CN101524344B - 为皮肤提供镇痛效果的组合物 - Google Patents
为皮肤提供镇痛效果的组合物 Download PDFInfo
- Publication number
- CN101524344B CN101524344B CN2009101281302A CN200910128130A CN101524344B CN 101524344 B CN101524344 B CN 101524344B CN 2009101281302 A CN2009101281302 A CN 2009101281302A CN 200910128130 A CN200910128130 A CN 200910128130A CN 101524344 B CN101524344 B CN 101524344B
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- CN
- China
- Prior art keywords
- potassium
- composition
- skin
- amine
- weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- 239000000203 mixture Substances 0.000 title claims abstract description 65
- 206010033474 Pain of skin Diseases 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract description 27
- 230000000202 analgesic effect Effects 0.000 claims abstract description 23
- 150000001412 amines Chemical class 0.000 claims abstract description 20
- 230000001953 sensory effect Effects 0.000 claims abstract description 16
- 150000003839 salts Chemical class 0.000 claims abstract description 10
- 125000006577 C1-C6 hydroxyalkyl group Chemical group 0.000 claims abstract description 4
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 4
- 239000001257 hydrogen Substances 0.000 claims abstract description 4
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims abstract description 4
- 239000002981 blocking agent Substances 0.000 claims abstract 4
- NSOXQYCFHDMMGV-UHFFFAOYSA-N Tetrakis(2-hydroxypropyl)ethylenediamine Chemical compound CC(O)CN(CC(C)O)CCN(CC(C)O)CC(C)O NSOXQYCFHDMMGV-UHFFFAOYSA-N 0.000 claims description 38
- 229910001414 potassium ion Inorganic materials 0.000 claims description 23
- PHZLMBHDXVLRIX-UHFFFAOYSA-M potassium lactate Chemical compound [K+].CC(O)C([O-])=O PHZLMBHDXVLRIX-UHFFFAOYSA-M 0.000 claims description 21
- 239000001521 potassium lactate Substances 0.000 claims description 21
- 235000011085 potassium lactate Nutrition 0.000 claims description 21
- 229960001304 potassium lactate Drugs 0.000 claims description 21
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims description 14
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical group [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 claims description 12
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 claims description 8
- 239000001103 potassium chloride Substances 0.000 claims description 7
- 235000011164 potassium chloride Nutrition 0.000 claims description 7
- 230000005764 inhibitory process Effects 0.000 claims description 6
- NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Chemical compound [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 claims description 6
- -1 potassium fluorosilicate Chemical compound 0.000 claims description 5
- IOLCXVTUBQKXJR-UHFFFAOYSA-M potassium bromide Chemical compound [K+].[Br-] IOLCXVTUBQKXJR-UHFFFAOYSA-M 0.000 claims description 4
- 229910000027 potassium carbonate Inorganic materials 0.000 claims description 4
- KMUONIBRACKNSN-UHFFFAOYSA-N potassium dichromate Chemical compound [K+].[K+].[O-][Cr](=O)(=O)O[Cr]([O-])(=O)=O KMUONIBRACKNSN-UHFFFAOYSA-N 0.000 claims description 4
- FGIUAXJPYTZDNR-UHFFFAOYSA-N potassium nitrate Chemical compound [K+].[O-][N+]([O-])=O FGIUAXJPYTZDNR-UHFFFAOYSA-N 0.000 claims description 4
- VKJKEPKFPUWCAS-UHFFFAOYSA-M potassium chlorate Chemical compound [K+].[O-]Cl(=O)=O VKJKEPKFPUWCAS-UHFFFAOYSA-M 0.000 claims description 2
- NNFCIKHAZHQZJG-UHFFFAOYSA-N potassium cyanide Chemical compound [K+].N#[C-] NNFCIKHAZHQZJG-UHFFFAOYSA-N 0.000 claims description 2
- 235000007715 potassium iodide Nutrition 0.000 claims description 2
- 235000010333 potassium nitrate Nutrition 0.000 claims description 2
- 239000004323 potassium nitrate Substances 0.000 claims description 2
- OTYBMLCTZGSZBG-UHFFFAOYSA-L potassium sulfate Chemical compound [K+].[K+].[O-]S([O-])(=O)=O OTYBMLCTZGSZBG-UHFFFAOYSA-L 0.000 claims description 2
- 229910052939 potassium sulfate Inorganic materials 0.000 claims description 2
- 235000011151 potassium sulphates Nutrition 0.000 claims description 2
- RYCLIXPGLDDLTM-UHFFFAOYSA-J tetrapotassium;phosphonato phosphate Chemical compound [K+].[K+].[K+].[K+].[O-]P([O-])(=O)OP([O-])([O-])=O RYCLIXPGLDDLTM-UHFFFAOYSA-J 0.000 claims description 2
- QLOKJRIVRGCVIM-UHFFFAOYSA-N 1-[(4-methylsulfanylphenyl)methyl]piperazine Chemical compound C1=CC(SC)=CC=C1CN1CCNCC1 QLOKJRIVRGCVIM-UHFFFAOYSA-N 0.000 claims 1
- ZKDNBOAOTQCXLM-UHFFFAOYSA-N 2,3-dihydroxybutanedioic acid;potassium;sodium Chemical compound [Na].[K].OC(=O)C(O)C(O)C(O)=O ZKDNBOAOTQCXLM-UHFFFAOYSA-N 0.000 claims 1
- 238000005299 abrasion Methods 0.000 claims 1
- XUIXOJXQJNMJGQ-UHFFFAOYSA-N n-propan-2-yl-n',n'-bis[2-(propan-2-ylamino)ethyl]ethane-1,2-diamine Chemical compound CC(C)NCCN(CCNC(C)C)CCNC(C)C XUIXOJXQJNMJGQ-UHFFFAOYSA-N 0.000 claims 1
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- 230000036407 pain Effects 0.000 abstract description 20
- 208000024891 symptom Diseases 0.000 abstract description 12
- 230000007803 itching Effects 0.000 abstract 1
- NPYPAHLBTDXSSS-UHFFFAOYSA-N Potassium ion Chemical compound [K+] NPYPAHLBTDXSSS-UHFFFAOYSA-N 0.000 description 22
- 239000002537 cosmetic Substances 0.000 description 19
- 238000002360 preparation method Methods 0.000 description 16
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- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 8
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- 231100000765 toxin Toxicity 0.000 description 8
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- 206010061218 Inflammation Diseases 0.000 description 6
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- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 6
- 239000007787 solid Substances 0.000 description 6
- ZFMITUMMTDLWHR-UHFFFAOYSA-N Minoxidil Chemical compound NC1=[N+]([O-])C(N)=CC(N2CCCCC2)=N1 ZFMITUMMTDLWHR-UHFFFAOYSA-N 0.000 description 5
- 201000008937 atopic dermatitis Diseases 0.000 description 5
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- 238000000034 method Methods 0.000 description 5
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- IVVNZDGDKPTYHK-JTQLQIEISA-N 1-cyano-2-[(2s)-3,3-dimethylbutan-2-yl]-3-pyridin-4-ylguanidine Chemical compound CC(C)(C)[C@H](C)N=C(NC#N)NC1=CC=NC=C1 IVVNZDGDKPTYHK-JTQLQIEISA-N 0.000 description 4
- 206010012438 Dermatitis atopic Diseases 0.000 description 4
- YKPUWZUDDOIDPM-SOFGYWHQSA-N capsaicin Chemical compound COC1=CC(CNC(=O)CCCC\C=C\C(C)C)=CC=C1O YKPUWZUDDOIDPM-SOFGYWHQSA-N 0.000 description 4
- 230000002757 inflammatory effect Effects 0.000 description 4
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- 229960002310 pinacidil Drugs 0.000 description 4
- SCVFZCLFOSHCOH-UHFFFAOYSA-M potassium acetate Chemical compound [K+].CC([O-])=O SCVFZCLFOSHCOH-UHFFFAOYSA-M 0.000 description 4
- OSCJHTSDLYVCQC-UHFFFAOYSA-N 2-ethylhexyl 4-[[4-[4-(tert-butylcarbamoyl)anilino]-6-[4-(2-ethylhexoxycarbonyl)anilino]-1,3,5-triazin-2-yl]amino]benzoate Chemical compound C1=CC(C(=O)OCC(CC)CCCC)=CC=C1NC1=NC(NC=2C=CC(=CC=2)C(=O)NC(C)(C)C)=NC(NC=2C=CC(=CC=2)C(=O)OCC(CC)CCCC)=N1 OSCJHTSDLYVCQC-UHFFFAOYSA-N 0.000 description 3
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 3
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 description 3
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 3
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- 230000036592 analgesia Effects 0.000 description 3
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/132—Amines having two or more amino groups, e.g. spermidine, putrescine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cosmetics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/043,373 US20090227683A1 (en) | 2008-03-06 | 2008-03-06 | Compositions for Providing an Analgesic Effect to the Skin |
| US12/043,373 | 2008-03-06 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101524344A CN101524344A (zh) | 2009-09-09 |
| CN101524344B true CN101524344B (zh) | 2012-09-12 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009101281302A Expired - Fee Related CN101524344B (zh) | 2008-03-06 | 2009-03-05 | 为皮肤提供镇痛效果的组合物 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20090227683A1 (https=) |
| EP (1) | EP2135622B1 (https=) |
| JP (1) | JP2009227672A (https=) |
| CN (1) | CN101524344B (https=) |
| AU (1) | AU2009200827A1 (https=) |
| BR (1) | BRPI0900482A2 (https=) |
| CA (1) | CA2657074A1 (https=) |
| RU (1) | RU2009107974A (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110274776A1 (en) | 2010-05-07 | 2011-11-10 | Michael Anthonavage | Compositions comprising extracts of southernwood and an amine compound |
| KR101413185B1 (ko) | 2012-06-07 | 2014-06-27 | 경상대학교산학협력단 | 염 혼합물의 가축 및 가금류 설사병 치료용 용도 |
| US9522168B2 (en) | 2014-05-29 | 2016-12-20 | Johnson & Johnson Consumer Inc. | Topical compositions comprising Acmella oleracea extracts and uses thereof |
| JP7840953B2 (ja) | 2020-12-02 | 2026-04-06 | ユニリーバー・アイピー・ホールディングス・ベスローテン・ヴェンノーツハップ | 局所消毒組成物 |
| WO2023213198A1 (zh) * | 2022-05-04 | 2023-11-09 | 华东师范大学 | 芳香稠环化合物作为trek-1激活剂的用途、包含其的药物组合物、镇痛剂 |
| WO2026052310A1 (en) | 2024-09-06 | 2026-03-12 | Unilever Ip Holdings B.V. | Cosmetic composition |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1111128A (zh) * | 1994-01-14 | 1995-11-08 | 布里斯托尔-米尔斯·斯奎布公司 | 含吡氧噻嗪的皮肤表面抗炎组合物 |
| US20060193815A1 (en) * | 2005-02-25 | 2006-08-31 | Michael Southall | Compositions containing amines and use thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2697118A (en) * | 1953-07-28 | 1954-12-14 | Wyandotte Chemicals Corp | Totally hydroxypropylated alkylene diamines |
| MXPA00002509A (es) * | 1999-03-12 | 2014-04-30 | Pfizer | Composiciones que comprenden un ingrediente activo a base de una sal de potasio, incluyendo composiciones orales para reducir la sensibilidad del nervio dental y, la dentina que comprende un aromatizante distinto del mentol.. |
-
2008
- 2008-03-06 US US12/043,373 patent/US20090227683A1/en not_active Abandoned
-
2009
- 2009-03-03 AU AU2009200827A patent/AU2009200827A1/en not_active Abandoned
- 2009-03-05 CA CA002657074A patent/CA2657074A1/en not_active Abandoned
- 2009-03-05 JP JP2009051579A patent/JP2009227672A/ja not_active Abandoned
- 2009-03-05 RU RU2009107974/15A patent/RU2009107974A/ru not_active Application Discontinuation
- 2009-03-05 CN CN2009101281302A patent/CN101524344B/zh not_active Expired - Fee Related
- 2009-03-05 EP EP09250632A patent/EP2135622B1/en not_active Not-in-force
- 2009-03-06 BR BRPI0900482-3A patent/BRPI0900482A2/pt not_active IP Right Cessation
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1111128A (zh) * | 1994-01-14 | 1995-11-08 | 布里斯托尔-米尔斯·斯奎布公司 | 含吡氧噻嗪的皮肤表面抗炎组合物 |
| US20060193815A1 (en) * | 2005-02-25 | 2006-08-31 | Michael Southall | Compositions containing amines and use thereof |
Non-Patent Citations (6)
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| A randomized, placebo-controlled trial of 5% and 2% topical minoxidil solutions in the treatment of female pattern hair loss;Lucky A W et al;《J AM ACAD DERMATOL》;20040430;第50卷(第4期);参见第541-553页 * |
| channel openers in mice.《Journal of Dermatological Science》.2004,第35卷(第1期),参见第71-73页. * |
| Evaluation of antipruritic effects of several agents on scratching behavior by NC/Nga mice;N.Takano et al;《European Journal of Pharmacology》;20040714;第495卷(第2-3期);参见第159-165页 * |
| LuckyAWetal.Arandomized placebo-controlled trial of 5% and 2% topical minoxidil solutions in the treatment of female pattern hair loss.《J AM ACAD DERMATOL》.2004 |
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Also Published As
| Publication number | Publication date |
|---|---|
| JP2009227672A (ja) | 2009-10-08 |
| RU2009107974A (ru) | 2010-09-10 |
| EP2135622A3 (en) | 2010-06-09 |
| AU2009200827A1 (en) | 2009-09-24 |
| CA2657074A1 (en) | 2009-09-06 |
| US20090227683A1 (en) | 2009-09-10 |
| CN101524344A (zh) | 2009-09-09 |
| EP2135622B1 (en) | 2012-05-02 |
| EP2135622A2 (en) | 2009-12-23 |
| BRPI0900482A2 (pt) | 2009-11-03 |
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