WO2023226489A1

WO2023226489A1 - Dual-system cryotherapeutic system based on pre-cooling with cryogenerator

Info

Publication number: WO2023226489A1
Application number: PCT/CN2023/077872
Authority: WO
Inventors: 吴银龙; 徐彬凯; 杨迟; 张紫金; 常兆华; 谢彦杰
Original assignee: 上海导向医疗系统有限公司
Priority date: 2022-05-26
Filing date: 2023-02-23
Publication date: 2023-11-30
Also published as: CN114668481B; CN114668481A

Abstract

Provided is a dual-system cryotherapeutic system based on pre-cooling with a cryogenerator, comprising a gas source (1), a gas treatment unit (2), and a pressure adjusting unit (3) that are sequentially arranged. The pressure adjusting unit (3) is connected with at least two ablation probes (6) by means of at least two cryogenic pre-cooling systems (4), respectively. The cryogenic pre-cooling system (4) comprises a cryoablation channel (42) and a gas return pre-cooling channel (43). The cryoablation channel (42) comprises a cryogenic gas inlet pipeline (422), and at least one coupler (423) and at least one cryogenerator (424) that are arranged on the cryogenic gas inlet pipeline (422). A gas inlet of the cryogenic gas inlet pipeline (422) is connected with a gas outlet of the pressure adjusting unit (3), and a gas outlet of the cryogenic gas inlet pipeline (422) is connected with a gas inlet of the corresponding ablation probe (6). The gas return pre-cooling channel (43) comprises a gas return pipeline (431) and the coupler (423) arranged on the gas return pipeline (431). A gas inlet of the gas return pipeline (431) is connected with a gas return end of the ablation probe (6), and a discharge port of the gas return pipeline (431) is in communication with the atmosphere. Gas in the cryogenic gas inlet pipeline (422) can be subjected to a thermal exchange with gas in the gas return pipeline (431) by means of the coupler (423), and then cooled at a low temperature by means of a cold sink pre-cooled by the cryogenerator (424).

Description

A dual-system cryogenic treatment system based on cryogenic refrigerator pre-cooling

Technical field

The invention belongs to the field of medical technology, and in particular relates to a dual-system low-temperature treatment system based on pre-cooling by a low-temperature refrigerator.

Background technique

Cryotherapy is a treatment method that uses freezing of local tissue to controllably destroy or remove living tissue. As a minimally invasive targeted surgery, cryoablation has the characteristics of less trauma, less side effects, and accurate curative effect. It also has the advantages of clear boundary of the ablation ball, participation in activating the body's tumor immune function, no damage to large blood vessels, and no obvious pain, etc., so that the tumor can be effectively treated. Ultra-low temperature targeted cryotherapy and hyperthermia have become a reality. In recent years, cryosurgery has been widely used in the treatment of metastatic liver cancer, prostate cancer, kidney cancer, etc.

The existing low-temperature cryoablation technology mainly uses high-pressure gas throttling, such as argon-helium knife. The principle of use is to use high-pressure argon gas to throttle. The disadvantage is that it uses 5000psi (35MPa) high-pressure argon gas and the working pressure is 3000Psi (20Mpa). The rate is 15/35. Shanghai Guidance Medical System Co., Ltd. uses pre-cooled nitrogen throttling, using 15Mpa conventional industrial nitrogen, the working pressure is 10Mpa, and the gas source utilization rate is 5/15. Therefore, although low-pressure industrial gas can be utilized by using industrial nitrogen, the gas utilization rate is low. Therefore, a technology that can both use conventional industrial nitrogen and improve gas utilization rate is continued.

Contents of the invention

In order to solve the above problems, the present invention provides a dual-system cryogenic treatment system based on cryogenic refrigerator pre-cooling, including a gas source, a gas processing unit and a pressure regulating unit arranged in sequence. The pressure regulating unit passes through at least two sets of low-temperature pre-cooling systems. The cold system is respectively connected to at least two ablation needles;

The low-temperature precooling system includes a cryoablation channel and a return air precooling channel:

The cryoablation channel includes a low-temperature air inlet pipeline and at least one coupler and at least one refrigerator provided on the low-temperature air inlet pipeline. The air inlet of the low-temperature air inlet pipeline is connected to the air outlet of the pressure adjustment unit. , the air outlet of the low-temperature air inlet pipeline is connected to the air inlet of the corresponding ablation needle;

The return air pre-cooling channel includes a return air pipeline and the coupler provided on the return air pipeline. The air inlet of the return air pipeline is connected to the air return end of the ablation needle. The exhaust port is connected to the outside atmosphere; the gas in the low-temperature air inlet pipe can first conduct heat exchange with the gas in the return air pipe through the coupler, and then pass through the cold sink pre-cooled by the refrigerator for low-temperature processing. cool down.

Preferably, the low-temperature precooling system further includes an energy enhancement channel, the energy enhancement channel includes an energy enhancement pipeline and at least one energy intensifier and at least one refrigerator provided in the energy enhancement pipeline, so The air inlet of the energy enhancement pipeline is connected to the air outlet of the pressure adjustment unit. The residual gas in the air source can be pre-cooled by the energy enhancer and the refrigerator, and then pre-cooled by the refrigerator. The cooling medium in the cooling medium.

Preferably, the energy enhancement pipeline includes a connected energy enhancement air intake pipeline and an energy enhancement return air pipeline, and both the energy enhancer and the refrigerator include an air intake channel connected to the energy enhancement air intake pipeline. A return air channel is connected to the energy-enhanced air return pipeline. A throttling device is provided between the air outlet of the energy-enhanced air intake pipeline and the air return port of the energy-enhanced air return pipeline. The energy-enhanced air intake pipeline The air inlet is connected to the air outlet of the pressure adjustment unit, and the exhaust port of the energy enhancement return air pipeline is connected to the outside atmosphere.

Preferably, the low-temperature precooling system further includes a rewarming channel, the rewarming channel includes a normal temperature air inlet pipeline, and the normal temperature air inlet pipeline is connected to the air outlet of the pressure adjustment unit and the ablation needle connector respectively. Air inlet connection.

Preferably, the normal temperature air intake pipeline is provided with a solenoid valve and a one-way valve.

Preferably, the pressure regulating unit includes a plurality of control pipelines and pressure regulating valves, solenoid valves and pressure transmitters located on the control pipelines, and the air inlets of several control pipelines are connected to the gas respectively. The air outlet of the processing unit is connected, and the air outlets of several control pipelines are respectively connected with the air inlet of each pipeline of the low-temperature precooling system.

Preferably, the gas treatment unit includes a gas drying filter, and the gas drying filter is disposed on the outlet pipeline of the gas source.

Preferably, the low-temperature air intake pipeline is provided with a solenoid valve, a one-way valve and a pressure transmitter.

Preferably, the low-temperature precooling system further includes a rapid exhaust channel, which includes a rapid exhaust pipeline and a solenoid valve located on the rapid exhaust pipeline. The rapid exhaust pipeline Communicated with the low temperature air intake pipeline.

Preferably, the return air line is also provided with a pressure relief valve and a pressure transmitter. The pressure transmitter is used to detect the pressure of the return air line. When the pressure of the return air line is higher than the set value, , relieve the pressure through the pressure relief valve.

Compared with the prior art, the present invention has the following technical effects:

1. The present invention provides a low-temperature treatment system based on low-temperature refrigerator pre-cooling. Each low-temperature pre-cooling system is independently controlled, that is, two or more low-temperature pre-cooling systems are designed in parallel, which can avoid one Low temperature pre-cooling If the system is abnormal and surgery cannot be performed, dual sets of low-temperature pre-cooling systems can also be used for joint use of multiple knives. When pre-cooling is turned on, the number of ablation needles to be used or the number of ablation needles to be used is pre-judged based on the size of the frozen tissue to determine the number of refrigerators to start. When the number of ablation needles used is less than 3, a refrigerator can be started first for pre-cooling. cold, another refrigeration machine is available as an alternative. The invention can use the air source to purge the system that is not started, thereby reducing ice blockage in the system caused by low temperature. After the purge is completed, another refrigerator is turned on as a backup cold source according to the needs of subsequent consecutive surgeries.

2. The air source is connected to at least two ablation needles through at least two sets of low-temperature pre-cooling systems. Each low-temperature pre-cooling system is independently controlled and can realize independent freezing, rewarming, purging, exhaust and other functions for multiple parts. The function of simultaneously freezing tumors improves the utilization of the gas source.

3. The low-temperature pre-cooling system has independent air inlet pipelines, air return pipelines, and rewarming pipelines. The number of ablation needles and the freezing time of the ablation needles can be adjusted as needed to achieve multiple and conformal treatment of tumors.

4. In the present invention, the gas source can be a conventional industrial gas source or a high-pressure argon gas source. The utilization rate of the conventional industrial gas source is increased to 67%, an increase of 100%; the utilization rate of the high-pressure argon gas source is increased to 67%. 85.7%, an increase of 100%.

5. The present invention can cool the cooling temperature to below -160°C, and at the same time, the gas source pressure can be utilized to 5MPa, increasing the gas source utilization rate by 50% to 100%, which is much higher than the original technical solution and the traditional argon and helium knife.

6. The preferred refrigerator of the present invention is an opposed refrigerator, which can avoid the vibration problem caused by a single-head low-temperature refrigerator.

Description of the drawings

In order to more clearly illustrate the technical solutions of the embodiments of the present invention, a brief introduction will be made below to the drawings needed to be used in the description of the embodiments. It is obvious that the drawings in the following description are only some embodiments of the present invention and are not relevant to the present invention. For those skilled in the art, other drawings can also be obtained based on these drawings without exerting creative efforts. In the attached picture:

Figure 1 is a schematic diagram of a dual-system cryogenic treatment system based on cryogenic refrigerator pre-cooling provided in the preferred embodiment 1 of the present invention;

Figure 2 is a schematic diagram of the connection structure of a dual-system cryogenic therapy system based on cryogenic refrigerator pre-cooling provided by the preferred embodiment 1 of the present invention;

Figure 3 is a schematic diagram of a dual-system cryogenic treatment system based on cryogenic refrigerator pre-cooling provided in the preferred embodiment 2 of the present invention;

Figure 4 is a schematic diagram of the connection structure of a dual-system cryogenic treatment system based on cryogenic refrigerator pre-cooling provided in the preferred embodiment 2 of the present invention;

Figure 5 is a schematic diagram of a dual-system cryogenic treatment system based on cryogenic refrigerator pre-cooling provided in preferred embodiment 3 of the present invention;

Figure 6 is a schematic diagram of the connection structure of a dual-system cryogenic therapy system based on cryogenic refrigerator pre-cooling provided in preferred embodiment 3 of the present invention;

Figure 7 is a schematic diagram of a dual-system cryogenic treatment system based on cryogenic refrigerator pre-cooling provided in preferred embodiment 4 of the present invention;

Figure 8 is a schematic diagram of the connection structure of a dual-system cryogenic therapy system based on cryogenic refrigerator pre-cooling provided in preferred embodiment 4 of the present invention.

Detailed ways

A dual-system cryogenic treatment system based on cryogenic refrigerator pre-cooling, including a gas source, a gas processing unit and a pressure regulating unit arranged in sequence. The pressure regulating unit communicates with at least two ablation needles through at least two sets of cryogenic pre-cooling systems. Connected, in the present invention, one set of low-temperature pre-cooling systems corresponds to one or more ablation needles. When one set of low-temperature pre-cooling systems fails, it does not affect the use of another set of low-temperature pre-cooling systems, which can avoid the need for one set of low-temperature pre-cooling systems. If the cold system is abnormal and surgery cannot be performed, dual low-temperature pre-cooling can also be used for combined use of multiple knives.

The low-temperature pre-cooling system includes a cryo-ablation channel and a return air pre-cooling channel. The cryo-ablation channel includes a low-temperature air inlet pipeline and at least one coupler and at least one refrigerator provided on the low-temperature air inlet pipeline. The air inlet of the air inlet pipeline is connected to the air outlet of the pressure adjustment unit, and the air outlet of the low temperature air inlet pipeline is connected to the air inlet of the corresponding ablation needle;

The return air pre-cooling channel includes a return air pipeline and the coupler provided on the return air pipeline. The air inlet of the return air pipeline is connected to the air return port of the ablation needle. The exhaust of the return air pipeline The air port is connected to the outside atmosphere; the gas in the low-temperature air inlet pipe can first conduct heat exchange with the gas in the return air pipe through the coupler, and then be cooled at low temperature by the cold sink pre-cooled by the refrigerator .

In the present invention, each set of low-temperature pre-cooling systems is independently controlled, that is, two or more sets of low-temperature pre-cooling systems are designed in parallel, which can not only prevent one set of low-temperature pre-cooling systems from being abnormal and prevent surgery, but also use Dual sets of low-temperature pre-cooling systems allow for joint use of multiple knives. When precooling is turned on, predict the number of ablation needles to be used based on the size of the frozen tissue or the number of ablation needles to start. When the number of ablation needles used is less than 3, you can start it first. Start one refrigerator for pre-cooling and the other refrigerator as a backup. The invention can use the air source to purge the system that is not started, thereby reducing ice blockage in the system caused by low temperature. After the purge is completed, another refrigerator is turned on as a backup cold source according to the needs of subsequent consecutive surgeries.

The present invention does not limit the number of low-temperature precooling systems and the number of ablation needles, and can be set according to actual use requirements. The present invention will be described in detail below with reference to specific embodiments. The following examples will help those skilled in the art to further understand the present invention, but do not limit the present invention in any form. It should be noted that, for those of ordinary skill in the art, several changes and improvements can be made without departing from the concept of the present invention. These all belong to the protection scope of the present invention.

Example 1

Please refer to Figures 1 and 2, a dual-system cryogenic treatment system based on cryogenic refrigerator pre-cooling, including a gas source 1, a gas processing unit 2 and a pressure regulating unit 3 connected in sequence through pipelines. The pressure regulating unit 3 Two sets of low-temperature pre-cooling systems 4 are connected to two ablation needles 6 respectively.

In this embodiment, each low-temperature pre-cooling system 4 is independently controlled, and each low-temperature pre-cooling system 4 can realize independent functions such as freezing, rewarming, and purging.

In this embodiment, the gas processing unit 2 includes a gas drying filter 22. The gas drying filter 22 is provided on the outlet pipeline 21 of the gas source 1 and is used to filter impurity moisture in the gas. And store part of the gas to keep the gas pipeline in a positive pressure state. The outlet pipeline 21 of the air source 1 can also be provided with a solenoid valve, a pressure transmitter, etc. This embodiment does not impose specific restrictions on this and can be set according to actual usage requirements.

The pressure regulating unit 3 is used to detect the pipeline pressure and regulate the on-off control of gas, as well as the working pressure and switching of working modes during operation. In this embodiment, the pressure regulating unit 3 includes several control pipelines (the several control pipelines in this embodiment are respectively the control pipeline 31, the control pipeline 31' and the control pipeline 31") and the The pressure regulating valve, solenoid valve and pressure transmitter on the control pipeline (the control pipeline 31 is provided with a pressure regulating valve 32, a pressure transmitter 33 and a solenoid valve 34, and the control pipeline 31' is provided with a pressure regulating valve 32', Pressure transmitter and solenoid valve 34', pressure regulating valve 32", pressure transmitter and solenoid valve 34") are provided on the control pipeline 31"), control pipeline 31, control pipeline 31' and control pipeline 31" The air inlets are all connected to the air outlets of the gas processing unit 2, and the air outlets of the control pipeline 31, the control pipeline 31' and the control pipeline 31" are respectively connected to the pipelines of the low-temperature precooling system 4. Air inlet connection.

The structure of each low-temperature pre-cooling system 4 is the same. Therefore, each low-temperature pre-cooling system 4 includes the following channels:

Rewarming channel 41, the rewarming channel 41 includes a normal temperature air inlet pipe 413, and the normal temperature air inlet pipe 413 There is a solenoid valve 411 (used to regulate the opening and closing of the gas pipeline) and a one-way valve 412 (to prevent the reverse flow of gas). The air inlet of the normal temperature air intake pipeline 413 is connected with the air outlet of the control pipeline 31 , the air outlet of the normal temperature air inlet pipe 413 is connected with the air inlet of the ablation needle connector 5 .

Cryoablation channel 42. The cryoablation channel 42 includes a low-temperature air inlet pipe 422 and a coupler 423 and a refrigerator 424 which are sequentially provided on the low-temperature air inlet pipe 422. The air inlets of the low-temperature air inlet pipe 422 are respectively Connected to the air outlets of the control pipeline 31' and the control pipeline 31", the coupler 423 and the refrigerator 424 are both provided with a first air inlet channel connected to the low-temperature air inlet pipeline 422. The low-temperature air inlet pipeline 422 has The air outlet is connected to the air inlet end of the ablation needle connector 5. In this embodiment, the low-temperature air inlet pipeline 422 is also provided with a solenoid valve 421, a pressure transmitter, and a temperature sensor for detecting the pressure of the pipeline and adjusting The gas pipeline is on and off. And the gas outlet section of the low-temperature gas inlet pipeline 422 (that is, the gas inlet section of the ablation needle connector 5) is also provided with a one-way valve 425. In this embodiment, the refrigerator 424 is a Stirling refrigerator. , pulse tube refrigerator or thermoacoustic refrigerator.

Return air pre-cooling channel 43. The return air pre-cooling channel 43 includes a return air pipeline 431 and the coupler 423 provided on the return air pipeline 431. The air inlet of the return air pipeline 431 is in contact with the ablation needle. The return air end of the joint 5 is connected, and the coupler 423 is provided with a first return air channel connected to the return air pipeline 431. The exhaust port of the return air pipeline 431 is connected to the outside atmosphere; the low-temperature air inlet pipeline 422 The gas can first perform heat exchange with the gas in the return gas pipeline 431 through the coupler 423, and then be refrigerated by the refrigerator 424. In this embodiment, the return air line 431 is also provided with a pressure relief valve and a pressure transmitter. The pressure transmitter is used to detect the pressure of the return air line 431. When the pressure of the return air line 431 When it is higher than the set value, the pressure is released through the pressure relief valve.

The rapid exhaust channel 44 includes a rapid exhaust pipeline 441 and a solenoid valve 442 located on the rapid exhaust pipeline 441. One end of the rapid exhaust pipeline 441 is connected to the rapid exhaust pipeline 441. The low-temperature air intake pipeline 422 is connected, and the other end is connected to the outside atmosphere.

A one-way valve is added to the inlet and outlet of ablation needle 6 with a certain starting pressure of 15 psi to prevent air from entering from the inlet and outlet of ablation needle 6. In addition, the remaining air in the pipeline after the operation is used to adjust the on and off of the solenoid valve through the control system. A certain amount of gas is introduced into the relevant pipelines to keep the pipelines in a positive pressure state to avoid the negative pressure caused by low temperature in the pipelines from sucking in air, causing the water vapor in the air to condense into liquid, which will solidify and block at low temperatures. Pipes or ruptured pipes may cause ice blockage and risk of gas leakage.

How the different working modes work:

First, the gas in the gas source 1 is dried and filtered by the gas drying filter 22 and then enters the pressure regulating unit 3. The pressure regulating unit 3 realizes the circulation of gases of different pressures according to different working modes.

purge mode

The gas after drying and filtering is adjusted to the corresponding working pressure through the pressure regulating unit 3 through the pressure reducing valve 32', and the working gas is controlled to enter the working gas pipeline through the on and off of the solenoid valve 34', and at the same time through the solenoid valve 421 and the solenoid valve 421 'Control the gas to enter different cryoablation channels, and then enter the coupler 423 and the refrigerator 424 in sequence for low-temperature pre-cooling. After the low-temperature pre-cooling is completed, it enters the connected joint 5 through the low-temperature dual-channel ablation needle connector 5 and then returns after throttling. The coupler 423 and the rapid pre-cooling coupler 423 can avoid the influence of slow cooling of the ablation needle 6 caused by the temperature of the coupler 423 being higher than the cooling sink temperature.

cryoablation mode

The cryoablation mode is divided into a rapid cooling stage and a stable working stage:

In the rapid cooling stage, the pressure regulating unit 3 is adjusted to the corresponding working pressure through the pressure reducing valve 32', and the working gas is controlled to enter the working gas pipeline through the on and off of the solenoid valve 34', while the gas is controlled through the solenoid valve 421 and the solenoid valve 421'. Enter different cryoablation channels (where the solenoid valve 421 and the solenoid valve 411 are located in one cryogenic refrigeration system, and the solenoid valve 421' and the solenoid valve 411' are located in another cryogenic refrigeration system) and enter the coupler 423 and the refrigerator 424 Perform low-temperature pre-cooling. After the low-temperature pre-cooling is completed, enter the cryo-ablation needle 6 through the low-temperature dual-channel ablation needle connector 5. After the inside of the ablation needle 6 is throttled through the J-T groove inside the ablation needle 6, it rapidly expands and vaporizes inside the tip to produce a refrigeration effect, rapidly releasing the cold energy to generate a low temperature below -150°C, quickly freezing the diseased tissue, and then using the low temperature The dual-channel ablation needle connector 5 returns to the coupler 423. Since the return air temperature is relatively low, after fully utilizing the cooling capacity through the coupler 423, the gas becomes normal temperature and pressure and is discharged into the air.

During the stable working stage, since the gas pipeline of the ablation needle 6 has established a stable working cycle, a relatively low pressure can be used to achieve stable operation of the ablation needle 6, while avoiding the waste of the gas source 1 and extending the use time of the gas cylinder. . The working process is as follows: the pressure regulating unit 3 adjusts to the corresponding working pressure through the pressure reducing valve 32", and the working gas is controlled to enter the working gas pipeline through the on and off of the solenoid valve 34", and is controlled by the solenoid valve 421 and the solenoid valve 421' at the same time. The gas enters different ablation channels to achieve stable operation of the ablation needle 6 .

rewarming mode

The pressure regulating unit 3 is adjusted to the corresponding working pressure through the pressure reducing valve 32, and the working gas is controlled to enter the working gas pipeline through the on and off of the solenoid valve 34. At the same time, the gas is controlled to enter different rewarming conditions through the solenoid valve 411 and the solenoid valve 411'. channel to realize that the gas can quickly pass through the low-temperature dual-channel ablation needle connector 5 and enter the cryoablation needle 6 without pre-cooling. At the same time, it cooperates with the rewarming control module 45 in the control unit to output voltage and current to realize rapid rewarming of the ablation needle 6. At the same time, through The gas circulation protects the ablation needle 6 to avoid overheating and damaging the organs and tissues.

Quick exhaust mode

When an abnormality occurs in the equipment or the freezing is completed, the ablation needle 6 can be quickly exhausted through the on/off of the solenoid valve 442 and the solenoid valve 442' and the normal return air line.

Example 2

Please refer to Figures 3 and 4. In this embodiment, based on Embodiment 1, the low-temperature precooling system 4 adds an energy enhancement channel. Since the remaining gas pressure lower than the working pressure is about 8-10MPa, the high-pressure argon gas The remaining gas pressure of source 1 is higher at about 20MPa. The conventional treatment of the remaining gas is directly recovered by the manufacturer. Since the gas contains a large amount of energy when it is throttled from a high-pressure state to a low-pressure state, direct recovery causes great waste. Therefore, more advanced utilization of gas energy can be achieved through energy enhancement systems through different temperature transitions. The energy enhancement system is mainly used in the start-up stage and cold storage stage of the low-temperature refrigerator 424: During the start-up stage of the low-temperature refrigerator 424, the rapid cooling of the pre-cooling system can be achieved, the cooling time of the low-temperature refrigerator 424 can be shortened, and the low-temperature refrigerator 424 can be quickly cooled down. It enters a stable working state and greatly shortens the preparation time for surgery. During the standby cooling storage stage of the cryogenic freezing system between consecutive surgeries, the remaining gas can be used to bring a lower temperature to the cryogenic cryogenic sink to achieve faster cooling of the ablation needle 6, lower ablation temperature, and a larger ablation range.

In this embodiment, the low-temperature precooling system 4 also includes an energy enhancement channel 46. The energy enhancement channel 46 includes an energy enhancement pipeline, the energy enhancer 463 and a refrigerator provided in the energy enhancement pipeline. 424. Since the energy enhancer 463 is a coupler, the energy enhancer 463 can be an additional coupler, or the coupler 423 can be used (it is enough to open a gas channel on the coupler 423 that communicates with the energy enhancement pipeline 462. ), this embodiment takes as an example that the energy enhancement channel 46 includes an energy enhancement pipeline 462 and an energy enhancement device 463 and a refrigerator 424 that are sequentially provided on the energy enhancement pipeline 462. The air inlet of the energy enhancement pipeline 462 is connected to the air outlet of the pressure adjustment unit 3 , and the air outlet of the energy enhancement pipeline 462 is connected to the outside atmosphere. The residual gas in the air source 1 passes through the energy booster pipeline 462 and is pre-cooled by the energy booster 463 and the refrigerator 424, and then the cold storage medium in the refrigerator 424 is pre-cooled.

In this embodiment, the energy enhancer 463 and the refrigerator 424 are arranged in sequence on the energy enhancement pipeline 462. Specifically, the energy enhancement pipeline 462 includes a connected energy enhancement air intake pipeline 4621 and an energy enhancement return air pipeline 4622. The energy enhancer 463 and the refrigerator 424 both include intake air connected to the energy enhancement air intake pipeline 4621. channel and the return air channel connected to the energy enhancement return air pipe 4622 (the air inlet channels of the energy enhancer 463 and the refrigerator 424 are sequentially arranged on the energy enhancement air inlet pipe 4621, the energy enhancer 463 and the refrigerator The return air passages of 424 are sequentially arranged on the energy-enhancing return air pipe 4622), and the energy-enhancing air intake pipe A throttling device 464 is provided between the air outlet of the energy enhancement return air pipeline 4621 and the air return outlet of the energy enhancement air intake pipeline 4622. The air inlet of the energy enhancement air intake pipeline 4621 is connected with the air outlet of the pressure adjustment unit 3. The exhaust port of the energy-enhancing return air pipeline 4622 is connected to the outside atmosphere.

The utilization of the energy enhancement system is mainly during the start-up phase and cold storage phase of the low-temperature refrigerator:

During the start-up phase of the cryogenic refrigerator, rapid cooling of the cryogenic pre-cooling system 4 can be achieved, shortening the cooling time of the cryogenic refrigerator, quickly bringing the cryogenic refrigerator into a stable working state, and greatly shortening the preparation time for surgery. During the interval between consecutive surgeries, in the standby cooling storage stage of the cryogenic precooling system 4, the remaining gas can be used to bring a lower temperature to the cryogenic cold sink to achieve faster cooling of the ablation needle 6, lower ablation temperature, and a larger ablation range.

working principle:

The gas is adjusted to the corresponding working pressure through the pressure reducing valve 32" through the pressure regulating unit 3, and the working gas is controlled to enter the energy enhancement channel 46 through the on and off of the solenoid valve 34". At the same time, the solenoid valve 461 of the energy enhancement pipeline 462 enters the energy enhancement channel. The air pipeline 4621 enters the energy-enhanced air inlet pipeline 4621 and then enters the coupler 423 and the refrigerator 424 in sequence for low-temperature pre-cooling. After the low-temperature pre-cooling is completed, the high-grade cooling capacity is used through the throttling device 464 to realize the pre-cooling of the refrigerator 424. Cold, after the pre-cooling of the refrigerator 424 is completed, it enters the coupler 423, and the remaining cold energy is recycled through the coupler 423 to become gas at normal temperature and pressure and enters the air, realizing complete utilization of the energy from high-pressure gas to low-pressure gas.

By calculation, after the 60SLM gas with 1200PSI pressure is throttled through the coupler 423 and the refrigerator 424, the cooling capacity of about 10W can be generated in the refrigerator 424 at -110°C. The 60SLM gas with the pressure of 725PSI is throttled through the coupler 423 and the refrigerator. After 424 is throttled, the refrigerator 424 at -110°C can generate about 7W of cooling capacity. Utilizing the gas in the 40L gas source 1 from 1200PSI pressure to 725PSI can generate an average of about 20.16kJ of heat, converted into The pre-cooling time can be shortened by about 5% to 10%.

Example 3

Please refer to Figures 5 and 6. In order to enhance the refrigeration effect, this embodiment adds a refrigerator to the cryoablation channel 42 of Embodiment 1. That is, this embodiment uses a two-stage cryogenic refrigerator. Specifically, the cryoablation channel 42 It includes a low-temperature air intake pipe 422, a coupler 423, a front-stage refrigerator 424 and a rear-stage refrigerator 426 that are sequentially provided on the low-temperature air intake pipe 422.

Compared with Embodiment 1, this embodiment adds a stage of low-temperature refrigerator 426, which can realize the hierarchical utilization of the energy of the low-temperature refrigerator, gradually reduce the nitrogen pre-cooling temperature, and at the same time avoid the cooling temperature of the refrigerator due to the large temperature difference in the nitrogen pipeline. rebound, and dependence on the refrigeration capacity of the subsequent stage refrigerator 426. For example, under normal conditions, the cold energy carried by the return air of the ablation needle can pre-cool the inlet air of the ablation needle to below -60°C in the coupler, and then pre-cool it to -120°C in the cryogenic refrigerator 424 Below, this requires a higher cooling capacity of the cryogenic refrigerator 424. For example, if a first-stage cryogenic refrigerator 426 is added, the front-stage cryogenic refrigerator 424 will pre-cool the ablation needle inlet air from -60°C to -90°C, and the subsequent stage of refrigeration will The machine 424 only needs to pre-cool the ablation needle inlet air from -90°C to -120°C, which reduces the cooling capacity requirement of the low-temperature refrigerator by 50%; at the same time, because the working temperature of the front-stage refrigerator 424 is lower than that of the rear-stage low-temperature refrigerator 426 The temperature is high. According to the refrigeration principle, when the cooling temperature remains unchanged, the lower the refrigeration temperature, the higher the refrigeration efficiency. According to calculations and tests, the refrigeration efficiency of -90°C can be increased by 50% compared to the refrigeration efficiency of -120°C, which means savings The amount of electricity can also reach more than 15%, which can also achieve the purpose of energy saving and emission reduction.

Example 4

Please refer to Figures 7 and 8. This embodiment is in Embodiment 3, that is, the low-temperature precooling system 4 further includes an energy enhancement channel 46. The energy enhancement channel 46 includes an energy enhancement pipe 462 and an energy enhancement pipe located in the energy enhancement pipe. The energy booster 463, the front-stage refrigerator 424 and the back-stage refrigerator 426 on the road 462. Since the energy booster 463 is a coupler, the energy booster 463 can be an additional coupler, or a cryoablation channel can be used. 42 (that is, a gas channel connected to the energy enhancement pipeline 462 is provided on the coupler 423). In this embodiment, the energy enhancement channel 46 includes the energy enhancement pipeline 462 and the energy enhancement pipeline 462 in turn. Take the energy enhancer 463, the front-stage cryogenic refrigerator 424, the rear-stage coupler 427 and the rear-stage cryogenic refrigerator 426 on 462 as an example.

In this embodiment, the energy enhancer 463, the front-stage low-temperature refrigerator 424, and the rear-stage low-temperature refrigerator 426 are arranged on the energy enhancement pipeline 462 in order. Specifically, the energy enhancement pipeline 462 includes a connected energy enhancement air inlet pipeline 4621 and an energy enhancement return air pipeline 4622. The energy enhancer 463, the front-stage low-temperature refrigerator 424 and the rear-stage low-temperature refrigerator 426 all include connected The air inlet passage on the energy enhancement air inlet pipe 4621 and the return air passage connected to the energy enhancement return air pipe 4622 (the air inlet passage of the energy enhancer 463, the front-stage low-temperature refrigerator 424 and the rear-stage low-temperature refrigerator 426 are arranged on the energy-enhancing air intake pipeline 4621 in sequence, and the return air passages of the energy intensifier 463, the front-stage low-temperature refrigerator 424, and the rear-stage low-temperature refrigerator 426 are arranged in sequence on the energy-enhancing return air pipeline 4622), so A throttling device 464 is provided between the air outlet of the energy-enhanced air intake pipe 4621 and the air return port of the energy-enhanced air return pipe 4622. The air inlet of the energy-enhanced air intake pipe 4621 is connected to the pressure regulating unit 3 The air outlet of the energy enhancement return air pipeline 4622 is connected with the outside atmosphere.

According to calculations, after the 60SLM gas with 1200 PSI pressure is pre-cooled to -70°C, and then throttled after the low-temperature cooling of the subsequent stage, the cooling capacity of about 45W can be generated in the low-temperature cooling of -120°C. The cooling capacity generated in 1 minute can be The extended ablation needle 6 is used for 0.5 minutes to pre-cool the 60SLM gas with a pressure of 725 PSI to -70°C. After passing through the energy enhancer 463 and subsequent low-temperature cooling and throttling, the gas can be generated at a low-temperature cooling of -120°C. The cooling capacity is about 22W. Utilizing the gas in 40L gas source 1 from 1200PSI pressure to 725PSI can generate an average heat of about 41.6kJ. amount, converted into pre-cooling time can be shortened by about 15%.

Specific embodiments of the present invention have been described above. It should be understood that the present invention is not limited to the specific embodiments described above. Those skilled in the art can make various changes or modifications within the scope of the claims, which does not affect the essence of the present invention. The embodiments of the present application and the features in the embodiments can be combined with each other arbitrarily without conflict.

Claims

A dual-system cryogenic treatment system based on cryogenic refrigerator pre-cooling, which is characterized in that it includes a gas source, a gas processing unit and a pressure regulating unit arranged in sequence, and the pressure regulating unit is connected to at least one through at least two sets of low-temperature pre-cooling systems. Two ablation needles are connected;

The low-temperature precooling system includes a cryoablation channel and a return air precooling channel:

The cryoablation channel includes a low-temperature air inlet pipeline and at least one coupler and at least one refrigerator provided on the low-temperature air inlet pipeline. The air inlet of the low-temperature air inlet pipeline is connected to the air outlet of the pressure adjustment unit. , the air outlet of the low-temperature air inlet pipeline is connected to the air inlet of the corresponding ablation needle;

The return air pre-cooling channel includes a return air pipeline and the coupler provided on the return air pipeline. The air inlet of the return air pipeline is connected to the air return end of the ablation needle. The exhaust port is connected to the outside atmosphere; the gas in the low-temperature air inlet pipe can first conduct heat exchange with the gas in the return air pipe through the coupler, and then pass through the cold sink pre-cooled by the refrigerator for low-temperature processing. cool down.
A dual-system cryogenic treatment system based on cryogenic refrigerator pre-cooling according to claim 1, characterized in that the low-temperature pre-cooling system further includes an energy enhancement channel, and the energy enhancement channel includes an energy enhancement pipeline and equipment. At least one energy enhancer in the energy enhancement pipeline and at least one refrigerator, the air inlet of the energy enhancement pipeline is connected to the air outlet of the pressure adjustment unit, and the remaining residual gas in the air source is After the gas is pre-cooled by the energy enhancer and the refrigerator, the cold storage medium in the refrigerator can then be pre-cooled.
A dual-system cryogenic treatment system based on cryogenic refrigerator pre-cooling according to claim 2, characterized in that the energy enhancement pipeline includes a connected energy enhancement air inlet pipeline and an energy enhancement return air pipeline, and the Both the energy enhancer and the refrigerator include an air inlet channel connected to the energy enhanced air inlet pipeline and a return air channel connected to the energy enhanced air return pipeline. The air outlet of the energy enhanced air inlet pipeline and the energy enhanced air inlet pipeline A throttling device is provided between the air return ports of the enhanced energy return air pipeline. The air inlet of the energy enhanced air intake pipeline is connected to the air outlet of the pressure adjustment unit. The exhaust port of the energy enhanced return air pipeline is connected to the outside world. Atmospheric connectivity.
A dual-system cryogenic treatment system based on cryogenic refrigerator pre-cooling according to claim 1, characterized in that the low-temperature pre-cooling system also includes a rewarming channel, and the rewarming channel includes a normal temperature air inlet pipeline, so The normal temperature air inlet pipeline is connected to the air outlet of the pressure adjustment unit and the air inlet of the ablation needle connector respectively.
A dual-system cryogenic treatment system based on cryogenic refrigerator pre-cooling according to claim 4, characterized in that a solenoid valve and a one-way valve are provided on the normal temperature air inlet pipeline.
A dual-system cryogenic therapy system based on cryogenic refrigerator precooling according to any one of claims 1 to 5, characterized in that the pressure adjustment unit includes a plurality of control pipelines and a A pressure regulating valve, a solenoid valve and a pressure transmitter, several air inlets of the control pipelines are respectively connected to the gas outlets of the gas processing unit, and several gas outlets of the control pipelines are respectively connected to the low-temperature precooling Connect the air inlets of each pipeline in the system.
A dual-system cryogenic treatment system based on cryogenic refrigerator pre-cooling according to claim 1, characterized in that the gas processing unit includes a gas drying filter, and the gas drying filter is arranged on the gas source. on the outlet pipeline.
A dual-system cryogenic treatment system based on cryogenic refrigerator pre-cooling according to claim 1, characterized in that the cryogenic air inlet pipeline is provided with a solenoid valve, a one-way valve and a pressure transmitter.
A dual-system cryogenic therapy system based on cryogenic refrigerator pre-cooling according to claim 1, characterized in that the low-temperature pre-cooling system further includes a rapid exhaust channel, and the rapid exhaust channel includes a rapid exhaust pipe. and a solenoid valve located on the rapid exhaust pipeline, and the rapid exhaust pipeline is connected with the low-temperature air intake pipeline.
A dual-system cryogenic treatment system based on cryogenic refrigerator pre-cooling according to claim 1, characterized in that the return air pipeline is also provided with a pressure relief valve and a pressure transmitter, and the pressure transmitter is used for The pressure of the return air pipeline is detected, and when the pressure of the return air pipeline is higher than the set value, the pressure is released through the pressure relief valve.