CN101547916A - mGluR5调节剂 - Google Patents

mGluR5调节剂 Download PDF

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Publication number
CN101547916A
CN101547916A CNA2007800451517A CN200780045151A CN101547916A CN 101547916 A CN101547916 A CN 101547916A CN A2007800451517 A CNA2007800451517 A CN A2007800451517A CN 200780045151 A CN200780045151 A CN 200780045151A CN 101547916 A CN101547916 A CN 101547916A
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China
Prior art keywords
methyl
triazole
compound
phenyl
chloro
Prior art date
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Pending
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CNA2007800451517A
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English (en)
Chinese (zh)
Inventor
M·伊萨克
A·斯拉西
L·爱德华兹
P·达夫
T·辛
T·斯特法纳克
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AstraZeneca AB
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AstraZeneca AB
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39032082&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN101547916(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Publication of CN101547916A publication Critical patent/CN101547916A/zh
Pending legal-status Critical Current

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

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CNA2007800451517A 2006-10-05 2007-09-25 mGluR5调节剂 Pending CN101547916A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US82832506P 2006-10-05 2006-10-05
US60/828,325 2006-10-05

Publications (1)

Publication Number Publication Date
CN101547916A true CN101547916A (zh) 2009-09-30

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ID=39032082

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2007800451517A Pending CN101547916A (zh) 2006-10-05 2007-09-25 mGluR5调节剂

Country Status (21)

Country Link
US (1) US7772235B2 (enExample)
EP (1) EP2079730A1 (enExample)
JP (1) JP2010505809A (enExample)
KR (1) KR20090060328A (enExample)
CN (1) CN101547916A (enExample)
AR (1) AR062965A1 (enExample)
AU (1) AU2007303889B2 (enExample)
BR (1) BRPI0719155A2 (enExample)
CA (1) CA2665083A1 (enExample)
CL (1) CL2007002757A1 (enExample)
CO (1) CO6220935A2 (enExample)
IL (1) IL197722A0 (enExample)
MX (1) MX2009003227A (enExample)
NO (1) NO20091626L (enExample)
NZ (1) NZ575657A (enExample)
PE (1) PE20081378A1 (enExample)
RU (1) RU2439068C2 (enExample)
SA (1) SA07280518B1 (enExample)
TW (1) TW200821305A (enExample)
UY (1) UY30610A1 (enExample)
WO (1) WO2008041075A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018010163A1 (zh) * 2016-07-15 2018-01-18 泸州东方农化有限公司 一种1,2,4-三唑-3-硫酮化合物的合成方法及其中间体

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TW200922586A (en) * 2007-10-26 2009-06-01 Astrazeneca Ab Thiophene 1,2,4-triazole derivatives as modulators of mGluR5
WO2009054787A1 (en) * 2007-10-26 2009-04-30 Astrazeneca Ab 1,2,4-triazole carboxylic acid derivatives as modulators of mglur5
WO2009054790A1 (en) * 2007-10-26 2009-04-30 Astrazeneca Ab Amide linked heteroaromatic derivatives as modulators of mglur5
AU2008317544A1 (en) * 2007-10-26 2009-04-30 Astrazeneca Ab Amino 1,2,4-triazole derivatives as modulators of mGluR5
WO2009054786A1 (en) * 2007-10-26 2009-04-30 Astrazeneca Ab 1,2,4-triazole aryl n-oxides derivatives as modulators of mglur5
WO2009054785A1 (en) * 2007-10-26 2009-04-30 Astrazeneca Ab 1,2,4-triazole ether derivatives as modulators of mglur5
AU2009282523A1 (en) * 2008-08-12 2010-02-18 Astrazeneca Ab A crystalline form of 4- (5-{ (IR) -1- [5- (3- chlorophenyl) isoxazol-3-yl] ethoxy } - 4 -methyl- 4H- 1, 2,4- triazol-3-yl) pyridine
RU2011103225A (ru) * 2008-08-12 2012-09-20 Астразенека Аб (Se) Новая кристаллическая форма 4-(5-{(1r)-1-[5-(3-хрорфенил)изоксазол-3-ил]этокси}-4-метил-4h-1,2,4-триазол-3-ил)пиридина
CN102256950A (zh) * 2008-12-18 2011-11-23 阿斯利康(瑞典)有限公司 制备1-[5-(3-氯-苯基)-异噁唑-3-基]-乙酮和(r)-1-[5-(3-氯-苯基)-异噁唑-3-基]-乙醇的新方法
US20100273805A1 (en) * 2009-04-23 2010-10-28 Astrazeneca Ab Sulphide bridged derivatives as modulators of mglur5 733
RU2012116124A (ru) * 2009-09-21 2013-10-27 Вандербилт Юниверсити О-БЕНЗИЛ НИКОТИНАМИДНЫЕ АНАЛОГИ КАК ПОЗИТИВНЫЕ АЛЛОСТЕРИЧЕСКИЕ МОДУЛЯТОРЫ mGluR5
WO2012058128A2 (en) * 2010-10-28 2012-05-03 Merck Sharp & Dohme Corp. Caprolactam mglur5 receptor modulators
US8703946B2 (en) 2010-12-08 2014-04-22 Vanderbilt University Substituted pyrazolo[1,5-A]pyrazine compounds as allosteric modulators of mGluR5 receptors
JP2013545822A (ja) * 2010-12-17 2013-12-26 ヴァンダービルト ユニバーシティー ｍＧｌｕＲ５受容体のアロステリック調節剤としての、二環式トリアゾールラクタムおよびピラゾールラクタム
US8471027B2 (en) 2011-04-06 2013-06-25 Hoffmann-La Roche Inc. Adamantyl compounds
EP2857387A1 (en) 2013-10-07 2015-04-08 Boehringer Ingelheim International Gmbh Process for manufacturing 1,6-dihydro-6-oxo-4-pyridazine carboxylic acid
CA3075727A1 (en) 2017-09-18 2019-03-21 Goldfinch Bio, Inc. Pyridazinones and methods of use thereof

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KR20050033070A (ko) * 2002-08-09 2005-04-08 아스트라제네카 에이비이 메타보트로픽 글루타메이트 수용체-5의 조절제로서[1,2,4]옥사디아졸
US7585881B2 (en) * 2004-02-18 2009-09-08 Astrazeneca Ab Additional heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
GB0420722D0 (en) * 2004-09-17 2004-10-20 Addex Pharmaceuticals Sa Novel allosteric modulators
GB0514296D0 (en) 2005-07-12 2005-08-17 Novartis Ag Organic compounds
AR058807A1 (es) * 2005-09-29 2008-02-27 Astrazeneca Ab 5-(fenilisoxazoletoxi)-triazol-3-il piridinas sustituidas, para el tratamiento de trastornos mediados por el receptor mglur5
TW200808800A (en) * 2006-05-05 2008-02-16 Astrazeneca Ab MGluR5 modulators V
TW200811157A (en) * 2006-05-05 2008-03-01 Astrazeneca Ab mGluR5 modulators I

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018010163A1 (zh) * 2016-07-15 2018-01-18 泸州东方农化有限公司 一种1,2,4-三唑-3-硫酮化合物的合成方法及其中间体
CN109311823A (zh) * 2016-07-15 2019-02-05 泸州东方农化有限公司 一种1,2,4-三唑-3-硫酮化合物的合成方法及其中间体
US10781186B2 (en) 2016-07-15 2020-09-22 Oriental (Luzhou) Agrochemicals Co., Ltd. Method of synthesizing l,2,4-triazole-3-thione compounds and intermediates thereof
CN109311823B (zh) * 2016-07-15 2023-01-24 泸州东方农化有限公司 一种1,2,4-三唑-3-硫酮化合物的合成方法及其中间体

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BRPI0719155A2 (pt) 2014-02-04
WO2008041075A1 (en) 2008-04-10
US20080125436A1 (en) 2008-05-29
AU2007303889B2 (en) 2011-02-24
JP2010505809A (ja) 2010-02-25
IL197722A0 (en) 2009-12-24
RU2439068C2 (ru) 2012-01-10
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