CN108478276B - Minimally invasive steam probe for tumor treatment and treatment equipment - Google Patents
Minimally invasive steam probe for tumor treatment and treatment equipment Download PDFInfo
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- CN108478276B CN108478276B CN201810581886.1A CN201810581886A CN108478276B CN 108478276 B CN108478276 B CN 108478276B CN 201810581886 A CN201810581886 A CN 201810581886A CN 108478276 B CN108478276 B CN 108478276B
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- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00636—Sensing and controlling the application of energy
- A61B2018/00696—Controlled or regulated parameters
- A61B2018/00714—Temperature
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00636—Sensing and controlling the application of energy
- A61B2018/00696—Controlled or regulated parameters
- A61B2018/00744—Fluid flow
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B2018/044—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating the surgical action being effected by a circulating hot fluid
- A61B2018/048—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating the surgical action being effected by a circulating hot fluid in gaseous form
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Abstract
The invention provides a minimally invasive steam probe for tumor treatment and treatment equipment, wherein the minimally invasive steam probe for tumor treatment comprises a needle tube, a needle tip arranged at one end of the needle tube and a handle arranged at the opposite end of the needle tube, a shunt part close to the needle tube is arranged in the handle, one end of the handle far away from the needle tube is provided with an inflow joint, and one side of the handle close to the end of the needle tube is provided with a reflux joint; the inlet end of the reflux joint is communicated with the reflux liquid outlet of the flow dividing part; the tube wall of the needle tube is provided with a treatment section close to the needle point and a heat insulation section far away from the needle point, the needle tube is internally provided with a central tube, and the central tube penetrates through the needle tube and the handle area to serve as an inflow channel of steam. The minimally invasive steam probe for tumor treatment provided by the invention only has heat exchange in the working process, and no substance enters human tissues, so that the minimally invasive steam probe is a purely physical green treatment mode.
Description
Technical Field
The invention belongs to the technical field of thermal ablation equipment for tumor treatment, and particularly relates to a minimally invasive steam probe for tumor treatment and treatment equipment.
Background
Aiming at the treatment of malignant tumors, the method has long been a great challenge facing the biomedical engineering community at home and abroad. Surgical excision, radiation therapy and chemotherapy are considered as the most standard treatment means for one time. However, the surgical excision is damaged greatly and causes limb stuffiness, and side effects caused by radiotherapy and chemotherapy often bring serious physical and psychological pains to patients, and all the factors inevitably reduce the survival rate and the survival quality of the patients. Therefore, the minimally invasive treatment means which can not only effectively kill tumor cells but also ensure low injury and toxic and side effects is sought, and the minimally invasive treatment means become a great target for pursuing the clinical medical field and biomedical engineering field.
At present, minimally invasive interventional physical therapy has become a development front of the related fields, and corresponding technologies have also become a high point for developing the market of advanced medical equipment. Among the various efforts, hyperthermia is a new physiotherapy that has been developed very rapidly in recent years. The high-temperature hyperthermia is a physical treatment method for killing tumors by heating, and has the remarkable advantages of definite curative effect, strong directionality and the like, so that the high-temperature hyperthermia is widely regarded by the clinical medical community; in particular, the side effect of the hyperthermia technology is far lower than that of conventional radiotherapy and chemotherapy, so that the "green therapy" is earned in the clinical treatment of tumors, and the hyperthermia technology is rapidly developed at home and abroad.
The existing thermotherapy equipment mainly uses radio frequency and microwaves, has a complex structure and high cost, and is difficult to popularize widely. For example, a microwave hyperthermia machine needs to generate a complex circuit to generate microwave output, and because the electromagnetic field generated by the machine can interfere with temperature measurement, the temperature measurement requirement is high, and a protective device is needed to be adopted at a probe so as not to damage normal tissues; while other thermal therapeutic machines such as radio frequency, ultrasound, etc. are prone to cause overheating pain without cold water. All these hyperthermia machine probes are based on the use of complex field-effect emissions, the design of their cooling system is relatively difficult and the dosage is difficult to determine when hyperthermia is performed.
Disclosure of Invention
Aiming at the defects existing in the prior art, the invention provides a minimally invasive steam probe for tumor treatment and treatment equipment, which can effectively solve the problems.
The technical scheme adopted by the invention is as follows:
the invention provides a minimally invasive steam probe for tumor treatment, which comprises a needle tube (43), a needle tip (44) arranged at one end of the needle tube (43) and a handle (42) arranged at the opposite end of the needle tube (43); a shunt part (46) close to the needle tube (43) is arranged in the handle (42), one end of the handle (42) far away from the needle tube (43) is provided with an inflow joint (41), and one side of the handle (42) close to the end of the needle tube (43) is provided with a reflux joint (45); the inlet end of the reflux joint (45) is communicated with a reflux liquid outlet of the shunt part (46);
the tube wall of the needle tube (43) is provided with a treatment section close to the needle point (44) and a heat insulation section far away from the needle point (44), the needle tube (43) is internally provided with a central tube (431), and the central tube (431) penetrates through the needle tube (43) and the handle (42) to serve as an inflow channel of steam;
the tail end of the central tube (431) is communicated with a steam outlet cavity (435), and high-temperature steam conveyed by the central tube (431) is condensed into liquid in the steam outlet cavity (435);
an inner fin (434) is circumferentially arranged on the inner wall surface of the needle tube (43) positioned in the treatment section, a space gap is formed between the inner fin (434) and the outer wall of the central tube (431) of the treatment section to serve as a first backflow channel (436), an inlet of the first backflow channel (436) is communicated with the steam outlet cavity (435), and condensed liquid in the steam outlet cavity (435) enters the first backflow channel (436);
an outer sleeve (437) coaxially coated on the central tube (431) is arranged in the middle section area of the central tube (431), and the tail end of the outer sleeve (437) is arranged in front of the inlet of the backflow joint (45) to serve as a backflow liquid inlet of the diversion part (46);
a space gap between the outer sleeve (437) and the central tube (431) is used as a second backflow channel (432), an outlet end of the first backflow channel (436) is communicated with an inlet end of the second backflow channel (432), and an outlet end of the second backflow channel (432) is communicated with a backflow liquid inlet of the diversion part (46);
a heat insulating layer (433) is provided between the inner wall surface of the needle tube (43) and the outer wall surface of the outer sleeve (437) in the heat insulating section.
Preferably, the shunt part (46) comprises an annular shunt tube sleeved outside the central tube (431), the inner wall of the annular shunt tube is provided with a step structure, so that the aperture in the tube close to one end of the needle point (44) is L1 and used for being connected with the tail end of the outer sleeve (437), the aperture in the tube far away from one end of the needle point (44) of the annular shunt tube is L2 and used for being connected with the central tube (431) with the handle side extending out of the tail end of the outer sleeve (437), L1 is more than L2, a through hole is formed in the side face, close to the backflow joint (45), of the annular shunt tube, and the backflow joint (45) is vertically connected at the through hole.
Preferably, the L1 is equal to the outer diameter of the outer sleeve (437), and the L2 is equal to the outer diameter of the center tube (431).
Preferably, the projection of the end of the outer sleeve (437) in the direction of the central tube (431) is closer to the needle tip (44) than the projection of the return connection (45) in the direction of the central tube (431).
Preferably, an adapting structure matched with an external conveying pipe is arranged in the handle (42) near the inflow joint (41), and the inlet end of the central pipe (431) is communicated with the outlet end of the adapting structure.
Preferably, the heat insulation layer (433) is filled with a multi-layer heat insulation material, the heat insulation material comprises one or two of a radiation screen and a spacer, the material of the radiation screen comprises a metal foil and/or a metal-plated film, and the material of the spacer comprises non-woven fabric and/or nylon.
Preferably, the start end of the outer sleeve (437) is located within the treatment zone.
Preferably, the outer diameter of the needle tube (43) is 0.5 mm-10 mm;
and/or
The length is 1 mm-500 mm;
and/or
The manufacturing material is one or more of stainless steel, titanium and titanium alloy.
Preferably, the shape of the needle tip (44) is cone, triangular prism tip, quadrangular tip or polygonal tip;
and/or
One or more of carbon fiber, metal wire mesh, fin and liquid metal are adopted in the needle tip (44) to enhance heat exchange;
and/or
The angle of the needle tip (44) is 1-180 degrees.
Preferably, a return pipe is arranged at the outlet of the return joint (45), and the return pipe is in the shape of a straight pipe, a corrugated pipe or a combination thereof;
and/or
The return pipe is made of rubber, plastic, metal or carbon fiber.
The invention also provides a minimally invasive steam probe treatment device for tumor treatment, which comprises a treatment device host and a probe (4); the treatment equipment host comprises a steam generating device (2), a working medium recovery device (5) and a control system (1), and the probe (4) is a minimally invasive steam probe for tumor treatment;
the control system (1) is electrically connected with the steam generating device (2) and is used for controlling the temperature, pressure and flow of steam generated by the steam generating device (2); the outlet of the steam generating device (2) is communicated with an inflow joint (41) of the minimally invasive steam probe for tumor treatment and is used for conveying high-temperature and high-pressure steam to the minimally invasive steam probe for tumor treatment; the reflux joint (45) of the minimally invasive steam probe for tumor treatment is communicated with the inlet of the working medium recovery device (5) and is used for conveying condensed liquid to the working medium recovery device (5).
Preferably, the heat source of the steam generating device (2) is one or more of an electric heating heat source, a microwave heating heat source, an eddy heating heat source, an optical heating heat source, an ultrasonic heating heat source, a chemical reaction heating heat source or a heat source for directly generating steam through chemical reaction.
Preferably, the steam generated by the steam generating device (2) is one or a mixture of more of water steam, methanol steam, formic acid steam, ethanol steam, acetic acid steam, ethyl ester steam, propanol steam, propionic acid steam and propyl ester steam.
Preferably, the working medium recovery device (5) is one or more of a condensation working medium recovery device, a physical adsorption working medium recovery device, a chemical reaction working medium recovery device, a natural evaporation working medium recovery device and a heating evaporation working medium recovery device.
Preferably, the tumor therapy device further comprises a temperature sensor arranged on the minimally invasive steam probe for tumor therapy; the temperature sensor is connected with the control system (1), and the temperature sensor is a platinum resistor or a thermocouple.
The minimally invasive steam probe and the treatment equipment for tumor treatment provided by the invention have the following advantages:
the minimally invasive steam probe for tumor treatment provided by the invention has the advantages that only heat exchange exists in the working process, no substances enter human tissues, and the minimally invasive steam probe is a pure physical green treatment mode, and has no toxicity and little side effect; the working temperature is adjustable, and the medicine is suitable for treating tumors of different sizes. The device also has the advantages of convenient use and low price of working medium, and is easy to popularize.
Drawings
Fig. 1 is a schematic diagram of the whole front structure of a minimally invasive vapor probe treatment apparatus for tumor treatment according to the present invention;
FIG. 2 is a schematic view of the overall structure of the back of a minimally invasive vapor probe treatment apparatus for tumor treatment according to the present invention;
FIG. 3 is a schematic diagram of the structure of a minimally invasive vapor probe for tumor therapy according to the present invention;
fig. 4 is an enlarged view of a portion of the left part of fig. 3.
Wherein:
1-a control system; 2-a steam generating device; 3-a display; 4-probe; 5-a working medium recovery device;
4-probe; 41-inflow joint; 42-handle; 43-needle tube; 44-needle tip; 45-reflux joint; 46-a split;
411-groove; 431-a central tube; 432-a second return channel; 433-a thermal insulation layer; 434-inner fins; 435-a steam outlet chamber; 436-first return channel; 437-outer sleeve.
Detailed Description
In order to make the technical problems, technical schemes and beneficial effects solved by the invention more clear, the invention is further described in detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are for purposes of illustration only and are not intended to limit the scope of the invention.
Referring to fig. 3 to 4, in one aspect, the present invention provides a minimally invasive steam probe for tumor treatment, comprising a needle tube 43, a needle tip 44 disposed at one end of the needle tube 43, and a handle 42 disposed at the opposite end of the needle tube 43, wherein a shunt 46 is disposed inside the handle 42 and close to the needle tube 43, an inflow joint 41 is disposed at one end of the handle 42 far from the needle tube 43, and a reflux joint 45 is disposed at one side of the handle 42 close to the end of the needle tube; the inlet end of the return fitting 45 communicates with the return outlet of the shunt portion 46.
The tube wall of the needle tube 43 has a treatment section close to the needle tip 44 and a heat insulation section far from the needle tip 44, the needle tube 43 has a central tube 431, and the central tube 431 penetrates through the needle tube 43 and the handle 42 to serve as an inflow channel of steam.
The end of the central tube 431 communicates with the vapor outlet chamber 435 where the high temperature vapor delivered through the central tube 431 condenses to a liquid.
An inner fin 434 (inner fin) is circumferentially provided on the inner wall surface of the needle tube 43 in the treatment section, and a space gap is provided between the inner fin 434 and the outer wall of the center tube of the treatment section as a first return passage 436. The inlet of the first return channel 436 communicates with the vapor outlet chamber 435 where the condensed liquid enters the first return channel 436.
The middle section of the central tube 431 is provided with an outer sleeve 437 coaxially surrounding the central tube 431, and the end of the outer sleeve 437 is provided before the inlet of the return joint 45 as a return liquid inlet of the flow dividing part 46.
The space gap between the outer sleeve 437 and the center tube 431 serves as a second return passage 432, the outlet end of the first return passage 436 being in communication with the inlet end of the second return passage 432, the outlet end of the second return passage 432 being in communication with the return liquid inlet of the flow dividing portion 46. A heat insulating layer 433 is provided between the inner wall surface of the needle tube 43 and the outer wall surface of the outer sleeve 437 in the heat insulating section.
Wherein, the inflow joint 41 and the return joint 45 are both arranged on the handle 42; the inflow connector 41 may be connected by one or more of a screw thread, a quick-connect connector, a direct-connect connector and a gas connector.
Further, the diversion portion 46 includes an annular diversion tube sleeved outside the central tube 431, and an inner wall of the annular diversion tube has a step-shaped structure, so that an inner tube aperture near one end of the needle tip 44 is L1, and is used for connecting with a tail end of the outer sleeve 437; the aperture of the inner tube of the end of the annular shunt tube far away from the needle tip 44 is L2, which is used for connecting a central tube 431 with the handle side extending out of the tail end of the outer sleeve 437, wherein L1 is more than L2, the side surface of the annular shunt tube near the backflow joint 45 is provided with a through hole, and the backflow joint 45 is vertically connected at the through hole.
Further, L1 is equal to the outer diameter of the outer sleeve 437, and L2 is equal to the outer diameter of the center tube 431. In this way, after the return liquid enters from the outlet end of the second return passage 432 from the side L1 of the annular shunt tube, no outlet is provided on the side L2, and the return liquid can only flow out from the return joint 45.
Further, the projection of the distal end of the outer sleeve 437 in the direction of the central tube 431 is closer to the needle tip 44 than the projection of the return joint 45 in the direction of the central tube 431.
In this way, the annular shunt tube of the shunt portion 46 is positioned on the surface (connecting the central tube 431) near the handle 42 as an inlet for the incoming flow of steam, and the steam is condensed into liquid along the central tube 431 toward the needle portion, and then flows toward the end of the outer sleeve 437 (the backflow liquid inlet of the shunt portion 46) through the second backflow passage 432 after passing through the first backflow passage 436, and enters the inner space of the annular choke tube, and flows toward the backflow joint 45 through the backflow liquid outlet of the shunt portion 46 under the action of gravity along the space gap formed between the outer side wall of the central tube 431 and the inner side wall of the annular choke tube.
Further, the beginning of the outer sleeve 437 is located within the treatment zone.
Further, an adapting structure matched with the external conveying pipe is arranged in the handle 42 near the inflow joint 41, and the inlet end of the central pipe 431 is communicated with the outlet end of the adapting structure. In this case, as an embodiment, the adapting structure may be a groove 411 or a protrusion, and the adapting structure mainly serves to be connected to an external delivery pipe, which is not limited herein.
Further, the insulating layer 433 is filled with a multi-layer insulating material, the insulating material includes one or both of a radiation screen and a spacer, the material of the radiation screen includes a metal foil and/or a metallized film, and the material of the spacer includes a nonwoven fabric and/or nylon.
Specifically, multiple layers of insulation materials may be added within the vacuum layer of the probe to enhance the vacuum insulation performance. The multi-layer heat insulating material is composed of one or two of a radiation screen and a spacer, wherein the radiation screen comprises a metal foil and a metal plating film (such as aluminum, gold, silver and the like), and the spacer comprises a non-woven fabric, nylon and other materials with poor heat conducting performance. The arrangement mode is that the radiation screens and the spacers are alternately arranged at intervals, namely one spacer layer and one radiation screen layer.
As another embodiment of the present invention, the insulating layer 433 may be a vacuum layer.
By the insulating layer 433, the temperature of the steam is prevented from decreasing during the course of the delivery to the tumor site (the treatment section of the needle tube 43), thereby affecting the treatment effect.
In addition, an inner fin 434 is circumferentially provided on the inner wall surface of the needle tube 43 located in the treatment section, and a space gap is provided between the inner fin 434 and the outer wall of the central tube of the treatment section as a first return passage 436; the essence here is the position closest to the tumor part, and the heat insulation layer 433 is not arranged at the position, but the inner fin 434 is arranged at the position, because the high-efficiency heat exchange performance of the inner fin tube is adopted for the treatment area, and the high-efficiency heat exchange between the high-temperature steam and the tumor tissue can be realized, so that the high-temperature steam can effectively act on the tumor tissue position, and the thermal ablation is realized. After the liquid condensed in the vapor outlet chamber 435 passes through the first return passage 436, the second return passage 432, the split portion 46, and the return joint 45 in this order, it is connected to the working fluid recovery device 5 for recovery of the return liquid.
As one embodiment of the present invention, the outer diameter of the needle tube 43 is 0.5mm to 10mm; the length is 1 mm-500 mm; the manufacturing material is one or more of stainless steel, titanium and titanium alloy.
Further, a needle tip 44 is arranged outside the outlet end of the central tube 431 and is used for penetrating into the tumor; the angle of the needle tip 44 is 1 deg. to 180 deg.. The needle tip 44 is in the shape of a cone, a triangular tip, a quadrangular tip, or a polygonal tip. The needle tip 44 adopts one or more of carbon fiber, metal wire mesh, fins and liquid metal to enhance heat exchange, so as to realize thermal ablation of tumor tissues.
Further, a return pipe is arranged at the outlet of the return joint 45, and the return pipe is in the shape of a straight pipe, a corrugated pipe or a combination of the two. The reflux pipe is made of rubber, plastic, metal or carbon fiber.
The center tube 431 in the needle tube 43 penetrates the needle tube 43 and the handle 42 region to serve as a steam inflow passage. The inlet end of the steam inflow channel (a central pipe 431) is communicated with the steam generating device 2 through the inflow joint 41, and the steam is conveyed to the central pipe 431 through the steam generating device 2; the outlet end of the central tube 431 is communicated with the steam outlet chamber 435, and the steam output from the central tube 431 is condensed into liquid in the steam outlet chamber 435; then, the liquid flows through the first return channel 436 and then flows through the second return channel 432 to the end of the outer sleeve 437 (the return liquid inlet of the flow dividing part 46), and enters the inner space of the throttle pipe, and flows through the return liquid outlet of the flow dividing part 46 to the return joint 45 under the action of gravity along the space gap formed between the outer side wall of the center pipe 431 and the inner side wall of the throttle pipe.
In another aspect of the present invention, a minimally invasive vapor probe treatment device for tumor treatment is provided, comprising a treatment device host and a probe; the treatment equipment host comprises a steam generating device 2, a working medium recovery device 5 and a control system 1, and the probe is a minimally invasive steam probe for tumor treatment; the control system 1 is electrically connected with the steam generating device 2 and is used for controlling the temperature, pressure and flow rate of steam generated by the steam generating device 2.
Referring to fig. 1 to 2, a minimally invasive vapor probe treatment apparatus for tumor treatment, comprising:
(1) Steam generator
The steam generating device 2 is used for generating high-temperature steam required by the treatment process under the control of the control system.
In practical applications, the heat source of the steam generating device 2 is one or more of an electric heating source, a microwave heating source, an eddy heating source, an optical heating source, an ultrasonic heating source, a chemical reaction heating source or a steam heat source directly generated by chemical reaction.
The steam generated by the steam generating device 2 can be one or a mixture of more of water steam, methanol steam, formic acid steam, ethanol steam, acetic acid steam, ethyl ester steam, propanol steam, propionic acid steam and propyl ester steam.
(2) Probe with a probe tip
The probe is used for conveying high-temperature steam generated by the steam generating device to a tumor part to perform efficient thermal ablation, and does not cause thermal damage to normal tissues on a probe puncture path;
further, the probe also comprises a temperature sensor arranged on the probe (a reflux joint or a probe head part); the temperature sensor is connected with the control system 1.
Further, the temperature sensor is a platinum resistor or a thermocouple.
The probe is provided with a temperature sensor for temperature monitoring during treatment. The temperature sensor is a platinum resistor or a thermocouple; temperature sensors may be mounted at various locations on the probe, including within the tip, within the vapor inflow channel, and/or within the return channel.
(3) Working medium recovery device
And the working medium recovery device is used for recovering, processing and storing the working medium subjected to thermal ablation.
In practical application, the working medium recovery device 5 may be one or more of a condensation working medium recovery device, a physical adsorption working medium recovery device, a chemical reaction working medium recovery device, a natural evaporation working medium recovery device and a heating evaporation working medium recovery device. The chemical reaction working medium recovery device is as follows: the recycled working medium is consumed through the reaction. On one hand, the working medium can be prevented from being polluted by the working medium recovery device; on the other hand, for example, when the adsorption recovery mode is adopted, the adsorbed working medium becomes solid rather than liquid, so that other subsequent treatments are convenient.
(4) Display device
The display device is used for displaying the running state of the minimally invasive steam probe treatment equipment and can also perform touch control. The display may employ a single display or multiple displays to achieve the display function.
(5) Control system
The control system is electrically connected with the steam generating device 2, and can adjust one or more parameters of steam flow, pressure and temperature (used for controlling the temperature, pressure and flow of steam generated by the steam generating device 2) according to treatment requirements.
The control system may be implemented in one or more of a programmable logic controller, a printed circuit, and an integrated circuit. The control system may employ one or more of a keyboard, mouse, touch pad, touch screen, gesture-operated device as an input device.
Further, a display 3 of a minimally invasive vapor probe treatment apparatus for tumor treatment is connected to the control system 1.
Further, the heat source of the steam generating device 2 is one or more of an electric heating heat source, a microwave heating heat source, an eddy current heating heat source, an optical heating heat source, an ultrasonic heating heat source, a chemical reaction heating heat source or a steam heat source directly generated by chemical reaction.
Further, the steam generated by the steam generating device 2 is one or a mixture of more of water steam, methanol steam, formic acid steam, ethanol steam, acetic acid steam, ethyl ester steam, propanol steam, propionic acid steam and propyl ester steam.
Further, the working medium recovery device 5 is one or more of a condensation working medium recovery device, a physical adsorption working medium recovery device, a chemical reaction working medium recovery device, a natural evaporation working medium recovery device and a heating evaporation working medium recovery device.
The invention provides a minimally invasive steam probe treatment device for tumor treatment, which comprises the following working principle processes:
when the device is used, the control system controls the steam generating device 2 to generate high-temperature steam with required flow, pressure and temperature, the steam is controlled to flow into the probe 4 connected with the equipment host, the steam enters the steam outlet cavity 435 at the needle point part through the handle 42 and the central pipe 431 of the probe 4, heat is released in the steam outlet cavity 435 at the needle point part, and the steam is condensed into liquid; and then flows to the working medium recovery device 5 through the first return passage 436, the second return passage 432, the split portion 46, and the return joint 45. In the invention, in the process of conveying high-temperature steam through a steam inflow channel, a return channel (a first return channel 436 and a second return channel 432) is coaxially arranged outside the steam inflow channel (a central pipe 431), and then a heat insulation layer 433 is coaxially arranged outside the return channel; the insulating layer 433 has a smooth surface structure and functions at two points: firstly, the high-temperature steam can be prevented from being cooled in the conveying process, so that the treatment effect is affected; on the other hand, the heat insulating layer 433 can protect the normal tissue on the needle tube puncture path, and prevent the high-temperature steam from scalding the normal tissue on the needle tube puncture path. The second return pipe 432 is provided between the steam inflow passage (center pipe 431) and the heat insulating layer 433, and functions as: since the temperature of the condensed liquid recovered from the return line is also high, normal tissue in the needle penetration path can still be protected by the insulating layer 433. Through the coaxial mode of setting of three-layer, have the ingenious advantage of structural design. In the invention, the inner fin 434 is arranged on the treatment section of the needle tube 43, so that the heat exchange between high-temperature steam and tumor tissues can be enhanced, and the thermal ablation effect can be improved. In addition, a pump can be installed at the outlet end of the second backflow pipeline 432, under the action of the pump, after the high-temperature steam reaches the steam outlet cavity 435 through the steam inflow channel (the central pipe 431), the high-temperature steam can quickly exchange heat with tumor tissues, and the condensed liquid can quickly leave the tumor tissues through the backflow pipeline; the new high-temperature steam is immediately delivered to act on the tumor tissue, so that the new high-temperature steam is always kept to act on the tumor tissue continuously, and the treatment effect is remarkable. In the treatment process, the working parameters such as the pressure, the temperature, the flow and the like of the steam can be regulated by the control system, and the treatment temperature is monitored by the temperature sensor.
The minimally invasive steam probe treatment equipment for tumor treatment provided by the invention has the following advantages:
the minimally invasive steam probe treatment equipment for tumor treatment provided by the invention has the advantages that only heat exchange exists in the working process, no substances enter human tissues, and the minimally invasive steam probe treatment equipment is a pure physical green treatment mode, and has no toxicity and little side effect; the working temperature is adjustable, and the medicine is suitable for treating tumors of different sizes. The device also has the advantages of convenient use and low price of working medium, and is easy to popularize.
The invention provides a minimally invasive steam probe and treatment equipment for tumor treatment, which are thermal ablation equipment for tumor treatment, can convey high-temperature steam to a tumor part to implement efficient thermal ablation, does not cause thermal damage to normal tissues on a probe puncture path, has the advantages of simple working principle, convenient use and low working medium price, and can be widely applied to a wide patient population.
The foregoing is merely a preferred embodiment of the present invention and it should be noted that modifications and adaptations to those skilled in the art may be made without departing from the principles of the present invention, which is also intended to be covered by the present invention.
Claims (15)
1. A minimally invasive steam probe for tumor treatment, which is characterized by comprising a needle tube (43), a needle tip (44) arranged at one end of the needle tube (43), and a handle (42) arranged at the opposite end of the needle tube (43); a shunt part (46) close to the needle tube (43) is arranged in the handle (42), one end of the handle (42) far away from the needle tube (43) is provided with an inflow joint (41), and one side of the handle (42) close to the end of the needle tube (43) is provided with a reflux joint (45); the inlet end of the reflux joint (45) is communicated with a reflux liquid outlet of the shunt part (46);
the tube wall of the needle tube (43) is provided with a treatment section close to the needle point (44) and a heat insulation section far away from the needle point (44), the needle tube (43) is internally provided with a central tube (431), and the central tube (431) penetrates through the needle tube (43) and the handle (42) to serve as an inflow channel of steam;
the tail end of the central tube (431) is communicated with a steam outlet cavity (435), and high-temperature steam conveyed by the central tube (431) is condensed into liquid in the steam outlet cavity (435);
an inner fin (434) is circumferentially arranged on the inner wall surface of the needle tube (43) positioned in the treatment section, a space gap is formed between the inner fin (434) and the outer wall of the central tube (431) of the treatment section to serve as a first backflow channel (436), an inlet of the first backflow channel (436) is communicated with the steam outlet cavity (435), and condensed liquid in the steam outlet cavity (435) enters the first backflow channel (436);
an outer sleeve (437) coaxially coated on the central tube (431) is arranged in the middle section area of the central tube (431), and the tail end of the outer sleeve (437) is arranged in front of the inlet of the backflow joint (45) to serve as a backflow liquid inlet of the diversion part (46);
a space gap between the outer sleeve (437) and the central tube (431) is used as a second backflow channel (432), an outlet end of the first backflow channel (436) is communicated with an inlet end of the second backflow channel (432), and an outlet end of the second backflow channel (432) is communicated with a backflow liquid inlet of the diversion part (46);
a heat insulating layer (433) is provided between the inner wall surface of the needle tube (43) and the outer wall surface of the outer sleeve (437) in the heat insulating section.
2. The minimally invasive steam probe for tumor treatment according to claim 1, wherein the shunt part (46) comprises an annular shunt tube sleeved outside the central tube (431), the inner wall of the annular shunt tube has a stepped structure, so that the aperture in the tube near one end of the needle tip (44) is L1, the aperture in the tube near one end of the outer sleeve (437) is L2, the aperture in the tube far from one end of the needle tip (44) of the annular shunt tube is L2, the handle side is connected to a central tube (431) extending outside the end of the outer sleeve (437), L1 > L2, a through hole is formed in the side surface of the annular shunt tube near the backflow connector (45), and the backflow connector (45) is vertically connected at the through hole.
3. The minimally invasive vapor probe for tumor treatment of claim 2, wherein L1 is equal to an outer diameter of the outer cannula (437), and L2 is equal to an outer diameter of the central tube (431).
4. A minimally invasive vapor probe for tumor treatment according to claim 3, characterized in that the projection of the end of the outer sleeve (437) in the direction of the central tube (431) is closer to the needle tip (44) than the projection of the return connection (45) in the direction of the central tube (431).
5. A minimally invasive vapor probe for tumor treatment according to claim 1, characterized in that an adapter structure is provided inside the handle (42) close to the inflow connector (41) for mating with an external delivery tube, the inlet end of the central tube (431) being in communication with the outlet end of the adapter structure.
6. A minimally invasive vapor probe for tumor treatment according to claim 1, characterized in that the insulating layer (433) is filled with a multilayer insulating material comprising one or both of a radiation screen and a spacer, the material of the radiation screen comprising a metal foil and/or a metallized film, the material of the spacer comprising a nonwoven and/or nylon.
7. The minimally invasive vapor probe for tumor treatment of claim 1, wherein the start end of the outer sleeve (437) is located within the treatment zone.
8. A minimally invasive vapor probe for tumor treatment according to claim 1, characterized in that the outer diameter of the needle tube (43) is 0.5-10 mm;
and/or
The length is 1 mm-500 mm;
and/or
The manufacturing material is one or more of stainless steel, titanium and titanium alloy.
9. A minimally invasive vapor probe for tumor treatment according to claim 1, characterized in that the needle tip (44) is conical, triangular, quadrangular or polygonal in shape;
and/or
One or more of carbon fiber, metal wire mesh, fin and liquid metal are adopted in the needle tip (44) to enhance heat exchange;
and/or
The angle of the needle tip (44) is 1-180 degrees.
10. Minimally invasive vapor probe for tumor treatment according to claim 1, characterized in that a return tube is provided at the outlet of the return connection (45), the return tube being in the shape of a straight tube, a bellows or a combination thereof;
and/or
The return pipe is made of rubber, plastic, metal or carbon fiber.
11. A minimally invasive steam probe treatment device for tumor treatment, which is characterized by comprising a treatment device host and a probe (4); the treatment equipment host comprises a steam generating device (2), a working medium recycling device (5) and a control system (1), wherein the probe (4) is a minimally invasive steam probe for tumor treatment according to any one of claims 1-10;
the control system (1) is electrically connected with the steam generating device (2) and is used for controlling the temperature, pressure and flow of steam generated by the steam generating device (2); the outlet of the steam generating device (2) is communicated with an inflow joint (41) of the minimally invasive steam probe for tumor treatment and is used for conveying high-temperature and high-pressure steam to the minimally invasive steam probe for tumor treatment; the reflux joint (45) of the minimally invasive steam probe for tumor treatment is communicated with the inlet of the working medium recovery device (5) and is used for conveying condensed liquid to the working medium recovery device (5).
12. The minimally invasive vapor probe treatment apparatus for tumor treatment according to claim 11, wherein the heat source of the vapor generation device (2) is one or more of an electrical heating heat source, a microwave heating heat source, an eddy heating heat source, a photo heating heat source, an ultrasonic heating heat source, a chemical reaction heating heat source, or a chemical reaction direct generation vapor heat source.
13. The minimally invasive vapor probe treatment apparatus for tumor treatment according to claim 11, wherein the vapor generated by the vapor generation device (2) is one or more of water vapor, methanol vapor, formic acid vapor, ethanol vapor, acetic acid vapor, ethyl ester vapor, propanol vapor, propionic acid vapor, and propyl ester vapor.
14. The minimally invasive vapor probe treatment device for tumor treatment according to claim 11, wherein the working medium recovery device (5) is one or more of a condensation working medium recovery device, a physical adsorption working medium recovery device, a chemical reaction working medium recovery device, a natural evaporation working medium recovery device, and a heating evaporation working medium recovery device.
15. The minimally invasive vapor probe treatment apparatus for tumor treatment of claim 11, further comprising a temperature sensor disposed on the minimally invasive vapor probe for tumor treatment; the temperature sensor is connected with the control system (1), and the temperature sensor is a platinum resistor or a thermocouple.
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| CN202211652248.7A CN116211441A (en) | 2018-06-07 | 2018-06-07 | Minimally invasive steam probe for tumor treatment and treatment equipment |
| CN201810581886.1A CN108478276B (en) | 2018-06-07 | 2018-06-07 | Minimally invasive steam probe for tumor treatment and treatment equipment |
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| KR20230153425A (en) * | 2021-03-03 | 2023-11-06 | 보스톤 싸이엔티픽 싸이메드 인코포레이티드 | Systems and devices for steam generation |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1318350A (en) * | 2000-04-14 | 2001-10-24 | 中国科学院低温技术实验中心 | Vapor probe thermotherapeutic instrument for treating tumor and resulting in slight wound |
| WO2008003642A1 (en) * | 2006-07-04 | 2008-01-10 | Bracco Imaging Spa | Device for localized thermal ablation of biological tissues, particularly tumoral tissues or the like |
| CN101292897A (en) * | 2007-04-25 | 2008-10-29 | 中国科学院理化技术研究所 | Cold-hot probe therapy system |
| CN204275012U (en) * | 2014-11-26 | 2015-04-22 | 程权 | Medical Wicresoft injection-type crochet hook |
| CN107975953A (en) * | 2017-12-01 | 2018-05-01 | 西安交通大学 | Wing heat exchange structure and stepped utilization method in one kind extraction dry-hot-rock geothermal energy |
| CN208065263U (en) * | 2018-06-07 | 2018-11-09 | 海杰亚（北京）医疗器械有限公司 | A kind of minimally invasive vapor probe and therapeutic equipment for oncotherapy |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9936996B2 (en) * | 2010-03-30 | 2018-04-10 | Medtronic ATS Medical, Inc. | Cryoprobe having internal warming fluid capabilities |
-
2018
- 2018-06-07 CN CN202211652248.7A patent/CN116211441A/en active Pending
- 2018-06-07 CN CN201810581886.1A patent/CN108478276B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1318350A (en) * | 2000-04-14 | 2001-10-24 | 中国科学院低温技术实验中心 | Vapor probe thermotherapeutic instrument for treating tumor and resulting in slight wound |
| WO2008003642A1 (en) * | 2006-07-04 | 2008-01-10 | Bracco Imaging Spa | Device for localized thermal ablation of biological tissues, particularly tumoral tissues or the like |
| CN101292897A (en) * | 2007-04-25 | 2008-10-29 | 中国科学院理化技术研究所 | Cold-hot probe therapy system |
| CN204275012U (en) * | 2014-11-26 | 2015-04-22 | 程权 | Medical Wicresoft injection-type crochet hook |
| CN107975953A (en) * | 2017-12-01 | 2018-05-01 | 西安交通大学 | Wing heat exchange structure and stepped utilization method in one kind extraction dry-hot-rock geothermal energy |
| CN208065263U (en) * | 2018-06-07 | 2018-11-09 | 海杰亚（北京）医疗器械有限公司 | A kind of minimally invasive vapor probe and therapeutic equipment for oncotherapy |
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