CN103549992A - Mixed gas feeder of target knife and method for controlling cooling capacity output - Google Patents

Mixed gas feeder of target knife and method for controlling cooling capacity output Download PDF

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CN103549992A
CN103549992A CN 201310589953 CN201310589953A CN103549992A CN 103549992 A CN103549992 A CN 103549992A CN 201310589953 CN201310589953 CN 201310589953 CN 201310589953 A CN201310589953 A CN 201310589953A CN 103549992 A CN103549992 A CN 103549992A
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controller
targeting
pressure
knife
solenoid valve
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CN 201310589953
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CN103549992B (en )
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常兆华
赵庆孝
叶萍
徐彬凯
宋玲
沈礼兰
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上海导向医疗系统有限公司
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Abstract

The invention relates to a mixed gas feeder of a target knife and a method for controlling refrigeration capacity output. The feeder comprises two steel cylinders, two gas flow controllers, a mixing chamber, a high-voltage pressure controller, a high-voltage magnetic valve, a low-voltage pressure controller, a low-voltage magnetic valve, a controller, a pre-cooling system and a target knife, wherein different gases with the Joule-Thomson effect are filled in the two steel cylinders; the gases flow out of the steel cylinders, enters the mixing chamber to be fully mixed after being subjected to flow regulation by the flow controller, flows through the pressure controllers and the magnetic valves in sequence, enters the pre-cooling system to be pre-cooled, and flows to a target zone for throttling cooling. According to the invention, the flow of the two steel cylinders can be regulated to be different through the controller so as to realize the situation that two gases are mixed in an arbitrary mixing rate; the throttling cooling property of N2 and Ar is fully utilized, so that the cooling capacity of an input knife head is accurately controlled, different cooling capacity requirements for cryoablation of tumors at different parts are met, the cryoablation effect is guaranteed and effective utilization rate of the cooling capacity of the pre-cooling system is improved at the same time, the gas source is saved, and burdens of a patient are alleviated.

Description

靶向刀混合气体供气装置及控制冷量输出的方法 Method knife targeting a mixed gas supply device and the control of the cold output of

技术领域 FIELD

[0001] 本发明涉及一种肿瘤冷冻消融用靶向刀的混合气体供气装置及控制冷量输出的方法,用来使靶向刀的靶向区快速降至消融温度后,控制输入靶向区的冷量。 After [0001] The present invention relates to a method for tumor cryoablation cold air supply device and the control output of the mixed gas knife targeting, the targeting tool to enable targeting the ablation zone temperature dropped quickly, targeting control input cold zone.

背景技术 Background technique

[0002] 2010年,恶性肿瘤已经成为世界上致死率最高的疾病。 [0002] In 2010, the cancer death rate has become the highest disease in the world. 如果不采取行动,预计2030年全世界将有2600万新增病例,死亡人数达到1700万人。 If no action is taken, is expected in 2030 the world will have 26 million new cases, the death toll reached 17 million. 因只有大约20%左右的肿瘤患者能够接受外科切除手术,冷冻消融、射频消融、微波、激光热疗等肿瘤微创治疗技术正成为当代临床医学发展的前沿,冷冻消融是其中一种具有代表意义的技术。 Because only about 20% of cancer patients about to undergo a surgical resection can, cryoablation, radiofrequency ablation, microwave, laser hyperthermia cancer and other minimally invasive treatment technology is becoming the forefront of contemporary clinical development, cryoablation is one representative of significance Technology. 其主要通过低温器械,有控制地使病灶组织经历降温、冻结、复温过程,从而造成肿瘤细胞的不可逆损伤甚至坏死。 The main instrument by low temperature, in a controlled manner so that tissue lesions undergo cooling, freezing, thawing process, resulting in irreversible damage to tumor cells and even necrosis. 冷冻消融对肿瘤细胞的杀伤机制是:细胞脱水和皱缩;细胞内冰晶形成的机械损伤;细胞电解质毒性浓缩和PH值改变;细胞膜蛋白质成分变性;血流淤积和微血栓形成;以及免疫效应等。 Cryoablation of tumor cell killing mechanism is: cell dehydration and shrinkage; mechanical damage intracellular ice crystal formation; cytotoxic cell electrolyte concentration and PH value change; membrane protein denaturation component; blood sedimentation and micro thrombosis; and other immune effector . 冷冻消融不仅手术创伤小,而且具有定位精确、止血镇痛、术后并发症少、安全性高等优点,深受广大医生与患者的好评。 Cryoablation not only surgical trauma, but also precise positioning, bleeding pain, fewer complications, safety, etc., by the majority of doctors and patients at home.

[0003]目前已经问世的冷冻消融系统主要氛围两大类:一类是液氮系统靶向刀,利用物质由液体变成气体时需要吸收大量的汽化潜热的原理使组织快速降温;另一类是气体节流系统靶向刀,利用高压气体流经小孔绝热节流时温度的变化,完成冷冻消融的降复温治疗过程。 [0003] has now come out of the atmosphere cryoablation system mainly into two categories: one is liquid nitrogen system targeting knives, need to absorb a large amount of latent heat of vaporization of principle when the use of material from a liquid to a gas enables organizations to quickly cool down; and the other targeting system is throttled gas knife changes using a high pressure gas through an adiabatic expansion orifice temperature, drop complete rewarming cryoablation therapy. 液氮系统靶向刀可以看做第一代靶向刀,有如下缺点:刀头降温速度较慢,不利于肿瘤细胞的杀死;靶向刀直径较大,不利于微创治疗;设备体积较庞大,液氮储存需特种设备,不便于运输。 Nitrogen targeting system can be viewed as a first generation of targeted knife blade, has the following disadvantages: slow cooling head, is not conducive to kill tumor cells; targeting larger diameter cutter is not conducive to minimally invasive treatment; equipment size relatively large, liquid nitrogen storage need special equipment, not easy to transport. 气体节流系统靶向刀是目前临床应用的主流,代表产品为氩氦刀,可以看做第二代靶向刀。 Gas throttling knife targeting system is the mainstream clinical application, is representative of the product cryosurgical can be seen as a second-generation targeting knife. 其使用氩气节流降温、氦气升温,具有装置小巧轻便、刀头升降温迅速等优点。 Using an argon throttle cool, warm helium gas, having a compact and lightweight devices, the advantages of rapid heating and cooling head. 但是所需氩气瓶压力高达5000psi,运输及使用时均存在一定安全隐患,且氩气、氦气均为稀有气体,价格较高并难于购买。 But the required argon gas cylinders at pressures up to 5000psi, there are some security risks when both transport and use, and argon, and helium gas are rare, and difficult to buy a higher price.

[0004] 氮气节流靶向刀可以看做是第三代靶向刀,氮气工作压力为1200psi,气瓶压力为2100psi,是医院常备的气体。 [0004] The nitrogen expansion can be viewed as targeting knife blade targeting the third generation, working pressure of 1200 psi nitrogen gas, the cylinder pressure of 2,100 psi, gas standing hospital. 但若要氮气节流靶向刀达到治疗温度,必须对氮气预冷,预冷后的氮气再在靶向刀的靶向区节流降温至治疗温度。 But to achieve therapeutic knife targeted throttling nitrogen temperature, the nitrogen must be precooled, targeted throttling area precooled nitrogen gas and then cooled in a targeted knife to the treatment temperature. 根据氮气的热力学性质分析,单纯的氮气节流靶向刀对预冷系统的依赖性较强,随靶向刀工作时预冷温度的上升,靶向刀的靶向区将不能维持所需的低温,多把靶向刀联合应用时,这一现象将更早出现,严重影响消融效果及靶向刀的使用范围。 The thermodynamic properties of nitrogen analysis, a simple throttle nitrogen precooling system targeting knife strong dependence on the rise in temperature during operation with pre-cooled knife targeting, the targeting region targeted knife will not maintain the required low temperature, combined with the targeting of the knife, this phenomenon will occur sooner, seriously affecting the use of effects and targeted ablation knife. 若采用氩气作为工质,上述情况会有较为明显的改善,但是氩气节流初期,降温速度缓慢,而冷冻消融开始时,因肿瘤组织血供丰富,热负荷很大,需要很大的冷量才能抑制肿瘤组织的血液灌注热,并快速冻结肿瘤组织。 If argon gas as the working fluid, the above-described situation will be more significantly improved, but the initial integrity argon stream, slow cooling, while cryoablation begins, large cold rich blood supply due to tumor tissue, a large thermal load, it is necessary in order to suppress the amount of heat the tumor tissue blood perfusion, and quickly frozen tumor tissue. 同时,随消融过程的进行,肿瘤组织内的血管大部分冻结,血供显著减少,靶向区外壁被冰球包围,刀内很小的冷量即能与组织内的热负荷达成热平衡,使靶向区温度维持稳定。 Meanwhile, with the ablation process, most of the blood vessels within the tumor tissue freezing, significantly reduced blood supply, is surrounded by an outer wall targeting region puck, i.e., a small amount of cold heat to reach thermal equilibrium with the tissue cutter in the load, the target to maintain a stable temperature zone. 此时,过大的气体流量并不能使刀头温度进一步降低,反而会造成预冷系统冷量以及气体的大量浪费。 At this time, excessive gas flow does not make head temperature was further lowered, it will cause a lot of waste pre-cooling systems and cold gas. 这一现象,所有用于肿瘤冷冻消融的气体节流冷冻系统均存在。 This phenomenon, all the gas throttle refrigeration system for cryoablation of tumors are present. 因此,单纯的为靶向刀供应预冷后的氮气(N2)或者氩气(Ar),或者存在冷量不足、或者存在初期降温过慢等问题,均不能有效的适应临床实际需要,造成资源的浪费并加重患者的经济负担。 Therefore, the simple supply targeting knife after the pre-cooled nitrogen (N2) or argon (Ar), or there is insufficient cooling capacity, or the existence of the initial slow cooling and so on, are not clinically effective adaptation to actual needs, resulting in resources waste and increase the financial burden of patients.

发明内容 SUMMARY

[0005] 本发明针对现有气体节流冷冻系统存在的不足及实际需求,提供一种混合气体的供气装置及控制冷量输出的方法,该装置结构简单,方便易用;该方法能充分利用各正焦-汤气体的节流特性,在保证靶向区快速降温又减小对预冷系统的依赖的同时,精确控制输入靶向区的冷量,以更小的气体流量维持刀头于治疗温度,提高预冷系统冷量的有效利用率,保证多刀联用时的治疗效果。 [0005] The present invention is for the presence of a gas expansion refrigeration system of the conventional and less than the actual demand, to provide a mixed gas supply device and the control method of the cold output of the apparatus is simple in structure, easy to use; the method can be sufficiently n by each power - soup gas throttle characteristic, to ensure that the targeted area in turn reduces the dependence on the rapid cooling while pre-cooling system, the control input precisely targeted cold zone to maintain the gas flow rate smaller bit the treatment temperature, improve the effective utilization of the precooling refrigeration system to ensure therapeutic effect when combined with the multi-tool.

[0006] 为了解决上述技术问题,本发明的采用的技术方案是: [0006] To solve the above problem, a technical solution of the present invention is:

一种靶向刀混合气体供气装置,包括钢瓶A、钢瓶B、气体流量控制器A、气体流量控制器B、混合室、高压压力控制器、低压压力控制器、高压电磁阀、低压电磁阀、控制器、预冷系统和靶向刀,其特点是:钢瓶A和钢瓶B内分别装有氮气和氩气,钢瓶A和钢瓶B分别通过流量控制器A3、流量控制器B4连接混合室,混合室内混合的氮气和氩气的混合气体出气管分成二路:一路经高压压力控制器和高压电磁阀连接预冷系统,另一路经低压压力控制器和低压电磁阀连接预冷系统,预冷系统连接靶向刀;流量控制器A、流量控制器B、高压电磁阀、低压电磁阀分别与控制器相连接。 One targeting knife mixed gas supply means comprises a cylinder A, B cylinder, gas flow controller A, gas flow controller B, misch chamber, the high pressure control, low pressure control, the high-pressure solenoid valve, a low pressure solenoid valve , a controller, and a targeting tool precooling system, characterized by: each equipped with a nitrogen and argon gas cylinders A and B cylinders, cylinders A and B, respectively, by the cylinder flow controllers A3, B4 flow controller connected to the mixing chamber, mixing chamber and mixed gas of nitrogen mixed gas of argon into the trachea Road: the way through the high-pressure and high-pressure control solenoid valve is connected precooling system, another low pressure path and a low pressure solenoid valve connected to the controller precooling system, precooling knife linked to a targeting system; flow controllers A, B flow controllers, pressure solenoid valve, a low pressure solenoid valve are connected to the controller.

[0007] 混合室内氮气所占的体积百分浓度调节范围为0%~100%之间。 [0007] The volume percent of nitrogen concentration adjusting range of the mixing chamber is occupied by between 0% to 100%. 高压压力控制器输出压力设定范围为1500psi~1800psi之间;低压压力控制器输出压力设定范围为800psi~1200psi之间。 High pressure controller output pressure is set in the range of between 1500psi ~ 1800psi; low pressure controller output pressure setting range is between 800psi ~ 1200psi. 混合气体进入祀向刀之前经预冷系统(预冷的温度为< _80°C。革巴向刀包含有靶向区,所述靶向刀的数量为I~8把。 Gas mixture into the number of Si knife before (pre-cooled to a temperature of <_80 ° C. Gerba system comprising the pre-cooled knife has targeted region, the targeting of I ~ 8 knife handle.

[0008] 一种利用上述靶向刀混合气体供气装置控制冷量输出的方法,包括三种方法: 第一种方法:首先在控制器上选择“压力调节”模式,此时,高压电磁阀打开,低压电磁 [0008] A method for controlling the amount of cooling gas supply means using the output of the mixing blade targeting, comprising three methods: The first method: first selecting "pressure regulator" mode on the controller, at this time, the high pressure solenoid valve open, low-voltage electromagnetic

阀关闭,靶向刀的靶向区快速降温,3分钟后低压电磁阀打开,高压电磁阀关闭,使靶向刀混合气体供气装置以低压输出混合气体,减小靶向区冷量,同时保持靶向区温度不变。 Valve is closed, the targeted area targeted knife rapid cooling after 3 minutes low pressure solenoid valve opens, the high pressure solenoid valve is closed, so that the knife targeting a mixed gas supply means for a mixed gas of low voltage output, reducing the amount of cooling targeting region, while keep the temperature constant targeted area.

[0009] 第二种方法:首先在控制器上选择“功率调节”模式并设定输出功率为0%~100%间的任意数值,设定低压电磁阀关闭,高压电磁阀开启或高压电磁阀关闭,低压电磁阀开启,靶向刀工作时,开启的低压电磁阀或高压电磁阀通过调节占空比的方式按照设定功率值输出混合气体至靶向区。 [0009] The second method: First select the "power adjustment" mode and set the output power of any value between 0% and 100%, setting the low pressure solenoid valve is closed, the solenoid valve opens the high pressure or high pressure on the solenoid valve controller Close the low pressure solenoid valve open, when the targeting work tool, a low pressure solenoid valve opening pressure solenoid valve or a mixed gas to the targeted value output area according to the set power by adjusting the duty cycle mode.

[0010] 第三种方法:首先在控制器上选择“混合比调节”模式,设定低压电磁阀关闭,高压电磁阀开启或高压电磁阀关闭,低压电磁阀开启,靶向刀工作的前5分钟,控制器将混合室内氮气所占的体积百分浓度设定为51%~100%间的任意数值,中间5分钟,控制器将混合室内氮气所占的体积百分浓度设定为50%,最后5分钟,控制器将混合室内氮气所占的体积百分浓度设定为0%~49%间的任意数值。 [0010] The third method: First select "mixing ratio adjustment" mode, set the low-pressure solenoid valve is closed, the solenoid valve opens the high-pressure or high-pressure solenoid valve is closed, the low pressure solenoid valve open, rake targeted work on the controller 5 min, the controller mixing chamber volume percent of nitrogen concentration is set to be occupied by any number between 51% to 100%, intermediate 5 minutes, the controller will mixed volume percentage occupied by the nitrogen concentration in the room is set at 50% , the last 5 minutes, the controller will volume percentage occupied by the nitrogen concentration in the mixed chamber is set to any value between 0% and 49%.

[0011] 本发明的有益效果是: [0011] Advantageous effects of the present invention are:

本发明的靶向刀混合气体供气装置的主要特点为:该装置包括钢瓶和对应数量的流量控制器,可以通过流量控制器方便的控制混合室内气体的混合比,以充分发挥不同气体节流特性,适应不同部位肿瘤的实际消融需求;该装置以高压压力控制器、高压电磁阀组成高压气体通路,以低压压力控制器和低压电磁阀组成低压气体通路。 The main features of the present invention knife targeting a mixed gas supply means is: the apparatus comprises a cylinder and a corresponding number of flow controllers, can easily control the mixing ratio of the gas chamber through the flow controller to its full throttle different gases properties, to adapt to different parts of the tumor ablation actual needs; the control means to the high-pressure, high-pressure gas composition pressure solenoid valve passage to the low pressure and low pressure control valve is composed of a low-pressure gas passage solenoid. 通过相应电磁阀的开断,可以控制气体管路压力或冷冻功率,实现消融开始时靶向刀靶向区的快速降温,以及待靶向区温度稳定后更小的气体流量,从而在节约气体的同时更高效的利用气体预冷系统的冷量。 By breaking the appropriate solenoid valve, or the pressure gas line may be controlled power freezing, rapid cooling knife targeting targeted ablation zone begins, and the region to be temperature stabilized gas flow targeting smaller, thereby saving gas while gas precooling refrigeration system, more efficient use. [0012] 本发明的靶向刀混合气体供气装置的另一特点为:两个钢瓶内分别为N2和Ar。 [0012] Another feature of the present invention knife targeting a mixed gas supply means is: the two cylinders are N2 and Ar. 通过在消融过程中控制两种气体的混合比,可以控制输入靶向区的冷量及降温速度,以适应不同部位肿瘤及同一部位肿瘤不同消融阶段对冷量的不同需求。 By controlling the two gases in the mixing ratio of the ablation process, it can be targeted to the control input of the cold zone and the cooling speed, to adapt to different parts of the tumor and in different parts of the tumor ablation stage of the same needs of different cooling capacity. 比如,消融肝、肺等制冷量需求大且要求快速降温的肿瘤,增大N2比例,消融乳腺等制冷量需求小但要求控温精准不损伤正常组织的肿瘤,则增大Ar比例。 For example, the cooling capacity ablation of liver, lung and other needs and the requirements for rapid cooling of the tumor, increasing the proportion of N2, ablation of breast and other needs of small cooling capacity but requires precise temperature control tumor without damaging the normal tissue, increase the proportion of Ar.

[0013] 本发明的靶向刀混合气体供气装置的另一特点为:该装置的高压压力控制器输出压力可以设定为1500psi~1800psi ;低压压力控制器输出压力可以设定为800psi~1200psi。 [0013] Another feature of the present invention knife targeting a mixed gas supply means are: high-pressure output of the pressure control device can be set to 1500psi ~ 1800psi; controller output pressure of the low pressure can be set to 800psi ~ 1200psi . 配合不同比例的混合气体,以高压气体实现靶向区的快速降温,然后以适当低压的气体维持靶向区温度,提高预冷系统冷量的有效利用率。 With different proportions of the mixed gas, the gas at high pressure to achieve rapid cooling of the targeting region, then maintained at an appropriate temperature region targeted pressure gas, improve the effective utilization of the precooling refrigeration system.

[0014] 本发明最大的优势在于,提供的靶向刀混合气体供气装置整体结构简单,能方便地以任意混合比混合两种气体,充分发挥不同气体节流降温时的优势,并能根据实际消融情况调节气体输出压力的大小、冷冻功率或气体混合比;结合本发明提供的控制冷量输出的三种方法,能实现靶向区的快速降温,以及对输入靶向区冷量的精确控制,提高预冷系统冷量的有效利用率并节约气源,满足临床上多刀联用的需要。 [0014] The greatest advantage of the present invention is to provide a knife targeting a mixed gas supply an overall configuration of a simple apparatus, can be easily mixed in an arbitrary mixing ratio of the two gases, take full advantage of the different gases when throttled cooling, and according to ablation actual situation regulate the gas pressure in the output magnitude, power or frozen gas mixing ratio; combination of three methods to control the amount of cold output of the present invention provides, to achieve rapid cooling of the targeting region, and the precise targeting of the cold zone input control and improve precooling refrigeration system effective utilization and conservation of gas supply, combined with a multi-tool to meet clinical needs.

附图说明 BRIEF DESCRIPTION

[0015] 图1是本发明的靶向刀混合气体供气装置的结构示意图。 [0015] FIG. 1 is a structural diagram of the present invention knife targeting a mixed gas supply means.

具体实施方式 Detailed ways

[0016] 下面结合附图1和具体实施例,进一步阐述本发明。 [0016] Figures 1 and below in conjunction with specific embodiments, further illustrate the present invention. 这些实施例应理解为仅用于说明本发明而不用于限制本发明的保护范围。 These examples should be understood as merely illustrative of the invention and are not intended to limit the scope of the present invention. 在阅读了本发明记载的内容之后,本领域技术人员可以对本发明作各种改动或修改,这些等效变化和修饰同样落入本发明权利要求所限定的范围。 After having read the description of the present invention, those skilled in the art that various changes or modifications may be made to the present invention, such equivalent variations and modifications are also within the claims of the invention defined in the scope.

[0017] 如图1所示,本发明的靶向刀混合气体供气装置,包括钢瓶Al、钢瓶B2、气体流量控制器A3、气体流量控制器B4、混合室5、高压压力控制器6、低压压力控制器7、高压电磁阀 [0017] As shown in FIG. 1, the present invention knife targeting a mixed gas supply means comprises a cylinder Al, cylinder B2, gas flow controller A3, gas flow controller B4, the mixing chamber 5, the high-pressure controller 6 low pressure controller 7, the high pressure solenoid valve

8、低压电磁阀9、控制器10、预冷系统11和靶向刀12。 8, the low pressure solenoid valve 9, the controller 10, 11 and precooling system targeting the knife 12.

[0018] 钢瓶Al和钢瓶B2内分别装有氮气和氩气,钢瓶Al和钢瓶B2分别通过流量控制器A3、流量控制器B4连接混合室5,混合室5内混合的氮气和IS气的混合气体出气管分成二路:一路经高压压力控制器6和高压电磁阀8连接预冷系统11,另一路经低压压力控制器(7)和低压电磁阀9连接预冷系统11,预冷系统11连接靶向刀12 ;流量控制器A3、流量控制器B4、高压电磁阀8、低压电磁阀9分别与控制器10相连接。 [0018] Al cylinder and the inner cylinder B2 are equipped with a nitrogen and argon, cylinders Al and B2, respectively, the flow through the cylinder controller A3, a mixed gas of nitrogen and IS mixed within the mixing chamber 5, the mixing chamber 5 connected to the flow controller B4 Road into the gas outlet pipe: the way through the high pressure control valve 6 and the solenoid 8 is connected to pre-cooling the high pressure system 11, the other passing low pressure controller (7) and the low pressure electromagnetic valve 9 is connected precooling system 11, system 11 precooling linked to a targeting knife 12; a flow controller A3, a flow controller B4, the high pressure electromagnetic valve 8, a low pressure solenoid valve 9 are connected to the controller 10.

[0019] 混合室5内氮气所占的体积百分浓度调节范围为0%~100%之间。 Volume percentage concentration is adjusted within the range of [0019] the mixing chamber 5 nitrogen accounts for 0% to 100%. 高压压力控制器6输出压力设定范围为1500psi~1800psi之间;低压压力控制器7输出压力设定范围为800psi~1200psi之间。 The controller 6 outputs the high-pressure pressure is set in the range of between 1500psi ~ 1800psi; low pressure controller 7 outputs the set pressure range is between 800psi ~ 1200psi. 混合气体进入靶向刀(12)之前经预冷系统11预冷的温度为≤-80°C。 Gas mixture into the targeted knife (12) prior to a pre-cooled by the precooling system 11 temperature ≤-80 ° C. 靶向刀12包含有靶向区13,靶向刀12的数量为I~8把。 Targeting blade 12 comprises a targeting region 13, blade 12 is targeted to the number of I ~ 8 handle.

[0020] 钢瓶Al与钢瓶B2内具有正焦-汤效应的不同气体,气体由钢瓶Al、钢瓶B2内流出,分别经流量控制器A3、流量控制器B4调节流量后进入混合室5充分混合,依次经高压压力控制器6、低压压力控制器7、高电磁阀8和低压电磁阀9,进入预冷系统8预冷后流至靶向区13处节流制冷。 [0020] The inner cylinder of Al and has a positive power cylinder B2 - Thomson effect of different gases, gas flow from the cylinder inner cylinder Al B2, respectively, via flow controllers A3, B4 flow controller regulating the flow of mixed into the mixing chamber 5, 6 sequentially through the high pressure control, low pressure controller 7, the high and low pressure solenoid valves 8 the solenoid valve 9, after entering the precooling system 8 at a pre-cooled stream 13 into the targeted region expansion cooling.

[0021] 本发明优选实施例提供的利用靶向刀混合气体供气装置控制冷量输出的方法有二种: [0021] The embodiments of the present invention preferably provides the use of a method to target mixed gas knife to control the cold output of the gas supply means are two kinds:

方法一.在控制器上选择“压力调节”模式,设定高压压力控制器输出压力为1500psi,设定低压压力控制器输出压力为1200psi,设定凡所占的体积百分浓度为50%。 Method a. Is selected on the controller "pressure regulator" mode, the high-pressure controller output is set to 1500 psi pressure, low pressure controller output pressure set to 1200 psi, where the set volume percentage occupied by a concentration of 50%. 消融开始时,高压电磁阀打开,低压电磁阀关闭,靶向区快速降温,使靶向区周围组织迅速冻结形成一定体积的冰球。 Beginning ablation, high pressure solenoid valve is opened, the low pressure solenoid valve is closed, rapid cooling targeted area, so that the surrounding tissue targeting region formed rapidly freezing a volume of pucks. 3min后低压电磁阀打开,高压电磁阀关闭,装置以低压输出混合气体,有效降低气体流量,靶向区温度仍然不变。 3min after the low pressure solenoid valve opens, the high pressure solenoid valve is closed, a mixed gas of low voltage output means, effectively reducing the gas flow rate, the temperature of the targeted area remains unchanged. 此模式适用于消融肝、肺等需要快速降温及较大制冷量的深部肿瘤。 This mode is suitable for ablation of liver, lung and other needs of rapid cooling and a larger cooling capacity of deep tumors.

[0022] 方法二.在控制器上选择“功率调节”模式,设定输出功率为50%,设定N2所占的体积百分浓度为40%,设定高压电磁阀关闭,低压电磁阀开启,设定低压压力控制器输出压力为llOOpsi。 [0022] Method 2. Select "power adjustment" mode, the output power is set at 50%, setting the volume percentage occupied by the N2 concentration of 40%, setting a high-pressure solenoid valve is closed, the low pressure solenoid valve open in the controller , low pressure setting for the pressure controller output llOOpsi. 此时,低压电磁阀在设定的循环周期内开启、关闭的时间各占一半,从而使消融过程中,供气装置仅有一半的时间为靶向刀供气,减少了一半的用气量。 At this time, the solenoid valve open in the low pressure cycle set off time each half, so that the ablation process, the air supply means only half the time to target gas knife, gas consumption was reduced by half. 此模式适用于前列腺等需要冷量较小,且为保护临近重要组织希望降温较为平缓的肿瘤。 This mode is for prostate requires less cooling capacity, and for the protection of important organizations want to close more gentle cooling of tumors.

[0023] “功率调节”模式下,若为三把靶向刀同时使用,可设定输出功率为33%,设定N2所占的体积百分浓度为60%,设定高压电磁阀开启,低压电磁阀关闭,设定高压压力控制器输出压力为I600psi。 [0023] "Power adjust" mode, if it is targeted to three knives simultaneously, the output power can be set to 33%, the volume percentage occupied by setting N2 concentration of 60%, setting pressure solenoid valve open, a low pressure solenoid valve is closed, the set pressure of the high-pressure controller output I600psi. 消融开始后,三把靶向刀在设定的循环周期内依次开启并关闭,开启的间隔时间即为设定循环周期的33%,此时,虽然是三把靶向刀同时使用,但同一时间实际上只有一把靶向刀在工作,可以显著减小用气量并保证消融的效果。 After beginning ablation, three knife targeting sequentially turned on to set the cycle and closed, the interval is set to 33% is the open cycle, in which case, although the three knife targeted simultaneously, but at the same time is actually only a knife targeted at work, it can significantly reduce gas consumption and to ensure that the ablation effect.

[0024] 方法三.在控制器上选择“混合比调节”模式,设定低压电磁阀开启,高压电磁阀关闭,设定低压压力控制器输出压力为lOOOpsi。 [0024] Method 3. Select on the controller "mixing ratio adjustment" mode, set the low-pressure electromagnetic valve is open, the high pressure solenoid valve is closed, the set controller output pressure of the low pressure lOOOpsi. 设定消融开始的5分钟N2所占的体积百分比为80%,随后的5分钟,设定N2所占的体积百分浓度为50%,消融的最后5分钟,设定N2所占的体积百分浓度为20%。 Ablation volume N2 is set five minutes starting percentage of 80%, followed by five minutes, to set the volume percentage occupied by the N2 concentration of 50%, the ablation of the last 5 minutes, the volume occupied by one hundred set N2 partial concentration of 20%. 此模式适用于乳腺等需要冷量稍大、降温稍快,又需要精确控温以防止冻伤表皮组织的浅表肿瘤。 This mode is suitable for mammary gland slightly larger amount of cooling required, cooling slightly faster, but requires precise temperature control to prevent frostbite superficial tumors epidermal tissue.

Claims (8)

  1. 1.一种靶向刀混合气体供气装置,包括钢瓶A (I)、钢瓶B (2)、气体流量控制器A (3)、气体流量控制器B (4)、混合室(5)、高压压力控制器(6)、低压压力控制器(7)、高压电磁阀(8)、低压电磁阀(9)、控制器(10)、预冷系统(11)和靶向刀(12),其特征在于:所述钢瓶A(I)和钢瓶B (2)内分别装有氮气和氩气,钢瓶A (I)和钢瓶B (2)分别通过流量控制器A (3)、流量控制器B (4)连接混合室(5),混合室(5)内混合的氮气和氩气的混合气体出气管分成二路:一路经高压压力控制器(6)和高压电磁阀(8)连接预冷系统(11),另一路经低压压力控制器(7)和低压电磁阀(9)连接预冷系统(11),预冷系统(11)连接靶向刀(12);所述流量控制器A (3)、流量控制器B (4)、高压电磁阀(8)、低压电磁阀(9)分别与控制器(10)相连接。 A knife targeting a mixed gas supply means comprises a cylinder A (I), cylinder B (2), the gas flow controller A (3), gas flow controller B (4), the mixing chamber (5), High pressure controller (6), a low pressure controller (7), high pressure solenoid valve (8), a low pressure solenoid valve (9), the controller (10), pre-cooling system (11) and a targeting tool (12), wherein: said cylinder A (I) B and cylinders are fitted with a nitrogen gas and argon (2), the cylinder A (I) B and the cylinder (2), respectively by a flow controller A (3), the flow controller B (4) connected to the mixing chamber (5), mixed in the mixing chamber (5) a mixed gas of nitrogen and argon into the trachea Road: the way through the high-pressure controller (6) and the high pressure electromagnetic valve (8) connected to the pre- cooling system (11), the other passing low pressure controller (7) and a low pressure solenoid valve (9) is connected precooling system (11), pre-cooling system (11) linked to a targeting tool (12); the flow controller A (3), a flow controller B (4), a high-pressure solenoid valve (8), a low pressure solenoid valve (9) are connected to the controller (10).
  2. 2.根据权利要求1所述的靶向刀混合气体供气装置,其特征在于:所述混合室(5)内氮气所占的体积百分浓度调节范围为0%~100%之间。 2. Targeting the knife according to claim 1, a mixed gas supply means, wherein: the volume percentage of the concentration is adjusted within the range of the mixing chamber (5) between the nitrogen gas accounts for 0% to 100%.
  3. 3.根据权利要求1所述的靶向刀混合气体供气装置,其特征在于:所述高压压力控制器(6)输出压力设定范围为1500psi~1800psi之间;低压压力控制器(7)输出压力设定范围为800psi~1200psi之间。 3. The tool as claimed in claim 1 targeting mixed gas supply means, wherein: said high-pressure controller (6) is set in the range between the output pressure 1500psi ~ 1800psi; low pressure controller (7) output pressure is set in the range of between 800psi ~ 1200psi.
  4. 4.根据权利要求1所述的靶向刀混合气体供气装置,其特征在于:所述混合气体进入靶向刀(12)之前经预冷系统(11)预冷的温度为≤_80°C。 4. The tool of claim 1 targeting mixed gas supply means, wherein: said gas mixture into the targeted knife (12) prior to the pre-chilling system (11) pre-cooled to a temperature of ≤_80 ° C .
  5. 5.根据权利要求1所述的靶向刀混合气体供气装置,其特征在于:所述靶向刀(12)包含有靶向区(13),所述靶向刀(12)的数量为I~8把。 The targeting of the knife according to claim 1, a mixed gas supply means, characterized in that: said targeting blade (12) comprises a targeting region (13), the number of the targeting tool (12) is I ~ 8 handle.
  6. 6.一种利用权利要求1-5任何一项所述的靶向刀混合气体供气装置控制冷量输出的方法,其特征在于:首先在控制器(10)上选择“压力调节”模式,此时,高压电磁阀(8)打开,低压电磁阀(9)关闭,靶向刀(12)的靶向区(13)快速降温,3分钟后低压电磁阀(9)打开,高压电磁阀(8)关闭,使靶向刀混合气体供气装置以低压输出混合气体,减小靶向区(13)冷量,同时保持靶向区(13 )温度不变。 A use of any of claims 1-5 knife targeting a mixed gas supply means said cold output control method, characterized by: first selecting "pressure regulator" mode on the controller (10), At this time, the high pressure electromagnetic valve (8) is opened, the low pressure solenoid valve (9) closed, targeting tool (12) of the targeted region (13) rapid cooling, 3 minutes after the low-pressure electromagnetic valve (9) opens, the high pressure electromagnetic valve ( 8) closing the knife targeting a mixed gas supply means for a mixed gas of low voltage output, reduced targeting cold zone (13), while maintaining the targeted area (13) constant temperature.
  7. 7.一种利用权利要求1-5任何一项所述的靶向刀混合气体供气装置控制冷量输出的方法,其特征在于:首先在控制器(10)上选择“功率调节”模式并设定输出功率为0%~100%间的任意数值,设定低压电磁阀(9)关闭,高压电磁阀(8)开启或高压电磁阀(8)关闭,低压电磁阀(9)开启,靶向刀(12)工作时,开启的低压电磁阀(9)或高压电磁阀(8)通过调节占空比的方式按照设定功率值输出混合气体至靶向区(13)。 A use of any of claims 1-5 knife targeting a mixed gas supply means said cold output control method, characterized by: first selecting "power adjustment" mode on the controller (10) and output power is set to any value between 0% and 100%, setting the low-pressure electromagnetic valve (9) is closed, high pressure solenoid valve (8) opening or high-pressure solenoid valve (8) is closed, a low pressure solenoid valve (9) is turned on, the target in operation the knife (12), a low pressure solenoid valve opening (9) or a high-pressure solenoid valve (8) by way of adjusting the duty cycle according to a set value of the output power of the mixed gas to the targeted area (13).
  8. 8.一种利用权利要求1-5任何一项所述的靶向刀混合气体供气装置控制冷量输出的方法,其特征在于:首先在控制器(10)上选择“混合比调节”模式,设定低压电磁阀(9)关闭,高压电磁阀(8)开启或高压电磁阀(8)关闭,低压电磁阀(9)开启,靶向刀(12)工作的前5分钟,控制器( 10)将混合室(5)内氮气所占的体积百分浓度设定为51%~100%间的任意数值,中间5分钟,控制器(10)将混合室(5)内氮气所占的体积百分浓度设定为50%,最后5分钟,控制器(10)将混合室(5)内氮气所占的体积百分浓度设定为0%~49%间的任意数值。 A use of any of claims 1-5 knife targeting a method for controlling the cooling gas supply device for mixing the output, wherein: First select the "mixing ratio adjustment" mode on the controller (10) , setting the low-pressure electromagnetic valve (9) is closed, high pressure solenoid valve (8) opening or high-pressure solenoid valve (8) is closed, a low pressure solenoid valve (9) open, targeting tool (12) work in five minutes before the controller ( 10) mixing chamber (5) volume percent occupied by the nitrogen concentration is set to any value between 51% to 100%, intermediate 5 minutes, the percentage of nitrogen (10) to the mixing chamber (5) of the controller percentage concentration by volume of 50% is set, the last 5 minutes, the volume percentage concentration (10) mixing chamber (5) occupied by nitrogen controller is set to any value between 0% and 49%.
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