CN105852960B - Gas throttling type cryosurgical device and control method thereof - Google Patents
Gas throttling type cryosurgical device and control method thereof Download PDFInfo
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- CN105852960B CN105852960B CN201610225817.8A CN201610225817A CN105852960B CN 105852960 B CN105852960 B CN 105852960B CN 201610225817 A CN201610225817 A CN 201610225817A CN 105852960 B CN105852960 B CN 105852960B
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/02—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/0053—Cabins, rooms, chairs or units for treatment with a hot or cold circulating fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00005—Cooling or heating of the probe or tissue immediately surrounding the probe
- A61B2018/00011—Cooling or heating of the probe or tissue immediately surrounding the probe with fluids
- A61B2018/00017—Cooling or heating of the probe or tissue immediately surrounding the probe with fluids with gas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00571—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
- A61B2018/00577—Ablation
- A61B2018/00583—Coblation, i.e. ablation using a cold plasma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/02—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
- A61B2018/0231—Characteristics of handpieces or probes
- A61B2018/0237—Characteristics of handpieces or probes with a thermoelectric element in the probe for cooling purposes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/02—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
- A61B2018/0231—Characteristics of handpieces or probes
- A61B2018/0262—Characteristics of handpieces or probes using a circulating cryogenic fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F2007/0054—Heating or cooling appliances for medical or therapeutic treatment of the human body with a closed fluid circuit, e.g. hot water
- A61F2007/0055—Heating or cooling appliances for medical or therapeutic treatment of the human body with a closed fluid circuit, e.g. hot water of gas, e.g. hot air or steam
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- Health & Medical Sciences (AREA)
- Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Vascular Medicine (AREA)
- Otolaryngology (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Compressors, Vaccum Pumps And Other Relevant Systems (AREA)
- Thermotherapy And Cooling Therapy Devices (AREA)
Abstract
The invention discloses a gas throttling type cryosurgical device and a control method thereof, which can realize various rewarming methods: the invention utilizes the gas temperature recovery (flow separation temperature recovery) which is divided from the high-pressure freezing gas and limited to be lower than the throttling working pressure; utilizing residual gas with the pressure lower than the freezing working pressure to rewarm (residual gas rewarming); using normal pressure gas for rewarming (normal pressure rewarming); utilizing throttling heating type gas rewarming (throttling rewarming); and (4) closing an air source and rewarming the equipment in the exhaust process (exhaust rewarming). The invention also introduces a gas preheating device, improves the temperature recovery efficiency and temperature, and realizes three functions of freezing, temperature recovery and heating. The invention corrects the technical prejudice that the throttling refrigeration type gas can only be used for refrigeration, solves the difficulty of rewarming of gas throttling type cryosurgical equipment, improves the utilization rate of the gas, reduces the operation cost, saves energy, protects the environment, improves the rewarming performance and increases the function of thermal therapy, and is beneficial to promoting the popularization and the improvement of the cryoablation technology.
Description
Technical field
The present invention relates to cryosurgery treatment medical instrument, invented a kind of gas throttling type cryosurgery system and its
Control method.
Background technology
Cryosurgery treatment is to damage earliest to make in method and human history with ablation lesion tissue using ultralow temperature
Pathological tissues ablation techniques.From nineteen sixty American Psychiatry surgeon Irving Cooper and engineer Arnold Lee
It has invented probe shape liquid nitrogen freezing apparatus and has been used for after freezing brain tissue, using liquid nitrogen as cryogenic fluid (refrigerant), heated nitrogen
Liquid nitrogen frozen surgical device as high temperature refrigerant (heating agent) is applied to treat various tumours.But liquid nitrogen frozen equipment complexity is stupid
Weight, operating difficulties and curative effect it is not good enough once made cryosurgery treatment sink into for a long time pause and decline.
From generation nineteen ninety, outside the gas throttling type cryogenic freezing headed by argon helium knife based on Joule-Thomson principle
The invention and extensive use of section's system, make cryosurgery regain the accreditation of medical field, have brought back to life cryogenic freezing surgical intervention
Technology.Such as using the argon helium knife of high pressure argon gas freezing and general pressure helium rewarming by oncology, Invasive Technology Department, Urology Surgery, chest
The clinical departments such as surgery, liver and gall surgical department, division of respiratory disease, Gastroenterology dept. use, and swell for liver cancer, lung cancer, cancer of pancreas, prostate cancer, kidney
The cryoablation treatment of the various good malignant entity tumors such as knurl, bone tumour, brain tumor, soft tissue neoplasm becomes clinical commonly used
One of tumour cryoablation method.
Cryogenic fluid is transported to target tissue and is named as freezer unit to the device that it is freezed by the present invention.In cryosurgery
In research and practice, freezer unit is also referred to as cryoprobe, frozen probe rod, cryoprobe, cryoprobe, freezing sacculus, freezes electrode, is super
Cold surery device, cryoprobe, cryotip or cryoneedle etc..
The two aspects that cryosurgery treatment technology needs to be rapidly frozen and rewarming thaws.According to its operation principle and use
Cryogenic fluid (refrigerant), main freezing mode has：
(1) liquid gasification type：The freezing mode of gasification heat absorption using cryogenic liquid (such as liquid nitrogen) as cryogenic fluid, such as
Liquid nitrogen frozen equipment.The advantages of such freezing mode is that common cryogenic liquid easily obtains, and of low cost.Shortcoming is fortune
Defeated and storage is inconvenient, and equipment volume is huge and heavy；Cryogenic liquid is exported by equipment connecting tube to freezer unit, must
Heat insulation layer is protected, and causes pipeline and freezer unit coarse stiff；And because freezer unit often has " gas blocks up " that stopping and resetting in art is needed to set
The problem of standby.Meanwhile freezing starting is slow and freezing rate is low, causes cell dehydration and influences refrigerating effect and local recurrence
The problem of rate is high.
(2) gas throttling type：The freezing mode of low temperature is generated using the Joule-Thomson throttle effect of high pressure gas, such as
Argon helium knife uses equipment of the compressed gas as cryogenic fluid with other.Its advantage be using gas at normal temperature, air shooter and
Freezer unit bar is not required to insulated heat, avoids the splash, leakage and frostbite of cryogenic freezing liquid；Controllability is good, easy to operate, freezing speed
Degree is fast, freezer unit diameter is thin.The drawback is that frozen gas operating pressure is high, and because pressure decline leads to cryogenic fluid waste very
Greatly.If argon helium knife is usually using 40 liters of argon bottles of full bottle pressure 35MPa, argon gas minimum operating pressure is 20MPa during freezing, often
Bottle can only use 1~1.5 hour, and the argon gas restriction effect less than 20MPa drastically reduces, and there are few refrigerating effects.Consider equipment
Itself is divided, and when gas cylinder output pressure is less than 21MPa, equipment exports to the pressure of freezer unit and will be less than 20MPa, can only discard.
Namely only have about 40% can utilize in whole bottle gas, 60% must discard.This brings greatly production, transport and using wave
Take.
The rewarming or heating function of freezing equipment be realize that modern cryosurgery generally acknowledges " freezing-rewarming-freezes again-again
Rewarming " Two-way Cycle therapeutic modality and function necessary to freezer unit is exited from freezing tissue.According to high temperature refrigerant (heating agent)
Type and method, main rewarming mode have：
(1) low-pressure gas of heating is passed through freezer unit, using heat transfer, directly heats inside freezer unit, such as liquid nitrogen frozen
The rewarming of equipment.The advantages of such rewarming mode is of low cost, technology maturation.Shortcoming is that liquid nitrogen plant needs to be equipped with additionally
Gas recycling, compression, storage and heating unit, volume is larger, complicated and rewarming speed is slower.
(2) heat-producing units such as electric heating, radio frequency, microwave, the laser being placed in freezer unit heating rewarming is utilized.Its advantage is not
It need to use or less use gas.The drawback is that rewarming speed is slower；And need by the inputs such as electric current be in direct contact tissue,
Inside the extremely low freezer unit of temperature, special electric shock and electromagnetic interference equivalent risk are generated.
(3) the direct heat production in freezer unit using the gas of throttle effect heat production under room temperature, as argon helium knife is answered using helium
Temperature (helium reversal temperature is 40K, throttling expansion heat release under room temperature).Such rewarming mode brings the rewarming being exceedingly fast and response speed
Degree, controllability is good, and simple in structure, does not need to extra means.But shortcoming is that the helium of rewarming belongs to expensive rare gas, according to
Rely import, price is about 8~10 times of same amount peer argon gas, and cost is very high；Helium heating ability is limited simultaneously, only up to reach
Arrive 320K or so.
Invention content
The present invention solves the existing rewarming problem of gas throttling type cryosurgery therapeutic equipment, corrects for throttling refrigeration type
Gas is only used for the technical prejudice that refrigeration, proposes to utilize throttling refrigeration type high pressure gas shunting rewarming and exhaust rewarming, profit
Thermal gas rewarming and the new gas throttle-type that can actively heat are caused with high pressure residual air and general body rewarming of calming the anger, compatible throttling
Cryosurgery system designs and implements scheme, can be economical and freezing is neatly realized, answers three kinds of functions of mild heat.It lifts below
Example argon helium knife, but the present invention includes all cryogenic freezing surgical devices using gas throttling effect, is not limited to argon helium knife.
In order to solve above-mentioned rewarming technical problem, a kind of gas throttling type Cryo-surgical apparatus proposed by the present invention, base
This structure includes high pressure freezing gas circuit, low pressure feeding pneumatic, low pressure pyrogenicity gas circuit, shunting gas circuit, freezer unit appendix and freezing
Device；The high pressure freezing gas circuit includes the high pressure gas input pipe, the frozen gas manifold that are sequentially connected with high-pressure air source gas outlet
With freezer unit appendix, the high pressure gas input pipe is equipped with high pressure air gauge and high-pressure pressure regulating valve, and the high pressure gas is defeated
The junction for entering pipe and the frozen gas manifold is equipped with high-pressure limiting valve, on the high pressure gas input pipe, positioned at the height
The pipeline section between pressure regulator valve and the high-pressure limiting valve is pressed to be equipped with the first threeway；The low pressure feeding pneumatic includes：With high pressure
Residual air delivery outlet that residual air air source is connected, the general pressure delivery outlet being connected with general pressurized air source, the helium delivery outlet being connected with helium gas source；
The junction of the high pressure residual air air source and the residual air delivery outlet is equipped with residual air air gauge and residual air pressure regulator valve；It is described general to calm the anger
Source and the junction of general pressure delivery outlet are equipped with general pressure air gauge and general pressure pressure regulator valve；The helium gas source and the helium delivery outlet
Junction is equipped with helium air gauge and helium pressure regulator valve；The low pressure pyrogenicity gas circuit includes low pressure confluence tracheae and pyrogenicity gas is total
Pipe, one end of low pressure confluence tracheae are low-pressure gas input port, the residual air delivery outlet, the general pressure delivery outlet and described
One of helium delivery outlet is connected to the low-pressure gas input port；The other end of the low pressure confluence tracheae is connected to consistent hot gas
Manifold；The low pressure confluence tracheae is equipped with low-voltage solenoid valve and low pressure pressure limiting valve, and the low pressure is converged on tracheae, positioned at described
Pipeline section between low-voltage solenoid valve and low pressure pressure limiting valve is equipped with the second threeway；Between first threeway and second threeway
Shunting tracheae is connected with, the shunting tracheae is equipped with solenoid diverter valve, and the shunting tracheae and the solenoid diverter valve are formed
The shunting gas circuit；The freezer unit appendix is connected to the end of the frozen gas manifold and the pyrogenicity gas main
Between, and pass through the air inlet pipe that the 4th threeway is connected to freezer unit, it is total that the frozen gas is located on the freezer unit appendix
Pipeline between the end of pipe and the 4th threeway is equipped with freezer unit and freezes solenoid valve, is located on the freezer unit appendix
Pipeline between the end of the pyrogenicity gas main and the 4th threeway is equipped with freezer unit heating electromagnetic valve.
Another technical solution proposed by the present invention is that the gas throttling type Cryo-surgical apparatus and above-mentioned basic structure are not
It is same to be only that：Wherein, it is independent to be equipped with a helium input pipe, the helium is connected to by helium delivery outlet input from helium gas source
Pipe, the helium input pipe are equipped with the helium air gauge, the helium pressure regulator valve, helium solenoid valve and helium pressure limiting valve,
The helium input pipe accesses pyrogenicity gas main at third threeway.
Further, the pyrogenicity gas main is equipped with gas heater.
The cause in the end and the low-pressure heating gas circuit of the frozen gas manifold of the high pressure freezing gas circuit
The end of hot gas manifold is parallel with a plurality of freezer unit appendix, every freezer unit appendix by the 4th threeway of multiple series connection
End be connected with a freezer unit.Realize that more freezer units synchronize freezing or rewarming operation.
It is the freezer unit freezing solenoid valve that is connect with freezer unit appendix, freezer unit heating electromagnetic valve, the 4th threeway, cold
Freeze device air inlet pipe and freezer unit constitute one be connected to the total pipe end of the frozen gas and the pyrogenicity gas main end it
Between component A；It is characterized in that, it is parallel between the total pipe end of the frozen gas and the pyrogenicity gas main end more
A component A realizes that more freezer units independently freeze or rewarming operates.
The freezer unit is the gas throttling refrigeration type freezing that low temperature is generated using the Joule-Thomson throttle effect of gas
Device；The high-pressure air source is the mixture that throttling expansion causes one or more of cold gas；The high-pressure air source, the height
Discard gas air source, the general pressurized air source and the helium gas source come from appointing in gas cylinder, gas tank, air pump, Dewar tank and compressor
What is at one.
Using the invention described above gas throttling type Cryo-surgical apparatus, following several rewarming modes can be realized：
First, rewarming mode is shunted：
High-pressure pressure regulating valve, solenoid diverter valve and freezer unit heating electromagnetic valve are opened, simultaneously closes off low-voltage solenoid valve and freezing
Device freezes solenoid valve；Rewarming gas is drawn by first threeway on the high pressure gas input pipe, through the shunting tracheae and
The solenoid diverter valve by second threeway, accesses the low pressure confluence tracheae, through the low pressure pressure limiting valve pressure limiting, connects
Enter the pyrogenicity gas main, controlled by the freezer unit heating electromagnetic valve, through the freezer unit appendix and the described 4th 3
Logical output realizes that rewarming is operated to the freezer unit by heat exchange, when freezer temps reach 0 DEG C to normal body temperature or institute
It states high pressure air gauge and shows that air pressure when being down to 1 atmospheric pressure, terminates the shunting rewarming；
2nd, residual air rewarming mode：
The residual air delivery outlet is connected to the low-pressure gas input port, opens residual air pressure regulator valve, low-voltage solenoid valve and cold
Freeze device heating electromagnetic valve, simultaneously close off solenoid diverter valve and freezer unit freezing solenoid valve；Rewarming gas is from the high pressure residual air gas
Source regulates and controls through the residual air air gauge and the residual air pressure regulator valve, and accessing the low-pressure gas by the residual air delivery outlet inputs
Mouthful, then through the low-voltage solenoid valve, access the low pressure confluence tracheae, through the low pressure pressure limiting valve pressure limiting, access the pyrogenicity
Gas main is controlled by the freezer unit heating electromagnetic valve, is exported through the freezer unit appendix and the 4th threeway to institute
Freezer unit is stated, realizes that rewarming operates by heat exchange, when freezer temps reach 0 DEG C to normal body temperature or the residual air air pressure
When table shows that 1 atmospheric pressure is down in air pressure, terminate the residual air rewarming；
3rd, general pressure rewarming mode：
The general pressure delivery outlet is connected to the low-pressure gas input port, opens general pressure pressure regulator valve, low-voltage solenoid valve and cold
Freeze device heating electromagnetic valve, simultaneously close off solenoid diverter valve and freezer unit freezing solenoid valve；General body of calming the anger is passed through from the general pressurized air source
The general pressure air gauge and the general pressure pressure regulator valve regulation and control access the low-pressure gas input port by the general pressure delivery outlet, then
Through the low-voltage solenoid valve, the low pressure confluence tracheae is accessed, through the low pressure pressure limiting valve pressure limiting, it is total to access the pyrogenicity gas
Pipe is controlled by the freezer unit heating electromagnetic valve, is exported through the freezer unit appendix and the 4th threeway to the freezing
Device realizes that rewarming operates by heat exchange, and when freezer temps reach 0 DEG C to normal body temperature or the general pressure air gauge is shown
When 1 atmospheric pressure is down in air pressure, terminate the general pressure rewarming；
4th, throttle rewarming mode, there is one of two following situations：
First, helium directly inputs the low-pressure gas input port and by the situation of low pressure pressure limiting valve pressure limiting, helium is opened
Pressure regulator valve, low-voltage solenoid valve and freezer unit heating electromagnetic valve simultaneously close off solenoid diverter valve and freezer unit freezing solenoid valve；Helium
By the helium gas source, through the helium air gauge and the helium pressure regulator valve, the low pressure gas is accessed by the helium delivery outlet
Body input port, then through the low-voltage solenoid valve, access the low pressure confluence tracheae, through the low pressure pressure limiting valve pressure limiting, access institute
Pyrogenicity gas main is stated, is controlled by the freezer unit heating electromagnetic valve, it is defeated through the freezer unit appendix and the 4th threeway
Go out to the freezer unit, by the heat release that throttles, (helium pressure is more than helium throttling work pressure after by the low pressure pressure limiting valve
During power) or heat exchange (when helium pressure is less than helium throttling operating pressure after by the low pressure pressure limiting valve) realization rewarming behaviour
Make, when freezer temps reach 0 DEG C to normal body temperature or when the helium air gauge shows that 1 atmospheric pressure is down in air pressure, knot
The beam throttling rewarming；
Second is that helium accesses the pyrogenicity gas main via independent helium access and sets the helium pressure limiting valve
The situation for the operating pressure that throttles for helium is opened helium pressure regulator valve, helium solenoid valve and freezer unit heating electromagnetic valve, is simultaneously closed off
The low-voltage solenoid valve, solenoid diverter valve and freezer unit freezing solenoid valve；Helium is by the helium gas source, through the helium input pipe
On the helium air gauge, the helium pressure regulator valve, the helium solenoid valve and the helium pressure limiting valve, in the described 3rd 3
Logical place, accesses the pyrogenicity gas main；It is controlled through the freezer unit appendix and the freezer unit heating electromagnetic valve, by described
It at 4th threeway, then exports to the freezer unit, by the heat release that throttles, (helium pressure is more than after by the low pressure pressure limiting valve
Helium throttle operating pressure when) or heat exchange (after by the low pressure pressure limiting valve helium pressure be less than helium throttle work pressure
During power) realize rewarming operation, when freezer temps reach 0 DEG C to normal body temperature or the helium air gauge shows that air pressure is down to
During 1 atmospheric pressure, terminate the throttling rewarming；
5th, rewarming mode is vented, including one of two following situations：
First, after the refrigeration operation that throttles, close the high-pressure pressure regulating valve and open freezing solenoid valve simultaneously, the high pressure
The frozen gas that accumulates will be continually fed into freezer unit in freezing gas circuit, until freezer temps reach 0 DEG C to during normal body temperature or
When the high pressure air gauge shows that 1 atmospheric pressure is down in air pressure, terminate exhaust rewarming；
Second is that closing the residual air pressure regulator valve, the general pressure pressure regulator valve and the helium pressure regulator valve after rewarming operation, open
The low-voltage solenoid valve or the low-voltage solenoid valve and helium solenoid valve, the freezer unit heating electromagnetic valve, the low pressure line
Middle residue pyrogenicity gas will be continually fed into the freezer unit, until freezer temps reach 0 DEG C to during normal body temperature or all gas
When pressure table shows that 1 atmospheric pressure is down in air pressure, terminate exhaust rewarming,
Compared with prior art, the beneficial effects of the invention are as follows：
(1) rewarming is shunted：The present invention corrects for the technology prejudice that throttling refrigeration type high pressure gas is only used for freezing, by dividing
Stream and pressure limiting, make it be directly used in rewarming.Our research indicate that when the argon pressure for being passed through freezer unit is less than the section of its 20MPa
When flowing operating pressure, throttling cooling-down effect weakens and disappears rapidly；At this time the room temperature argon gas (300K) in freezer unit will with outside it
Portion freezing tissue (100-273K) heat exchange and realize rewarming.
(2) it is vented rewarming：The present invention utilizes the process of emptying equipment residual air to be used for freezer unit rewarming.Cryosurgery apparatus makes
Emptying equipment residual air is needed after, because all air sources at this time are turned off and effect through pressure limiting valve, gas pressure will drop in equipment
Under refrigeration operating pressure, exhaust process will have rewarming effect.The argon gas of the refrigeration of freezer unit discharge at this time is by the argon with pyrogenicity
Gas/helium is together freezer unit rewarming, had both realized emptying residual air, and had also realized rewarming, and had killed two birds with one stone, and is further reduced to gas
It is required that and use cost.
(3) residual air rewarming：The present invention takes full advantage of less than freezing operating pressure, cannot be used for the residual high pressure freezed cause
Cold air is used for rewarming.Argon gas during argon helium knife use less than 21MPa cannot use, and can only retract gas generation quotient by bottle entirely
Bleed off residual air with again it is filling could keep 99.999% high-purity requirement.The present invention utilizes such residual air rewarming, reaches and holds high
Effect similar in expensive helium rewarming.
(4) general pressure rewarming：The present invention can also be used the common general arbitrary gas for pressing filling (12~15MPa) and be used for rewarming.
This kind of general body of calming the anger is seen everywhere and uses general compressed steel bottle (cost is 1/8th of high-pressure cylinder), and gas price is about same
/ 10th of volume high pressure gas.
(5) throttle rewarming：The present invention is also compatible with throttling pyrogenicity rewarming gas (such as helium) rewarming and is integrated into low pressure rewarming
In pipeline, to play the efficiency of helium rapid rewarming.Ours the study found that since helium reversal temperature is close to absolute zero simultaneously
Degree, and its pyrogenicity ability (Joule-Thomson coefficient) that throttles is not varied with temperature between 150K~400K and is changed, and introduces gas
Heater, which heats helium, will be superimposed throttling rewarming and conduction pyrogenicity double effects, greatly enhance the rewarming effect and speed of device.
(6) gas preheats：The present invention is also introduced into gas-heating apparatus preheating rewarming gas, it is made to be used to controllably heat lesion
Tissue, realizes tumor thermotherapy effect.
To sum up, the present invention is gases used at low cost：By the use of the shunting of high pressure argon gas, residual air and general body of calming the anger as rewarming gas
Body, cost will be significantly lower than rare throttling pyrogenicity type high-purity helium (8 times or more of difference)；Rewarming is vented by using equipment
And using the high-pressure air source residual air rewarming that cannot be used for freezing, gas effciency can be improved, avoids wasting, energy conservation and environmental protection.This
I.e. using existing helium rewarming technology, the general body rewarming of calming the anger that high pressure residual air can also be used and be seen everywhere does not need to for invention
Independent gas collection, compression and pushing meanss reduce equipment and using threshold, promote the universal of cryoablation technology.Pass through
Gas heater is introduced, low-pressure gas can be directly preheated to tumor thermotherapy temperature and input freezer unit, breach existing equipment
Heat up limit value, improves heating performance and increases the function of thermotherapy.
Description of the drawings
Fig. 1 is the schematic diagram of gas throttling type Cryo-surgical apparatus embodiment 1 of the present invention；
Fig. 2 is the schematic diagram of gas throttling type Cryo-surgical apparatus embodiment 2 of the present invention；
Fig. 3 is the schematic diagram of gas throttling type Cryo-surgical apparatus embodiment 3 of the present invention；
Fig. 4 is the schematic diagram of gas throttling type Cryo-surgical apparatus embodiment 4 of the present invention；
Fig. 5 is the schematic diagram of gas throttling type Cryo-surgical apparatus embodiment 5 of the present invention；
Fig. 6 is the schematic diagram of gas throttling type Cryo-surgical apparatus embodiment 6 of the present invention；
Fig. 7 is freezer arrangements schematic diagram used in the present invention；
Fig. 8 is the result of the test that embodiment 1 is vented rewarming pattern；
Fig. 9 is the result of the test of 1 residual air rewarming pattern of embodiment.
In figure：
1a- high-pressure air source 1b- high pressure air gauge 1c- high-pressure pressure regulating valves
2- high pressure gas input pipe 3- the first threeway the second threeways of 4-
5- high-pressure limiting valve 6- frozen gas manifold 7- freezer units freeze solenoid valve
8- freezer unit appendix 9- freezer unit 9a- freezer unit air inlet pipe
9c-J-T mouthfuls of 9d- expansion chambers of 9b- heat exchange fins
9e- freezer unit outer wall 9f- back cavity 9h- freezer unit air outlet pipes
9i- thermometric galvanic couple 10a- high pressure residual air air source 10b- residual air air gauges
The general pressurized air sources of 10c- residual air pressure regulator valve 10d- residual air delivery outlet 11a-
The general pressure general pressure delivery outlets of pressure regulator valve 11d- of the general pressure air gauge 11c- of 11b-
12a- helium gas source 12b- helium air gauge 12c- helium pressure regulator valves
12d- helium delivery outlets 13- shunts tracheae 14- solenoid diverter valves
15- helium input pipe 16- helium solenoid valve 17- helium pressure limiting valves
18- low-pressure gases input port 19- low-voltage solenoid valve 20- low pressure confluence tracheae
21- low pressure pressure limiting valve 22- third threeway 23- gas heaters
The 4th threeways of 24- pyrogenicity gas main's 25- freezer unit heating electromagnetic valves 26-
Specific embodiment
Technical solution of the present invention is described in further detail in the following with reference to the drawings and specific embodiments, it is described specific
Embodiment is only explained the present invention, is not intended to limit the invention.The freezer unit that all embodiments use is U.S.
The freezer unit (Φ 1.7mm, Φ 2.4mm, Φ 3.8mm etc.) of HealthTronics companies of state manufacture.
Embodiment 1：As shown in Figure 1, a kind of gas throttling type Cryo-surgical apparatus of the present invention, including high pressure freezing gas circuit,
Low pressure feeding pneumatic, low pressure pyrogenicity gas circuit, shunting gas circuit, freezer unit appendix 8 and freezer unit 9.
The high pressure freezing gas circuit includes the high pressure gas input pipe 2 being sequentially connected with high-pressure air source 1a gas outlets and freezing
Gas main 6, and the high pressure gas input pipe 2 is equipped with high pressure air gauge 1b and high-pressure pressure regulating valve 1c, the high pressure gas are defeated
The junction for entering the pipe 2 and frozen gas manifold 6 is equipped with high-pressure limiting valve 5；On the high pressure gas input pipe 2, positioned at institute
The pipeline section stated between high-pressure pressure regulating valve 1c and the high-pressure limiting valve 5 is equipped with the first threeway 3.
The low pressure feeding pneumatic includes：The residual air delivery outlet 10d being connected with high pressure residual air air source 10a and general pressurized air source
General pressure delivery outlet 11d, the helium delivery outlet 12d being connected with helium gas source 12a that 11a is connected；The high pressure residual air air source 10a and institute
The junction for stating residual air delivery outlet 10d is equipped with residual air air gauge 10b and residual air pressure regulator valve 10c；The general pressurized air source 11a and general pressure
The junction of delivery outlet 11d is equipped with general pressure air gauge 11b and general pressure pressure regulator valve 11c；The helium gas source 12a is exported with the helium
The junction of mouth 12d is equipped with helium air gauge 12b and helium pressure regulator valve 12c.
The high-pressure air source 1 is the mixture that throttling expansion causes one or more of cold gas；The high-pressure air source
1a, the high pressure residual air air source 10a, the general pressurized air source 11a and the helium gas source 12a come from gas cylinder, gas tank, air pump, Du
Any one in crock and compressor.
The low pressure pyrogenicity gas circuit includes low pressure confluence tracheae 20 and pyrogenicity gas main 24, the low pressure confluence tracheae 20
One end for low-pressure gas input port 18, the residual air delivery outlet 10d, the general pressure delivery outlet 11d and the helium delivery outlet
To be detachably connected between 12d and the low-pressure gas input port 18；The other end of the low pressure confluence tracheae 20 is connected to institute
State pyrogenicity gas main 24；The low pressure confluence tracheae 20 is equipped with low-voltage solenoid valve 19 and low pressure pressure limiting valve 21, the low pressure
The pipeline section to converge on tracheae 20, between the low-voltage solenoid valve 19 and the low pressure pressure limiting valve 21 is equipped with the second threeway 4.
Shunting tracheae 13 is connected between first threeway 3 and second threeway 4, the shunting tracheae 13 is equipped with
Solenoid diverter valve 14, the shunting tracheae 13 and the solenoid diverter valve 14 constitute the shunting gas circuit；
The freezer unit appendix 8 be connected to the frozen gas manifold 6 and the pyrogenicity gas main 24 end it
Between, and pass through the air inlet pipe 9a that the 4th threeway 26 is connected to freezer unit 9, the freezing gas is located on the freezer unit appendix 8
Pipeline between the end of body manifold 6 and the 4th threeway 26 is equipped with freezer unit and freezes solenoid valve 7, the freezer unit gas transmission
Pipeline on pipe 8 between the end of the pyrogenicity gas main 24 and the 4th threeway 26 is equipped with freezer unit heating electricity
Magnet valve 25.
The freezer unit 9 in the present invention is the gas section that low temperature is generated using the Joule-Thomson throttle effect of gas
Flow refrigeration type freezer unit.A kind of its typical structure is as shown in fig. 7, the freezer unit 9 includes freezer unit air inlet pipe 9a, heat exchange wing
9b, J-T mouthfuls of 9c of piece, expansion chamber 9d, freezer unit outer wall 9e, back cavity 9f and freezer unit air outlet pipe 9h, the point of the expansion chamber 9d
End is equipped with thermometric galvanic couple 9i, and the temperature of the freezer unit is measured in real time by the thermometric galvanic couple 9i.
Certainly, the geometry of heretofore described 9 application obscure portions of freezer unit and detail structure are unrestricted, should
Can be any one in cheese, spherical shape, elliposoidal, sacculus shape, needle-shaped, column, rod-shaped and tubulose with the geometry of part
Kind；The difference of its thin portion structure can be cryoprobe, frozen probe rod, cryoprobe, cryoprobe, freezing sacculus, freezing electrode, surpass
One kind in cold surery device, cryoprobe, cryotip and cryoneedle.
The control method that embodiment 1 is realized is as follows：
Frozen mode：Throttling frozen type high pressure gas is exported by high-pressure air source 1a, by high pressure air gauge 1b and high pressure pressure regulation
Valve 1c regulates and controls, and through high pressure gas input pipe 2, accesses high-pressure limiting valve 5, through pressure limiting to after freezing operating pressure, access freezing gas
Body manifold 6.When starting freezer unit freezing solenoid valve 7, high pressure frozen gas is passed through cold by freezer unit appendix 8 through the 4th threeway 26
Freeze device air inlet pipe 9a；The throttling expansion at freezer unit air inlet pipe 9a end J-T mouthful 9c of the frozen gas of input to expansion chamber 9d, is led to
Cross adjacent freezer unit outer wall 9e and surrounding tissue heat exchange, absorption refrigeration；The cryogenic gas of back cavity 9f reflux is through heat exchange wing
With freezer unit air inlet pipe 9a air inlets heat exchange occurs for piece 9b, after cooling air inlet is to improve throttle effect, chilled device air outlet pipe 9h
It flows out and discharges into air.The temperature of freezer unit is measured in real time by the thermometric galvanic couple 9i for being placed in freezer unit front inner wall.
The rewarming pattern that the embodiment of the present invention 1 is realized can be divided into shunting rewarming pattern, residual air according to the source of rewarming gas
Rewarming pattern, general pressure rewarming pattern, throttling rewarming pattern and exhaust rewarming pattern, wherein, residual air rewarming pattern, general pressure rewarming mould
In formula and throttling rewarming pattern, the residual air delivery outlet, general pressure one of the delivery outlet and the helium delivery outlet are connected to described
Low-pressure gas input port.Each rewarming pattern is detailed below：
(1) rewarming pattern is shunted：High-pressure pressure regulating valve 1c, solenoid diverter valve 14 and freezer unit heating electromagnetic valve 25 are opened, together
When close low-voltage solenoid valve 19 and freezer unit freezing solenoid valve 7；Rewarming gas is drawn by the first threeway 3 on high pressure gas input pipe 2
Go out, through shunting tracheae 13 and solenoid diverter valve 14, pass through the second threeway 4, access low pressure confluence tracheae 20, through the low pressure pressure limiting
21 pressure limiting of valve accesses the pyrogenicity gas main 24, is controlled by the freezer unit heating electromagnetic valve 25, through the freezer unit gas transmission
Pipe 8 and the 4th threeway 26 are exported to the freezer unit 9, realize that rewarming operates by heat exchange, when freezer temps reach 0
DEG C to during normal body temperature or the high pressure air gauge 1b show air pressure be down to 1 atmospheric pressure when, terminate the shunting rewarming.
(2) residual air rewarming pattern：The residual air delivery outlet 10d is connected to the low-pressure gas input port 18, opens residual air
Pressure regulator valve 10c, low-voltage solenoid valve 19 and freezer unit heating electromagnetic valve 25 simultaneously close off solenoid diverter valve 14 and freezer unit freezing electricity
Magnet valve 7；Rewarming gas is from the high pressure residual air air source 10a, through the residual air air gauge 10b and the residual air pressure regulator valve 10c tune
Control accesses the low-pressure gas input port 18 by the residual air delivery outlet 10d, then through the low-voltage solenoid valve 19, described in access
Low pressure confluence tracheae 20, through 21 pressure limiting of low pressure pressure limiting valve, accesses the pyrogenicity gas main 24, is heated by the freezer unit
Solenoid valve 25 controls, and is exported through the freezer unit appendix 8 and the 4th threeway 26 to the freezer unit 9, passes through heat exchange
Realize rewarming operation, when freezer temps reach 0 DEG C to normal body temperature or the residual air air gauge 10b shows that air pressure is down to 1
During a atmospheric pressure, terminate the residual air rewarming.
(3) general pressure rewarming pattern：The general pressure delivery outlet 11d is connected to the low-pressure gas input port 18, opens general pressure
Pressure regulator valve 11c, low-voltage solenoid valve 19 and freezer unit heating electromagnetic valve 25 simultaneously close off solenoid diverter valve 14 and freezer unit freezing electricity
Magnet valve 7；Rewarming gas is from the general pressurized air source 11a, through the general pressure air gauge 11b and the general pressure pressure regulator valve 11c regulation and control, by
The general pressure delivery outlet 11d accesses the low-pressure gas input port 18, then through the low-voltage solenoid valve 19, accesses the low pressure and converge
Flow tube 20 through 21 pressure limiting of low pressure pressure limiting valve, accesses the pyrogenicity gas main 24, by the freezer unit heating electromagnetic valve
25 controls, export through the freezer unit appendix 8 and the 4th threeway 26 to the freezer unit 9, are realized by heat exchange multiple
Temperature operation, when freezer temps reach 0 DEG C to normal body temperature or the general pressure air gauge 11b shows that 1 air is down in air pressure
During pressure, terminate the general pressure rewarming.
(4) throttle rewarming pattern：The helium delivery outlet 12d is connected to the low-pressure gas input port 18, helium is by helium
Air source 12a regulates and controls through helium air gauge 12b and helium pressure regulator valve 12c, by helium delivery outlet 12d, is connected to low-pressure gas input port
18, then through low-voltage solenoid valve 19, import low pressure confluence tracheae 20；When the helium from low pressure confluence tracheae 20 is through low pressure pressure limiting valve
21 pressure limitings are to helium operating pressure 6.9MPa or more, access pyrogenicity gas main 24, and chilled device heating electromagnetic valve 25 is controlled
System, chilled device appendix 8 and the 4th threeway 26 are exported to freezer unit air inlet pipe 9a, this throttling rewarming gas is in freezer unit
Throttling expansion is surrounding through adjacent freezer unit outer wall 9e to heat release pyrogenicity during expansion chamber 9d at air inlet pipe 9a end J-T mouthful 9c
Organize rewarming；When the helium from low pressure confluence tracheae 20, pressure is less than helium operating pressure after 21 pressure limiting of low pressure pressure limiting valve
During 6.9MPa, helium will realize that rewarming is operated by heat exchange, when freezer temps reach 0 DEG C to normal body temperature, terminate this
Throttle rewarming.
(5) rewarming pattern is vented, including one of two following situations：
First, high pressure gas rewarming after throttling refrigeration operation, closes the high-pressure pressure regulating valve 1c and opens freezing electromagnetism simultaneously
Valve 7, the high pressure, which freezes the frozen gas accumulated in gas circuit, will be continually fed into freezer unit 9, due to being passed through the gas of freezer unit 9 at this time
Body pressure is down to it and is freezed under operating pressure, and throttling refrigeration effect will disappear, which will become rewarming gas.This rewarming gas
Body freezer unit expansion chamber 9d through adjacent freezer unit outer wall 9e and around freezing tissue heat exchange and pyrogenicity；The gas warp of reflux
Back cavity 9f and freezer unit air outlet pipe 9h are discharged into air.Until freezer temps reach 0 DEG C to during normal body temperature or described
When high pressure air gauge 1b shows that 1 atmospheric pressure is down in air pressure, terminate exhaust rewarming；
Second is that low pressure exhaust rewarming, closed after rewarming operation the residual air pressure regulator valve 10c, the general pressure pressure regulator valve 11c or
The helium pressure regulator valve 12c, opens the low-voltage solenoid valve 19 and the freezer unit pyrogenicity solenoid valve 25, in the low pressure line
Remaining pyrogenicity gas will be continually fed into the freezer unit 9 as its rewarming, until freezer temps reach 0 DEG C to during normal body temperature or
When all air gauges show that 1 atmospheric pressure is down in air pressure, terminate exhaust rewarming.
Embodiment 2：As shown in Fig. 2, it is located on the basis of above-described embodiment 1, on the pyrogenicity gas main 24 described
Pipeline between low pressure pressure limiting valve 21 and freezer unit pyrogenicity solenoid valve 25 is equipped with gas heater 23, makes low pressure rewarming gas pre-
Freezer unit is inputted after heat again, so as to enhance the effect of multiple mild heat.
The control method that embodiment 2 is realized includes frozen mode and rewarming pattern, is answered according to the source difference of rewarming gas
Warm pattern can be divided into (1) shunting rewarming pattern, (2) residual air rewarming pattern, (3) general pressure rewarming pattern, (4) throttling rewarming pattern and
(5) rewarming pattern is vented, control process mode corresponding with embodiment 1 is essentially identical, adds simply by the gas of introducing
Hot device 23 can directly preheat low-pressure gas and input freezer unit, breach the heating limit value and heating rate of existing equipment, improve
Heating performance and the function of increasing thermotherapy.
Embodiment 3：As shown in figure 3, the basic structure phase of the gas throttling type Cryo-surgical apparatus and above-described embodiment 1
Seemingly, difference is：The present embodiment helium access is detached with other low-pressure gas accesses, and sets the helium solenoid valve of independent control
With helium pressure limiting valve, i.e. helium accesses an independent helium input pipe 15 by the helium gas source 12a, and the other end is in third threeway
It is connected to the pyrogenicity gas main 24 at 22, is equipped with the helium air gauge 12b, described on the helium input pipe 15 successively
Helium pressure regulator valve (12c), helium solenoid valve 16 and helium pressure limiting valve 17.
Embodiment 3 sets independent 17 pressure limiting of helium pressure limiting valve to helium throttling pyrogenicity operating pressure (6.9MPa).
And remaining low pressure rewarming gas can not be limited by 21 pressure limiting of low pressure pressure limiting valve to arbitrary default operating pressure by helium operating pressure
System can make full use of the efficiency of throttling pyrogenicity rapid rewarming and improve the utilization rate of low-pressure gas.
The control method that embodiment 3 is realized includes frozen mode and rewarming pattern：
Frozen mode：With embodiment 1.
Rewarming pattern：According to the source of rewarming gas, can be divided into：
(1) rewarming pattern is shunted：With embodiment 1；
(2) residual air rewarming pattern：With embodiment 1；
(3) general pressure rewarming pattern：With embodiment 1；
(4) helium rewarming pattern：Helium, through helium air gauge 12b and helium pressure regulator valve 12c, accesses helium by helium gas source 12a
Gas input pipe 15, and through helium solenoid valve 16 and helium pressure limiting valve 17, after pressure limiting to helium pyrogenicity operating pressure, through third threeway
22, access pyrogenicity gas main 24；Chilled device heating electromagnetic valve 25 controls again, through the freezer unit appendix 8 and described
Four threeways 26 are exported to freezer unit air inlet pipe 9a, implement the operation of freezer unit rewarming.
(5) it is vented rewarming pattern：With embodiment 1.
Embodiment 4：As shown in figure 4, it is located on the basis of above-described embodiment 3, on the pyrogenicity gas main 24 described
Pipeline between third threeway 22 and freezer unit pyrogenicity solenoid valve 25 is equipped with gas heater 23, makes low pressure rewarming gas (packet
Include helium) preheating after input freezer unit again, so as to enhance the effect of multiple mild heat.
The control method that embodiment 4 is realized includes frozen mode and rewarming pattern, is answered according to the source difference of rewarming gas
Warm pattern can be divided into：(1) shunting rewarming pattern, (2) residual air rewarming pattern, (3) general pressure rewarming pattern, (4) throttling rewarming pattern
(5) rewarming pattern is vented, control process mode corresponding with embodiment 3 is essentially identical, simply by the gas of introducing
Heater 23 can directly preheat low-pressure gas and input freezer unit, breach the heating limit value and heating rate of existing equipment, carry
High warming can and increase the function of thermotherapy.
Embodiment 5：As shown in figure 5, on the basis of above-described embodiment 1-4, the freezer unit appendix (8) is positioned at described
Have the described 4th 3 of multiple series connection on pipeline section between freezer unit freezing solenoid valve (7) and freezer unit heating electromagnetic valve (25)
Logical (26), each 4th threeway (26) connect a freezer unit (9) respectively.The control method of embodiment 5 such as embodiment
Any control method is essentially identical in 1-4, and more freezer units finally can be achieved and synchronize freezing or rewarming.
Embodiment 6：As shown in fig. 6, on the basis of above-described embodiment 1-4, the freezer unit appendix 8 and disposed thereon
The freezer unit freezing solenoid valve 7, freezer unit heating electromagnetic valve 25, the 4th threeway 26, air inlet pipe 9a and freezer unit 9 constitute one
The component A being connected between 6 ends of frozen gas manifold and 24 end of pyrogenicity gas main, in the frozen gas
Multiple component A are parallel between 6 ends of manifold and 24 end of pyrogenicity gas main.The control method of embodiment 6
If any control method is essentially identical in embodiment 1-4, the mutually independent freezing of more freezer units or rewarming finally can be achieved.
Verification experimental verification：
(1) exhaust rewarming verification：Freezing exhaust rewarming is carried out to 1 technical solution of embodiment (no gas preheating) to test
Card：The 2.4mm diameter freezer units that HealthTronics companies of the U.S. manufacture are connected to the device first, before the freezer unit
End frozen portions be totally submerged in 36~37 DEG C of thermostatted waters close to body temperature, temperature probe be respectively placed in water neutralization be fixed on it is cold
Freeze device front end；Using 25MPa (3500psi) the high pressure argon gas sources higher than argon gas throttling operating pressure as high-pressure air source 1, high pressure
Pressure limiting valve 5 is arranged on 20MPa (2800psi), starts to test at 22 DEG C of room temperature." frozen mode " first is used, opens high pressure tune
Pressure valve 1c and freezer unit freezing solenoid valve 7, freezer unit is refrigerated to -100 DEG C and forms normal ice hockey by high pressure argon gas to stop after five minutes
Only freeze.Start " exhaust rewarming " operating mode immediately, close high-pressure pressure regulating valve 1c and freezer unit freezing solenoid valve 7 is kept to open
It opens, gas is gradually discharged from freezer unit 9 in device, air pressure declines from 20MPa (2800psi), by freezer unit rewarming in 180 seconds
To 10 DEG C or more.Result of the test is as shown in Figure 8.This is the experiment proves that the good result of exhaust rewarming.
(2) residual air rewarming is verified：Residual air rewarming verification experimental verification has been carried out to 1 technical solution of embodiment：First by the U.S.
The 2.4mm diameter freezer units of HealthTronics companies manufacture are connected to the device, and the freezer unit front end frozen portions are complete
It is immersed in close in 36~37 DEG C of thermostatted waters of body temperature, 21 DEG C of room temperature；Temperature probe is respectively placed in water neutralization and is fixed on freezer unit
Probe distal end.Using 25MPa (3500psi) the high pressure argon gas sources higher than argon gas throttling operating pressure as high-pressure air source 1, residual air
Air source 10a is used below remaining 17.5MPa (2500psi) the pressure argon gas of argon gas refrigeration operating pressure and sets low pressure pressure limiting valve
21 be 12.5MPa (1800psi)." frozen mode " first is used, opens high-pressure pressure regulating valve 1c and freezer unit freezing solenoid valve 7, it is high
Pressure argon gas by freezer unit be refrigerated to -100 DEG C and formed normal ice hockey close after five minutes freezer unit freezing solenoid valve 7 stop freezing.
Start " residual air rewarming pattern " immediately, open low-voltage solenoid valve 19 and freezer unit heating electromagnetic valve 25, pressure limiting 12.5MPa
The low-pressure argon of (1800psi) will input freezer unit 9, by 9 rewarming of freezer unit to 0 DEG C or more in 200 seconds.Result of the test is as schemed
Shown in 9.This is the experiment proves that the effect of residual air rewarming.
Although above in conjunction with figure, invention has been described, and the invention is not limited in above-mentioned specific embodiment parties
Formula, above-mentioned specific embodiment is only schematical rather than restricted, and those of ordinary skill in the art are in this hair
Under bright enlightenment, without deviating from the spirit of the invention, many variations can also be made, these belong to the guarantor of the present invention
Within shield.
Claims (9)
1. a kind of gas throttling type Cryo-surgical apparatus, including high pressure freezing gas circuit, low pressure feeding pneumatic, low pressure pyrogenicity gas circuit,
Shunt gas circuit, freezer unit appendix (8) and freezer unit (9)；
The high pressure freezing gas circuit includes：The high pressure gas input pipe (2) that is sequentially connected with high-pressure air source (1a) gas outlet and cold
Freeze gas main (6), the high pressure gas input pipe (2) is equipped with high pressure air gauge (1b) and high-pressure pressure regulating valve (1c), described
High pressure gas input pipe (2) and the junction of the frozen gas manifold (6) are equipped with high-pressure limiting valve (5), the high pressure gas
Pipeline section on input pipe (2), between the high-pressure pressure regulating valve (1c) and the high-pressure limiting valve (5) is equipped with the first threeway
(3)；
It is characterized in that：
The low pressure feeding pneumatic includes：The residual air delivery outlet (10d) being connected with high pressure residual air air source (10a) and general pressurized air source
(11a) connected general pressure delivery outlet (11d), the helium delivery outlet (12d) being connected with helium gas source (12a)；The high pressure residual air gas
Source (10a) and the junction of the residual air delivery outlet (10d) are equipped with residual air air gauge (10b) and residual air pressure regulator valve (10c)；It is described
The junction of general pressurized air source (11a) and general pressure delivery outlet (11d) is equipped with general pressure air gauge (11b) and general pressure pressure regulator valve (11c)；Institute
It states helium gas source (12a) and the junction of the helium delivery outlet (12d) is equipped with helium air gauge (12b) and helium pressure regulator valve
(12c)；
The low pressure pyrogenicity gas circuit includes：Low pressure confluence tracheae (20) and pyrogenicity gas main (24), the low pressure confluence tracheae
(20) one end is low-pressure gas input port (18), the residual air delivery outlet (10d), the general pressure delivery outlet (11d) and described
It is to be detachably connected between helium delivery outlet (12d) and the low-pressure gas input port (18)；The low pressure confluence tracheae
(20) the other end is connected with the pyrogenicity gas main (24)；The low pressure confluence tracheae (20) is equipped with low-voltage solenoid valve
(19) converge with low pressure pressure limiting valve (21), the low pressure on tracheae (20), positioned at the low-voltage solenoid valve (19) and the low pressure
Pipeline section between pressure limiting valve (21) is equipped with the second threeway (4)；
Shunting tracheae (13) is connected between first threeway (3) and second threeway (4), it is described to shunt on tracheae (13)
Equipped with solenoid diverter valve (14), the shunting tracheae (13) and the solenoid diverter valve (14) constitute the shunting gas circuit；
The freezer unit appendix (8) is connected to the end of the frozen gas manifold (6) and the pyrogenicity gas main (24)
End between, and pass through the 4th threeway (26) and be connected to the freezer unit air inlet pipe (9a), the freezer unit air inlet pipe (9a)
It is connected with the freezer unit (9)；On the freezer unit appendix (8), positioned at the end of the frozen gas manifold (6) with it is described
Pipeline between 4th threeway (26) is equipped with freezer unit freezing solenoid valve (7), on the freezer unit appendix (8), positioned at institute
The pipeline stated between the end of pyrogenicity gas main (24) and the 4th threeway (26) is equipped with freezer unit heating electromagnetic valve
(25)。
2. a kind of gas throttling type Cryo-surgical apparatus, including high pressure freezing gas circuit, low pressure feeding pneumatic, low pressure pyrogenicity gas circuit,
Shunt gas circuit, freezer unit appendix (8) and freezer unit (9)；
The high pressure freezing gas circuit includes：The high pressure gas input pipe (2) that is sequentially connected with high-pressure air source (1a) gas outlet and cold
Freeze gas main (6), the high pressure gas input pipe (2) is equipped with high pressure air gauge (1b) and high-pressure pressure regulating valve (1c), described
High pressure gas input pipe (2) and the junction of the frozen gas manifold (6) are equipped with high-pressure limiting valve (5), the high pressure gas
Pipeline section on input pipe (2), between the high-pressure pressure regulating valve (1c) and the high-pressure limiting valve (5) is equipped with the first threeway
(3)；
It is characterized in that：
The low pressure feeding pneumatic includes：The residual air delivery outlet (10d) being connected with high pressure residual air air source (10a) and general pressurized air source
(11a) connected general pressure delivery outlet (11d), the helium input pipe (15) being connected with helium gas source (12a)；The high pressure residual air air source
(10a) and the junction of the residual air delivery outlet (10d) are equipped with residual air air gauge (10b) and residual air pressure regulator valve (10c)；It is described general
The junction of pressurized air source (11a) and general pressure delivery outlet (11d) is equipped with general pressure air gauge (11b) and general pressure pressure regulator valve (11c)；It is described
Helium input pipe (15) is equipped with helium air gauge (12b), helium pressure regulator valve (12c), helium solenoid valve (16) and helium pressure limiting
Valve (17)；
The low pressure pyrogenicity gas circuit includes：Low pressure confluence tracheae (20) and pyrogenicity gas main (24), the low pressure confluence tracheae
(20) one end be low-pressure gas input port (18), the residual air delivery outlet (10d) and it is described it is general press delivery outlet (11d) with it is described
Low-pressure gas input port is to be detachably connected between (18)；The other end of the low pressure confluence tracheae (20) passes through third threeway
(22) it is connected with the pyrogenicity gas main (24), meanwhile, the helium input pipe (15) is connect by the third threeway (22)
Enter pyrogenicity gas main (24)；
The low pressure confluence tracheae (20) is equipped with low-voltage solenoid valve (19) and low pressure pressure limiting valve (21), the low pressure confluence tracheae
(20) on：The second threeway (4) is equipped on the pipeline section between the low-voltage solenoid valve (19) and low pressure pressure limiting valve (21),
Positioned at the low pressure pressure limiting valve (21)
Shunting tracheae (13) is connected between first threeway (3) and second threeway (4), it is described to shunt on tracheae (13)
Equipped with solenoid diverter valve (14), the shunting tracheae (13) and the solenoid diverter valve (14) constitute the shunting gas circuit；
The freezer unit appendix (8) is connected to the end of the frozen gas manifold (6) and the pyrogenicity gas main (24)
End between, and pass through the 4th threeway (26) and be connected to freezer unit air inlet pipe (9a), the freezer unit air inlet pipe (9a) and institute
Freezer unit (9) is stated to be connected；On the freezer unit appendix (8), positioned at the end and the described 4th of the frozen gas manifold (6)
Pipeline between threeway (26) is equipped with freezer unit freezing solenoid valve (7), on the freezer unit appendix (8), positioned at the cause
Pipeline between the end of hot gas manifold (24) and the 4th threeway (26) is equipped with freezer unit heating electromagnetic valve (25).
3. gas throttling type Cryo-surgical apparatus according to claim 1 or claim 2, which is characterized in that the pyrogenicity gas main
(24) end is equipped with gas heater (23).
4. gas throttling type Cryo-surgical apparatus according to claim 1 or claim 2, which is characterized in that the freezer unit appendix
(8) there are multiple series connection on the pipeline section between freezer unit freezing solenoid valve (7) and freezer unit heating electromagnetic valve (25)
The 4th threeway (26), each 4th threeway (26) is respectively connected with freezer unit air inlet pipe (9a), the freezing
Device air inlet pipe (9a) is connected with freezer unit (9).
5. gas throttling type Cryo-surgical apparatus according to claim 1 or claim 2, which is characterized in that the freezer unit appendix
(8), freezer unit freezing solenoid valve (7), the freezer unit heating electromagnetic valve (25), the 4th threeway (26), it is described into
Tracheae (9a) and the freezer unit (9), which constitute, is connected to frozen gas manifold (6) ends and the pyrogenicity gas main
(24) the component A between end；It is in parallel between frozen gas manifold (6) ends and pyrogenicity gas main (24) end
There are multiple component A.
6. gas throttling type Cryo-surgical apparatus according to claim 1 or claim 2, which is characterized in that the freezer unit (9) is profit
The gas throttling refrigeration type freezer unit of low temperature is generated with the Joule-Thomson throttle effect of gas.
7. gas throttling type Cryo-surgical apparatus according to claim 1 or claim 2, which is characterized in that the high-pressure air source (1a)
It is the mixture that throttling expansion causes one or more of cold gas；The high-pressure air source (1a), the high pressure residual air air source
(10a), the general pressurized air source (11a) and the helium gas source (12a) come from gas cylinder, gas tank, air pump, Dewar tank and compressor
Any one.
8. a kind of control method of gas throttling type Cryo-surgical apparatus, it is characterised in that：
Using gas throttling type Cryo-surgical apparatus as described in any such as claim 1 and 3 to 7, and including following a kind of or more
Kind rewarming mode：
(1) rewarming mode is shunted：High-pressure pressure regulating valve (1c), solenoid diverter valve (14) and freezer unit heating electromagnetic valve (25) are opened,
Simultaneously close off low-voltage solenoid valve (19) and freezer unit freezing solenoid valve (7)；Rewarming gas is by the high pressure gas input pipe (2)
First threeway (3) is drawn, and through the shunting tracheae (13) and the solenoid diverter valve (14), passes through second threeway
(4), the low pressure confluence tracheae (20) is accessed, through low pressure pressure limiting valve (21) pressure limiting, accesses the pyrogenicity gas main
(24), it is controlled by the freezer unit heating electromagnetic valve (25), it is defeated through the freezer unit appendix (8) and the 4th threeway (26)
Go out to the freezer unit (9), realize that rewarming operates by heat exchange, when freezer temps reach 0 DEG C to normal body temperature or institute
It states air gauge (1b) and shows that air pressure when being down to 1 atmospheric pressure, terminates the shunting rewarming；
(2) residual air rewarming mode：
The residual air delivery outlet (10d) is connect with the low-pressure gas input port (18), meanwhile, the general pressure delivery outlet
(11d) and the helium delivery outlet (12d) are not connect with the low-pressure gas input port (18)；Open residual air pressure regulator valve
(10c), low-voltage solenoid valve (19) and freezer unit heating electromagnetic valve (25) simultaneously close off solenoid diverter valve (14) and freezer unit freezing
Solenoid valve (7)；Rewarming gas is from the high pressure residual air air source (10a), through the residual air air gauge (10b) and the residual air pressure regulation
Valve (10c) regulates and controls, and the low-pressure gas input port (18) is accessed, then through the low voltage electromagnetic by the residual air delivery outlet (10d)
Valve (19) accesses the low pressure confluence tracheae (20), through low pressure pressure limiting valve (21) pressure limiting, accesses the pyrogenicity gas main
(24), it is controlled by the freezer unit heating electromagnetic valve (25), it is defeated through the freezer unit appendix (8) and the 4th threeway (26)
Go out to the freezer unit (9), realize that rewarming operates by heat exchange, when freezer temps reach 0 DEG C to normal body temperature or institute
It states residual air air gauge (10b) and shows that air pressure when being down to 1 atmospheric pressure, terminates the residual air rewarming；
(3) general pressure rewarming mode：
The general pressure delivery outlet (11d) is connect with the low-pressure gas input port (18), meanwhile, the residual air delivery outlet
(10d) and the helium delivery outlet (12d) are not connect with the low-pressure gas input port (18)；Open general pressure pressure regulator valve
(11c), low-voltage solenoid valve (19) and freezer unit heating electromagnetic valve (25) simultaneously close off solenoid diverter valve (14) and freezer unit freezing
Solenoid valve (7)；Rewarming gas is from the general pressurized air source (11a), through the general pressure air gauge (11b) and the general pressure pressure regulator valve
(11c) regulates and controls, and the low-pressure gas input port (18) is accessed, then through the low-voltage solenoid valve by the general pressure delivery outlet (11d)
(19), the low pressure confluence tracheae (20) is accessed, through low pressure pressure limiting valve (21) pressure limiting, accesses the pyrogenicity gas main
(24), it is controlled by the freezer unit heating electromagnetic valve (25), it is defeated through the freezer unit appendix (8) and the 4th threeway (26)
Go out to the freezer unit (9), realize that rewarming operates by heat exchange, when freezer temps reach 0 DEG C to normal body temperature or institute
It states general pressure air gauge (11b) and shows that air pressure when being down to 1 atmospheric pressure, terminates the general pressure rewarming；
(4) throttle rewarming mode：
The helium delivery outlet (12d) is connect with the low-pressure gas input port (18), meanwhile, the residual air delivery outlet
(10d) and the general pressure delivery outlet (11d) do not connect with the low-pressure gas input port (18)；Open helium pressure regulator valve
(12c), low-voltage solenoid valve (19) and freezer unit heating electromagnetic valve (25) simultaneously close off solenoid diverter valve (14) and freezer unit freezing
Solenoid valve (7)；Helium is regulated and controled through the helium air gauge (12b) and helium pressure regulator valve (12c) by the helium gas source (12a), by
Helium delivery outlet (12d) is connected to low-pressure gas input port (18), then through low-voltage solenoid valve (19), imports the low pressure confluence gas
It manages (20), through low pressure pressure limiting valve (21) pressure limiting, accesses the pyrogenicity gas main (24)；By the freezer unit heating electromagnetic
Valve (25) controls, and through the freezer unit appendix (8) and the 4th threeway (26) output to the freezer unit (9), this throttles
Rewarming gas heat release pyrogenicity when throttling expansion is to expansion chamber 9d at freezer unit air inlet pipe 9a end J-T mouthful 9c, through adjacent cold
It is surrounding tissue rewarming to freeze device outer wall 9e；When freezer temps reach 0 DEG C to normal body temperature or the helium air gauge (12b)
When 1 atmospheric pressure is down in display air pressure, terminate the throttling rewarming；
(5) rewarming mode is vented, including one of two following situations：
First, after the refrigeration operation that throttles, close the high-pressure pressure regulating valve (1c) and open freezing solenoid valve (7) simultaneously, it is described
The frozen gas accumulated in high pressure freezing gas circuit will be continually fed into freezer unit (9), until freezer temps reach 0 DEG C to regular
When warm or when the high pressure air gauge (1b) shows that 1 atmospheric pressure is down in air pressure, terminate exhaust rewarming；
Second is that the residual air pressure regulator valve (10c), the general pressure pressure regulator valve (11c) and the helium pressure regulation are closed after rewarming operation
Valve (12c) opens the low-voltage solenoid valve (19) and the freezer unit pyrogenicity solenoid valve (25), and residue causes in the low pressure line
Hot gas will be continually fed into the freezer unit (9), until freezer temps reach 0 DEG C to during normal body temperature or all air gauges are shown
When showing that 1 atmospheric pressure is down in air pressure, terminate exhaust rewarming.
9. a kind of control method of gas throttling type Cryo-surgical apparatus, it is characterised in that：Using such as claim 2 and 3 to 7
Any gas throttling type Cryo-surgical apparatus, and including one or more of rewarming mode：
(1) rewarming mode is shunted：High-pressure pressure regulating valve (1c), solenoid diverter valve (14) and freezer unit heating electromagnetic valve (25) are opened,
Simultaneously close off low-voltage solenoid valve (19) and freezer unit freezing solenoid valve (7)；Rewarming gas is by the high pressure gas input pipe (2)
First threeway (3) is drawn, and through the shunting tracheae (13) and the solenoid diverter valve (14), passes through second threeway
(4), the low pressure confluence tracheae (20) is accessed, through low pressure pressure limiting valve (21) pressure limiting, accesses the pyrogenicity gas main
(24), it is controlled by the freezer unit heating electromagnetic valve (25), it is defeated through the freezer unit appendix (8) and the 4th threeway (26)
Go out to the freezer unit (9), realize that rewarming operates by heat exchange, when freezer temps reach 0 DEG C to normal body temperature or institute
It states high pressure air gauge (1b) and shows that air pressure when being down to 1 atmospheric pressure, terminates the shunting rewarming；
(2) residual air rewarming mode：
The residual air delivery outlet (10d) is connect with the low-pressure gas input port (18), meanwhile, the general pressure delivery outlet
(11d) is not connect with the low-pressure gas input port (18), opens residual air pressure regulator valve (10c), low-voltage solenoid valve (19) and freezing
Device heating electromagnetic valve (25) simultaneously closes off solenoid diverter valve (14) and freezer unit freezing solenoid valve (7)；Rewarming gas is from the height
Discard gas air source (10a) regulates and controls through the residual air air gauge (10b) and the residual air pressure regulator valve (10c), is exported by the residual air
Mouth (10d) accesses the low-pressure gas input port (18), then through the low-voltage solenoid valve (19), accesses the low pressure confluence tracheae
(20), through low pressure pressure limiting valve (21) pressure limiting, the pyrogenicity gas main (24) is accessed, by the freezer unit heating electromagnetic valve
(25) it controls, through the freezer unit appendix (8) and the 4th threeway (26) output to the freezer unit (9), is handed over by heat
It changes and realizes rewarming operation, when freezer temps reach 0 DEG C to normal body temperature or the residual air air gauge (10b) shows air pressure drop
During to 1 atmospheric pressure, terminate the residual air rewarming；
(3) general pressure rewarming mode：
The general pressure delivery outlet (11d) is connect with the low-pressure gas input port (18), meanwhile, the residual air delivery outlet
(10d) is not connect with the low-pressure gas input port (18), opens general pressure pressure regulator valve (11c), low-voltage solenoid valve (19) and freezing
Device heating electromagnetic valve (25) simultaneously closes off solenoid diverter valve (14) and freezer unit freezing solenoid valve (7)；Rewarming gas is from described general
Pressurized air source (11a) regulates and controls through the general pressure air gauge (11b) and the general pressure pressure regulator valve (11c), by the general pressure delivery outlet
(11d) accesses the low-pressure gas input port (18), then through the low-voltage solenoid valve (19), accesses the low pressure confluence tracheae
(20), through low pressure pressure limiting valve (21) pressure limiting, the pyrogenicity gas main (24) is accessed, by the freezer unit heating electromagnetic valve
(25) it controls, through the freezer unit appendix (8) and the 4th threeway (26) output to the freezer unit (9), is handed over by heat
It changes and realizes rewarming operation, when freezer temps reach 0 DEG C to normal body temperature or the general pressure air gauge (11b) shows air pressure drop
During to 1 atmospheric pressure, terminate the general pressure rewarming；
(4) throttle rewarming mode：
Helium pressure regulator valve (12c), helium solenoid valve (16) and freezer unit heating electromagnetic valve (25) are opened, simultaneously closes off low voltage electromagnetic
Valve (19), solenoid diverter valve (14) and freezer unit freezing solenoid valve (7)；Helium is by the helium gas source (12a), through the helium gas
Table (12b) and the helium pressure regulator valve (12c) are pressed, accesses the helium input pipe (15), and through the helium solenoid valve (16)
With the helium pressure limiting valve (17), through the third threeway (22), the pyrogenicity gas main (24) is accessed；Again through the freezing
Device heating electromagnetic valve (25) controls, and through the freezer unit appendix (8) and the 4th threeway (26), exports to the freezer unit
(9), realize that rewarming operates by throttling expansion heat release inside it, when freezer temps reach 0 DEG C to normal body temperature or
When the helium air gauge (12b) shows that 1 atmospheric pressure is down in air pressure, terminate the throttling rewarming；
(5) rewarming mode is vented, including one of two following situations：
First, after the refrigeration operation that throttles, close the high-pressure pressure regulating valve (1c) and open freezing solenoid valve (7) simultaneously, it is described
The frozen gas accumulated in high pressure freezing gas circuit will be continually fed into freezer unit (9), until freezer temps reach 0 DEG C to regular
When warm or when the high pressure air gauge (1b) shows that 1 atmospheric pressure is down in air pressure, terminate exhaust rewarming；
Second is that the residual air pressure regulator valve (10c), the general pressure pressure regulator valve (11c) and the helium pressure regulation are closed after rewarming operation
Valve (12c) opens the low-voltage solenoid valve (19), the helium solenoid valve (16) and the freezer unit pyrogenicity solenoid valve (25),
Remaining pyrogenicity gas will be continually fed into the freezer unit (9) in the low pressure line, until freezer temps reach 0 DEG C to normal
During body temperature or when all air gauges show that 1 atmospheric pressure is down in air pressure, terminate exhaust rewarming.
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| CN106768606A (en) * | 2016-12-15 | 2017-05-31 | 南通华夏飞机工程技术股份有限公司 | Cold air testboard |
| CN109481003A (en) * | 2018-12-29 | 2019-03-19 | 天津美电医疗科技有限公司 | A kind of low temperature nitrogen Cryoablation system |
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