CN101530582A - Traditional Chinese medicine composition for treating chronic bronchitis and preparation method thereof - Google Patents

Abstract

The invention relates to a traditional Chinese medicine composition for treating chronic bronchitis. The traditional Chinese medicine composition is prepared by platycodon root, honey, apricot seed, liquoric root, star anise, oyster shell, clam shell, tangerine peel, Indigowoad root, Chinese magnoliavine fruit, pinellia tuber, heartleaf houttuynia herb, unibract fritillary bulb, thunberg fritillary bulb, earthworm, baical skullcap root, tatarian aster root, sessile stemona root, figwort root and/or a pharmaceutically acceptable carrier. The invention further relates to a preparation method of the traditional Chinese medicine composition. The traditional Chinese medicine composition has the effects of removing heat-phlegm, lowering adverse qi and relieving cough and is used for treating cough, sputum, asthma, recurrent respiratory tract infections and other symptoms caused by chronic bronchitis.

Description

A kind of Chinese medicine composition for the treatment of chronic bronchitis and preparation method thereof

Technical field

The present invention relates to a kind of Chinese medicine composition, specifically, relate to a kind of Chinese medicine composition for the treatment of chronic bronchitis and preparation method thereof.

Technical background

Chronic bronchitis is meant the chronic nonspecific inflammation of trachea, bronchial mucosa and surrounding tissue thereof.Clinically with cough up for a long time, expectoration or with pant and repeatedly the outbreak be feature.Chronic cough, expectoration or with panting, annual outbreak continues 3 months, continuous 2 years or more than, and can get rid of the heart, other illness of lung and outbreak repeatedly, part patient can develop into obstructive emphysema, chronic pulmonary heart disease.This disease is a commonly encountered diseases, and crowd's prevalence 4% is mainly in middle-aged and elderly people, can be up to 13% more than 50 years old.Main cause has formed bronchial chronic nonspecific inflammation for the repeated infection of virus and antibacterial.When there's a sudden fall in temperature, respiratory tract small blood vessel spasm ischemia, defense function are beneficial to pathogenic when descending; Chronic stimulations such as smog dust, atmosphere pollution also can be fallen ill; Smoking makes bronchospasm, mucosa variation, ciliary movement reduction, mucous secretion increase favourable infection.

The most onsets of chronic bronchitis are very hidden, and it is special that the beginning symptom there is no except that tussiculaing, so be difficult for being noted by patient.Before part patient's onset medical histories such as acute upper respiratory tract infection such as acute pharyngolaryngitis, flu, acute bronchitis are arranged earlier, and originally many in morbidity cold season, later symptom is promptly lasting, repeatedly outbreak.

The main clinical manifestation of chronic bronchitis is cough, expectoration, asthma and recurrent respiratory tract infection:

(1) cough: for a long time, repeatedly, the cough that increases the weight of gradually is the outstanding behaviours of primary disease.The lighter is only in the winter-spring season morbidity, and especially with the most obvious before and after getting up early morning, daytime, cough was less.Summer and autumn, cough alleviates or disappears.The patient with severe symptoms then the four seasons all cough, Winter-Spring aggravation, day and night cough, sooner or later particularly violent.

(2) expectoration: the general expectorant mucus spume shape that is white in color, rise more morning, often is difficult for bringing up because of thickness.Infecting or the back symptom of catching cold is aggravated rapidly, amount of expectoration increases, and viscosity increases, or is yellow purulent sputum or with panting.The accidental cause play is coughed and sputum mixed with blood.

(3) asthma: when merging respiratory tract infection, because the mucous membrane of bronchiole congestion and edema, sputum obstruction and bronchus tube chamber are narrow, can produce asthma (panting) symptom.Patient's bottleneck throat sound of stridulating when breathing has wheezing sound during auscultation of lung.This is the type of outstanding behaviours to pant, and is referred to as asthmatic bronchitis clinically; But its outbreak situation is again unlike typical bronchial asthma.

(4) repeated infection: when cold season or temperature cataclysm, respiratory tract infection repeatedly takes place easily.Patient asthma this moment increases the weight of, amount of expectoration showed increased and be purulence, and with malaise, fear of cold, heating etc.Moist sound appears in pulmonary, the numeration of leukocyte of having a blood test increase etc.Respiratory tract infection repeatedly especially easily makes elderly patients, and sb.'s illness took a turn for the worse, must fully pay attention to.

The traditional Chinese medical science thinks that chronic bronchitis belongs to " cough " " phlegm retention " diseases range such as " cough with asthma ".Just on the books in Huangdi's Internal Classics.As " element asks 5 constant virtues political affairs big opinion " cloud: " gold is too late ... its cough with asthma, its dirty lung ... its disease is breathed heavily." pointed out the disease of cough with asthma, its disease being located in the lung, and the deficiency and excess of lung all can cause cough with asthma.The Therapeutic Principle of " sick disease drink person, when with warm medicine and it " is discussed and pointed out to the Han dynasty Zhang Zhongjing at " Medical Treasures of the Golden Chamber " special secondary school piece of writing, the traditional Chinese medical science sage of the past has the argumentation of " lung is not hindered and do not coughed, and spleen is not hindered not chronic cough, kidney do not hinder do not breathe heavily ".If the cold-evil does not remove for many years, cause the spleen YANG deficiency, failure of the spleen to transport and transform then, being difficult of essence of water and grain given birth to and is QI and blood, and accumulatively wet raise phlegm is stopped up on the phlegm-damp in lung on the contrary, causes impairment of purifying and descending function of the lung and causes cough, abundant expectoration, asthma.As seen, deficiency of spleen-YANG and kidneyYANG is the main pathological basis of primary disease, and the internal organs deficiency and coldness that has deficiency of spleen-YANG and kidneyYANG to cause is the place of its pathological essence.

Chronic bronchitis heals than refractory, normal easily recurrence.Therefore, primary disease is not when showing effect, to set upright gas.During morbidity then to attack heresy.Symptomatic treatment in acute condition, radical treatment in chronic case.

The traditional Chinese medical science adopts this disease of decoction for the treatment of removing heat-phlegm, sending down the abnormal ascending QI cough-relieving.

Summary of the invention

The purpose of this invention is to provide a kind of Chinese medicine composition for the treatment of chronic bronchitis.

The present invention also aims to provide a kind of preparation method of this Chinese medicine composition.

In order to realize purpose of the present invention, the invention provides a kind of Chinese medicine composition for the treatment of chronic bronchitis, be to make by effective ingredient and/or pharmaceutically acceptable carrier, described effective ingredient is made by weight by following raw materials according:

Radix Platycodonis 10-20 part Mel 15-20 part Semen Armeniacae Amarum 15-20 part

Radix Glycyrrhizae 20-30 part Fructus Anisi Stellati 5-10 part Concha Ostreae 5-15 part

Breathe out shell 20-30 part Pericarpium Citri Reticulatae 20-30 part Radix Isatidis 10-25 part

Fructus Schisandrae Chinensis 10-15 part Rhizoma Pinelliae 5-10 part Herba Houttuyniae 10-15 part

Bulbus Fritillariae Cirrhosae 25-35 part Bulbus Fritillariae Thunbergii 25-30 part Pheretima 5-10 part

Radix Scutellariae 5-10 part Radix Asteris 5-10 part Radix Stemonae 15-20 part

Radix Scrophulariae 20-35 part

Effective ingredient is preferably made by weight by following raw materials according:

Radix Platycodonis 16 gram Mel 18 gram Semen Armeniacae Amarums 18 grams

Radix Glycyrrhizae 26 gram Fructus Anisi Stellatis 8 gram Concha Ostreaes 11 grams

Breathe out shell 26 gram Pericarpium Citri Reticulataes 26 gram Radix Isatidis 22 grams

The Fructus Schisandrae Chinensis 13 gram Rhizoma Pinelliaes 8 gram Herba Houttuyniae 13 grams

Bulbus Fritillariae Cirrhosae 31 gram Bulbus Fritillariae Thunbergii 28 gram Pheretimas 8 grams

The Radix Scutellariae 8 gram Radix Asteriss 8 gram Radixs Stemonae 18 grams

Radix Scrophulariae 27 grams

The present invention also provides a kind of preparation method of this Chinese medicine composition, comprises the steps:

(1) Kazakhstan shell, Concha Ostreae powder are broken into impalpable powder, and be standby;

(2) Rhizoma Pinelliae, Radix Glycyrrhizae, Radix Platycodonis, Mel, Semen Armeniacae Amarum, Fructus Anisi Stellati, Pericarpium Citri Reticulatae, Radix Isatidis, Fructus Schisandrae Chinensis, Herba Houttuyniae, Bulbus Fritillariae Cirrhosae, Bulbus Fritillariae Thunbergii, Pheretima, Radix Scutellariae, Radix Asteris, the Radix Stemonae, Radix Scrophulariae decocts with water secondary, each 2 hours, filter, merging filtrate, left standstill 48 hours, get supernatant, it is the thick paste of 1.20 (60 ℃) that concentrating under reduced pressure becomes relative density, adds ethanol to 65%, and room temperature left standstill 48 hours, get supernatant, it is the thick paste of 1.15 (60 ℃) that concentrating under reduced pressure becomes relative density, adds above-mentioned fine powder, drying, be ground into fine powder, make granule with pharmaceutically acceptable carrier, capsule, pill and tablet.

Pharmaceutical composition of the present invention can with receivable carrier pharmaceutically, for example: filler such as starch, microcrystalline Cellulose etc.; Binding agent such as vitamin derivative, starch etc.; Mode by granule, capsule, pill, tablet oral administration is used.

Chinese medicine composition of the present invention has the effect of removing heat-phlegm, sending down the abnormal ascending QI cough-relieving, is used for the diseases such as cough, expectoration, asthma and recurrent respiratory tract infection that chronic bronchitis causes.

The specific embodiment

Following examples are used to illustrate the present invention, but are not used for limiting the scope of the invention.

Embodiment 1 Chinese medicinal composition granules of the present invention

(1) breathe out shell 260g, Concha Ostreae 150g and be ground into impalpable powder, standby;

(2) Radix Platycodonis 200g, Radix Glycyrrhizae 260g, Rhizoma Pinelliae 80g, Semen Armeniacae Amarum 180g, Fructus Anisi Stellati 80g, Pericarpium Citri Reticulatae 260g, Radix Isatidis 220g, Fructus Schisandrae Chinensis 130g, Herba Houttuyniae 130g, Bulbus Fritillariae Cirrhosae 310g, Bulbus Fritillariae Thunbergii 280g, Pheretima 80g, Radix Scutellariae 80g, Radix Asteris 80g, Placenta Hominis 80g, Radix Stemonae 180g, Radix Scrophulariae 270g decocts with water secondary, each 2 hours, filter, merging filtrate, left standstill 48 hours, get supernatant, it is the thick paste of 1.20 (60 ℃) that concentrating under reduced pressure becomes relative density, add above-mentioned fine powder, drying is ground into fine powder, adds, dextrin 1000g, lactose 800g, mixing, wet granulation promptly with 70% ethanol (being dissolved with Mel 180g).

Embodiment 2 Chinese medicinal composition capsules agent of the present invention

(1) breathe out shell 260g, Concha Ostreae 150g and be ground into impalpable powder, standby;

(2) Radix Platycodonis 200g, Radix Glycyrrhizae 260g, Rhizoma Pinelliae 80g, Semen Armeniacae Amarum 180g, Fructus Anisi Stellati 80g, Pericarpium Citri Reticulatae 260g, Radix Isatidis 220g, Fructus Schisandrae Chinensis 130g, Herba Houttuyniae 130g, Bulbus Fritillariae Cirrhosae 310g, Bulbus Fritillariae Thunbergii 280g, Pheretima 80g, Radix Scutellariae 80g, Radix Asteris 80g, Placenta Hominis 80g, Radix Stemonae 180g, Radix Scrophulariae 270g decocts with water secondary, each 2 hours, filter, merging filtrate, left standstill 48 hours, get supernatant, it is the thick paste of 1.20 (60 ℃) that concentrating under reduced pressure becomes relative density, add above-mentioned fine powder, dry, be ground into fine powder, add Mel 180g, dextrin 700g mixing, in the capsulae vacuus of packing into promptly.

Embodiment 3 Chinese medicine composition tablets of the present invention

(1) breathe out shell 260g, Concha Ostreae 150g and be ground into impalpable powder, standby;

(2) Radix Platycodonis 200g, Radix Glycyrrhizae 260g, Rhizoma Pinelliae 80g, Semen Armeniacae Amarum 180g, Fructus Anisi Stellati 80g, Pericarpium Citri Reticulatae 260g, Radix Isatidis 220g, Fructus Schisandrae Chinensis 130g, Herba Houttuyniae 130g, Bulbus Fritillariae Cirrhosae 310g, Bulbus Fritillariae Thunbergii 280g, Pheretima 80g, Radix Scutellariae 80g, Radix Asteris 80g, Placenta Hominis 80g, Radix Stemonae 180g, Radix Scrophulariae 270g decocts with water secondary, each 2 hours, filter, merging filtrate, left standstill 48 hours, get supernatant, it is the thick paste of 1.20 (60 ℃) that concentrating under reduced pressure becomes relative density, add above-mentioned fine powder and Mel 180g, drying is ground into fine powder, add starch 200, microcrystalline Cellulose 100, low substituted cellulose 50, with 70% alcohol granulation, tabletting, coating are promptly.

Embodiment 4 Chinese medicine composition pills of the present invention

(1) breathe out shell 260g, Concha Ostreae 150g and be ground into impalpable powder, standby;

(2) Radix Platycodonis 200g, Radix Glycyrrhizae 260g, Rhizoma Pinelliae 80g, Semen Armeniacae Amarum 180g, Fructus Anisi Stellati 80g, Pericarpium Citri Reticulatae 260g, Radix Isatidis 220g, Fructus Schisandrae Chinensis 130g, Herba Houttuyniae 130g, Bulbus Fritillariae Cirrhosae 310g, Bulbus Fritillariae Thunbergii 280g, Pheretima 80g, Radix Scutellariae 80g, Radix Asteris 80g, Placenta Hominis 80g, Radix Stemonae 180g, Radix Scrophulariae 270g decocts with water secondary, each 2 hours, filter, merging filtrate, left standstill 48 hours, get supernatant, it is the thick paste of 1.20 (60 ℃) that concentrating under reduced pressure becomes relative density, add above-mentioned fine powder and Mel 180g, drying is ground into fine powder, add refined honey 40 and an amount of water, general ball, drying, polishing is promptly.

Claims (4)

1, a kind of Chinese medicine composition for the treatment of chronic bronchitis is to be made by effective ingredient and/or pharmaceutically acceptable carrier, it is characterized in that described effective ingredient is made by weight by following raw materials according:

Radix Platycodonis 10-20 part Mel 15-20 part Semen Armeniacae Amarum 15-20 part

Radix Glycyrrhizae 20-30 part Fructus Anisi Stellati 5-10 part Concha Ostreae 5-15 part

Breathe out shell 20-30 part Pericarpium Citri Reticulatae 20-30 part Radix Isatidis 10-25 part

Fructus Schisandrae Chinensis 10-15 part Rhizoma Pinelliae 5-10 part Herba Houttuyniae 10-15 part

Bulbus Fritillariae Cirrhosae 25-35 part Bulbus Fritillariae Thunbergii 25-30 part Pheretima 5-10 part

Radix Scutellariae 5-10 part Radix Asteris 5-10 part Radix Stemonae 15-20 part

Radix Scrophulariae 20-35 part.

2, Chinese medicine composition as claimed in claim 1 is characterized in that described effective ingredient made by weight by following raw materials according:

18 parts in 18 parts of Semen Armeniacae Amarums of 16 parts of Mel of Radix Platycodonis

11 parts of 8 portions of Concha Ostreaes of 26 portions of Fructus Anisi Stellatis of Radix Glycyrrhizae

Breathe out 22 parts of 26 parts of Radix Isatidis of 26 parts of Pericarpium Citri Reticulataes of shell

13 parts of 8 parts of Herba Houttuyniae of 13 parts of Rhizoma Pinelliaes of Fructus Schisandrae Chinensis

8 parts of 28 parts of Pheretimas of 31 parts of Bulbus Fritillariae Thunbergii of Bulbus Fritillariae Cirrhosae

18 parts of 8 parts of Radixs Stemonae of 8 portions of Radix Asteriss of Radix Scutellariae

27 parts of Radix Scrophulariaes.

3,, it is characterized in that described Chinese medicine composition can be made into granule, capsule and tablet as the arbitrary described Chinese medicine composition of claim 1-2.

4, a kind of preparation method as the arbitrary described Chinese medicine composition of claim 1-3 comprises the steps:

(1) Kazakhstan shell, Concha Ostreae powder are broken into impalpable powder, and be standby;

(2) Rhizoma Pinelliae, Radix Glycyrrhizae, Radix Platycodonis, Mel, Semen Armeniacae Amarum, Fructus Anisi Stellati, Pericarpium Citri Reticulatae, Radix Isatidis, Fructus Schisandrae Chinensis, Herba Houttuyniae, Bulbus Fritillariae Cirrhosae, Bulbus Fritillariae Thunbergii, Pheretima, Radix Scutellariae, Radix Asteris, the Radix Stemonae, Radix Scrophulariae decocts with water secondary, each 2 hours, filter, merging filtrate, left standstill 48 hours, get supernatant, it is the thick paste of 1.20 (60 ℃) that concentrating under reduced pressure becomes relative density, adds ethanol to 65%, and room temperature left standstill 48 hours, get supernatant, it is the thick paste of 1.15 (60 ℃) that concentrating under reduced pressure becomes relative density, adds above-mentioned fine powder, drying, be ground into fine powder, make granule with pharmaceutically acceptable carrier, capsule, pill and tablet.