CN101543593A - A traditional Chinese medicine composition for protecting gastric mucosa and a manufacturing method thereof - Google Patents
A traditional Chinese medicine composition for protecting gastric mucosa and a manufacturing method thereof Download PDFInfo
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- CN101543593A CN101543593A CN200910039184A CN200910039184A CN101543593A CN 101543593 A CN101543593 A CN 101543593A CN 200910039184 A CN200910039184 A CN 200910039184A CN 200910039184 A CN200910039184 A CN 200910039184A CN 101543593 A CN101543593 A CN 101543593A
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Abstract
The invention provides a traditional Chinese medicine composition for protecting gastric mucosa; raw material for cranking out the composition comprises: 1-10 weight parts of longan pulp, 10-30 weight parts of Gordon euryale seeds, 10-30 weight parts of yam, 10-30 weight parts of lotus seeds, 20-40 weight parts of blighted wheat, 1-20 weight parts of barbary wolfberry fruit, and 1-10 weight parts of liquorice. The composition of the invention has various forms of achievements, for instance, directly grinding the raw materials into fine powder to crank out pulvis, or extracting effective constituents in the raw materials by means of a water extraction method, an alcohol extraction method or a water-extraction alcohol-depositing method, and then with proper accessory to crank out common oral dosage of tablet and pill, etc.; besides, health drink can be cranked out by diluting the obtained effective constituents with water with a confecting of sugar, and the like flavoring agent.
Description
Technical Field
The invention relates to the field of medicine, in particular to a medicinal preparation.
Background
The stomach is the main organ for realizing the digestion and absorption functions of the human body, and most of food can be converted into nutrient substances which can be absorbed by the human body after being ground by the stomach wall and acted with gastric juice secreted by the gastric mucosa.
With the increasing pace of life, the increasing pressure of working and living, and the change of dietary structure, the incidence of gastropathy is higher and higher, and various gastropathy are accompanied with a certain degree of gastric mucosa injury. Commonly used gastric mucosa protective agents include colloids, citric acid buttons, sucralfate, gastrodine, Maizilin-S, prostaglandins, and the like. Western medicines for treating gastric mucosa injury have great side effects, are used for treating symptoms and root causes, are often accompanied by drug resistance and drug dependence, and are usually taken by general patients with gastric diseases at any time without leaving the body.
The traditional Chinese medicine considers that the spleen and the stomach are the acquired root. Spleen governs ascending, and food essence is distributed; the stomach governs descending, and the water and grain dregs descend. The physiological functions of the spleen and the stomach are closely matched to finish the digestion of food and the distribution of essence together, thereby providing power and source for the life activities of human bodies. Whether the spleen and stomach are in coordination with each other to promote the clear and descend the turbid is the key to the normal or abnormal functioning of the spleen and stomach. Modern people have fast pace of life, irregular eating, abnormal hunger and satiety, and the unskilled diet structure leads to the inability of the spleen and stomach to normally take food essence. Spleen qi fails to ascend clear due to deficiency of spleen qi, food fails to transport and transform, and qi and blood do not generate source. The stomach failing to descend and turbid causes poor appetite, stomach distension and stomachache. Vomiting due to adverse rising of stomach-qi, hiccup, etc.
The traditional Chinese medicine has the characteristics and advantages of preventing and treating gastric mucosa injury. In recent years, a lot of research works are carried out by a plurality of scholars in the field, and a plurality of Chinese herbal single medicines and compound preparations are found and proved to have obvious gastric mucosa protection effects, so that the Chinese herbal medicine can resist gastric acid and pepsin, strengthen gastric mucosa and mucus barrier, improve and regulate gastric mucosa blood flow, induce synthesis and release of endogenous protection factors of gastric mucosa, strengthen gastric mucosa cell protection effect, resist free radical damage and other mechanisms to play a role in preventing and treating gastric mucosa damage. In traditional Chinese medicines for preventing and treating gastric mucosa injury, a compound is mainly used, and patent 200710009573.0 discloses a medicine for repairing gastric mucosa in 'a medicine for repairing gastric mucosa', raw materials of the medicine comprise rhizoma bletillae, rhizoma atractylodis macrocephalae, radix cynanchi paniculatae, fructus aurantii immaturus, semen Alpiniae and rhizoma pinelliae, but the rhizoma bletillae, the radix cynanchi paniculatae, the semen Alpiniae and the rhizoma pinelliae in the formula are all small in toxicity and cannot be taken as health care products and daily food for a long time. Patent 200710070443.8 discloses a Chinese medicinal composition for protecting gastric mucosa prepared from herba plantaginis and herba Taraxaci, and its preparation method, which has simple formulation and single effect, and can not prevent and treat gastric mucosa injury radically. In addition, the patents of the related medicines for protecting the gastric mucosa are looked up, the single medicines or the western medicine monomer component combination are mostly adopted, the effect of protecting the gastric mucosa is achieved by inhibiting gastric acid and transiently strengthening the gastric mucosa wall, the function of strengthening the gastric mucosa for a long time is not achieved, and the effect of fundamentally preventing and treating the injury of the gastric mucosa is achieved.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine composition for protecting gastric mucosa.
The technical scheme for solving the problems is as follows:
a traditional Chinese medicine composition for protecting gastric mucosa is prepared from the following raw materials: 1-10 parts of longan aril, 10-30 parts of gordon euryale seed, 10-30 parts of Chinese yam, 10-30 parts of lotus seed, 20-40 parts of blighted wheat, 1-20 parts of wolfberry fruit and 1-10 parts of liquorice.
In the composition of the present invention, the raw materials are preferably used in an amount of: 3-8 parts of longan pulp, 5-15 parts of gordon euryale seed, 5-15 parts of Chinese yam, 5-15 parts of lotus seed, 20-25 parts of blighted wheat, 3-8 parts of wolfberry fruit and 2-8 parts of liquorice; preferably, the method comprises the following steps: 8 parts of longan pulp, 15 parts of gordon euryale seed, 15 parts of Chinese yam, 15 parts of lotus seed, 20 parts of light wheat, 4 parts of wolfberry fruit and 2 parts of liquorice.
The composition of the invention also comprises medically acceptable auxiliary materials.
The composition can be prepared into oral preparations such as powder, granules, tablets, capsules, oral liquid and the like. When the composition is powder, the raw materials are directly ground into powder and mixed to obtain the composition. When the composition of the invention is prepared into granules, tablets, capsules or oral liquid and other oral dosage forms, the active ingredients in the raw materials can be prepared by a water extraction method, an alcohol extraction method or a water extraction and alcohol precipitation method, and then medically acceptable auxiliary materials are added to prepare the composition by a conventional method. Wherein,
the water extraction method comprises the following steps: taking arillus longan, gordon euryale seed, Chinese yam, lotus seed, light wheat, wolfberry fruit and liquorice, extracting with water for 1-2 times, adding 10-20 times of water each time, decocting for 45-120 minutes, and filtering; combining the filtrates, and concentrating under reduced pressure at 50-80 deg.C until the relative density is 1.1-1.35 at 60 deg.C.
The alcohol extraction method comprises the following steps: taking arillus longan, gordon euryale seed, Chinese yam, lotus seed, light wheat, wolfberry fruit and liquorice, and carrying out reflux extraction for 1-2 times by using 65-85% (v/v) ethanol, wherein 10-20 times of ethanol is added for extraction for 0.5-3 hours each time; combining the extracts, and concentrating under reduced pressure at 50-80 deg.C until the relative density is 1.1-1.35 at 60 deg.C. .
The effective component of the composition of the present invention may also be supercritical carbon dioxide (SFE-CO)2) Extracting or ultrasonic extracting.
The composition of the invention can be used as a medicament for preventing and treating gastric mucosal injury, and can also be used as a beverage for daily health care. The preparation method of the beverage comprises the following steps: taking arillus longan, gordon euryale seed, Chinese yam, lotus seed, light wheat, wolfberry fruit and liquorice, decocting the raw materials for 30-45 minutes by using 10-20 times of water, taking decoction, adding water for quantification, filtering, and adding glucose, high fructose syrup and white sugar.
The arillus longan is aril arillus longan Dimocarpus longan lour.
The gorgon fruit is dried mature kernel of gorgon Euryale ferox Salisb.
The yam of the invention is dried rhizome of Dioscorea opposita opposissiate Thunb.
The lotus seed is dry mature seed of Nelumbo nucifera Gaertn.
The light wheat of the invention is an immature caryopsis of a gramineous annual or perennial herbaceous plant wheat Triticum aestivum L.
The wolfberry fruit is dry mature fruit of Lycium barbarum L of Solanaceae.
The licorice is the dried root and rhizome of Glycyrrhiza uralensis Fishch of Leguminosae.
The composition is a compound traditional Chinese medicine with the stomach nourishing function, which consists of arillus longan, gordon euryale seed, Chinese yam, lotus seed, medlar, blighted wheat and liquorice. In the prescription, the longan pulp is warm in nature and sweet in taste, has the functions of benefiting spleen and stomach and tonifying qi and blood, and is a monarch drug in the prescription in the way that the longan pulp can nourish blood, calm nerves, promote mentality, arrest sweating, stimulate appetite and benefit spleen in Yunnan herbal medicine. The gorgon fruit is neutral in nature and sweet in taste, and has the functions of tonifying spleen and stopping diarrhea; chinese yam is neutral in nature and sweet in taste, and can tonify spleen, tonify lung, strengthen kidney and replenish essence, so that the Chinese yam can tonify middle-jiao and strength qi in the statement of Shen nong's herbal; the lotus seeds can nourish heart, tonify kidney, tonify spleen and astringe intestines; the three medicines are combined, and have the functions of tonifying and astringing, and the longan pulp has the functions of tonifying spleen and qi, invigorating stomach and astringing, and is used as a ministerial medicine. Wolfberry fruit, fructus lycii, as an adjuvant drug, has the effects of replenishing essence and benefiting qi, nourishing stomach yin, astringing yin and removing dampness in cooperation with light wheat, and tonifying but not greasy. Licorice root, radix Glycyrrhizae is neutral in nature and sweet in taste, and can be used as a guiding drug for treating weakness of the spleen and stomach and harmonizing the effects of other drugs in the recipe. The composition of the whole formula is mainly prepared by taking conditioning as main part and supplementing as auxiliary part, and the effects of nourishing the stomach and tonifying the spleen are achieved by conditioning the qi movement of the spleen and the stomach, tonifying the spleen and assisting transportation, harmonizing the stomach and stopping flow, transporting and transforming food essence, and simultaneously tonifying the spleen and the stomach, tonifying the stomach and the yin and enhancing the functions of the spleen and the stomach.
In order to better understand the present invention, the effect of the composition of the present invention on preventing and treating gastric mucosal injury is further illustrated by pharmacological experiments.
First, acute gastric mucosal injury experiment
(I) effects on acute gastric mucosal injury caused by Anhydrous ethanol
1. Purpose(s) to
The protective effect of the composition on the model rats with acute gastric mucosa injury caused by absolute ethyl alcohol is observed.
2. Material
2.1 reagent
The composition of the invention was prepared as in example 4.
2.2 animals
48 SD rats with SPF grade and weight of 180-220 g, each half of male and female, provided by the Experimental animal center of Guangzhou university of traditional Chinese medicine. The test is carried out for 3d (temperature 24-26 deg.C, humidity 60-70%).
2.3 instruments and apparatus
Dissecting instruments, vernier calipers, absolute ethanol were manufactured by tianjin chemical reagent (lot 031105); formaldehyde was produced by the Daloc Chemicals plant of Tianjin (batch No. 20080218).
3. Method of producing a composite material
Healthy SD rats are selected, half male and half female rats are selected, the weight is 180-220 g, and the SD rats are randomly divided into a model group and high, medium and low dose groups of the composition. Continuously performing intragastric administration for 30 days and 1 time per day according to 10ml/kg body weight, performing constant volume distilled water drenching for model groups, fasting for 24 hours before experiment, keeping water forbidden, 1 hour after last administration, drenching 1.0ml absolute ethyl alcohol for each rat, removing cervical vertebra after 1 hour, killing the rat, performing laparotomy, taking stomach, clamping cardia end, injecting 5ml of 10% formaldehyde solution from pyloric end, clamping pyloric end, fixing in formaldehyde solution with the same concentration for 20min, then cutting stomach wall along greater curvature of stomach, taking the total length of gastric mucosa injury as ulcer index (diameter is larger than 1mm, length is doubled), performing statistical treatment by t test, and calculating ulcer inhibition percentage. The results are shown in Table 1.
4. Results
TABLE 1 Effect of the compositions of the present invention on acute gastric mucosal injury caused by Anhydrous ethanol (x. + -.s)
Note: comparison with model groups:*P<0.05。
the incidence of the damage of the rat gastric mucosa caused by the absolute ethyl alcohol is 100 percent, and the ulcer index and the ulcer inhibition rate are often used as the observation indexes of the experiment. The experiment shows that: after the composition of the invention is continuously infused into the stomach of a mouse for 30 days, each dosage group has the tendency of inhibiting the acute gastric mucosa injury of the rat caused by absolute ethyl alcohol.
(II) Effect on stress-induced acute gastric mucosal injury
1. Purpose(s) to
The protective effect of the composition of the invention on the acute gastric mucosa injury model rats caused by stress is observed.
2. Material
2.1 reagent
The composition of the invention was prepared as in example 4.
2.2 animals
48 SD rats with SPF grade and weight of 180-220 g, each half of male and female, provided by the Experimental animal center of Guangzhou university of traditional Chinese medicine. The test is carried out for 3d (temperature 24-26 deg.C, humidity 60-70%).
2.3 instruments and apparatus
Dissecting instruments, vernier calipers, formaldehyde were produced by the mao chemicals factory, Tianjin (batch number 20080218).
3. Method of producing a composite material
Effect on stress-induced gastric mucosal injury rat model
Healthy SD rats are selected, half male and half female rats are selected, the weight is 180-220 g, and the SD rats are randomly divided into a model group and high, medium and low dose groups of the composition. Continuously performing gastric lavage and drug administration for 30 days and 1 time per day according to 10ml/kg body weight, performing constant volume distilled water drench for a model group, fasting before an experiment for 24 hours, fixing a rat in a rat copper wire fixing cage 1 hour after the last drug administration, and soaking the rat in standing water in a constant temperature water bath with the temperature of 18-20 ℃ to ensure that the water surface depth is flush with xiphoid process. After water immersion stress for 20h, the animals are sacrificed, the abdomen is opened, the stomach is taken out, 5ml of 10% formaldehyde solution is injected from the pyloric end, the pyloric end and the cardia end are clamped and closed, the formaldehyde solution with the same concentration is placed into the pyloric end and fixed for 10min, then the stomach wall is cut along the greater curvature of the stomach, the sum of the damage lengths of the gastric mucosa is used as an ulcer index (the diameter of the stomach exceeds 1mm, the length is doubled), and the differences of all groups are compared. The percentage of ulcer inhibition was calculated. Results were statistically processed using the t-test. The results are shown in Table 1.
TABLE 2 Effect of the composition of the present invention on stress induced acute gastric mucosal injury in rats (x. + -.s)
Note: comparison with model groups:*P<0.05。
the stimulation factors (restraining water immersion, freezing and hunger) with certain intensity are applied to animals to form acute gastric ulcer, the generation of the stress gastric ulcer is related to factors such as reduction of blood flow of gastric mucosa, hypermotility of stomach, hypersecretion of gastric acid and the like, and the ulcer index and the ulcer inhibition rate are commonly used as observation indexes of experiments. The experiment shows that: after the mice are continuously perfused with the composition for 30 days, each dosage group has the tendency of protecting the action of acute gastric mucosa injury model rats caused by stress.
6. Small knot
According to the requirements of health food inspection and evaluation technical specification-2003 of the national ministry of health, the influence of the composition on an acute gastric mucosal injury model rat caused by absolute ethyl alcohol and stress is researched by combining experimental methods of relevant chapters of Chenqi's research thought and method of traditional Chinese medicine efficacy ' (1 st edition) and traditional Chinese medicine pharmacology research methodology ' (2 nd edition), the experimental results show that each dose group of the composition has the tendency of reducing gastric ulcer index and improving ulcer inhibition rate, and the two experimental methods show positive results, so that the tested object can be judged to have the effect of protecting acute gastric mucosal injury.
Model for chronic and chronic gastric mucosa damage
(one) Effect on animal models of acetic acid-induced chronic gastric mucosal injury
1. Purpose(s) to
The protective effect of the composition of the invention on rats with chronic gastric mucosal injury model caused by acetic acid is observed.
2. Material
2.1 reagent
The composition of the invention was prepared as in example 4.
2.2 animals
48 SD rats with SPF grade and weight of 180-220 g, each half of male and female, provided by the Experimental animal center of Guangzhou university of traditional Chinese medicine. The test is carried out for 3d (temperature 24-26 deg.C, humidity 60-70%).
2.3 instruments and apparatus
Dissecting instruments, vernier calipers, KM2255 full-automatic paraffin slicer, manufactured by the company muca, germany; the TP102 type full-automatic biological tissue dehydrator is manufactured by German Leica; the EG1140 paraffin embedding machine is manufactured by german come card company; the 5010 type full-automatic dyeing machine is manufactured by come card company of germany; the BX50 type biomicroscope is produced by olympus, japan; the YABO200 type bleaching and drying machine is produced by China Abbo company; the MIAS-type medical image analysis management system is manufactured by north navigation corporation of china. Acetic acid was produced by Guangzhou chemical laboratories (batch No. 200401033); chloral hydrate was produced by chemical reagents of Kemiou, Tianjin, Inc. (batch No. 20070823). Formaldehyde was produced by the Daloc Chemicals plant of Tianjin (batch No. 20080218).
3. Method of producing a composite material
Healthy SD rats are selected, half male and half female, the weight is 180-210 g, and the SD rats are randomly divided into a model group and high, medium and low dose groups of the composition. After fasting for 12 hours before the experiment, the animals are lightly anesthetized with 10% chloral hydrate on the same day of the experiment, fixed and disinfected conventionally, the abdominal wall (2-3 cm) is cut along the ventral midline under the xiphoid process of the sternum, the glandular stomach is gently hooked out, a micro-injector is horizontally inserted into the serosa at the junction of the ventral side of the stomach, the stomach body and the pyloric sinus, and 0.4-0.5 mm below the serosa, and 0.05ml of 20% acetic acid is injected to form the pimple. The stomach was gently returned to the abdomen, and the abdominal muscle layer and skin were sutured. And (4) performing postoperative conventional feeding, wherein from the day of the operation, the rats are subjected to intragastric administration for 1 time every day according to the weight of 10ml/kg, and the rats in the model group are subjected to intragastric administration with distilled water with equal volume for 30 days continuously. Animals were sacrificed at 31d, the stomach was removed and fixed with 10% formaldehyde solution for 10min, the stomach wall was cut along the greater curvature of the stomach, the ulcer index was represented by the mean of the longest and shortest diameters of the ulcer, statistical treatment was performed by t-test, and the inhibition rate was calculated.
Finally, the rat stomach was fixed with 10% formalin, dehydrated with ethanol series, sectioned embedded in paraffin, and stained by HE for histopathological examination. See table 3.
TABLE 3 Effect of the composition of the present invention on acetic acid induced chronic gastric mucosal injury (x. + -.s) in rats
Note: comparison with model groups:*P<0.05。
the pathological result shows that the gastric mucosa defect of the rat in the model group reaches more than 2/3, the epithelium is obviously peeled off, the mucosa is thinned, and the mucosal epithelial tissue is infiltrated by mononuclear cells, lymphocytes and plasma cells. The composition has the advantages that the gastric mucosa defect of rats in high and medium dose groups is less than 1/3, the epithelium is not obviously peeled and thinned, the gastric mucosa has slight edema, and the submucosa has inflammatory cell infiltration; the gastric mucosa of the rats in the low-dose group has mucosal defect, and the epithelium is slightly peeled off. It can be seen that the composition of the present invention has certain improvement in the damage to rat gastric mucosa compared with the model group.
Acetic acid has a corrosive effect, and a certain amount of acetic acid injected under serosa of rat stomach can cause gastric mucosa injury to form ulcer, and the ulcer index and the ulcer inhibition rate are common indexes for experimental study of gastric injury. The experiment shows that: after the rats are continuously perfused with the composition of the invention for 30 days, each dose group has the tendency of inhibiting the acute gastric mucosa injury of the rats caused by acetic acid. The pathological results show that the composition has certain improvement effect on rats with gastric mucosa injury.
6. Small knot
According to the requirements of health food inspection and evaluation technical specification-2003 of the national ministry of health, the influence of the composition on rats with chronic gastric mucosa injury models caused by acetic acid is researched by combining experimental methods of relevant chapters of Chenqi's research thought and method of traditional Chinese medicine efficacy ' (1 st edition) and traditional Chinese medicine pharmacology research methodology ' (2 nd edition), and experimental results show that each dose group of the composition has the tendency of reducing gastric ulcer index and improving ulcer inhibition rate. From pathological results, the gastric mucosal epithelium of the rat in the model group is obviously exfoliated, the mucosa is thinned, and the mucosal epithelial tissue is infiltrated by mononuclear cells, lymphocytes and plasma cells.
Detailed Description
Example 1: tablet formulation
Taking 1g of longan pulp, 10g of gordon euryale seed, 10g of Chinese yam, 10g of lotus seed, 20g of blighted wheat, 1g of medlar and 1g of liquorice, heating and refluxing for 1 time by using 60% (v/v) ethanol, adding 10 times of ethanol for extraction for 0.5 hour each time, combining extracting solutions obtained in two times, filtering, recovering ethanol under reduced pressure at 80 ℃, concentrating into an extract with the relative density (60 ℃) of 1.1-1.35, drying at 105 ℃ to obtain a dry extract, crushing the dry extract into powder, adding starch and carboxymethyl cellulose, uniformly mixing, granulating, tabletting, coating and preparing into tablets.
Example 2: hard capsule
Heating and refluxing 10g of arillus longan, 30g of semen euryales, 30g of Chinese yam, 30g of lotus seeds, 40g of light wheat, 20g of medlar and 10g of liquorice with 75% (v/v) of ethanol for 2 times, and adding 20 times of ethanol for extraction for 2 hours each time; mixing extractive solutions, recovering ethanol at 65 deg.C under reduced pressure, concentrating to obtain extract with relative density (60 deg.C) of 1.1-1.35, spray drying to obtain spray dried powder, granulating, and making into hard gelatin capsule.
Example 3: soft capsule
Taking 3g of longan pulp, 5g of gordon euryale seed, 5g of Chinese yam, 5g of lotus seed, 20g of blighted wheat, 3g of medlar and 2g of liquorice, heating and refluxing for 1 time by using 70% (v/v) ethanol, adding 15 times of ethanol for extraction for 3 hours each time, combining extracting solutions, recovering ethanol under reduced pressure at 50 ℃, concentrating into an extract with the relative density (60 ℃) of 1.1-1.35, spray drying to obtain spray dried powder, adding vegetable oil, mixing uniformly, filling into soft capsules, and preparing into soft capsules.
Example 4: oral liquid
Adding water into 8g of longan pulp, 15g of gordon euryale seed, 15g of Chinese yam, 15g of lotus seed, 25g of light wheat, 8g of medlar and 8g of liquorice, extracting for 2 times, adding 10 times of water each time, and decocting for 120 minutes. Mixing the two decoctions, filtering to obtain a co-decoction, concentrating the decoction to obtain an extract with a relative density (60 deg.C) of 1.1-1.35, diluting the concentrated solution with water to 100 times, and adding sucrose as correctant to obtain oral liquid.
Example 5: beverage and its preparing process
Extracting arillus longan 8g, semen euryales 15g, rhizoma Dioscoreae 15g, semen Nelumbinis 15g, fructus Tritici Levis 20g, fructus Lycii 4g and Glycyrrhrizae radix 2g with water for 1 time, adding 20 times of water, decocting for 45 min, filtering to obtain decoction, adding water to 6000ml, filtering, adding appropriate amount of glucose, fructose syrup and white sugar, and making into beverage.
Example 6: pill preparation
Taking 6g of longan pulp, 20g of gordon euryale seed, 15g of Chinese yam, 20g of lotus seed, 30g of light wheat, 9g of medlar and 9g of liquorice, heating and refluxing for 2 times by using 80% ethanol, adding 10 times of ethanol for extraction for 3 hours each time, combining the two extracting solutions, recovering ethanol and concentrating to obtain a dry extract, crushing the dry extract into powder, adding starch and refined honey, uniformly mixing, making pills and preparing pills.
Example 7: tablet formulation
Taking 7g of longan pulp, 15g of gordon euryale seed, 20g of Chinese yam, 20g of lotus seed, 35g of blighted wheat, 10g of medlar and 1g of liquorice, adding water for extraction for 2 times, adding 15 times of water for each time, decocting for 60 minutes, filtering, obtaining co-decoction liquid, concentrating into extract with the relative density (60 ℃) of 1.1-1.35, drying at 105 ℃ to obtain dry extract, pulverizing the dry extract into powder, adding starch and carboxymethyl cellulose, uniformly mixing, granulating, tabletting, coating, and preparing into tablets.
Example 8: hard capsule
Adding water into 9g of longan pulp, 25g of gordon euryale seed, 25g of Chinese yam, 20g of lotus seed, 40g of light wheat, 10g of medlar and 10g of liquorice, extracting for 2 times, adding 20 times of water each time, decocting for 120 minutes, filtering, combining the decoction liquids of the two times, concentrating into an extract with the relative density (60 ℃) of 1.1-1.35, performing spray drying to obtain spray-dried powder, filling the spray-dried powder into a gelatin hard capsule, and preparing the hard capsule.
Example 9: granules
Taking 7g of longan pulp, 23g of gordon euryale seed, 20g of Chinese yam, 25g of lotus seed, 30g of light wheat, 6g of wolfberry fruit and 8g of liquorice, adding water for extraction for 2 times, adding 20 times of water for each time, decocting for 90 minutes, filtering, combining filtrates, concentrating the filtrate at 60 ℃ under reduced pressure to obtain thick paste with the relative density (60 ℃) of 1.1-1.35, drying the thick paste to obtain dry paste, crushing the dry paste into dry paste powder, and performing dry granulation to prepare particles.
Example 10: powder preparation
Grinding 7g of arillus longan, 23g of semen euryales, 20g of Chinese yam, 25g of lotus seeds, 30g of light wheat, 6g of wolfberry fruits and 8g of liquorice into fine powder, and uniformly mixing.
Claims (6)
1. A traditional Chinese medicine composition for protecting gastric mucosa is prepared from the following raw materials: 1-10 parts of longan aril, 10-30 parts of gordon euryale seed, 10-30 parts of Chinese yam, 10-30 parts of lotus seed, 20-40 parts of blighted wheat, 1-20 parts of wolfberry fruit and 1-10 parts of liquorice.
2. The composition of claim 1, wherein the raw materials are present in amounts of: 3-8 parts of longan pulp, 5-15 parts of gordon euryale seed, 5-15 parts of Chinese yam, 5-15 parts of lotus seed, 20-25 parts of blighted wheat, 3-8 parts of wolfberry fruit and 2-8 parts of liquorice.
3. The composition of claim 1, wherein the raw materials are present in amounts of: 8 parts of longan aril, 15 parts of gordon euryale seed, 15 parts of Chinese yam, 15 parts of lotus seed, 20 parts of light wheat, 4 parts of wolfberry fruit and 2 parts of liquorice.
4. The composition according to any one of claims 1 to 3, wherein the raw materials further comprise pharmaceutically acceptable excipients.
5. A process for preparing the composition of claim 4, which process comprises the steps of: taking arillus longan, gordon euryale seed, Chinese yam, lotus seed, light wheat, wolfberry fruit and liquorice, extracting with water for 1-2 times, adding 10-20 times of water each time, decocting for 45-120 minutes, and filtering; combining the filtrates, and concentrating under reduced pressure at 50-80 deg.C until the relative density is 1.1-1.35 at 60 deg.C; adding pharmaceutically acceptable adjuvants, and making into oral preparation by conventional method.
6. A process for preparing the composition of claim 4, which process comprises the steps of: taking arillus longan, gordon euryale seed, Chinese yam, lotus seed, light wheat, wolfberry fruit and liquorice, and carrying out reflux extraction for 1-2 times by using 65-85% (v/v) ethanol, wherein 10-20 times of ethanol is added for extraction for 0.5-3 hours each time; combining the extracting solutions, and concentrating under reduced pressure at 50-80 ℃ until the relative density measured at 60 ℃ is 1.1-1.35; adding pharmaceutically acceptable adjuvants, and making into oral preparation by conventional method.
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| US20140127334A1 (en) * | 2011-04-01 | 2014-05-08 | James Zhou | Drug compound for the control of blood glucose, blood lipids and weight |
| CN104814386A (en) * | 2015-05-27 | 2015-08-05 | 江西阿颖金山药食品集团有限公司 | Nutrient rice noodles for accessorily treating gastrointestinal diseases and checking diarrhea |
| CN107853397A (en) * | 2017-11-17 | 2018-03-30 | 荣成奥汛海洋生物科技有限公司 | A kind of auxiliary protection gastric mucosa function milk piece and its processing method |
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| CN1219543C (en) * | 2003-08-11 | 2005-09-21 | 合肥神鹿集团公司 | Chinese medicine for invigorating liver, kidney and spleen, nourishing blood, tranquilizing mind relaxing bowels and the prepn process of the Chinese medicine prepn |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20140127334A1 (en) * | 2011-04-01 | 2014-05-08 | James Zhou | Drug compound for the control of blood glucose, blood lipids and weight |
| US10894070B2 (en) * | 2011-04-01 | 2021-01-19 | James Zhou | Drug compound for the control of blood glucose, blood lipids and weight |
| CN104814386A (en) * | 2015-05-27 | 2015-08-05 | 江西阿颖金山药食品集团有限公司 | Nutrient rice noodles for accessorily treating gastrointestinal diseases and checking diarrhea |
| CN107853397A (en) * | 2017-11-17 | 2018-03-30 | 荣成奥汛海洋生物科技有限公司 | A kind of auxiliary protection gastric mucosa function milk piece and its processing method |
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