CN1935097A - Nitrogen precooled throttling tumour ultra low temperature therapeutical system - Google Patents
Nitrogen precooled throttling tumour ultra low temperature therapeutical system Download PDFInfo
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- CN1935097A CN1935097A CN 200510029863 CN200510029863A CN1935097A CN 1935097 A CN1935097 A CN 1935097A CN 200510029863 CN200510029863 CN 200510029863 CN 200510029863 A CN200510029863 A CN 200510029863A CN 1935097 A CN1935097 A CN 1935097A
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Abstract
The present invention discloses a nitrogen gas pre-cooling throttle tumor ultra-low temperature therapeutic system. Said invention adopts a compression-type refrigerator to pre-cool nitrogen gas. Said system can make normal-temperature high-pressure nitrogen gas be divided into two branches, one branch is passed through an electromagnetic valve, and fed into sleeve-type evaporator of the refrigerator and pre-cooled, then inputted into frozen probe and further throttled and cooled; another branch is passed through another electromagnetic valve, and fed into a heating heat-exchanger and healed, then inputted into frozen probe to heat the therapeutic region. Said invention can be extensively used in the urological department, tumor department, department of dermatology, department of gynecology, chest surgery and others.
Description
Technical field
The present invention is an a kind of novel tumor low temperature therapy system, relates in particular to a kind of nitrogen precooled throttling tumour ultra low temperature therapeutical system.
Background technology
Cryosurgery (cryosurgery) claims cold therapy again, and it refers to utilize cryosurgery tool, thereby making lesion tissue experience cooling, freezing and rewarming causes irreversible damage so that a downright bad clinical medicine of control arranged.Therefore, the cryosurgery operation is the quite effective a kind of method of treatment tumor.It can replace operation, and not only wound is small, and has the analgesia, reduces hemorrhage, response light and prevent advantage such as tumor diffusion.The cold therapy of tumor is that several the probes that thermocouple is installed that can control separately insert tumor locus, imposes low temperature at end of probe then tumor is killed.The ultimate principle of cold therapy tumor is the mechanical injuries of ice crystal formation and ice crystal in the cell, cell dehydration and shrinkage, the concentrated and pH value change of cell electrolyte toxicity, cell membrane lipid protein ingredient degeneration, blood stagnation and microthrombusis.In addition, refrigerated effect also may be relevant with immunity.Be applied to cold therapy at present and mainly contain two kinds of systems: liquid nitrogen system and argon helium system.Liquid nitrogen system is that the principle that need absorb a large amount of gasification latent heats when utilizing material to become gas by liquid reduces tissue temperature rapidly.In the operation liquid nitrogen is fed in the cryoprobe, gasification heat absorption when its contact tissue can make the temperature of treatment probe reduce rapidly, makes and organizes fast cooling, freezes, the air that passes to room temperature or heating then in probe makes organizes rewarming, through freeze-thaw cycle repeatedly tumor is killed.Argon helium knife is to utilize the adiabatic throttling effect of gas to finish the therapeutic process of cooling and rewarming, when the higher gas of pressure is flowed through the aperture adiabatic throttling, along with the decline temperature of pressure tends to change, some gas temperature descends, and some gas temperature rises, and the adiabatic throttling effect is also referred to as joule thomson effect.When cryoprobe internal recycle argon, argon is in the point of a knife rapid expansion, and freezing in a short period of time pathological tissues is at subzero 140 degree, during rewarming, helium is in the point of a knife rapid expansion, and heating is in the pathological tissues of ultralow temperature state rapidly, colds and heat succeed each other to make the tumor cell death of breaking.
Argon helium knife has excellent quick freezing performance, but also has certain deficiency, as: (1) lowers the temperature and heats up and only depend on gas differential pressure, and along with the consumption of gas, refrigeration performance reduces.(2) the operating pressure height of argon, therefore to the security requirement height of whole system, and transportation trouble.(3) argon is a rare gas, the cost height.(4) high pressure argon bottle (40MP
a) be difficult for obtaining, only be confined to few city, limited the popularization of argon helium system.
And for liquid nitrogen system, its biggest advantage is the cryogenic temperature that can provide lower, but its shortcoming is: (1) need carry out vacuum thermal insulator to the cryoprobe back segment because the temperature (196 ℃) of liquid nitrogen is lower, to avoid the cold injury health tissues, cause the diameter of cryoprobe bigger; (2) the liquid nitrogen transfer pipeline is owing to will design thermal insulation layer, and diameter is big, and in operation process because low temperature has to a certain degree stiff, be unfavorable for that the doctor uses.(3) temperature is lower in the cryoprobe handle operation process, and the doctor grips inconvenience.
Summary of the invention
The objective of the invention is above-mentioned deficiency, propose a kind of nitrogen precooled throttling tumour ultra low temperature therapeutical system at existing liquid nitrogen system and argon helium knife two big cold therapy systems.This system uses 5-10MP
aRoom temperature nitrogen, avoided high pressure argon (40MP
a) expensively, difficult obtain, problem such as transportation difficulty.This system has also avoided problems such as the cutter that conveying the caused footpath of low temperature liquid nitrogen is big, transfer pipeline is thick.
In order to realize the foregoing invention purpose, a kind of nitrogen precooled throttling tumour ultra low temperature therapeutical system that the present invention proposes, its innovative point is the nitrogen of normal temperature high voltage is divided into 2 branch roads, and one the tunnel after electromagnetic valve arrives the bushing type vaporizer pre-cooling of refrigeration machine, is input to the further throttling cooling of cryoprobe; Another road, is input to cryoprobe therapentic part is heated up after the reheat heat exchanger heating through another electromagnetic valve.
Cryoprobe of the present invention uses disclosed, general cryoprobe in the prior art.
As the preferred technical solution of the present invention, the nitrogen of above-mentioned normal temperature high voltage preferably behind low-temperature solenoid valve and microgranule steam filter, is further divided into 2 above-mentioned branch roads.
As another optimal technical scheme of the present invention, between above-mentioned low-temperature solenoid valve and the microgranule steam filter relief valve, nitrogen manual drain valve and nitrogen manual drain valve are installed preferably.
With respect to prior art, the present invention uses compressor formula refrigeration machine normal temperature high voltage nitrogen (5-10MP
a) being pre-chilled to (about 100 ℃) after the uniform temperature, reuse adiabatic throttling effect further reduces nitrogen temperature, with the kill tumor cell.During operation cryoprobe percutaneous or open surgery under ultrasonic image guiding are inserted into tumor locus, high pressure pre-cooling nitrogen are incorporated into the probe interior front end carry out throttling, further cooling.Can be used for urology department, oncology, department of dermatologry, gynecological, thoracic surgery, rectum section, department of general surgery, neurosurgery, department of otorhinolaryngology.System of the present invention uses 5-10MP
aRoom temperature nitrogen, avoided high pressure argon (40MP
a) expensively, difficult obtain, problem such as transportation difficulty, problems such as the cutter footpath that this system has also avoided low temperature liquid nitrogen to carry and caused is thick, operation inconvenience.
Description of drawings
Fig. 1 is the structural representation of system of the present invention.
Wherein: 1 is nitrogen cylinder; 2 is low-temperature solenoid valve; 4 is relief valve; 5 is the nitrogen manual drain valve; 6 is the nitrogen discharge high-pressure solenoid valve; 7 is microgranule steam filter; 8 is electromagnetic valve; 10 is the bushing type vaporizer; 11 is temperature thermocouple; 12 is electromagnetic valve; 14 is reheat heat exchanger; 15 is electric heater; 16 is temperature thermocouple; 18 is Pressure gauge; 19 is temperature thermocouple; 20 is cryoprobe; 21 is refrigeration machine.
The specific embodiment
Below in conjunction with accompanying drawing and embodiment the present invention is further described.
Be a kind of nitrogen precooled throttling tumour ultra low temperature therapeutical system that a preferred embodiment of the present invention proposes as shown in Figure 1.After high pressure nitrogen is drawn from nitrogen cylinder 1, be divided into two pipelines behind low-temperature solenoid valve 2 and microgranule steam filter 7: one through the bushing type vaporizer 10 of electromagnetic valve 8 to refrigeration machine 21.Bushing type vaporizer 10 is equipped with temperature thermocouple 11, gas carries out pre-cooling in bushing type vaporizer 10 after, carries out further throttling cooling to cryoprobe 20 front ends.Between bushing type vaporizer 10 and the cryoprobe 20 Pressure gauge 18 is installed, cryoprobe 20 inside are equipped with temperature thermocouple 19; Nitrogen another pipeline behind microgranule steam filter 7 is the rewarming pipeline, to reheat heat exchanger 14, to cryoprobe 20, temperature thermocouple 16 is installed in the reheat heat exchanger 14 by electric heater 15 heating backs through electromagnetic valve 12.In addition, between low-temperature solenoid valve 2 and the microgranule steam filter 7 relief valve 4, nitrogen discharge high-pressure solenoid valve 6 and nitrogen manual drain valve 5 are installed.
System of the present invention is input to the cryoprobe cooling by normal temperature high voltage nitrogen or heats up through pre-cooling or after heating, reach the purpose of treatment tumor.The means of pre-cooling be with compressor formula refrigeration machine in vaporizer carry out heat exchange.During operation cryoprobe percutaneous or open surgery under ultrasonic image guiding are inserted into tumor locus, low temperature kills tumor.
Claims (6)
1, a kind of nitrogen precooled throttling tumour ultra low temperature therapeutical system is characterized in that the nitrogen of normal temperature high voltage is divided into 2 branch roads, and one the tunnel after electromagnetic valve arrives the bushing type vaporizer pre-cooling of refrigeration machine, is input to the further throttling cooling of cryoprobe; Another road, is input to cryoprobe therapentic part is heated up after the reheat heat exchanger heating through another electromagnetic valve.
2, nitrogen precooled throttling tumour ultra low temperature therapeutical system according to claim 1 is characterized in that between bushing type vaporizer and the cryoprobe Pressure gauge being installed, and probe interior is equipped with temperature thermocouple.
3, nitrogen precooled throttling tumour ultra low temperature therapeutical system according to claim 1 is characterized in that the bushing type vaporizer is equipped with temperature thermocouple.
4, nitrogen precooled throttling tumour ultra low temperature therapeutical system according to claim 1 is characterized in that installing in the reheat heat exchanger temperature thermocouple.
5, nitrogen precooled throttling tumour ultra low temperature therapeutical system according to claim 1, the nitrogen that it is characterized in that normal temperature high voltage are further divided into described 2 branch roads of claim 1 behind low-temperature solenoid valve and microgranule steam filter.
6, nitrogen precooled throttling tumour ultra low temperature therapeutical system according to claim 5 is characterized in that between low-temperature solenoid valve and the microgranule steam filter relief valve, nitrogen manual drain valve and nitrogen manual drain valve being installed.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510029863 CN1935097A (en) | 2005-09-22 | 2005-09-22 | Nitrogen precooled throttling tumour ultra low temperature therapeutical system |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510029863 CN1935097A (en) | 2005-09-22 | 2005-09-22 | Nitrogen precooled throttling tumour ultra low temperature therapeutical system |
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| CN1935097A true CN1935097A (en) | 2007-03-28 |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101856266A (en) * | 2010-06-21 | 2010-10-13 | 重庆大学 | Liquid-nitrogen driving cold and hot minimally invasive cutter system |
| CN102026597A (en) * | 2008-04-01 | 2011-04-20 | 通用医疗公司 | Method and apparatus for cooling biological tissue |
| CN101732090B (en) * | 2009-11-10 | 2011-05-04 | 上海理工大学 | Cryoablation system with precooling device and control method thereof |
| CN101427955B (en) * | 2008-12-04 | 2011-07-20 | 浙江大学 | Low-temperature therapeutic equipment probe temperature control system |
| CN102014777B (en) * | 2008-04-24 | 2014-04-02 | 克莱米迪克斯有限责任公司 | Method and system for cryoablation treatment |
| US8864177B2 (en) | 2011-11-23 | 2014-10-21 | Esselte Corporation | Movable highlight strip |
| US9108453B2 (en) | 2011-11-23 | 2015-08-18 | R.R. Donnelley & Sons Company | Sortable notepad |
| CN105708541A (en) * | 2016-04-11 | 2016-06-29 | 赵国江 | Control method for throttling freezing type cryosurgery device |
| CN105852960A (en) * | 2016-04-11 | 2016-08-17 | 赵国江 | Gas throttle type cryosurgical device and method for controlling same |
-
2005
- 2005-09-22 CN CN 200510029863 patent/CN1935097A/en active Pending
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102026597A (en) * | 2008-04-01 | 2011-04-20 | 通用医疗公司 | Method and apparatus for cooling biological tissue |
| CN102014777B (en) * | 2008-04-24 | 2014-04-02 | 克莱米迪克斯有限责任公司 | Method and system for cryoablation treatment |
| CN101427955B (en) * | 2008-12-04 | 2011-07-20 | 浙江大学 | Low-temperature therapeutic equipment probe temperature control system |
| CN101732090B (en) * | 2009-11-10 | 2011-05-04 | 上海理工大学 | Cryoablation system with precooling device and control method thereof |
| CN101856266A (en) * | 2010-06-21 | 2010-10-13 | 重庆大学 | Liquid-nitrogen driving cold and hot minimally invasive cutter system |
| CN101856266B (en) * | 2010-06-21 | 2011-08-03 | 重庆大学 | Liquid-nitrogen driving cold and hot minimally invasive cutter system |
| US8864177B2 (en) | 2011-11-23 | 2014-10-21 | Esselte Corporation | Movable highlight strip |
| US9108453B2 (en) | 2011-11-23 | 2015-08-18 | R.R. Donnelley & Sons Company | Sortable notepad |
| CN105708541A (en) * | 2016-04-11 | 2016-06-29 | 赵国江 | Control method for throttling freezing type cryosurgery device |
| CN105852960A (en) * | 2016-04-11 | 2016-08-17 | 赵国江 | Gas throttle type cryosurgical device and method for controlling same |
| CN105852960B (en) * | 2016-04-11 | 2018-07-06 | 天津美电医疗科技有限公司 | Gas throttling type cryosurgical device and control method thereof |
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