CN101553247A - 免疫调节剂、含有免疫调节剂的制剂和组合物、用于评价免疫调节剂以及含有其的制剂和组合物的活性的测定和方法 - Google Patents
免疫调节剂、含有免疫调节剂的制剂和组合物、用于评价免疫调节剂以及含有其的制剂和组合物的活性的测定和方法 Download PDFInfo
- Publication number
- CN101553247A CN101553247A CNA200780039690XA CN200780039690A CN101553247A CN 101553247 A CN101553247 A CN 101553247A CN A200780039690X A CNA200780039690X A CN A200780039690XA CN 200780039690 A CN200780039690 A CN 200780039690A CN 101553247 A CN101553247 A CN 101553247A
- Authority
- CN
- China
- Prior art keywords
- compositions
- extract
- cell
- immunocyte
- type
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/20—Milk; Whey; Colostrum
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/57—Birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5047—Cells of the immune system
- G01N33/505—Cells of the immune system involving T-cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
- G01N2333/70514—CD4
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Cell Biology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Food Science & Technology (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Polymers & Plastics (AREA)
- Urology & Nephrology (AREA)
- Mycology (AREA)
- Nutrition Science (AREA)
- Developmental Biology & Embryology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Pathology (AREA)
- Toxicology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Communicable Diseases (AREA)
Abstract
Description
样品 | 对照 | 10μg/孔 | 100μg/孔 | 1000μg/孔 | |
250Da至2,000Da初乳级分 | 非受激(NS) | 14 | 52 | 50 | 37 |
用PHA刺激 | 388 | 336 | 253 | 127 | |
PHA刺激降低的% | 13.4 | 34.8 | 67.3 | ||
2,000Da至4,000Da初乳级分 | NS | 14 | 52 | 62 | 42 |
用PHA刺激 | 388 | 388 | 377 | 339 | |
PHA刺激降低的% | 0 | 2.8 | 12.6 | ||
4,000Da至8,000Da初乳级分 | NS | 14 | 69 | 50 | 46 |
用PHA刺激 | 388 | 378 | 250 | 207 | |
PHA刺激降低的% | 2.6 | 35.6 | 46.6 | ||
8,000Da至12,000Da初乳级分 | NS | 14 | 49 | 45 | 39 |
用PHA刺激 | 388 | 337 | 237 | 181 | |
PHA刺激降低的% | 13.1 | 38.9 | 53.4 | ||
2,000Da至4,000Da蛋级分 | NS | 14 | 49 | 33 | 44 |
用PHA刺激 | 388 | 228 | 161 | 148 | |
PHA刺激降低的% | 41.2 | 58.5 | 61.9 | ||
4,000Da至8,000Da蛋级分(包括TF) | NS | 14 | 54 | 47 | 44 |
用PHA刺激 | 388 | 354 | 230 | 158 | |
PHA刺激降低的% | 8.8 | 40.7 | 59.3 |
样品 | 对照 | 10μg | 100μg | 1000μg | |
250Da至2,000Da初乳级分 | 非受激(NS) | 12 | 14 | 12 | 17 |
用CMV刺激 | 316 | 468 | 338 | 345 | |
CMV刺激增加的% | 48.1 | 7.0 | 9.2 | ||
2,000Da至4,000Da初乳级分 | NS | 12 | 15 | 12 | 15 |
用CMV刺激 | 316 | 501 | 503 | 440 | |
CMV刺激增加的% | 58.5 | 59.1 | 39.2 | ||
4,000Da至8,000Da初乳级分 | NS | 12 | 22 | 16 | 19 |
用CMV刺激 | 316 | 473 | 476 | 475 | |
CMV刺激增加的% | 49.7 | 50.6 | 50.3 | ||
8,000Da至12,000Da初乳级分 | NS | 12 | 14 | 18 | 26 |
用CMV刺激 | 316 | 453 | 404 | 370 | |
CMV刺激增加的% | 43.4 | 27.8 | 17.1 | ||
2,000Da至4,000Da蛋级分 | NS | 12 | 26 | 61 | 108 |
用CMV刺激 | 316 | 305 | 349 | 350 | |
CMV刺激增加的% | -3.5 | 10.4 | 10.8 | ||
4,000Da至8,000Da蛋级分(包括TF) | NS | 12 | 34 | 39 | 108 |
用CMV刺激 | 316 | 310 | 280 | 381 | |
CMV刺激增加的% | -1.9 | -11.4 | 20.6 |
样品 | 对照 | 10μg | 100μg | 1000μg | |
2,000Da至4,000Da初乳级分 | NS | 4 | 10 | 3 | 4 |
用流感抗原刺激 | 827 | 1003 | 906 | 936 | |
ConA | 694 | ||||
流感抗原刺激增加的% | 21.3 | 9.6 | 13.2 | ||
4,000Da至8,000Da初乳级分(包括TF) | NS | 4 | 36 | 24 | 11 |
用流感抗原刺激 | 827 | 989 | 997 | 830 | |
ConA | 694 | ||||
流感抗原刺激增加的% | 19.6 | 20.6 | 0.4 |
成分 | 相对量(以重量计) |
牛初乳级分,上限MWCO 10,000Da(喷雾干燥) | 68% |
牛初乳级分,上限MWCO 3,000Da(纳米级分)(喷雾干燥) | 2% |
鸡蛋黄(喷雾干燥) | 30% |
成分 | 量(每份,每份大小=一粒胶囊) |
组合物A | 150mg |
锌(作为单甲硫氨酸) | 5mg |
CordyvantTM专利的多糖复合物 | 440mg |
IP-6(肌醇六磷酸) | |
大豆提取物(植物甾醇) | |
冬虫夏草(7%虫草酸) | |
β-葡聚糖(来自面包工厂酵母)(酿酒酵母)(Saacharomyces cerevisiae) | |
β-葡聚糖(来自燕麦)(Avena sativa) | |
姬松茸(Agaricus blazeii)提取物 | |
甘露聚糖(来自芦荟)(叶) | |
橄榄叶提取物(油橄榄(Olea europaea)) | |
灰树花(Grifola frondosa)(整株植物) | |
香菇(Lentinus edodes)(整株植物)(5∶1提取物) |
对照 | 纳米级分 | TF XF | 组合物A | 组合物B | |
非受激(NS) | 26 | 35 | 77 | 47 | 19 |
用PHA刺激 | 220 | 234 | 150 | 140 | 27 |
对照 | 纳米级分 | TF XF | 组合物A | 组合物B | |
非受激的(NS) | 1 | 2 | 13 | 27 | 51 |
用VZV刺激的 | 1 | 5 | 30 | 32 | 69 |
用ConA刺激的 | 288 |
Claims (24)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US84834806P | 2006-09-29 | 2006-09-29 | |
US60/848,348 | 2006-09-29 | ||
US11/855,944 | 2007-09-14 | ||
US11/855,944 US10471100B2 (en) | 2006-09-29 | 2007-09-14 | Nanofraction immune modulators, preparations and compositions including the same, and associated methods |
PCT/US2007/078947 WO2008042604A2 (en) | 2006-09-29 | 2007-09-19 | Immune modulators, preparations and compositions including immune modulators, tests for evaluating the activity of immune modulators and preparations and compositions including the same, and methods |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101553247A true CN101553247A (zh) | 2009-10-07 |
CN101553247B CN101553247B (zh) | 2015-08-19 |
Family
ID=39261440
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN200780039690.XA Active CN101553247B (zh) | 2006-09-29 | 2007-09-19 | 免疫调节剂、含有免疫调节剂的组合物及其用途 |
Country Status (15)
Country | Link |
---|---|
US (2) | US10471100B2 (zh) |
EP (1) | EP2068913B1 (zh) |
JP (3) | JP5592651B2 (zh) |
CN (1) | CN101553247B (zh) |
AU (1) | AU2007305076B2 (zh) |
CO (1) | CO6220833A2 (zh) |
EC (1) | ECSP099296A (zh) |
ES (1) | ES2658107T3 (zh) |
HK (1) | HK1138181A1 (zh) |
MX (1) | MX2009003324A (zh) |
MY (2) | MY158857A (zh) |
RU (2) | RU2518341C2 (zh) |
SG (1) | SG160430A1 (zh) |
TW (1) | TWI449530B (zh) |
WO (1) | WO2008042604A2 (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102172360A (zh) * | 2011-02-17 | 2011-09-07 | 南京大学 | 一种牛初乳提取物及其提取方法和应用 |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6866868B1 (en) * | 2003-09-15 | 2005-03-15 | 4Life Research, Lc | Compositions including different types of transfer factor, methods for making the compositions, and methods of treatment using the compositions |
US9028882B2 (en) | 2005-05-02 | 2015-05-12 | 4Life Patents, Llc | Nutraceutical gels |
MY162337A (en) | 2005-05-02 | 2017-06-15 | 4Life Res Llc | Transfer factor preparations and associated methods |
US10471100B2 (en) * | 2006-09-29 | 2019-11-12 | 4Life Patents, Llc | Nanofraction immune modulators, preparations and compositions including the same, and associated methods |
TW201105966A (en) * | 2009-05-05 | 2011-02-16 | 4Life Patents Llc | Methods and systems for assaying, maintaining, and enhancing the activity of the immune system of a subject |
AU2011332053B2 (en) | 2010-11-23 | 2016-06-02 | Pantheryx, Inc. | Compositions and methods for treatment in broad-spectrum, undifferentiated or mixed clinical applications |
WO2013039373A2 (es) * | 2011-09-13 | 2013-03-21 | Zepeda Lopez Hector Manuel | Extracto dializado de leucocitos de origen bazo de tiburón, para la obtención de factor de transferencia potencializado, y método de extracción, comprobación y conteo del mismo |
WO2013039374A2 (es) * | 2011-09-15 | 2013-03-21 | Zepeda Lopez Hector Manuel | Método de extracción, comprobación y conteo de extracto dializado de leucocitos de origen bazo de tiburón, para la obtención de factor de transferencia potencializado, específicamente diseñado para su uso como tratamiento contra la enfermedad conocida como vitíligo |
WO2013043032A2 (es) * | 2011-09-19 | 2013-03-28 | Zepeda Lopez Hector Manuel | Extracto dializado de leucocitos de origen bazo de tiburón para la obtención de factor de transferencia potencializado, específicamente diseñado para su uso como inmunomodulador y método de extracción, comprobación y conteo del mismo |
WO2013043033A2 (es) * | 2011-09-19 | 2013-03-28 | Zepeda Lopez Hector Manuel | Método de extracción, comprobacíon de extracto dializado de leucocitos de origen bazo de tiburón, para la obtención de factor de transferecia potencializado, específicamente diseñado para su uso como adyuvante potencializador de vacunas virales |
WO2013058640A2 (es) * | 2011-10-20 | 2013-04-25 | Zepeda Lopez Hector Manuel | Método de extracción, comprobación y conteo de extracto dializado de leucocitos de origen bazo de tiburón, para la obtención de factor de transferencia potencializado, específicamente diseñado para su uso como tratamiento contra la enfermedad conocida como asma |
MX338863B (es) * | 2011-12-16 | 2016-05-01 | Inst Politecnico Nacional | Metodo de obtencion de extracto dializable de leucocitos. |
US9566305B2 (en) | 2013-10-13 | 2017-02-14 | 4Life Patents, Llc | Therapeutic compositions and methods for addressing physiological stresses and aging |
KR101597540B1 (ko) * | 2014-01-22 | 2016-02-29 | 건국대학교 산학협력단 | 난황 추출물을 유효성분으로 함유하는 면역증강용 조성물 |
AU2018283314A1 (en) * | 2017-06-15 | 2020-01-16 | Miradx | Biomarkers for predicting tumor response to and toxicity of immunotherapy |
US10933097B1 (en) | 2020-03-05 | 2021-03-02 | King Saud University | Method of treating a bacterial infection using colostrum |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1460522A (zh) * | 2003-06-16 | 2003-12-10 | 郭占军 | 预防和治疗疾病的蛋黄抗体组合物及其制备方法 |
CN1762391A (zh) * | 2005-10-13 | 2006-04-26 | 复旦大学 | 一种牛初乳和香菇提取物组合物及其制备方法和用途 |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4402938A (en) * | 1980-05-29 | 1983-09-06 | Impro Products, Inc. | Food and the method of extracting the same from colostrum and milk |
JPS60208919A (ja) * | 1983-11-25 | 1985-10-21 | アムトロン・インコ−ポレイテツド | トランスフア−フアクタ−を初乳から得る方法、こうして得られたトランスフア−フアクタ−及びその使用 |
US4816563A (en) * | 1983-11-25 | 1989-03-28 | Amtron, Inc. | Process for obtaining transfer factor from colostrum, transfer factor so obtained and use thereof |
US5585098A (en) * | 1993-11-23 | 1996-12-17 | Ovimmune, Inc. | Oral administration of chicken yolk immunoglobulins to lower somatic cell count in the milk of lactating ruminants |
WO1997036008A1 (en) * | 1996-03-26 | 1997-10-02 | Biotechnology Transfer, Inc. | Methods for measurement of lymphocyte function |
WO1997035595A1 (en) | 1996-03-26 | 1997-10-02 | Dcv Biologics L.P. | Egg anti-inflammatory composition, method of isolation and use |
US7169571B2 (en) * | 1997-09-12 | 2007-01-30 | Cylex, Inc. | Methods for measurement of lymphocyte function |
CZ287956B6 (cs) * | 1997-11-04 | 2001-03-14 | Medipharm Cz, S. R. O. | Perorální přípravek k prevenci a léčbě parvovirózy psů |
US20020044942A1 (en) * | 2000-09-18 | 2002-04-18 | Chisolm Biological Laboratory, Llc | Transfer factor composition and process for producing same |
US6468534B1 (en) | 2000-09-21 | 2002-10-22 | 4Life Research, Lc | Methods for obtaining transfer factor from avian sources, compositions including avian-generated transfer factor, and methods of use |
WO2002038164A1 (en) | 2000-11-08 | 2002-05-16 | Lorus Therapeutics Inc. | Combination preparation of a biological response modifier and an anticancer agent and uses thereof |
US20030003117A1 (en) * | 2001-06-18 | 2003-01-02 | Michael Marenick | Hydrolyzed whole egg products & related methods |
KR20040105710A (ko) * | 2002-02-11 | 2004-12-16 | 아르키온 라이프 사이언씨즈 엘엘씨 | 정제된 사이토킨 억제인자 |
US20040005327A1 (en) * | 2002-05-16 | 2004-01-08 | Subramanian Iyer | Immune T-cell stimulation |
WO2004041071A2 (en) | 2002-11-04 | 2004-05-21 | 4Life Research, Lc | Compositions, systems, and methods for focusing a cell-mediated immune response |
US6866868B1 (en) * | 2003-09-15 | 2005-03-15 | 4Life Research, Lc | Compositions including different types of transfer factor, methods for making the compositions, and methods of treatment using the compositions |
US10471100B2 (en) | 2006-09-29 | 2019-11-12 | 4Life Patents, Llc | Nanofraction immune modulators, preparations and compositions including the same, and associated methods |
-
2007
- 2007-09-14 US US11/855,944 patent/US10471100B2/en active Active
- 2007-09-19 EP EP07814934.1A patent/EP2068913B1/en active Active
- 2007-09-19 AU AU2007305076A patent/AU2007305076B2/en active Active
- 2007-09-19 SG SG201001981-8A patent/SG160430A1/en unknown
- 2007-09-19 MX MX2009003324A patent/MX2009003324A/es active IP Right Grant
- 2007-09-19 WO PCT/US2007/078947 patent/WO2008042604A2/en active Application Filing
- 2007-09-19 CN CN200780039690.XA patent/CN101553247B/zh active Active
- 2007-09-19 MY MYPI20091276A patent/MY158857A/en unknown
- 2007-09-19 RU RU2009116274/15A patent/RU2518341C2/ru active
- 2007-09-19 ES ES07814934.1T patent/ES2658107T3/es active Active
- 2007-09-19 JP JP2009530527A patent/JP5592651B2/ja active Active
- 2007-09-27 TW TW096135902A patent/TWI449530B/zh active
-
2009
- 2009-03-27 MY MYPI2013003021A patent/MY188915A/en unknown
- 2009-04-29 CO CO09043396A patent/CO6220833A2/es active IP Right Grant
- 2009-04-29 EC EC2009009296A patent/ECSP099296A/es unknown
-
2010
- 2010-04-07 HK HK10103400.6A patent/HK1138181A1/zh unknown
-
2014
- 2014-01-27 RU RU2014102562A patent/RU2619555C2/ru active
- 2014-03-10 JP JP2014046094A patent/JP2014129413A/ja active Pending
-
2016
- 2016-06-22 JP JP2016123656A patent/JP6401744B2/ja active Active
-
2019
- 2019-11-11 US US16/679,908 patent/US11197894B2/en active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1460522A (zh) * | 2003-06-16 | 2003-12-10 | 郭占军 | 预防和治疗疾病的蛋黄抗体组合物及其制备方法 |
CN1762391A (zh) * | 2005-10-13 | 2006-04-26 | 复旦大学 | 一种牛初乳和香菇提取物组合物及其制备方法和用途 |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102172360A (zh) * | 2011-02-17 | 2011-09-07 | 南京大学 | 一种牛初乳提取物及其提取方法和应用 |
CN102172360B (zh) * | 2011-02-17 | 2013-04-24 | 南京大学 | 一种牛初乳提取物及其提取方法和应用 |
Also Published As
Publication number | Publication date |
---|---|
JP2010504988A (ja) | 2010-02-18 |
EP2068913B1 (en) | 2017-11-01 |
ECSP099296A (es) | 2010-02-26 |
RU2619555C2 (ru) | 2017-05-16 |
MX2009003324A (es) | 2009-06-30 |
CN101553247B (zh) | 2015-08-19 |
EP2068913A2 (en) | 2009-06-17 |
US20080081076A1 (en) | 2008-04-03 |
AU2007305076B2 (en) | 2011-04-28 |
JP2014129413A (ja) | 2014-07-10 |
US10471100B2 (en) | 2019-11-12 |
RU2518341C2 (ru) | 2014-06-10 |
WO2008042604A3 (en) | 2008-11-06 |
ES2658107T3 (es) | 2018-03-08 |
US11197894B2 (en) | 2021-12-14 |
AU2007305076A1 (en) | 2008-04-10 |
WO2008042604A2 (en) | 2008-04-10 |
CO6220833A2 (es) | 2010-11-19 |
JP5592651B2 (ja) | 2014-09-17 |
US20200069737A1 (en) | 2020-03-05 |
SG160430A1 (en) | 2010-04-29 |
RU2009116274A (ru) | 2010-11-10 |
HK1138181A1 (zh) | 2010-08-20 |
JP6401744B2 (ja) | 2018-10-10 |
JP2016196491A (ja) | 2016-11-24 |
TW200831116A (en) | 2008-08-01 |
TWI449530B (zh) | 2014-08-21 |
MY158857A (en) | 2016-11-15 |
MY188915A (en) | 2022-01-13 |
EP2068913A4 (en) | 2009-12-02 |
RU2014102562A (ru) | 2015-08-20 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN101553247A (zh) | 免疫调节剂、含有免疫调节剂的制剂和组合物、用于评价免疫调节剂以及含有其的制剂和组合物的活性的测定和方法 | |
US9220763B2 (en) | Nano-vehicle derived from tumor tissue, and cancer vaccine using same | |
Redmond et al. | Impaired macrophage function in severe protein-energy malnutrition | |
Jarosz et al. | The effect of feed supplementation with Zakarpacki zeolite (clinoptilolite) on percentages of T and B lymphocytes and cytokine concentrations in poultry | |
RU2040932C1 (ru) | Препарат, влияющий на тканевой обмен и применение штамма гриба fusarium sambucinum fuckel var ossicolum (berk.et curf) bilai для его получения | |
Vetchinkina et al. | Proteins and polysaccharides from vegetative mycelium of medicinal basidiomycete Lentinus edodes display cytotoxicity towards human and animal cancer cell lines | |
Fujii et al. | Genotoxicity and subchronic toxicity evaluation of Active Hexose Correlated Compound (AHCC) | |
Elmeligy et al. | Oxidative stress in Strongylus spp. infected donkeys treated with piperazine citrate versus doramectin | |
WO2016141774A1 (zh) | 吉林人参低聚肽在制备改善和增强性功能的食品或保健食品中的用途 | |
CA2448044A1 (en) | Korean acanthopanax senticosus extract, protein extract, crude protein-polysaccharide which were extracted from korean acanthopanax senticosus, and immunoregulating compositions comprising the same and use thereof | |
Revs | Effect of Cynodon dactylon on the heamatological parameters in the blood of Oreochromis mossambicus | |
Lai et al. | Influence of Ganoderma lucidum on blood biochemistry and immunocompetence in horses | |
CN102973508A (zh) | 一种复方黄芪多糖脂质体长效注射液及其制备方法 | |
KR20030069910A (ko) | 암치료제 | |
WO2011089525A2 (en) | Chia seed protein concentrate | |
JPWO2010008005A1 (ja) | ストレスによって誘導される免疫機能変調改善剤 | |
Oladele et al. | Haematological, serum biochemical and immunological changes associated with the inclusion of garlic (Allium sativum L.) meal in the diet of commercial layer chickens | |
JP2004059558A (ja) | きのこ類から生理活性物質の採取法及びその生理活性物質の製剤及びその使用法 | |
Brito et al. | Clinical parameters of goats infected with gastrointestinal nematodes and treated with condensed tannin | |
JP2006321779A (ja) | 経口摂取用製剤 | |
JP2008069113A (ja) | 経口摂取用製剤 | |
JP2003073298A (ja) | 免疫調整剤 | |
KR20100095280A (ko) | 함초 추출물을 함유한 면역 증강 활성 약학 조성물 | |
OLIVEIRA et al. | Performance of lambs fed diets with different proportions of physics nut meal (Jatropha curcas). | |
JPWO2002031497A1 (ja) | 血管新生能の検査手段 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
REG | Reference to a national code |
Ref country code: HK Ref legal event code: DE Ref document number: 1138181 Country of ref document: HK |
|
ASS | Succession or assignment of patent right |
Owner name: 4LIFE PATENTS LLC Free format text: FORMER OWNER: 4LIFE RES LC Effective date: 20141016 |
|
C41 | Transfer of patent application or patent right or utility model | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20141016 Address after: American Utah Applicant after: 4life Patents LLC Address before: American Utah Applicant before: 4LIFE Res LC |
|
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
REG | Reference to a national code |
Ref country code: HK Ref legal event code: GR Ref document number: 1138181 Country of ref document: HK |