, an annular heat exchange seam is formed between the front end of the return pipe and the probe rod, airflows can quickly flow in the annular heat exchange seam to enhance heat exchange effect, a cylinder (II) is formed between the inner part of the probe head and the front end of the return pipe, a galvanic couple type temperature sensor connected with a temperature meter can also be arranged on the front end of the return pipe, the front end of the cylinder (II) is provided with a finned type regenerator, and the head of the probe is in a tapered needle tip shape, a beveling needle tip shape or a round head needle tip shape. The present invention has the advantages of small diameter and wound, simple structure, easy manufacture, low cost, etc.
Description
Invention field
The invention belongs to and be used to cool off the body local tissue in the surgical operation, to reach the surgical operating instrument of destruction cancerous cell or benign tumor cells, neural temporary interruption, be used to destroy the circumferential weld throttle type cryoprobe of cancerous cell or benign tumor cells in particularly a kind of surgical operation.
Background technology
By frozen cell active mass's structure is carried out destructive surgical operation and be normally used for destroying cancerous cell and benign tumor cells.Cryosurgery also is used to neural temporary interruption and operates on operation back aim of alleviating pain in the regular hour to reach.With respect to operating on operation, the cryosurgery operation has many advantages: quick, almost painless, need not local anesthesia, and the risk of no postoperative infection stays cicatrix hardly.
Cause the mechanism of cytoclasis to be by cryosurgery:
If 1 tissue is slowly cooled, cell can lose moisture content in a large number, makes harmful electrolyte concentration raising in the cell, causes tissue necrosis;
If 2 tissues are cooled off fast, will form many and small ice crystal, make the ice crystal refinement, this moment, cell was not fragile.But in melting process, if ice to the phase transformation of water too soon, all ice crystals are by brief melting.If thawing speed lowers, the ice crystal that takes place to have melted will be cooled off its tissue on every side, thereby make some water form ice once more, recrystallization process will make some ice crystals be lengthened out and form the ice cutting edge of a knife or a sword, ice cutting edge of a knife or a sword thorn breaking cell wall causes cell death, thereby makes tissue necrosis.
When 3, metabolism continues, the supply of ice block cell nutrition and the processing of metabolite, cell death just takes place.
Surgical operation can use refrigerated source such as dry ice, liquid nitrogen to directly apply to pending tissue.The simplest method is to dip in liquid refrigerant with cotton swab, directly contacts into treatment sites with the cotton balls that soaks into cold-producing medium then, perhaps cold-producing medium is imported the metal catheter of a sealing, implements cryosurgery by metal catheter ejector refrigeration agent to application site.Yet, this method has many places of not complying with one's wishes: (1) is directly used cold-producing medium to cause and is organized quick freezing with the method for dipping in or spraying, and causes the ice crystal refinement rather than forms big ice crystal, cell is not easy dehydration, has reduced to destroy by high electrolysis concentration the generation of cell.After cold-producing medium left, heat froze organized delivery to quilt again in health, caused melting relatively fast, should not form the ice cutting edge of a knife or a sword, thereby had reduced the cell degree that wrecks that makes.Directly using cold-producing medium is the size of uncontrollable freezing area in the greatest problem of local organization, uncontrollable freezing degree, cooling time and heating-up time.
Cooper at first used liquid nitrogen as low-temperature receiver in 1961, adopted the metallic conduit of liquid nitrogen by sealing, flow to the tip of pipe under certain pressure, by the vaporization cooling effect of liquid nitrogen the local temperature of enduring cold was fallen and reach about-190 ℃.He has treated 100 routine parkinson with this device.
The operating theater instruments of using liquid nitrogen to make as low-temperature receiver is widely used.Particularly in the department of dermatologry for the treatment of nevus class, acne, freckle, wart etc.Yet the liquid nitrogen hypothermy unit tool in many aspects can not be satisfactory.At first, because the liquid nitrogen freezing probe is made of three concentric tubees, the center is that liquid nitrogen is input into pipe, and the centre is the gas concentric pipe ring clevis layer that backflows, and most external is a vacuum heat-preserving concentric tube annular gap.Like this, liquid nitrogen is only applicable to big cryoprobe, and for less freezing head, liquid nitrogen serious problems can occur in the most advanced and sophisticated evaporation of freezing head: owing to return from the tip, discharge nitrogen all around makes the part liquid nitrogen heating, can make the liquid nitrogen vaporization in the supply pipe.This is that liquid nitrogen partly evaporates formation gas in the supply pipe and make because the nitrogen of discharging than the liquid nitrogen temperature height in the supply pipe, has formed counter current heat exchange, hinders the nitrogen bubble that liquid nitrogen flows to the tip and form.Increasing liquid nitrogen pressure or reduction liquid nitrogen temperature can make liquid nitrogen supercool, thereby address this problem.But this makes system more complicated again; Secondly, liquid nitrogen uses inconvenient, the equipment complicated operation.
As coolant, rely on Jiao Er-refrigerating method of Thomson throttle effect to be subject to people's attention and to welcome with gas.Can produce refrigeration effect after gases such as high pressure oxygen, nitrogen and carbon dioxide under the room temperature throttling pore of flowing through, gas expansion and be called Jiao Er-Thomson throttle effect.Patent GB-2,337,000 utilizes this principle and the cold therapy machine invented, its structure is that gases at high pressure flow through from the tubule of innermost layer, head at probe has a throttling pore, gas reduces by throttle temperature, yet the shank of this cryoprobe is at low temperature state all, can not satisfy the requirement of some operation, particularly for the percutaneous cold therapy, except the needle point of cryoprobe, other parts of probe must the temperature remains within the normal range, otherwise, will cause the normal structure cold injury outside the operation application site.Longsworth has designed a serpentine pipe recuperative heat exchanger in cryoprobe in 1994, patent US-5,452,582, its structure is for as shown in Figure 6, one serpentine pipe is arranged in probe, and gases at high pressure are passed by in the pipe of serpentine pipe, become low-pressure low-temperature gas at end of probe gas after orifice restriction.Low-temp low-pressure gas skims over from the outside of serpentine pipe, thereby serpentine pipe becomes a recuperative heat exchanger, make reflux gas constantly heat up, and charge air flow can obtain pre-cooling effectively, thereby, make the temperature of probe along shank direction formation temperature gradient, the needle tip temperature at of probe is minimum, and probe is almost room temperature near the position of handle.Mikus etc. have further developed this invention, patent US-58000487, its structure is for as shown in Figure 7, they not only adopt finned serpentine pipe to increase heat exchange efficiency, and, also designed the heat-insulation layer of adiabator in the outside of heat exchanger, thereby make probe shank outside near room temperature, but this finned helix tube type probe, because built-in spiral tube exchanger, probe diameter can not be done very for a short time, does not satisfy the demand (freezing minimally invasive surgery needs diameter is 2mm or littler probe) of freezing minimally invasive surgery.
Summary of the invention
The objective of the invention is to overcome the existing defective of restriction of said structure complexity and serpentine pipe diameter, and the diameter that provides a kind of cooling to freeze operation usefulness is littler, the cryoinstrument of effect-circumferential weld throttle type cryoprobe is hindered by the Wicresoft that has that wound is littler, hinder cryosurgical requirement thereby satisfy Wicresoft, and its structure simple more, make easily, price is cheaper.
Technical scheme of the present invention is as follows:
Cryoprobe provided by the invention, comprise jointing 111, connecting duct 222, handle 333 and probe 444, the jointing 111 that is communicated with high-pressure air source is drawn from the main frame of cryosurgical treatment machine, enter inner chamber in the handle 333 by connecting duct 222, and be connected with the probe 444 that is connected with handle 333, it is characterized in that, described probe 444 comprises probe rod 777, be positioned within the probe rod 777 and and locate outwards concentric successively return duct 999 and the insulation casing of placing 888 by the axle center of probe rod 777, the length that is shorter in length than return duct 999 of insulation casing 888, between insulation casing 888 and return duct 999, form the narrow annular channel 771 of the dual function that plays gases at high pressure throttling and gas backheat, form between return duct 999 leading sections and the probe rod 777 air-flow is flowed therein fast to strengthen the heat exchange narrow annular channel 772 of heat exchange effect, formation cylinder II in probe 444 heads and between return duct 999 leading sections; Also can further comprise the galvanic couple formula temperature sensor 122 that is installed on return duct 999 front end side wall, the lead 123 of galvanic couple formula temperature sensor 122 passes the inner chamber of return duct 999 and links to each other with thermometric instrument 125 through handle 333, connecting duct 222 and a threeway 124 successively; The front end of described cylinder II is equipped with finned regenerator 121, and its fin shape is thread-shaped or profile of tooth; Described probe 444 nose shapes are the taper tip-like, the shape tip-like of cutting sth. askew or knob shape tip-like; The probe rod 777 of described probe 444 is flexible reinforcement polyamide hose, and its diameter is between 1.2-5mm, and length is between 100-1500mm; The material of described insulation casing 888 is the low nonmetallic materials of thermal conductivity, plastics or the fiberglass low as thermal conductivity; The length of described heat exchange narrow annular channel 772 is between 3～30mm, and the gap is between 0.05-0.3mm; The length of described narrow annular channel 771 is that the gap is between 0.01-0.02mm between 100～1450mm; The material of described return duct 999 is the high metal material of thermal conductivity, as red copper or rustless steel.
During use, high-pressure air source is drawn from the main frame of cryosurgical treatment machine by jointing 111, enters in the handle 333 through connecting duct 222 then, carries out in handle 333 after the source of the gas distribution, and source of the gas flows to probe 444; In handle 333, distribute later source of the gas, flow to the narrow annular channel 771 that forms by insulation casing 888 and return duct 999; Because there is viscosity in gas, gas will form pressure differential when flowing between the import of slit and outlet, thereby the specific volume of gas will increase suddenly before and after slit, realize joule-Thomson throttle effect, reach the purpose that gas refrigeration is lowered the temperature.The space that cryogenic gas after expanding is surrounded between by probe rod 777, probe rod head 110 and return duct 999 is in the cylinder II cold to be passed to the probe rod head, return handle 333 from return duct 999 at last, with tailing edge connecting duct 222, return the main frame of cryosurgical treatment machine through distribution of air flow by jointing 111.
The heat transfer of slit recuperative heat exchanger is that the tube wall thermal conductance by return duct realizes.High temperature side: the incoming flow gas in the slit passes through the tube wall of the mode of gaseous exchange with the heat transferred return duct; Low temperature is surveyed: tube wall will pass to the interior reflux gas of pipe by the mode of convection current again by the heat that high temperature side passes over.The temperature of high temperature side reduces like this, and the temperature of low temperature side improves, thereby has realized backheat;
The effect of backheat mainly contains 3 points: the first reduces the temperature of incoming flow gas, thereby makes that the later temperature of expansion is lower; It two is to improve refrigerating capacity, reduces air consumption; It three is axial direction formation temperature gradients along shank: far away more from needle point, the temperature of shank is high more, and this will be very beneficial for the cryosurgical enforcement of percutaneous;
So cryoprobe provided by the invention has simple in structure, be easy to make, the diameter of probe can be done littler and also only end of probe be in low temperature state below 0 ℃, other positions of shank all are higher than 0 ℃, thereby realize that really probe is little, and operation Wicresoft hinders.
Description of drawings
Accompanying drawing 1 and accompanying drawing 2 are respectively structural representation of the present invention;
Accompanying drawing 3 and accompanying drawing 4 are respectively the structural representation of probe 444;
Accompanying drawing 5-1, accompanying drawing 5-2 and accompanying drawing 5-3 are respectively the structural representation of difformity end of probe 110;
Accompanying drawing 6 is the structural representation of US 5,452,582 in the prior art;
Accompanying drawing 7 is the structural representation of US 5,800,488 in the prior art;
Wherein: jointing 111 connecting ducts 222 handles 333
Cylinder II galvanic couple formula temperature sensor 122
Finned regenerator 122 galvanic couple formula temperature sensor wires 123
The label of each parts is as follows in the accompanying drawing 6:
Room temperature end 16 long plastic tube 18 heat exchangers 20
Gases at high pressure air inlet pipe 22 cold head territories 26 capillary tubies 28
Heat exchanger 33 temperature sensors 34 finned tubes 35
Second temperature sensor 36
The label of each parts is as follows in the accompanying drawing 7::
High-pressure pipe 14 drainage tubes 19 heat exchangers 20
21 joules-Thomson of cooling fluid port of export nozzle, 22 expansion chambers 23
End plug 24 axles 25 gaps 26
Thermocouple 29
The specific embodiment
Further describe the present invention below in conjunction with drawings and Examples:
By Fig. 1-4 as can be known, cryoprobe provided by the invention, comprise jointing 111, connecting duct 222, handle 333 and probe 444, the jointing 111 that is communicated with high-pressure air source is drawn from the main frame of cryosurgical treatment machine, enter inner chamber in the handle 333 by connecting duct 222, and be connected with the probe 444 that is connected with handle 333, it is characterized in that, described probe 444 comprises probe rod 777, be positioned within the probe rod 777 and and locate outwards concentric successively return duct 999 and the insulation casing of placing 888 by the axle center of probe rod 777, the length that is shorter in length than return duct 999 of insulation casing 888, between insulation casing 888 and return duct 999, form the narrow annular channel 771 of the dual function that plays gases at high pressure throttling and gas backheat, form between return duct 999 leading sections and the probe rod 777 air-flow is flowed therein fast to strengthen the heat exchange narrow annular channel 772 of heat exchange effect, formation cylinder II in probe 444 heads and between return duct 999 leading sections; Also can further comprise the galvanic couple formula temperature sensor 122 that is installed on return duct 999 front end side wall, the lead 123 of galvanic couple formula temperature sensing 122 passes the inner chamber of return duct 999 and links to each other with thermometric instrument 125 through handle 333, connecting duct 222 and a threeway 124 successively; The front end of described cylinder II is equipped with finned regenerator 121, and its fin shape is thread-shaped or profile of tooth; Described probe 444 nose shapes are the taper tip-like, the shape tip-like of cutting sth. askew or knob shape tip-like; The probe rod 777 of described probe 444 is flexible reinforcement polyamide hose, and its diameter is between 1.2-5mm, and length is between 100-1500mm; The material of described insulation casing 888 is the low nonmetallic materials of thermal conductivity, plastics or the fiberglass low as thermal conductivity; The length of described heat exchange narrow annular channel 772 is between 3～30mm, and the gap is between 0.05-0.3mm; The length of described narrow annular channel 771 is that the gap is between 0.01-0.02mm between 100～1450mm; The material of described return duct 999 is the high metal material of thermal conductivity, as red copper or rustless steel.
Shown in Fig. 5-1, Fig. 5-2, Fig. 5-3, the shape of end of probe 110 can be according to the tapered tip-like of purposes different designs, the shape tip-like of cutting sth. askew or knob shape tip-like.
As shown in Figure 4,, a finned heat exchanger 121 can be installed in cylinder II, to increase heat exchange area and increase degree of disturbing, to strengthen heat exchange for increasing the heat exchange effect.
As shown in Figure 4, can be in return duct a prefabricated thermocouple temperature sensor 122, the lead-in wire 123 of thermocouple temperature sensor 122 passes and links to each other with thermometric instrument 125 on the cold therapy machine through handle 333, connecting duct 222 and threeway 124 successively from the inner chamber of return duct 999.Temperature with gas in the measuring probe head 110.
As shown in Figure 2, cryoprobe bar 777 can be made flexible, for example adopts and strengthens polyamide hose as probe shank material.
At a probe rod diameter is among the embodiment of 2mm or 5mm, probe length 400mm (can do to such an extent that grow " can grow to 1500mm " as required, also can do shortly " can be as short as 100mm), probe rod is selected the 1Cr18Ni9Ti material for use; Insulation casing is selected the polytetrafluoroethylmaterial material of excellent heat insulating performance for use, wall thickness 0.3mm.The probe rod head 110 of cryoprobe is made the shape of the syringe needle of cutting sth. askew.
In another embodiment, the probe rod diameter is 1.2mm, probe length 260mm.Probe rod is selected the 1Cr18Ni9Ti material for use; Insulation casing is selected polytetrafluoroethylmaterial material for use, wall thickness 0.2mm; The probe rod head of cryoprobe is made the shape of tapered needle.
In one embodiment, the cryosurgical treatment machine adopts the high pressure argon as cold coal, by joule-Thomson throttling refrigeration, by the mode of slit backheat of the present invention heat exchange, on the head of cryoprobe, can obtain-120 ℃ low temperature, and the temperature on the probe rod is higher than 0 ℃.
In another embodiment, the cryosurgical treatment machine adopts saturated carbon dioxide as cold coal, by joule-Thomson throttling refrigeration, can obtain-75 ℃ low temperature on the head of cryoprobe, and the temperature on the probe rod is higher than 0 ℃.
Claims (10)
1, a kind of circumferential weld throttle type cryoprobe, comprise jointing (111), connecting duct (222), handle (333) and probe (444), the jointing (111) that is communicated with high-pressure air source is drawn from the main frame of cryosurgical treatment machine, enter the interior inner chamber of handle (333) by connecting duct (222), and with and the probe (444) that is connected of handle (333) be connected, it is characterized in that, described probe (444) comprises probe rod (777), be positioned within the probe rod (777) and and locate outwards concentric successively return duct (999) and the insulation casing of placing (888) by the axle center of probe rod (777), the length that is shorter in length than return duct (999) of insulation casing (888), between insulation casing (888) and return duct (999), form the narrow annular channel (771) of the dual function that plays gases at high pressure throttling and gas backheat, form between return duct (999) leading section and the probe rod (777) and make mobile fast therein the heat exchange narrow annular channel (772) of air-flow, in probe (444) head and between return duct (999) leading section, form cylinder (II) with enhancing heat exchange effect.
2, by the described circumferential weld throttle type of claim 1 cryoprobe, it is characterized in that, also comprise the galvanic couple formula temperature sensor (122) that is installed on return duct (999) front end side wall, its lead (123) passes the inner chamber of return duct (999) and passes through handle (333), connecting duct (222) and a threeway (124) successively and links to each other with thermometric instrument (125).
3, by claim 1 or 2 described circumferential weld throttle type cryoprobes, it is characterized in that the front end of described cylinder (II) is equipped with finned regenerator (121), its fin shape is thread-shaped or profile of tooth.
By claim 1 or the 2 described circumferential weld throttle type cryoprobes that are used to cool off the body local tissue, it is characterized in that 4, described probe (444) nose shape is the taper tip-like, the shape tip-like of cutting sth. askew or knob shape tip-like.
By claim 1 or 2 described circumferential weld throttle type cryoprobes, it is characterized in that 5, the probe rod (777) of described probe (444) is flexible reinforcement polyamide hose, its diameter is between 1.2-5mm, and length is between 100-1500mm.
6, by claim 1 or 2 described circumferential weld throttle type cryoprobes, it is characterized in that the material of described insulation casing (888) is the low nonmetallic materials of thermal conductivity.
7, by claim 1 or 2 described circumferential weld throttle type cryoprobes, it is characterized in that the material of described insulation casing (888) is low plastics of thermal conductivity or fiberglass.
8, by claim 1 or 2 described circumferential weld throttle type cryoprobes, it is characterized in that the length of described heat exchange narrow annular channel (772) is that the gap is between 0.05-0.3mm between 3～30mm.
9, by claim 1 or 2 described circumferential weld throttle type cryoprobes, it is characterized in that the material of described return duct (999) is the high metal material of thermal conductivity.
10, by claim 1 or 2 described circumferential weld throttle type cryoprobes, it is characterized in that the length of described narrow annular channel (771) is that the gap is between 0.01-0.2mm between 100～1450mm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02149355 CN1212103C (en) | 2002-09-03 | 2002-11-13 | Circumferentia weld throttling type cryoprobe |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN02129542.5 | 2002-09-03 | ||
| CN02129542 | 2002-09-03 | ||
| CN 02149355 CN1212103C (en) | 2002-09-03 | 2002-11-13 | Circumferentia weld throttling type cryoprobe |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1480103A CN1480103A (en) | 2004-03-10 |
| CN1212103C true CN1212103C (en) | 2005-07-27 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 02149355 Expired - Fee Related CN1212103C (en) | 2002-09-03 | 2002-11-13 | Circumferentia weld throttling type cryoprobe |
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| Country | Link |
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| CN (1) | CN1212103C (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023111949A1 (en) * | 2021-12-15 | 2023-06-22 | Metrum Cryoflex Sp. z. o. o., Sp. k. | A cryosurgical probe and method of manufacturing thereof |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100408001C (en) * | 2005-04-14 | 2008-08-06 | 北京库蓝医疗设备有限公司 | Disposable freezing probe |
| CA2739072A1 (en) * | 2008-04-01 | 2009-12-03 | The General Hospital Corporation | Method and apparatus for cooling biological tissue |
| US7967815B1 (en) * | 2010-03-25 | 2011-06-28 | Icecure Medical Ltd. | Cryosurgical instrument with enhanced heat transfer |
| CN101893357A (en) * | 2010-07-26 | 2010-11-24 | 雷宜东 | Three-way throttle valve |
| US9108453B2 (en) | 2011-11-23 | 2015-08-18 | R.R. Donnelley & Sons Company | Sortable notepad |
| US8864177B2 (en) | 2011-11-23 | 2014-10-21 | Esselte Corporation | Movable highlight strip |
| US10390871B2 (en) * | 2015-02-20 | 2019-08-27 | Galil Medical Inc. | Cryoneedle |
| CN109237835B (en) * | 2018-09-27 | 2024-03-12 | 厦门理工学院 | Handheld dry ice filler |
| CN110236670A (en) * | 2019-06-21 | 2019-09-17 | 深圳市吉斯迪科技有限公司 | A kind of probe and the therapeutic device using the probe |
| CN110327109B (en) * | 2019-08-13 | 2024-09-13 | 上海导向医疗系统有限公司 | Adjustable cryoablation needle |
| CN114098943A (en) * | 2020-08-28 | 2022-03-01 | 深圳钮迈科技有限公司 | Single-pole air-cooling probe |
-
2002
- 2002-11-13 CN CN 02149355 patent/CN1212103C/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023111949A1 (en) * | 2021-12-15 | 2023-06-22 | Metrum Cryoflex Sp. z. o. o., Sp. k. | A cryosurgical probe and method of manufacturing thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1480103A (en) | 2004-03-10 |
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