CN101292897A - Cold and hot probe treatment system - Google Patents
Cold and hot probe treatment system Download PDFInfo
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- CN101292897A CN101292897A CNA2007100987352A CN200710098735A CN101292897A CN 101292897 A CN101292897 A CN 101292897A CN A2007100987352 A CNA2007100987352 A CN A2007100987352A CN 200710098735 A CN200710098735 A CN 200710098735A CN 101292897 A CN101292897 A CN 101292897A
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Abstract
The invention relates to a cold and hot probe treatment system, which comprises a working medium output device, a probe tube and a probe head, wherein the probe tube is tightly connected with the probe head, an incoming flow channel is arranged in the probe tube, one end of the incoming flow channel is communicated with the working medium output channel of the working medium output device, the other end of the incoming flow channel extends into the probe head, a backflow channel coaxial with the incoming flow channel is arranged outside the incoming flow channel, and a vacuum cavity is arranged between the outer wall of the backflow channel and the inner wall of the probe tube. The cold and hot probe treatment system also comprises a laser, an output optical fiber of the laser is connected into the probe head, the probe tube is also provided with a container cavity, and the container cavity is positioned at one end of the probe tube close to the working medium output device and is communicated with the backflow channel. The invention can conveniently realize the temperature reduction and temperature rise procedures of the needle head, and healthy tissues along the way are not damaged by cold and heat. The invention can have the double effects of deep low temperature freezing and high temperature heat treatment.
Description
Technical field
The invention belongs to technical field of medical instruments, specifically, the present invention relates to the combined type cold and hot probe device.
Background technology
The cryosurgery operation is a kind of quite effectively physiotherapy that the oncotherapy aspect emerges in recent years, its principle is by freezingly impelling the pathological tissues fast cooling, freeze and rewarming, thereby produces a series of irreversible damages and reach the method for eliminating focus.But Fa Zhan low temperature medical apparatus and instruments (cryoprobe) only possessed single cooling freezing function mostly in the past, and this can make the treatment curative effect be very limited.Recent research discloses, and by tumor being implemented after the cryogenic refrigeration destroyed tumor tissue to greatest extent of combined high-strength heating again, this becomes the starting point of developing novel minimally invasive medical equipment.
At present, can think current more advanced cold therapy device according to the argon-helium cutter of this principle invention in the world, its cutter contains two circuits at argon, helium, the technology that the quick refrigeration helium of argon then heated up rapidly when principle was to utilize throttling, thereby cause the function of rapid cooling and intensification at cutter head, by on irregular malignant tumor comprehensive constantly freezing, tumor focus thaws, to be reduced to Min. to the injury of tumor normal surrounding tissue, the effect that reach no wound, has no side effect.Yet though argon-helium cutter can be finished cooling and temperature-rise period fast, form is single relatively, and is limited by the intensification amplitude that the helium throttling realizes, the requirement that does not reach thermotherapy.In addition, owing to argon, helium source difficulty are treated large usage quantity, argon-helium cutter medical expense is very high, and argon-helium cutter need be used high tension unit, security requirement is arranged.This present situation has seriously hindered the progress of utilizing fast cooling and heating up treatment tumor new method.
Summary of the invention
The object of the present invention is to provide and a kind ofly realize by working medium absorption of fluids latent heat cooling and the compound mode by the laser release heat that big cold and big heat discharge and improve the cold and hot knife system that destroys the local tumor effect.
For this reason, the invention provides a kind of cold-hot probe therapy system, comprise the working medium output device, probe tube and probe, probe tube closely is connected with probe, it is characterized in that, be provided with circulation road in the probe tube, this comes an end of circulation road to be communicated with the working medium output channel of working medium output device and the other end extends in the probe, in probe tube, also be provided with the container chamber of return flow line and discharge backflow working medium, one end of return flow line is communicated with container chamber and the other end extends in the probe, this system also comprises laser instrument, and in the optical fiber action head access probe head of this laser instrument, the tube wall of probe tube has vacuum interlayer.
In the technique scheme, come the coaxial setting in circulation road and return flow line, the return flow line is positioned at the circulation road outside, and the vacuum interlayer of probe tube tube wall is the vacuum chamber that forms between return flow line outer wall and the probe tube inwall.
In the technique scheme, the output optical fibre of laser instrument inserts the incoming flow channel interior by the probe tube side and extends in the probe always, and the junction of its insertion is adopted and is tightly connected.
According to the present invention, the output optical fibre of laser instrument inserts in the return flow line by the probe tube side and extends in the probe always, and the junction of its insertion is adopted and is tightly connected, and output optical fibre is positioned at the described circulation road outside of coming, can be attached at central tube, also can keep certain distance with central tube.In addition, output optical fibre can adopt simple optical fiber or multifiber, when adopting multifiber, can adopt pencil to distribute or annular distribution.
In technique scheme, probe has the probe precursor, and the probe precursor is hollow cavity, is filled with Web materials in it.In addition, the probe outer wall is made greater than the material of 100W/ (mK) by thermal conductivity.In addition, the diameter of probe tube and probe is less than 6mm and greater than 1mm.
In the technique scheme, the refrigeration working medium of working medium output device is liquid cryogenic fluid, or the cryogenic fluid that forms after the gases at high pressure throttling.In the technique scheme, probe tube is provided with insulating connector near an end of working medium output device, and this insulating connector is provided with handle.In the technique scheme, probe tube and probe are threaded or are welded to each other.
The present invention has following technique effect: the invention provides a kind of fast cooling and high strength of can realizing and heat up with the cold and hot knife system of effective elimination tumor tissues, it can be easily change the tumor cooling and heat rewarming speed and the intensification level that changes probe pinpoint place tissue by means of high intensity laser beam by transporting of control internal flow working medium, realize complicated cooling and heating schedule thus, implementing on the efficient oncotherapy important value is arranged.
Structure of the present invention be mainly inner hollow and nearly wall place be the vacuum heat-insulation device can as required cryogenic fluid liquid nitrogen or laser be transported to tumor locus to be treated, and along do not catch a cold hot injury's meticulous probe therapy system of journey health tissues.
Cold-hot probe therapy system provided by the invention is a kind of cold and hot cutter armarium that has deep-frozen and the effect of high temperature thermotherapy economic benefits and social benefits concurrently.Combine the hemostasis gasification of the painless sterilization and the laser therapy of cold therapy, the cooling by cooperating between laser and the cryogen realizing the targeting lesion tissue, freeze, rewarming and hyperthermia, cause thoroughly necrosis of tissue thus.
Description of drawings
Fig. 1 is cold-hot probe therapy system figure of the present invention;
Fig. 2 is used to probe tube and the probe structural representation supplying incoming flow and transport Returning fluid for the present invention;
Fig. 2 A is an A-A profile among Fig. 2;
Fig. 2 B is a B-B profile among Fig. 2;
Fig. 2 C is a C-C profile among Fig. 2;
Fig. 2 D is a D-D profile among Fig. 2.
The Reference numeral catalog
Laser instrument 1; Probe tube 2; Probe 3; Insulation connecting leg 4; Optical fiber 5; Valve 6; Optical fiber action head 7; Dewar flask 10; Double-deck corrugated connecting tube 11; Vacuum chamber 21; Vacuum orifice 22; Return flow line 23; Come circulation road 24; Container chamber 25; Probe tube main body 27; Incoming flow channel end 31; Screw thread 32; Web materials 33 return flow line front ends 34; Probe precursor 35; Insulating connector 41; Handle 42;
The specific embodiment
Below in conjunction with the drawings and specific embodiments the present invention is done to describe further.
Embodiment 1
As shown in Figure 1, the invention provides a kind of high low temperature probe system that is used for oncotherapy, comprise laser instrument 1, probe tube 2, Dewar flask 10 and probe 3 etc., wherein laser instrument 1 coupled fiber output.In the present embodiment, refrigeration working medium is a liquid nitrogen, and the Dewar flask 10 of present embodiment is a liquid nitrogen container, chooses from the market to get final product.Probe tube 2 is served as reasons from the integrative-structure of back container chamber 25 that extremely before is arranged in order and circular probe tube body 27 formations, and circular probe tube body 27 front ends are provided with screw thread 32, and its axial centre is provided with circle hole shape and comes circulation road 24.Coming outside the circulation road 24, be provided with successively vertically that (vacuum chamber 21 is positioned at probe tube 2 and sealing with coming circulation road 24 annular return flow lines 23 concentric and that communicate with container chamber 25 (its section is seen Fig. 2 A) and ring vaccum chamber 21, can be with reference to figure 2), the tube wall of circular probe tube body 27 (its section is seen Fig. 2 B) is provided with the vacuum orifice 22 that communicates with annular vacuum chamber 21.The probe tube rear portion is connected with laser instrument 1 and Dewar flask 10, probe tube 2 front threads linking probe heads 3, probe 3 is served as reasons from the back to the annular return flow line front end 34 that before is arranged in order and the integrative-structure of probe precursor 35, its front end is circle or arc, the axial centre of probe 3 be provided with circular probe tube body 27 in the circular incoming flow channel end 31 that comes circulation road 24 to communicate, outside incoming flow channel end 31, be provided with annular fluid return flow line front end 34 (seeing profile 2C) vertically, probe precursor 35 is hollow cavity, be filled with Web materials 33 (seeing profile 2D) in it, probe 3 outer walls are selected with metal material or quartz glass.
Optical fiber inserts incoming flow channel end 31 by probe tube 2 sides, and the junction is adopted and is tightly connected.Optical fiber outer surface protective casing 5 adopts FEP (fluorinated ethylene propylene (FEP)) material, and machinery is more stable with thermal parameter.In order to guarantee that optical fiber action head 7 and tissue boundary can obtain isotropic heat radiation light, need remove the jacket layer of optical fiber 5 terminals, and adopt etching technique to produce successive emitting surface.Because etched fiber is comparatively responsive to mechanical stress, working position adopting quartz glass or diamond probe 3 can play the effect of protection optical fiber on the one hand, and on the other hand, the also etched quartz glass of inner surface has increased radiance.
According to the depth and the focus size of tumor locus to be treated, the length of probe tube and probe can be designed to different size, and caliber should be as far as possible little, so that treatment can reach Wicresoft or noinvasive.Thereby the probe tube of different length can be used with probe and satisfy different oncotherapy demands.The outermost layer circular ring path of probe tube is evacuated, and its objective is for the heat transfer between cryogenic fluid fluid and tube wall surrounding health tissue in the isolated as far as possible pipe, thereby avoids burning or the cold injury health tissues.The center of probe tube is for coming circulation road 24, and cryogenic liquid flows to its working position--probe thus.Between the annular vacuum chamber 21 that comes the circulation road 24 and the outside at probe tube center, be annular return flow line 23; return behind probe release heat or cold for high cryogenic fluid; also core flow is formed a kind of heat protection thus; so avoided the significantly variation of incoming flow working medium temperature; and be annular vacuum chamber 21 because of exocoel simultaneously, the heat of cryogenic fluid or cold can not pass to outer wall.Probe tube comes circulation road 24 to connect optical fiber 5 or Dewar flask 10, the working medium that container chamber 25 returns in order to storage, and its inner fluid is reusable, also can discharge on the spot.Replacement is threaded, and probe tube 2 and probe 3 can weld together.
Present embodiment provides the high cold probe that is used for oncotherapy, its probe precursor 35 is hollow cavity, be filled with Web materials 33 in it, the probe outer wall is selected (to require thermal conductivity greater than 100W/ (mK) with high thermal conductivity material, as opaque or transparent materials such as copper, rustless steel even diamond), so that heat exchange preferably takes place, help to discharge the laser heat, thereby improve thermotherapy effect with tumor to be treated.Probe 3 inwalls have fine voids, after entering probe, the working medium of probe tube 2 can penetrate into silk screen on every side along these spaces, this moment, working medium underwent phase transition heat exchange, emit a large amount of colds, because probe and surrounding tissue have good heat exchange, a large amount of heats or cold directly act on tumor tissues, thereby reach a high temperature or low temperature is killed the purpose of tumor.Fluid in the silk screen after heat absorption returns along probe tube internal reflux passage 23.Thus, the probe that originally is used for oncotherapy can be transferred to deep tumor place or certain tract such as positions such as digestive tract, rectum in the body with the lossless manner of minimum with heat or cold, reaches the purpose of destroyed tumor tissue.Probe can be circle, arcuation, be beneficial to enter deep tissue, avoid scratching along the journey tissue, and the diameter of probe tube and probe generally should as far as possible little (as being lower than 6mm), so that reduce mechanical damage when being punctured in the human body as far as possible to tissue, probe tube 2, probe 3 can be made into the counterpart of different length, therefore, the present invention is applicable to different depth, different size tumor thermotherapy usefulness.The end of probe top can be provided with thermocouple to measure the temperature of tumor locus in the therapeutic process, serves as a kind of thermotherapy supervising device.
Cryogenic media such as liquid nitrogen are contained in the Dewar flask, in the Dewar flask 10 resistance heating wire is housed, once energising, can heat liquid nitrogen in it, make it progressively to vaporize, because gas expansion makes the increased pressure in the whole closed system, when it arrives a certain size, just open the low-temperature solenoid valve in the Dewar flask 10, liquid nitrogen in the Dewar flask is sent to the double-deck corrugated connecting tube 11 that communicates with Dewar flask, enter probe tube 2 subsequently.
Cryogenic fluid outlet conduit (promptly being incubated connecting leg 4) is provided with valve 6, in case close, promptly stops transferring working medium.After opening liquid nitrogen side valve door 6, will lead to syringe needle 3 along probe tube 2, the sharp freezing that can organize by the liquid nitrogen of Dewar flask 10 outputs.High temperature is then produced by laser instrument, starts laser instrument, and heat is imported by optical fiber, and what then exercised is the high temperature thermotherapy.End of probe 3 is provided with certain temperature sensor (as thermocouple), and is connected to the input of data collecting instrument, and data collecting instrument is communicated with computer, during the treatment beginning, opens data collecting instrument and computer, can monitor each point for measuring temperature temperature.Certainly, temperature sensor also can be attached to the temperature-responsive of probe outer surface with monitoring skin.Store certain high low temperature therapy (promptly lower the temperature and heat up) program in the computer, for selecting for use.
When the laser action overlong time, the high power on surface, fibre-optic terminus can cause the carbonization of adjacent tissue.Adopt thermocouple temperature sensor monitoring fibre-optic terminus temperature, set marginal value, can start the cryogenic fluid valve, come small size cooling laser device, prevent that fiber tip from producing serious hot injury by liquid phase-change than low discharge when temperature surpasses.In addition, the Web materials in the present embodiment 33 can adopt aluminum, copper etc. to make.
The needed freezing mode of probe system provided by the invention also can adopt the gas throttling mode to realize.At this moment, incoming flow gas is different with the foregoing description should to be in high pressure conditions (more than 600 atmospheric pressure), Dewar flask 10 should be high pressure resistant device, but all the other device element structures all remain unchanged except that size, only needing in the future, circulation road 24 calibers are provided with forr a short time, as diameter at the capillary tube of 200 nanometers to 200 micrometer ranges, also can come the pipeline section of circulation road 24 before entering probe tube 2 to adopt reducing pipe, so that the high pressure incoming flow gas pressure that flows through is die-offed, reduce to 1 atmospheric pressure, thereby realize fast cooling.Select Joule-Thomson coefficient be positive gas as throttle air (as carbon dioxide), by behind the throttling arrangement, gas temperature reduces rapidly, thereby plays the purpose of cooling target tissue.The use of LASER HEATING element is then identical with embodiment 1.
Device of the present invention can be implemented cryosurgery separately, also can carry out the high temperature thermotherapy separately, also can be that the two combined and alternatively carries out, and switching between low temperature and high temperature and retention time can arbitrarily be adjusted, and promptly realize different freezing or thermotherapy effects thus.After closing all valves 6, promptly finish therapeutic process.And, when implementing the high-temperature laser thermotherapy, in time introduce cry-fluid, also can increase the thermotherapy scope to greatest extent, and the unlikely laser fiber that causes burns.In the past, in the water-cooled laserthermia, because intensity of cooling is not enough, it is very limited that the heated perimeter of optical fiber is actually.Among the present invention, the introducing of cryogen can make this situation be improved.
From the above mentioned, heat or cold that the present invention adopts derive from laser emission or fluid, and the procurement cost of laser equipment and liquid nitrogen working medium is not high, and the hot and cold amount that realizes is then quite remarkable.And probe tube and probe are made relatively easy, and no complicated circuit is simple in structure, radiationless, and the heating and the cooling degree of thermometric and evaluation tumor are more or less freely, good heat-insulation effect, and because of caliber less, very little to machinery and hot injury along the journey tissue.These features all make this instrument have bigger competitiveness.
The tumor therapeutic procedure that uses the present invention to realize is as follows:
During treatment, open the heater circuit in fluid container and the laser instrument, carry out preparation.Under guiding such as Medical Image System such as B ultrasonic, CT or MRI, probe is inserted position to be treated, open the fluid passage, then low temperature liquid nitrogen will flow to probe (also being tumor locus to be treated), owing at the end of probe liquid nitrogen evaporation heat absorption takes place, a large amount of colds is supplied to tissue by moment, so can rapidly tissue be freezed and be destroyed, and along the protective effect of journey owing to vacuum equipment, normal structure is not subjected to very big cooling influence, afterwards, the nitrogen vapor of generation returns and is discharged in the atmosphere along the return flow line; When tissue is frozen into to a certain degree, close the liquid nitrogen valve, start laser instrument rapidly, laser heats tumor tissues under visible light or infrared band, and moment is emitted a large amount of heats, and tissue can aggravate the destruction to tumor greatly because high strength is heated.
Core of the present invention is, realize quick freezing in new ways and heat up melting, thereby destroyed tumor tissue to greatest extent, it can be realized significantly easily and cold and hot fast amount is discharged the heating and cooling process that reaches the change deep tumor, cooling and intensification degree are very remarkable, and seriality is good, can realize complicated cooling and heating schedule, be suitable for each large, medium and small type hospital and use, the clinical therapy of tumor development of technology is significant for promoting.
Claims (10)
1, a kind of cold-hot probe therapy system, comprise the working medium output device, probe tube (2) and probe (3), described probe tube (2) and described probe (3) are connected to each other, it is characterized in that, be provided with circulation road (24) in the described probe tube (2), a described end that comes circulation road is communicated with the working medium output channel of described working medium output device and the other end extends in the described probe (3), also be provided with return flow line (23) in the described probe tube (2), this return flow line (23) extends in the described probe (3), described cold-hot probe therapy system also comprises laser instrument (1), and the optical fiber action head (7) of described laser instrument inserts in the described probe (3).
By the described system of claim 1, it is characterized in that 2, described probe tube (2) also has the container chamber (25) of discharging backflow working medium, described container chamber (25) is communicated with described return flow line (23).
3, by the described system of claim 1, it is characterized in that, describedly come circulation road (24) and the coaxial setting in described return flow line (23), described return flow line (23) is positioned at the described outside of coming circulation road (24), is formed with vacuum chamber (21) between the outer wall of the outer wall of the return flow line (23) of described probe tube (2) and described probe tube (2).
4, by the described system of claim 3, it is characterized in that, the output optical fibre (5) of described laser instrument (1) is inserted by described probe tube (2) side and describedly comes circulation road (24) inner and extend to described probe (3) always, and the junction of its insertion is adopted and is tightly connected.
5, by the described system of claim 3, it is characterized in that, it is characterized in that, the output optical fibre (5) of described laser instrument (1) inserts in the described return flow line (23) by described probe tube (2) side and extends to described probe (3) always, the junction of its insertion is adopted and is tightly connected, described output optical fibre (5) is positioned at described circulation road (24) outside of coming, and is attached at the described outer wall that comes circulation road or comes the outer wall of circulation road to keep certain distance with described.
6, by claim 1,2,3,4 or 5 described systems, it is characterized in that described probe (3) has probe precursor (35), described probe precursor is hollow cavity and is filled with Web materials (33) in inside.
7, by claim 1,2,3,4 or 5 described systems, it is characterized in that the outer wall of described probe (3) is made greater than the material of 100W/ (mK) by thermal conductivity.
8, by claim 1,2,3,4 or 5 described systems, it is characterized in that the diameter of described probe tube (2) and described probe (3) is less than 6mm and greater than 1mm.
9, by claim 1,2,3,4 or 5 described systems, it is characterized in that the refrigeration working medium of described working medium output device is liquid cryogenic fluid, or the cryogenic fluid that forms after the gases at high pressure throttling.
10, by claim 1,2,3,4 or 5 described systems, it is characterized in that an end of the close described working medium output device of described probe tube (2) is provided with insulating connector (41), on described insulating connector, be provided with handle (42).
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007100987352A CN101292897A (en) | 2007-04-25 | 2007-04-25 | Cold and hot probe treatment system |
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| CNA2007100987352A CN101292897A (en) | 2007-04-25 | 2007-04-25 | Cold and hot probe treatment system |
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| CN102949237A (en) * | 2011-08-24 | 2013-03-06 | 中国科学院理化技术研究所 | Probe heating device based on liquid metal |
| CN103536358A (en) * | 2012-07-17 | 2014-01-29 | 杨涛 | Laser bleeding stopping device |
| CN103691047A (en) * | 2013-12-30 | 2014-04-02 | 中国地质大学（武汉） | Infrared pulse laser-induced jet generator |
| CN106691675A (en) * | 2015-07-24 | 2017-05-24 | 广州保瑞医疗技术有限公司 | Intravascular laser heating whole body thermal therapy instrument |
| CN107049479A (en) * | 2009-10-27 | 2017-08-18 | 赫莱拉公司 | Delivery apparatus with coolable energy transmitting device |
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