CN101528940B - 用于产生4-羟基-l-异亮氨酸的方法 - Google Patents

用于产生4-羟基-l-异亮氨酸的方法 Download PDF

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Publication number
CN101528940B
CN101528940B CN2007800363018A CN200780036301A CN101528940B CN 101528940 B CN101528940 B CN 101528940B CN 2007800363018 A CN2007800363018 A CN 2007800363018A CN 200780036301 A CN200780036301 A CN 200780036301A CN 101528940 B CN101528940 B CN 101528940B
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China
Prior art keywords
isoleucine
ido
dna
dioxygenase
bacillus
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CN2007800363018A
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English (en)
Chinese (zh)
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CN101528940A (zh
Inventor
小寺智博
瑟奇·V·斯米尔诺夫
纳塔利亚·N·萨姆索诺瓦
维罗尼卡·A·科特利亚罗瓦
纳塔利亚·Y·拉什克维克
尤里·I·科兹洛夫
清水昌
小川顺
日比慎
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Ajinomoto Co Inc
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Ajinomoto Co Inc
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Priority claimed from PCT/JP2007/069520 external-priority patent/WO2008044614A1/en
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

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  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN2007800363018A 2006-09-28 2007-09-28 用于产生4-羟基-l-异亮氨酸的方法 Expired - Fee Related CN101528940B (zh)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
JP265452/2006 2006-09-28
JP2006265452 2006-09-28
US82957706P 2006-10-16 2006-10-16
US60/829,577 2006-10-16
JP2006345461 2006-12-22
JP345461/2006 2006-12-22
RU2007104645 2007-02-07
RU2007104645 2007-02-07
PCT/JP2007/069520 WO2008044614A1 (en) 2006-09-28 2007-09-28 Method for producing 4-hydroxy-l-isoleucine

Publications (2)

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CN101528940A CN101528940A (zh) 2009-09-09
CN101528940B true CN101528940B (zh) 2013-07-10

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JP (1) JP5246639B2 (enExample)
CN (1) CN101528940B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108504639A (zh) * 2018-04-03 2018-09-07 江南大学 一种异亮氨酸双加氧酶突变体及其应用

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2007147436A (ru) * 2007-12-21 2009-06-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU) Бактерия-продуцент (2s,3r,4s)-4-гидрокси-l-изолейцина и способ продукции (2s,3r,4s)-4-гидрокси-l-изолейцина
JP2010098975A (ja) * 2008-10-22 2010-05-06 Waseda Univ Ｌ−及びｄ−脂肪族アミノ酸水酸化物の製造方法
JP5140879B1 (ja) * 2012-06-22 2013-02-13 強化土株式会社 地盤改良工法
CN103865940B (zh) * 2014-04-03 2016-05-11 天津科技大学 一种l-异亮氨酸羟化酶基因及其基因工程菌与应用
CN104152505B (zh) * 2014-08-08 2016-11-23 江南大学 一种利用重组菌株转化制备4-羟基-l-异亮氨酸的方法
CN105566136A (zh) * 2016-01-19 2016-05-11 天津科技大学 一种从发酵液中分离提取4-羟基异亮氨酸的方法
CN105969785B (zh) * 2016-05-12 2019-11-22 天津科技大学 一种4-羟基异亮氨酸的合成方法
CN105779522B (zh) * 2016-05-17 2016-12-28 河南巨龙生物工程股份有限公司 一种微生物酶转化法生产l‑4‑羟基异亮氨酸的方法
WO2018181774A1 (ja) * 2017-03-31 2018-10-04 株式会社カネカ 新規モノオキシゲナーゼおよびその利用
CN107475267B (zh) * 2017-09-29 2020-07-14 天津科技大学 4-羟基异亮氨酸生产质粒与菌株以及4-羟基异亮氨酸的合成方法
CN109628476B (zh) * 2019-02-18 2021-01-29 江南大学 一种利用全细胞转化生产4-羟基异亮氨酸的方法
CN109929790B (zh) * 2019-03-29 2020-12-01 江南大学 一种生产4-羟基异亮氨酸的基因工程菌及其应用
CN110438097B (zh) * 2019-08-14 2020-12-29 江南大学 一种热稳定性与酶活提高的l-异亮氨酸羟化酶突变体
CN112280756B (zh) * 2020-10-29 2024-04-16 华东理工大学 异亮氨酸羟化酶突变体及在(2s,3r,4s)-4-羟基异亮氨酸合成中的应用
CN115141110B (zh) * 2021-03-29 2023-12-12 安徽华恒生物科技股份有限公司 一种l-缬氨酸发酵液的连续脱色方法
CN113233991A (zh) * 2021-05-27 2021-08-10 无锡晶海氨基酸股份有限公司 一种从全细胞催化液中提取4-羟基异亮氨酸的方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006093322A2 (en) * 2005-03-03 2006-09-08 Ajinomoto Co., Inc. Method for manufacturing 4-hydroxy-l-isoleucine or a salt thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006093322A2 (en) * 2005-03-03 2006-09-08 Ajinomoto Co., Inc. Method for manufacturing 4-hydroxy-l-isoleucine or a salt thereof

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
De Carolis Emidio等.2-Oxoglutarate-dependent dioxygenase and related enzymes:biochemical characterization.《Phytochemistry》.1994,第36卷(第5期),1093-1107. *
Haefele C.等.Characterization of a dioxygenase from trigonella foenum-graecum involved in 4-hydroxyisoleucine biosynthesis.《Phytochemistry》.1997,第44卷(第4期),563-566. *
Narender等.4-hydroxyisoleucine an unusual amino acid as antidyslipidemic anf antihyperglycemic agent.<Biooganic & medicinal chemistry letters>.2006,第16卷(第2期),293-296. *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108504639A (zh) * 2018-04-03 2018-09-07 江南大学 一种异亮氨酸双加氧酶突变体及其应用
CN108504639B (zh) * 2018-04-03 2020-12-29 江南大学 一种异亮氨酸双加氧酶突变体及其应用

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JP5246639B2 (ja) 2013-07-24
JP2008173116A (ja) 2008-07-31

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