CN107951558B - Multifunctional gas pipeline controlled cryoablation system - Google Patents
Multifunctional gas pipeline controlled cryoablation system Download PDFInfo
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- CN107951558B CN107951558B CN201711105077.5A CN201711105077A CN107951558B CN 107951558 B CN107951558 B CN 107951558B CN 201711105077 A CN201711105077 A CN 201711105077A CN 107951558 B CN107951558 B CN 107951558B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/02—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
- F17D—PIPE-LINE SYSTEMS; PIPE-LINES
- F17D1/00—Pipe-line systems
- F17D1/02—Pipe-line systems for gases or vapours
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
- F17D—PIPE-LINE SYSTEMS; PIPE-LINES
- F17D3/00—Arrangements for supervising or controlling working operations
- F17D3/01—Arrangements for supervising or controlling working operations for controlling, signalling, or supervising the conveyance of a product
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
- F17D—PIPE-LINE SYSTEMS; PIPE-LINES
- F17D3/00—Arrangements for supervising or controlling working operations
- F17D3/18—Arrangements for supervising or controlling working operations for measuring the quantity of conveyed product
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
- A61B2018/00345—Vascular system
- A61B2018/00351—Heart
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/02—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
- A61B2018/0212—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques using an instrument inserted into a body lumen, e.g. catheter
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/02—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
- A61B2018/0231—Characteristics of handpieces or probes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/02—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
- A61B2018/0231—Characteristics of handpieces or probes
- A61B2018/0262—Characteristics of handpieces or probes using a circulating cryogenic fluid
- A61B2018/0268—Characteristics of handpieces or probes using a circulating cryogenic fluid with restriction of flow
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/02—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
- A61B2018/0293—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques using an instrument interstitially inserted into the body, e.g. needle
Abstract
The invention relates to a multifunctional gas pipeline controlled cryoablation system.A gas in a gas cylinder flows through a low-temperature stage freezing pipeline or a first medium-low temperature stage freezing pipeline or a second medium-low temperature stage freezing pipeline or a gas-saving/power-adjusting freezing pipeline or a process normal-temperature pipeline after passing through a main pipeline and then enters a cryoablation needle through a gas inlet, or the gas flows through a return normal-temperature pipeline or a first medium-low temperature stage freezing pipeline after passing through the main pipeline and then enters the cryoablation needle through a gas return port; the gas returned from the cryoablation needle passes through the return air inlet and then flows through the return air exhaust pipeline to be exhausted into the air, or passes through the process air exhaust pipeline through the air inlet and then is exhausted into the air. The invention adopts a multifunctional gas pipeline control scheme, which is beneficial to optimizing the flow of the cryoablation operation, and can realize the functions of treatment at different temperature grades, ice ball control, gas saving, effectiveness improvement, safety and the like on the same system.
Description
Technical Field
The invention relates to a medical appliance for cryotherapy, in particular to a cryoablation system with a multifunctional gas pipeline control scheme.
Background
The cryoablation operation system generally conveys low-temperature working medium to the head of the cryoablation needle through a pipeline at the end of a host and a conveying pipe of the cryoablation needle, and the cold energy is released to lesion tissues and then returns along a concentric sleeve. The common cryosurgical instruments mainly comprise a liquid nitrogen cold knife based on phase change refrigeration and an argon helium knife based on throttling refrigeration. Currently, argon-helium knife manufactured by Endocare of the most widespread use in cryoablation therapy of malignant tumors. The argon-helium scalpel has the advantages of thin cryoprobe, small surgical wound, convenient surgical operation and the like, but also has the defects of higher temperature of a scalpel head, small single-needle ablation range, difficult acquisition of high-pressure argon and helium, relatively higher surgical cost and the like. The low-temperature cryotherapy system produced by Shanghai guided medical systems Limited uses a method that high-pressure nitrogen is precooled by a host machine and then flows to a cutter head for throttling, so that the cryotherapy system has higher refrigerating capacity than an argon-helium cutter, and meanwhile, an air source is cheaper and is easy to obtain, and the operation cost is reduced. .
The argon-helium knife completely depends on the throttling of the high-pressure gas to provide cold energy, so that the internal structure of the main machine is simple, and only one set of electronic components corresponding to the gas pipeline is included. The low-temperature freezing treatment system is provided with a precooling system, and also has the functions of freezing, rewarming, exhausting and the like, and the low-temperature freezing treatment system is relatively more complex in structure in order to fully utilize the cold energy of the precooling system and also comprises an air return utilization heat exchanger. The conventional multi-cutter system has limited space for gas pipelines, the same pipeline is used for freezing and rewarming, the same pipeline shares one pressure reducing valve, and a plurality of channels cannot be independent; in the freezing process, the working pressure is adjusted through a pressure reducing valve positioned at the gas cylinder, the working pressure required by the temperature reduction of the cryoablation needle is relatively high, and the working pressure can be properly adjusted after the cryoablation needle reaches the lowest temperature, so that the gas consumption can be saved; in addition, the system can only use nitrogen or argon as the gas source. Single-blade cryoablation systems such as flexible cold blade systems, produced by shanghai guided medical systems limited, contain only one cryoablation needle or flexible cold blade port, and thus have relatively ample space to place a more fully functioning gas line.
Disclosure of Invention
The invention provides a gas pipeline system which integrates multiple functions of low-temperature level freezing, medium-low temperature level freezing, gas-saving \ power regulation freezing, intake and return temperature recovery and the like, aiming at the defects of complex operation, single function and the like of the existing cryoablation system, particularly a single-blade system.
In order to solve the technical problems, the invention adopts the technical scheme that: a multifunctional gas pipeline controlled cryoablation system comprises a gas cylinder, a main pipeline and a cryoablation needle, wherein gas in the gas cylinder flows through a low-temperature stage freezing pipeline or a first medium-low temperature stage freezing pipeline or a second medium-low temperature stage freezing pipeline or a gas-saving/power-adjusting freezing pipeline or a process normal-temperature pipeline after passing through the main pipeline and then enters the cryoablation needle through a gas inlet, or the gas flows through a return normal-temperature pipeline or a first medium-low temperature stage freezing pipeline after passing through the main pipeline and then enters the cryoablation needle through a gas return port; the gas returned from the cryoablation needle passes through the return air inlet and then flows through the return air exhaust pipeline to be exhausted into the air, or passes through the process air exhaust pipeline through the air inlet and then is exhausted into the air.
The low-temperature-level freezing pipeline comprises a first pressure reducing valve, a second electromagnetic valve, a first one-way valve and a first safety unloading valve which are sequentially connected, and gas flows through the low-temperature-level freezing pipeline and then reaches the gas inlet through the gas return utilization heat exchanger and the low-temperature-level heat exchanger.
The first medium-low temperature level freezing pipeline comprises a third pressure reducing valve, a sixth electromagnetic valve and a fourth one-way valve which are connected in sequence, and gas flows through the medium-low temperature level freezing pipeline and then reaches the gas inlet or the gas return port through the medium-low temperature level heat exchanger; the second medium-low temperature level freezing pipeline comprises a second pressure reducing valve, a fourth electromagnetic valve, a sixth electromagnetic valve and a fourth one-way valve which are connected in sequence, and gas flows through the medium-low temperature level freezing pipeline and then reaches the gas inlet through the medium-low temperature level heat exchanger.
The gas-saving/power-adjusting freezing pipeline comprises a second pressure reducing valve, a fourth electromagnetic valve, a flow controller, a first safety unloading valve and a second one-way valve which are connected in sequence, and gas flows through the gas-saving/power-adjusting freezing pipeline, the return gas utilization heat exchanger and the low-temperature heat exchanger to reach the gas inlet.
The process normal-temperature pipeline comprises a second pressure reducing valve, a fourth electromagnetic valve, a sixth electromagnetic valve and a third one-way valve which are connected in sequence, and gas directly reaches the gas inlet through the process normal-temperature pipeline; the return normal temperature pipeline comprises a third pressure reducing valve, a fifth electromagnetic valve, a third one-way valve and a second safe unloading valve which are connected in sequence, and gas directly reaches the gas return port through the return normal temperature pipeline.
The return gas exhaust pipeline comprises a third electromagnetic valve and a second thermometer, and gas returned from the gas return port flows through the third electromagnetic valve and is exhausted to the atmosphere; the process exhaust pipeline comprises a seventh electromagnetic valve and a fifth pressure gauge, and the gas returned from the gas inlet flows through the seventh electromagnetic valve and is exhausted to the atmosphere.
The low-temperature-stage heat exchanger is an evaporator of a self-cascade refrigeration system or a cold end of a pulse tube refrigerator or a Stirling refrigerator.
The medium-low temperature stage heat exchanger is a first-stage or second-stage condensation evaporator of the self-cascade refrigeration system, or a medium-low temperature section below the cold end of the pulse tube refrigerator or the Stirling refrigerator.
The gas in the gas cylinder is any one of nitrogen, argon, nitrous oxide, carbon dioxide or nitrogen-argon mixed gas.
The cryoablation needle is a hard cryoablation needle for percutaneous puncture or a flexible cold knife passing through a natural cavity.
The invention has the beneficial effects that: the functions of low-temperature level freezing, medium-low temperature level freezing, gas/power saving regulation freezing, return and return temperature recovery, exhaust and the like are integrated in the same main machine, and various gases can be used for realizing the freezing of different temperature sections and adapting to different operation requirements; the gas-saving mode can be automatically started, the operation cost is saved, and the adjustment of different freezing powers can be more accurately realized through flow control; the temperature can be restored without precooling through a forward and return normal temperature pipeline, and the efficiency of the temperature restoring function is improved; the air can be directly exhausted from the air inlet or the over-high pressure of the return air passage can be released from the safety unloading valve, so that the safety of the operation is improved. In addition, the host computer is placed in to the relief pressure valve in, has avoided the manpower of gas cylinder department to adjust, and the gas cylinder can directly link the host computer, has increased the convenience of operation.
Drawings
FIG. 1 is a schematic view of a gas pipeline for a normal temperature pipeline and a middle and low temperature stage return pipeline of the present invention;
FIG. 2 is a schematic view of a gas pipeline of a normal temperature pipeline and a middle and low temperature stage route-sharing pipeline of the present invention;
FIG. 3 is a schematic view of a gas pipeline of a normal temperature pipeline running inlet pipeline and a medium and low temperature stage pipeline running return pipeline of the invention;
FIG. 4 is a schematic view of a gas pipeline of a normal temperature pipeline return pipeline and a medium and low temperature stage pipeline travel pipeline of the invention.
Detailed Description
The invention is further illustrated with reference to the following figures and specific examples.
As shown in fig. 1 to 4, the multifunctional gas pipeline controlled cryoablation system of the present invention has four gas pipeline schemes, each of which includes a gas cylinder 1, first to seventh electromagnetic valves 2 to 8, a drying filter 9, first to third pressure reducing valves 10 to 12, first to fourth check valves 13 to 16, first and second safety relief valves 17 to 18, a flow controller 23, a gas inlet 21, a gas return port 22, a return gas utilization heat exchanger 19, a low-temperature stage heat exchanger 20, a medium-low temperature stage heat exchanger 24, first to sixth pressure gauges 25 to 30, and first to sixth thermometers 31 to 36. The difference between fig. 1-4 is that the normal temperature pipeline and the medium and low temperature pipeline are located at different positions, either on the way of the process or on the way of the return.
FIG. 1 shows a gas pipeline scheme of the invention in which a normal temperature pipeline and a middle and low temperature stage pipeline are both return pipelines. The normal temperature pipeline and the middle and low temperature grade pipeline both go through the return pipeline of the upper pipeline, namely the processes of re-warming, non-precooling freezing and passing through the middle and low temperature grade heat exchanger, the gas enters the cryoablation needle from the return port 22, then returns from the gas inlet 21, and finally is discharged from the electromagnetic valve 8 (process exhaust pipeline).
The low-temperature-stage refrigeration pipeline comprises a first pressure reducing valve 10, a second electromagnetic valve 3, a first one-way valve 13, a first safety unloading valve 17, a second pressure gauge 26, a first thermometer 31, a third thermometer 31, a fourth thermometer 33 and a fourth thermometer 34 which are sequentially connected, and gas flows through the low-temperature-stage refrigeration pipeline, a return gas utilization heat exchanger 19 and a low-temperature-stage heat exchanger 20 to reach an air inlet 21.
The first medium-low temperature level freezing pipeline comprises a third pressure reducing valve 12, a sixth electromagnetic valve 7, a fourth one-way valve 16, a fourth pressure gauge 28 and a sixth thermometer 36 which are connected in sequence, and gas flows through the medium-low temperature level freezing pipeline and the medium-low temperature level heat exchanger 24 and reaches the air return port 22; the second middle and low temperature level freezing pipe comprises a second pressure reducing valve 11, fourth and sixth electromagnetic valves 5, 7, a fourth check valve 16, a third pressure gauge 27 and a sixth temperature gauge 36, and the gas flows through the middle and low temperature level freezing pipeline and the middle and low temperature level heat exchanger 24 to reach the gas inlet 21 (shown in fig. 4).
FIG. 2 is a gas pipeline scheme of the present invention for normal temperature pipeline and middle and low temperature stage. All pipelines of the scheme enter the cryoablation needle from the air inlet 21, return from the air inlet 21 and finally exhaust from the air return by utilizing the heat exchanger and the third electromagnetic valve 4 (return exhaust pipeline). The seventh solenoid valve 8 (process exhaust line) is used only for rapid pressure relief of the inlet line.
The process normal temperature pipeline comprises a second reducing valve 11, a fourth electromagnetic valve 5, a sixth electromagnetic valve 7, a third one-way valve 15 and a third pressure gauge 27 which are connected in sequence, and gas directly reaches the gas inlet 21 without passing through a heat exchanger.
Fig. 3 is a gas pipeline scheme of a normal temperature pipeline running inlet pipeline and a medium and low temperature stage pipeline running return pipeline of the invention. Only the medium-low temperature stage pipeline is taken as a return pipeline, namely, in the process of medium-low temperature stage freezing, gas enters the cryoablation needle from the return air port 22, then returns from the air inlet 21, and finally is discharged from the electromagnetic valve 8 (process exhaust pipeline). The normal temperature pipeline, the low temperature grade freezing pipeline and the gas-saving/power-adjusting freezing pipeline all enter the cryoablation needle from the gas inlet 22.
Fig. 4 is a gas pipeline scheme of a normal temperature pipeline return pipeline and a medium and low temperature stage pipeline travel pipeline of the invention. Only the normal temperature pipeline is led back to the process pipeline, namely, the process of rewarming or precooling and freezing is not carried out, the gas enters the cryoablation needle from the gas return opening 22, then returns from the gas inlet 21, and finally is discharged from the electromagnetic valve 8 (process exhaust pipeline). The processes of low-temperature level freezing, medium-low temperature level freezing and gas-saving/power regulation freezing all enter the cryoablation needle from the gas inlet 22.
The return normal temperature pipeline comprises a third reducing valve 12, a fifth electromagnetic valve 6, a third one-way valve 15, a second safety unloading valve 18 and a sixth pressure gauge 30 which are connected in sequence, and gas directly reaches the return air port 22 without passing through a heat exchanger.
As shown in fig. 1 to 4, the main piping includes the solenoid valve 2, the dry filter 9, and the pressure gauge 25. The return exhaust line includes the third electromagnetic valve 4 and the second thermometer 32, and the gas flow returned from the return port is discharged to the atmosphere through the return gas utilization heat exchanger 19 and the third electromagnetic valve 4. The process exhaust line includes the seventh solenoid valve 8 and the fifth pressure gauge 29, and the gas returned from the gas inlet 21 is discharged to the atmosphere through the seventh solenoid valve 8. The gas-saving/power-adjusting freezing pipeline comprises a second pressure reducing valve 11, a fourth electromagnetic valve 5, a flow controller 23, a first safety unloading valve 17, a second one-way valve 14, a third pressure gauge 27, a first thermometer 31, a third thermometer 31, a fourth thermometer 33 and a fourth thermometer 34 which are connected in sequence, and gas flows through the gas-saving/power-adjusting freezing pipeline, a return gas utilization heat exchanger 19 and a low-temperature heat exchanger 20 to reach a gas inlet 21.
The cryogenic stage heat exchanger 20 is the evaporator of a self-cascade refrigeration system, or the cold end of a pulse tube refrigerator or stirling cooler. The medium-low temperature stage heat exchanger 24 is a medium-low temperature section below the cold end of a first-stage or second-stage condensation evaporator or a pulse tube refrigerator or a Stirling refrigerator of the self-cascade refrigeration system.
The gas in the gas cylinder 1 is any one of nitrogen, argon, nitrous oxide, carbon dioxide or a nitrogen-argon mixed gas. The cryoablation needle is a hard cryoablation needle for percutaneous puncture or a flexible cold knife for natural orifice.
Example 1:
examples of the use of cryogenic stage freezing functions are as follows: the pressure reducing valve 10 is set to be 1500psi of outlet pressure, when the freezing function is started, the first to third electromagnetic valves 2, 3 and 4 are started, gas enters from the low-temperature-level freezing pipeline, the redundant cold energy of the returned gas is recycled through primary precooling of the returned gas utilization heat exchanger 19, then the gas enters the low-temperature-level heat exchanger 20 (such as an evaporator of a self-cascade refrigeration system) for further precooling to lower temperature, the low-temperature gas enters the cryoablation needle from the gas inlet 21 and reaches the temperature lower than that of the low-temperature-level heat exchanger 20 through the throttling action of a capillary tube, after the cold energy released at the needle is absorbed by tumors or other pathological tissues, the redundant cold energy returns through the gas return port 22, the redundant cold energy enters the returned gas utilization heat exchanger 19 for recycling, and the recycled gas is finally discharged to the atmosphere. During the freezing process, the fifth pressure gauge 29 and the sixth pressure gauge 30 respectively monitor the pressure of the inlet air and the return air in real time, and when the pressure is too high, the too high pressure is released through the first safety unloading valve 17 and the second safety unloading valve 18 respectively. After freezing is stopped, the third electromagnetic valve 4 and the seventh electromagnetic valve 8 are opened, and residual gas in the pipeline can be released quickly. The first and third temperature gauges 31, 33 and the fifth and second temperature gauges 35, 32 can monitor the amount of cooling provided by the return air utilization heat exchanger 19 and the third and fourth temperature gauges 33, 34 can monitor the amount of cooling provided by the low temperature stage heat exchanger 20.
Example 2:
examples of gas-saving/power-regulating freezing functions are as follows: and (3) a gas-saving mode: the second pressure reducing valve 11 is set to the outlet pressure of 1200psi, the freezing is firstly started, the process is as in embodiment 1, at this time, the needle head of the cryoablation needle starts to cool, when the needle head temperature reaches the lowest temperature (such as-150 ℃) and the return air is sufficiently pre-cooled by the heat exchanger (such as the thermometer 33 reaches-70 ℃), the second electromagnetic valve 3 is closed, and the fourth electromagnetic valve 5 and the flow controller 23 are simultaneously opened (fully opened), so that the working pressure of the system is reduced to 1200psi, the gas flow of the system is reduced, but the needle head temperature can still maintain the lowest temperature, and by doing so, the influence on the cold quantity of the needle head is small, and the air consumption of the gas cylinder 1 can be saved.
Power regulation mode: if the speed of ice hockey growth needs to be slowed down or the ice hockey growth needs to be stopped in the operation, the flow control value of the flow controller 23 can be reduced at the moment, the adjustment can be carried out on the premise of maintaining the temperature stability of the needle head, the larger the reduction value of the flow is, the smaller the cold quantity provided by the needle head is, and therefore the ice hockey growth can be slowed down, or the ice hockey is just maintained at the existing size.
Example 3:
examples of rewarming \ not precooling freezing functions are as follows: as shown in FIG. 1, during rewarming, the third pressure relief valve 12 is set to 300 psi. After the freezing is finished, the first to fourth electromagnetic valves 2, 3, 4 and 5 and the flow controller 23 are closed, when the rewarming function is started, the first, fifth and seventh electromagnetic valves 2, 6 and 8 are opened, gas directly enters the gas return pipeline of the cryoablation needle from the gas return port 22 without precooling, and enters the capillary tube after reaching the needle head, the throttling effect is avoided in the process, and a good rewarming effect can be achieved by matching with the heating module in the cryoablation needle. The gas returns from the gas inlet 21 and is then discharged to the atmosphere through the seventh solenoid valve 8. During the rewarming process, the pressure gauges 30 and 29 respectively monitor the pressure of the inlet air and the return air in real time, and when the pressure of the inlet air is too high, the too high pressure is released through the safety unloading valve 18. After the re-heating is stopped, the third and seventh electromagnetic valves 4 and 8 are opened, and the residual gas in the pipeline can be respectively and rapidly released. As shown in fig. 2, in the rewarming process, the second pressure reducing valve 11 is still set to 1200psi to satisfy the requirement of the air-saving/power-regulating refrigeration function. After the freezing is finished, the first to fourth electromagnetic valves 2, 3, 4 and 5 and the flow controller 23 are closed, when the rewarming function is started, the first, fourth and sixth electromagnetic valves 2, 5 and 7 are opened, gas directly enters the air inlet pipeline of the cryoablation needle from the air inlet 21 without precooling, and the purpose of rewarming is achieved at the needle head by matching with the heating module in the cryoablation needle. When the pipeline is used for a precooling and freezing function, carbon dioxide can be used as an air source, the carbon dioxide directly enters the needle head of the cryoablation needle without precooling for throttling and refrigerating, and the process is used for the operation modes of cryobiopsy, cryocutting, foreign matter extraction and the like of the flexible cold knife passing through a natural cavity.
Example 4:
examples of medium and low temperature stage freezing functions are as follows: if extensive freezing is not required (e.g., defibrillation freezing) or the freezing range of carbon dioxide is too small, nitrous oxide can be used as a gas source, which can reach a medium or low temperature of-90 to-70 ℃ at the needle of the cryoablation needle, but the pre-cooling temperature cannot be too low, which would cause the nitrous oxide to solidify and block the pipeline, as shown in fig. 3. The temperature of the first-stage heat exchanger of the self-cascade system is about-30 to-20 ℃, and the pre-cooling requirement of nitrous oxide can be met. When the medium-low temperature level is frozen and started, the first electromagnetic valve 2, the fifth electromagnetic valve 2, the seventh electromagnetic valve 6 and the seventh electromagnetic valve 8 are opened, at the moment, nitrous oxide enters the cryoablation needle from the air return port 22 after passing through the medium-low temperature level heat exchanger 24, the cryoablation needle used at the moment needs to be connected into an air inlet pipeline of the cryoablation needle from the air return port 22, and otherwise, the needle head cannot be throttled and refrigerated. The returned gas is discharged through the gas inlet 21 and the seventh solenoid valve 8. If the air needs to be exhausted, the third and seventh electromagnetic valves 4 and 8 are opened.
As shown in fig. 4, when the nitrous oxide is used for middle and low temperature grade freezing, the first, fourth, sixth and third electromagnetic valves 2, 5, 7 and 4 need to be opened, and the gas enters the cryoablation needle from the gas inlet 21 after passing through the middle and low temperature grade heat exchanger 24. The return gas is exhausted to the atmosphere through the return gas port 22, the return gas utilization heat exchanger 19 and the third electromagnetic valve 4.
Claims (8)
1. The utility model provides a cryoablation system of multi-functional gas pipeline control, includes gas cylinder, main pipeline, cryoablation needle, its characterized in that: the gas in the gas cylinder flows through a low-temperature-level freezing pipeline or a first medium-low-temperature-level freezing pipeline or a second medium-low-temperature-level freezing pipeline or a gas-saving/power-adjusting freezing pipeline or a process normal-temperature pipeline after passing through the main pipeline, then enters the cryoablation needle through the gas inlet, and flows through a return-stroke exhaust pipeline after passing through the gas return port to be discharged into the air; or the gas flows through the return normal temperature pipeline or the first medium-low temperature stage freezing pipeline after passing through the main pipeline, then enters the cryoablation needle through the gas return port, and the gas returned from the cryoablation needle flows through the process exhaust pipeline through the gas inlet and is exhausted into the air; the gas-saving/power-adjusting refrigeration pipeline comprises a second pressure reducing valve (11), a fourth electromagnetic valve (5), a flow controller (23), a first safety unloading valve (17) and a second one-way valve (14) which are connected in sequence, and gas flows through the gas-saving/power-adjusting refrigeration pipeline, a return gas utilization heat exchanger (19) and a low-temperature heat exchanger (20) to reach a gas inlet (21); the first medium-low temperature level freezing pipeline comprises a third reducing valve (12), a sixth electromagnetic valve (7) and a fourth one-way valve (16) which are connected in sequence, and gas flows through the medium-low temperature level freezing pipeline and then reaches an air inlet (21) or an air return port (22) through a medium-low temperature level heat exchanger (24); the second medium-low temperature level freezing pipeline comprises a second reducing valve (11), a fourth electromagnetic valve (5), a sixth electromagnetic valve (7) and a fourth one-way valve (16) which are sequentially connected, and gas flows through the medium-low temperature level freezing pipeline and then reaches the gas inlet (21) through the medium-low temperature level heat exchanger (24).
2. The multifunctional gas line controlled cryoablation system of claim 1 wherein: the low-temperature-level freezing pipeline comprises a first reducing valve (10), a second electromagnetic valve (3), a first one-way valve (13) and a first safety unloading valve (17) which are sequentially connected, and gas flows through the low-temperature-level freezing pipeline and then reaches an air inlet (21) through a return gas utilization heat exchanger (19) and a low-temperature-level heat exchanger (20).
3. The multifunctional gas line controlled cryoablation system of claim 1 wherein: the process normal-temperature pipeline comprises a second reducing valve (11), a fourth electromagnetic valve (5), a sixth electromagnetic valve (7) and a third one-way valve (15) which are connected in sequence, and gas directly reaches the gas inlet (21) through the process normal-temperature pipeline; the return normal-temperature pipeline comprises a third reducing valve (12), a fifth electromagnetic valve (6), a third one-way valve (15) and a second safety unloading valve (18) which are connected in sequence, and gas directly reaches the return port (22) through the return normal-temperature pipeline.
4. The multifunctional gas line controlled cryoablation system of claim 1 wherein: the return gas exhaust pipeline comprises a third electromagnetic valve (4) and a second thermometer (32), and gas returned from the gas return port (22) flows through the third electromagnetic valve (4) and is exhausted to the atmosphere; the process exhaust pipeline comprises a seventh electromagnetic valve (8) and a fifth pressure gauge (29), and the gas returned from the gas inlet (21) flows through the seventh electromagnetic valve (8) and is exhausted to the atmosphere.
5. The multifunctional gas line controlled cryoablation system of claim 2 wherein: the low-temperature-stage heat exchanger (20) is an evaporator of a self-cascade refrigeration system or a cold end of a pulse tube refrigerator or a Stirling refrigerator.
6. The multifunctional gas line controlled cryoablation system of claim 3 wherein: the medium-low temperature stage heat exchanger (24) is a medium-low temperature section below the cold end of a first-stage or second-stage condensation evaporator or a pulse tube refrigerator or a Stirling refrigerator of the self-cascade refrigeration system.
7. The multifunctional gas line controlled cryoablation system according to any of claims 1-6, wherein: the gas in the gas cylinder is any one of nitrogen, argon, nitrous oxide, carbon dioxide or nitrogen-argon mixed gas.
8. The multifunctional gas line controlled cryoablation system according to any of claims 1-6, wherein: the cryoablation needle is a hard cryoablation needle for percutaneous puncture or a flexible cold knife passing through a natural cavity.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711105077.5A CN107951558B (en) | 2017-11-10 | 2017-11-10 | Multifunctional gas pipeline controlled cryoablation system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711105077.5A CN107951558B (en) | 2017-11-10 | 2017-11-10 | Multifunctional gas pipeline controlled cryoablation system |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN107951558A CN107951558A (en) | 2018-04-24 |
| CN107951558B true CN107951558B (en) | 2021-05-14 |
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| CN109405327B (en) | 2018-12-26 | 2024-02-13 | 上海导向医疗系统有限公司 | Precooling device for cryotherapy and cryotherapy system |
| CN113616313B (en) * | 2021-08-12 | 2022-07-26 | 上海导向医疗系统有限公司 | Multi-channel cryoablation system and control method |
| CN114668481B (en) * | 2022-05-26 | 2023-01-24 | 上海导向医疗系统有限公司 | Dual-system cryotherapy system based on precooling of cryogenic refrigerator |
| CN115337092B (en) * | 2022-08-10 | 2023-12-19 | 海杰亚（北京）医疗器械有限公司 | Ablation system based on temperature control and temperature control method thereof |
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| JPH05118727A (en) * | 1991-10-24 | 1993-05-14 | Mitsubishi Heavy Ind Ltd | Supercooled water manufacturing device |
| US6592577B2 (en) * | 1999-01-25 | 2003-07-15 | Cryocath Technologies Inc. | Cooling system |
| US20140371733A1 (en) * | 2008-04-24 | 2014-12-18 | Cryomedix, Llc | All-Liquid Cryoablation Catheter |
| CN101584602A (en) * | 2008-05-20 | 2009-11-25 | 上海导向医疗系统有限公司 | Multi-stage precooling cryoablation method and equipment |
| CN101732090B (en) * | 2009-11-10 | 2011-05-04 | 上海理工大学 | Cryoablation system with precooling device and control method thereof |
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| US9956024B2 (en) * | 2014-07-11 | 2018-05-01 | Medtronic Cryocath Lp | Cryoablation method and system |
| CN104873265A (en) * | 2015-06-02 | 2015-09-02 | 北京迈迪顶峰医疗科技有限公司 | Freezing ablation system |
| CN105902310B (en) * | 2016-04-11 | 2018-07-06 | 天津美电医疗科技有限公司 | Cryosurgery device for adjusting air pressure to realize freezing and rewarming |
| CN105708541A (en) * | 2016-04-11 | 2016-06-29 | 赵国江 | Control method for throttling freezing type cryosurgery device |
| CN106420039A (en) * | 2016-10-12 | 2017-02-22 | 上海导向医疗系统有限公司 | Cryotherapy system through natural orifice of human body |
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