CN1969973A - Chinese medicinal soft capsule for treating stomachache - Google Patents
Chinese medicinal soft capsule for treating stomachache Download PDFInfo
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- CN1969973A CN1969973A CN 200510016340 CN200510016340A CN1969973A CN 1969973 A CN1969973 A CN 1969973A CN 200510016340 CN200510016340 CN 200510016340 CN 200510016340 A CN200510016340 A CN 200510016340A CN 1969973 A CN1969973 A CN 1969973A
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- soft capsule
- chinese medicinal
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- stomachache
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Abstract
Disclosed is a Chinese medicinal soft capsule for treating stomach pain, which comprises coptis root and evodia rutaecarpa benth by 6:1. The preparing process consists of disintegrating evodia rutaecarpa benth into medicinal powder, extracting other raw materials through dissolvent backflow, decompression concentrating the extraction solution, vacuum-drying or spray-drying, dispersing the medicinal powder with liquid auxiliary materials, forming through compacting, 95% ethanol eluting and drying.
Description
Affiliated field:
The invention belongs to a kind of Chinese medicine, particularly a kind of Chinese medicinal soft capsule for the treatment of stomachache, this soft capsule can be treated noisy, the acid regurgitation of gastric abscess, bitter taste due to the liver-fire invading the stomach, not desire for hot drinks.
Background technology:
Stomachache is very high commonly encountered diseases of crowd's sickness rate and frequently-occurring disease, and nearly about 80% the people of town dweller suffers from stomachache in various degree.Because the variation of dietary structure, surfeit delicious food savoury adds the change of live and work environment, and the stress aggravation is so the stomachache due to the liver-fire invading the stomach occupies the majority in this type of disease.In China 50～60 years old was the age occurred frequently, was the trend that increases by north orientation south, and the male is more than the women.Acute and chronic gastritis, peptic ulcer are global commonly encountered diseases.At present, treat this sick Zuojin Wan and left gold size capsule holdup time weak point under one's belt, be unfavorable for medicine absorption under one's belt, so slow, the whole curative effect of drug effect is relatively poor.In addition, accepted by the patient difficult aspect sanitary condition and the quality control.
Summary of the invention:
Purpose of the present invention just is to provide a kind of Chinese medicinal soft capsule for the treatment of stomachache, this Chinese medicinal soft capsule can prolong the medicine holdup time under one's belt, make medicine absorption under one's belt more abundant, more complete, thereby helping medicine is absorbed by the body, make medicine rapid-action, help improving oral administration biaavailability.
Technical scheme of the present invention is: a kind of Chinese medicinal soft capsule for the treatment of stomachache, form according to 6: 1 ratio by Rhizoma Coptidis and Fructus Evodiae two medicines, it is characterized in that: at first a part of evodiae powder is broken into the crude drug powder, all the other crude drugs solvent reflux, extract,, the solvent consumption is 1-5 a times of crude drug, extract 1-5 time, each 0.5-4 hour, behind the extracting solution concentrating under reduced pressure, adopt vacuum drying or spray drying, dry back medicated powder fully disperses with Auxiliary Liquid Material, behind press forming on the soft capsule press, wash ball with 95% ethanol, drying gets final product.
The ratio of described Auxiliary Liquid Material and crude drug powder and extract summation is 1: 1 to 3: 1.
Described Auxiliary Liquid Material is edible vegetable oil, salad oil, olive oil, Petiolus Trachycarpi oil, and be fat-soluble be again water miscible liquid polyethylene glycol, the mixture of one or more in these raw materials.
Molecular weight polyethylene glycol in the described liquid polyethylene glycol is 400,600,1000.
Add the suspending agent tween 80 in the described Auxiliary Liquid Material.
The addition of described suspending agent tween 80 is the 0.02%-2% of Auxiliary Liquid Material.
Advantage of the present invention is: disintegration of the present invention is long, has therefore prolonged the medicine holdup time under one's belt, makes medicine absorption under one's belt more abundant, more complete, so whole good effect.The present invention can significantly reduce ACTH and CORT (P＜0.01) in the blood plasma, therefore, on the curative effect of treatment gastric ulcer, not only be better than Zuojin Wan and left gold size capsule, and be better than in the sick control of stress ulcer utilization rate and occupy ranitidine (accounting for 31%) first of each chemical medicine.The chronic gastritis patient of treatment Helicobacter pylori infection, cure rate is up to 64.7%, is higher than 24.2% cure rate of furazolidone far away.3, block at treatment acute and chronic gastritis, gastric ulcer and gastrointestinal dysfunction, postoperative intestinal adhesion, extensive and effective using value arranged in the digestive system disease such as biliary colic.
The present invention shows by zoopery:
1. it has the gastric emptying of inhibition and suppresses the intestinal propulsion effect, 2,4,6g/kg all can obviously suppress the small intestinal gastric emptying, with matched group notable difference (P＜0.05) is arranged relatively, 1,2,3g/kg all can obviously suppress intestinal propulsion, with matched group notable difference (P＜0.01) is arranged relatively, the atropine inhibitory action of middle dosage and 2.5mg/kg is suitable.
2, antiulcer action, 6.7g crude drug/kg can promote experimental rat lesser gastric curvature ulcer healing, treat after five days, and healing rate reaches 93.33%, obviously are better than ranitidine (effective percentage is 81.25%) and normal saline matched group (effective percentage is 47.06%).0.245g/kg the present invention close to the suppression ratio (51.4%) that indomethacin causes rat ulcer with the suppression ratio (59.7%) of 1g/kg cimetidine, the two all has the difference (P＜0.01) of highly significant with matched group, the suppression ratio of the rat ulcer that ethanol is caused with dosage the present invention is lower than cimetidine, but with matched group significant difference (P＜0.05) is arranged.Height of the present invention (8.4g crude drug/kg), in (the 4.2g crude drug/kg) dosage all has the minimizing (P＜0.01) of highly significant to reducing the ranitidine there was no significant difference of stress gastric ulcer index and 0.3125mg/kg with model control group; Low dosage is (though 2.1g crude drug/kg) effect of the ranitidine of too late 0.3125mg/kg still obviously reduces (P＜0.01) than model control group.
3, gastric acid inhibitory secretion, 0.245g/kg of the present invention obviously reduces gastric acid secretion and gastric acid total amount, and relatively there were significant differences (P＜0.01) with matched group, suitable with the effect of 1g/kg cimetidine.(8.4g crude drug/kg) has the acid function of secreting of obvious suppression gastric mucosa to high dose, its pH value and normal control group are close substantially, with the inhibitory action no significant difference (P＞0.05) of the ranitidine of 0.3125mg/kg, and there were significant differences (P＜0.01) with model control group.
4 the present invention are strong to the protective effect of gastric heat type mucosa injury, and damage suppression ratio 91.2% has highly significant difference (P＜0.001) with model control group.Protective effect for the cool type of the stomach especially mucosa injury of stomach-cold type is poor, matches with the clinical indication type.
5, the present invention is an alkaloid to the inhibiting main effective site of gastric mucosa injury due to hydrochloric acid or the ethanol, the apparent in view minimizing of its ulcer index and matched group (P＜0.05).The alkaloid position is stronger than the inhibitory action of water soluble part.
The specific embodiment:
Embodiment 1:(is 1 kilogram for every part)
6 parts of prescription Rhizoma Coptidis
1 part of Fructus Evodiae
1 part of salad oil
0.5 part of suspending agent tween 80
Operation: 1/3 of Fructus Evodiae is ground into fine powder, all the other medicinal 60% alcohol reflux 3 times, each 1.5-3 hour, extracting solution decompression, recovery, concentrated back added the Fructus Evodiae fine powder and mix, then at vacuum drying below 70 ℃, pulverizing.Add the salad oil and the suspending agent tween 80 of recipe quantity, grind mixing fully, cross 100 mesh sieves with colloid mill.Suppress on the soft capsule press, be shaped, 95% ethanol is washed ball, drying, every ball 0.6g, yield rate 89%.
The present invention is made up of Rhizoma Coptidis and Fructus Evodiae two medicines, adopts the monarch drug Rhizoma Coptidis content in the high effective liquid chromatography for measuring patent medicine, adopts the adjuvant drug Fructus Evodiae in the thin layer chromatography qualitative identification patent medicine.Make left golden soft capsule that controlled quality standard be arranged, guaranteed the quality of product, stablized curative effect.
1 kilogram every part of embodiment 2:()
Prescription: 6 parts of Rhizoma Coptidis
1 part of Fructus Evodiae
1.3 parts of salad oils
Operation is except that not adding the tween 80 with embodiment 1
1 kilogram every part of embodiment 3:()
Prescription: 6 parts of Rhizoma Coptidis
1 part of Fructus Evodiae
1.3 parts in olive oil
Operation is except that not adding the tween 80 with embodiment 1.
Claims (6)
1, a kind of Chinese medicinal soft capsule for the treatment of stomachache is made up of according to 6: 1 ratio Rhizoma Coptidis and Fructus Evodiae two medicines, it is characterized in that: at first a part of evodiae powder is broken into the crude drug powder, all the other crude drugs solvent reflux, extract,, solvent consumption are 1-5 times of crude drug, extract 1-5 time, each 0.5-4 hour, behind the extracting solution concentrating under reduced pressure, adopt vacuum drying or spray drying, dry back medicated powder fully disperses with Auxiliary Liquid Material, behind press forming on the soft capsule press, wash ball with 95% ethanol, drying gets final product.
2, a kind of Chinese medicinal soft capsule for the treatment of stomachache according to claim 1, it is characterized in that: the ratio of described Auxiliary Liquid Material and crude drug powder and extract summation is 1: 1 to 3: 1.
3, a kind of Chinese medicinal soft capsule for the treatment of stomachache according to claim 1, it is characterized in that: described Auxiliary Liquid Material is edible vegetable oil, salad oil, olive oil, Petiolus Trachycarpi oil, and be fat-soluble be again water miscible liquid polyethylene glycol, the mixture of one or more in these raw materials.
4, a kind of Chinese medicinal soft capsule for the treatment of stomachache according to claim 1, it is characterized in that: the molecular weight polyethylene glycol in the described liquid polyethylene glycol is 400,600,1000.
5, a kind of Chinese medicinal soft capsule for the treatment of stomachache according to claim 1 is characterized in that: add the suspending agent tween 80 in the described Auxiliary Liquid Material.
6, a kind of Chinese medicinal soft capsule for the treatment of stomachache according to claim 1, it is characterized in that: the addition of described suspending agent tween 80 is the 0.02%-2% of Auxiliary Liquid Material.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510016340 CN1969973A (en) | 2005-11-23 | 2005-11-23 | Chinese medicinal soft capsule for treating stomachache |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510016340 CN1969973A (en) | 2005-11-23 | 2005-11-23 | Chinese medicinal soft capsule for treating stomachache |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1969973A true CN1969973A (en) | 2007-05-30 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200510016340 Pending CN1969973A (en) | 2005-11-23 | 2005-11-23 | Chinese medicinal soft capsule for treating stomachache |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104971240A (en) * | 2015-06-20 | 2015-10-14 | 沈健龙 | Traditional Chinese medicinal composition for treating liver fire invading stomach type chronic gastritis |
| CN106963742A (en) * | 2016-11-07 | 2017-07-21 | 澳门大学 | Chinese medicine solid-liquid capsule and preparation method thereof |
| CN107050246A (en) * | 2017-05-30 | 2017-08-18 | 胡建锋 | A kind of Chinese medicine for treating stomach trouble |
| CN113599364A (en) * | 2021-08-26 | 2021-11-05 | 贵州医科大学 | Method for preparing Zuojin pectin capsule |
-
2005
- 2005-11-23 CN CN 200510016340 patent/CN1969973A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104971240A (en) * | 2015-06-20 | 2015-10-14 | 沈健龙 | Traditional Chinese medicinal composition for treating liver fire invading stomach type chronic gastritis |
| CN106963742A (en) * | 2016-11-07 | 2017-07-21 | 澳门大学 | Chinese medicine solid-liquid capsule and preparation method thereof |
| CN107050246A (en) * | 2017-05-30 | 2017-08-18 | 胡建锋 | A kind of Chinese medicine for treating stomach trouble |
| CN113599364A (en) * | 2021-08-26 | 2021-11-05 | 贵州医科大学 | Method for preparing Zuojin pectin capsule |
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