PE20081378A1 - Derivados de 1,2,4-triazol como moduladores de mglur5 - Google Patents
Derivados de 1,2,4-triazol como moduladores de mglur5Info
- Publication number
- PE20081378A1 PE20081378A1 PE2007001288A PE2007001288A PE20081378A1 PE 20081378 A1 PE20081378 A1 PE 20081378A1 PE 2007001288 A PE2007001288 A PE 2007001288A PE 2007001288 A PE2007001288 A PE 2007001288A PE 20081378 A1 PE20081378 A1 PE 20081378A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- methyl
- triazole
- modulators
- etoxy
- Prior art date
Links
- NSPMIYGKQJPBQR-UHFFFAOYSA-N 4H-1,2,4-triazole Chemical class C=1N=CNN=1 NSPMIYGKQJPBQR-UHFFFAOYSA-N 0.000 title abstract 2
- 101150087728 Grm5 gene Proteins 0.000 title 1
- 102100038357 Metabotropic glutamate receptor 5 Human genes 0.000 title 1
- -1 3-CHLOROPHENYL Chemical class 0.000 abstract 2
- 102000016193 Metabotropic glutamate receptors Human genes 0.000 abstract 2
- 108010010914 Metabotropic glutamate receptors Proteins 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 abstract 1
- XIPUIGPNIDKXJU-UHFFFAOYSA-N [CH]1CC1 Chemical class [CH]1CC1 XIPUIGPNIDKXJU-UHFFFAOYSA-N 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 210000001072 colon Anatomy 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 208000021302 gastroesophageal reflux disease Diseases 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical group [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 1
- 230000002093 peripheral effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 208000011580 syndromic disease Diseases 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
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- A—HUMAN NECESSITIES
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Physical Education & Sports Medicine (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Psychology (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Cardiology (AREA)
- Anesthesiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Addiction (AREA)
- Reproductive Health (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US82832506P | 2006-10-05 | 2006-10-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20081378A1 true PE20081378A1 (es) | 2008-11-12 |
Family
ID=39032082
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2007001288A PE20081378A1 (es) | 2006-10-05 | 2007-09-25 | Derivados de 1,2,4-triazol como moduladores de mglur5 |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US7772235B2 (enExample) |
| EP (1) | EP2079730A1 (enExample) |
| JP (1) | JP2010505809A (enExample) |
| KR (1) | KR20090060328A (enExample) |
| CN (1) | CN101547916A (enExample) |
| AR (1) | AR062965A1 (enExample) |
| AU (1) | AU2007303889B2 (enExample) |
| BR (1) | BRPI0719155A2 (enExample) |
| CA (1) | CA2665083A1 (enExample) |
| CL (1) | CL2007002757A1 (enExample) |
| CO (1) | CO6220935A2 (enExample) |
| IL (1) | IL197722A0 (enExample) |
| MX (1) | MX2009003227A (enExample) |
| NO (1) | NO20091626L (enExample) |
| NZ (1) | NZ575657A (enExample) |
| PE (1) | PE20081378A1 (enExample) |
| RU (1) | RU2439068C2 (enExample) |
| SA (1) | SA07280518B1 (enExample) |
| TW (1) | TW200821305A (enExample) |
| UY (1) | UY30610A1 (enExample) |
| WO (1) | WO2008041075A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200922586A (en) * | 2007-10-26 | 2009-06-01 | Astrazeneca Ab | Thiophene 1,2,4-triazole derivatives as modulators of mGluR5 |
| WO2009054787A1 (en) * | 2007-10-26 | 2009-04-30 | Astrazeneca Ab | 1,2,4-triazole carboxylic acid derivatives as modulators of mglur5 |
| WO2009054790A1 (en) * | 2007-10-26 | 2009-04-30 | Astrazeneca Ab | Amide linked heteroaromatic derivatives as modulators of mglur5 |
| AU2008317544A1 (en) * | 2007-10-26 | 2009-04-30 | Astrazeneca Ab | Amino 1,2,4-triazole derivatives as modulators of mGluR5 |
| WO2009054786A1 (en) * | 2007-10-26 | 2009-04-30 | Astrazeneca Ab | 1,2,4-triazole aryl n-oxides derivatives as modulators of mglur5 |
| WO2009054785A1 (en) * | 2007-10-26 | 2009-04-30 | Astrazeneca Ab | 1,2,4-triazole ether derivatives as modulators of mglur5 |
| AU2009282523A1 (en) * | 2008-08-12 | 2010-02-18 | Astrazeneca Ab | A crystalline form of 4- (5-{ (IR) -1- [5- (3- chlorophenyl) isoxazol-3-yl] ethoxy } - 4 -methyl- 4H- 1, 2,4- triazol-3-yl) pyridine |
| RU2011103225A (ru) * | 2008-08-12 | 2012-09-20 | Астразенека Аб (Se) | Новая кристаллическая форма 4-(5-{(1r)-1-[5-(3-хрорфенил)изоксазол-3-ил]этокси}-4-метил-4h-1,2,4-триазол-3-ил)пиридина |
| CN102256950A (zh) * | 2008-12-18 | 2011-11-23 | 阿斯利康(瑞典)有限公司 | 制备1-[5-(3-氯-苯基)-异噁唑-3-基]-乙酮和(r)-1-[5-(3-氯-苯基)-异噁唑-3-基]-乙醇的新方法 |
| US20100273805A1 (en) * | 2009-04-23 | 2010-10-28 | Astrazeneca Ab | Sulphide bridged derivatives as modulators of mglur5 733 |
| RU2012116124A (ru) * | 2009-09-21 | 2013-10-27 | Вандербилт Юниверсити | О-БЕНЗИЛ НИКОТИНАМИДНЫЕ АНАЛОГИ КАК ПОЗИТИВНЫЕ АЛЛОСТЕРИЧЕСКИЕ МОДУЛЯТОРЫ mGluR5 |
| WO2012058128A2 (en) * | 2010-10-28 | 2012-05-03 | Merck Sharp & Dohme Corp. | Caprolactam mglur5 receptor modulators |
| US8703946B2 (en) | 2010-12-08 | 2014-04-22 | Vanderbilt University | Substituted pyrazolo[1,5-A]pyrazine compounds as allosteric modulators of mGluR5 receptors |
| JP2013545822A (ja) * | 2010-12-17 | 2013-12-26 | ヴァンダービルト ユニバーシティー | ｍＧｌｕＲ５受容体のアロステリック調節剤としての、二環式トリアゾールラクタムおよびピラゾールラクタム |
| US8471027B2 (en) | 2011-04-06 | 2013-06-25 | Hoffmann-La Roche Inc. | Adamantyl compounds |
| EP2857387A1 (en) | 2013-10-07 | 2015-04-08 | Boehringer Ingelheim International Gmbh | Process for manufacturing 1,6-dihydro-6-oxo-4-pyridazine carboxylic acid |
| EP3486235A4 (en) | 2016-07-15 | 2020-02-12 | Oriental (Luzhou) Agrochemicals. Co., Ltd. | SYNTHETIC METHOD FOR 1,2,4-TRIAZOLE-3-THION COMPOUND AND INTERMEDIATE PRODUCT THEREOF |
| CA3075727A1 (en) | 2017-09-18 | 2019-03-21 | Goldfinch Bio, Inc. | Pyridazinones and methods of use thereof |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20050033070A (ko) * | 2002-08-09 | 2005-04-08 | 아스트라제네카 에이비이 | 메타보트로픽 글루타메이트 수용체-5의 조절제로서[1,2,4]옥사디아졸 |
| US7585881B2 (en) * | 2004-02-18 | 2009-09-08 | Astrazeneca Ab | Additional heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists |
| GB0420722D0 (en) * | 2004-09-17 | 2004-10-20 | Addex Pharmaceuticals Sa | Novel allosteric modulators |
| GB0514296D0 (en) | 2005-07-12 | 2005-08-17 | Novartis Ag | Organic compounds |
| AR058807A1 (es) * | 2005-09-29 | 2008-02-27 | Astrazeneca Ab | 5-(fenilisoxazoletoxi)-triazol-3-il piridinas sustituidas, para el tratamiento de trastornos mediados por el receptor mglur5 |
| TW200808800A (en) * | 2006-05-05 | 2008-02-16 | Astrazeneca Ab | MGluR5 modulators V |
| TW200811157A (en) * | 2006-05-05 | 2008-03-01 | Astrazeneca Ab | mGluR5 modulators I |
-
2007
- 2007-09-21 TW TW096135382A patent/TW200821305A/zh unknown
- 2007-09-24 SA SA07280518A patent/SA07280518B1/ar unknown
- 2007-09-25 WO PCT/IB2007/002784 patent/WO2008041075A1/en not_active Ceased
- 2007-09-25 JP JP2009530956A patent/JP2010505809A/ja active Pending
- 2007-09-25 AR ARP070104214A patent/AR062965A1/es not_active Application Discontinuation
- 2007-09-25 PE PE2007001288A patent/PE20081378A1/es not_active Application Discontinuation
- 2007-09-25 US US11/902,784 patent/US7772235B2/en not_active Expired - Fee Related
- 2007-09-25 MX MX2009003227A patent/MX2009003227A/es not_active Application Discontinuation
- 2007-09-25 KR KR1020097006875A patent/KR20090060328A/ko not_active Withdrawn
- 2007-09-25 UY UY30610A patent/UY30610A1/es not_active Application Discontinuation
- 2007-09-25 RU RU2009111113/04A patent/RU2439068C2/ru not_active IP Right Cessation
- 2007-09-25 BR BRPI0719155-3A patent/BRPI0719155A2/pt not_active IP Right Cessation
- 2007-09-25 EP EP07804973A patent/EP2079730A1/en not_active Withdrawn
- 2007-09-25 CN CNA2007800451517A patent/CN101547916A/zh active Pending
- 2007-09-25 AU AU2007303889A patent/AU2007303889B2/en not_active Ceased
- 2007-09-25 CL CL200702757A patent/CL2007002757A1/es unknown
- 2007-09-25 CA CA002665083A patent/CA2665083A1/en not_active Abandoned
- 2007-09-25 NZ NZ575657A patent/NZ575657A/en not_active IP Right Cessation
-
2009
- 2009-03-19 IL IL197722A patent/IL197722A0/en unknown
- 2009-04-23 NO NO20091626A patent/NO20091626L/no not_active Application Discontinuation
- 2009-04-29 CO CO09043380A patent/CO6220935A2/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0719155A2 (pt) | 2014-02-04 |
| WO2008041075A1 (en) | 2008-04-10 |
| US20080125436A1 (en) | 2008-05-29 |
| AU2007303889B2 (en) | 2011-02-24 |
| CN101547916A (zh) | 2009-09-30 |
| JP2010505809A (ja) | 2010-02-25 |
| IL197722A0 (en) | 2009-12-24 |
| RU2439068C2 (ru) | 2012-01-10 |
| NO20091626L (no) | 2009-05-04 |
| RU2009111113A (ru) | 2010-11-10 |
| CO6220935A2 (es) | 2010-11-19 |
| TW200821305A (en) | 2008-05-16 |
| UY30610A1 (es) | 2008-05-02 |
| CA2665083A1 (en) | 2008-04-10 |
| AR062965A1 (es) | 2008-12-17 |
| SA07280518B1 (ar) | 2011-01-15 |
| NZ575657A (en) | 2011-03-31 |
| AU2007303889A1 (en) | 2008-04-10 |
| EP2079730A1 (en) | 2009-07-22 |
| CL2007002757A1 (es) | 2008-06-20 |
| KR20090060328A (ko) | 2009-06-11 |
| AU2007303889A2 (en) | 2010-07-15 |
| US7772235B2 (en) | 2010-08-10 |
| MX2009003227A (es) | 2009-04-06 |
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