CN101518241B - Tebuconazole water dispersible granule and preparation method thereof - Google Patents
Tebuconazole water dispersible granule and preparation method thereof Download PDFInfo
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- CN101518241B CN101518241B CN2008101011351A CN200810101135A CN101518241B CN 101518241 B CN101518241 B CN 101518241B CN 2008101011351 A CN2008101011351 A CN 2008101011351A CN 200810101135 A CN200810101135 A CN 200810101135A CN 101518241 B CN101518241 B CN 101518241B
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Abstract
The invention discloses a tebuconazole water dispersible granule and a preparation method thereof. The weight percentages of components in the formula of the tebuconazole water dispersible granule areThe invention discloses a tebuconazole water dispersible granule and a preparation method thereof. The weight percentages of components in the formula of the tebuconazole water dispersible granule areas follows: 45 percent to 80 percent of tebuconazole, 1 percent to 30 percent of disintegrating agent, 3 percent to 15 percent of dispersing agent, 3 percent to 5 percent of wetting agent, 0.1 percen as follows: 45 percent to 80 percent of tebuconazole, 1 percent to 30 percent of disintegrating agent, 3 percent to 15 percent of dispersing agent, 3 percent to 5 percent of wetting agent, 0.1 percent to 2 percent of binder, 0.1 percent to 0.5 percent of stabilizing agent and the balance of carrier. The preparation method comprises the steps: the components in the formula of the tebuconazole watet to 2 percent of binder, 0.1 percent to 0.5 percent of stabilizing agent and the balance of carrier. The preparation method comprises the steps: the components in the formula of the tebuconazole water dispersible granule are evenly mixed and pulverized into precursor powder by a super-micro air flow pulverizer; a certain proportion of deionized water is added into and evenly mixed with the precurr dispersible granule are evenly mixed and pulverized into precursor powder by a super-micro air flow pulverizer; a certain proportion of deionized water is added into and evenly mixed with the precursor powder; and then, the obtained mixture is granulized, dried and screened in sequence to obtain the tebuconazole water dispersible granule. The tebuconazole water dispersible granule overcomes defesor powder; and then, the obtained mixture is granulized, dried and screened in sequence to obtain the tebuconazole water dispersible granule. The tebuconazole water dispersible granule overcomes defects of wettable powder and reduces the use costs of farmers and environmental pollution during the processing and using processes thereof. As auxiliary agents with different components are added, thects of wettable powder and reduces the use costs of farmers and environmental pollution during the processing and using processes thereof. As auxiliary agents with different components are added, thetebuconazole water dispersible granule has the advantages of high active-compound content, high disintegration speed, good dispersibility, stable thermal storage, high sterilization efficiency, high stebuconazole water dispersible granule has the advantages of high active-compound content, high disintegration speed, good dispersibility, stable thermal storage, high sterilization efficiency, high safety in use, and the like.afety in use, and the like.
Description
Technical field
The present invention relates to a kind of agriculture chemicals fungicide, specifically relate to a kind of tebuconazole water dispersible granule and preparation method thereof, its product is mainly used in control plant epiphyte venereal disease evil.
Background technology
Agricultural chemicals is traditional to account for 80% like missible oil, pulvis and wetting powder etc. in China's preparation total amount, along with the development of processing formulation, the shortcoming of conventional dosage forms is apparent more outstanding.Contain organic solvents such as a large amount of xylol, toluene in the missible oil, not only environment has been caused than severe contamination, and the petrochemical industry resource has been caused waste.Wetting powder often occurs dust from flying because its granularity is very thin in production and use, not only endanger people's health, also can cause environmental pollution, and low amounts of dust is flown upward and is easy to make crops to produce poisoning.Pulvis subject matter is the dust drift, and volume is big, is difficult for metering, existing arid area and some particular places of only being used for.Water dispersible granules has effectively been avoided the weak point of these conventional dosage forms, draws and has utilized its advantage, and apparent specific gravity (gd) is big, and good fluidity is not stained with packing material, is easy to metering, storing and transporting security, and physical and chemical performance is stable, and toxicity is low, and auxiliary agent content is high, and suspensibility is high, good drug efficacy.The environmental protection formulation has liquid and solid pharmaceutical preparation advantage concurrently, and combination property is perfect comprehensively, and its development is very rapid, is considered to 21 century pesticide processing field and has one of formulation of development prospect most.
The Tebuconazole chemical name is (RS)-1-(4-chlorphenyl)-4,4-dimethyl-3-(1H-1,2; 4 triazol-1-yl methyl) penta-3-alcohol; Belonging to triazole bactericidal agent, is that sterol takes off basic inhibitor early, is to be used for seed treatment of important economic crops or the efficient germicide that face sprays; Can prevent and treat multiple rust, powdery mildew, net blotch, root rot, the head blight of cereal crop effectively, smut and kind pass zonate spot etc.
The main formulation of the Tebuconazole bactericide product of using on the agricultural chemicals market at present has missible oil and suspending agent, and efficient, low toxicity, environment amenable tebuconazole water dispersible granule are effectively used as yet.
Summary of the invention
The purpose of this invention is to provide a kind of tebuconazole water dispersible granule and preparation method thereof.
Another kind of purpose of the present invention is to overcome the shortcoming of prior art, provide a kind of with Tebuconazole be that the preparation of former medicine is efficient, low toxicity, environment amenable nuisanceless bactericide, and tebuconazole water dispersible granule can be used for preventing and treating plant epiphyte venereal disease evil.
The object of the invention is realized through following technical scheme:
A kind of tebuconazole water dispersible granule, the percentage by weight of each component is in the prescription: Tebuconazole 45～80%, disintegrant 1～30%; Dispersant 3～15%, wetting agent 3～5%; Binding agent 0.1～2%; Stabilizing agent 0.1～0.5%; All the other are carrier.
Described dispersant is selected from: one or more among phenethyl phenol polyethenoxy sodium sulphate, AEO series, NPE, lignosulfonates, NNO, MF, the BX.
Described wetting agent is selected from: one or more among the ABSNa K12.
Described disintegrant is selected from: one or more in bentonite, PEG, modified starch, mineral salt, white carbon black, the silica gel.
Described adhesive is selected from: one or more in Sodium Polyacrylate, PEG, sex change PVA, wooden sodium, dextrin, CMC, the xanthans.
Described stabilizing agent is selected from: one or more in sodium carbonate, sodium bicarbonate, sodium methoxide, sodium tartrate, Sodium Benzoate, sodium bicarbonate, diethylamine, triethylamine, sodium hydroxide, ammoniacal liquor, phosphoric acid, citric acid, the acetic acid.
Described carrier is selected from: one or more in kaolin, fine particle calcium carbonate, potter's clay, white carbon black, the diatomite.
The manufacturing process of said tebuconazole water dispersible granule is:
Formulation material is mixed, be ground into female powder, female powder is mixed adding a certain proportion of deionized water through micro jet, granulation then, drying, screening is after sample analysis, qualified can the packing.
Advantage of the present invention
Compared with prior art, tebuconazole water dispersible granule of the present invention has following advantage:
1. fungicide preparation of the present invention is difficult for producing the key to environment, people and animals and other beneficial organism safety.
2. fungicide preparation of the present invention does not have dust, the particle disintegration rate is fast and do not have bales stained.
3. fungicide preparation of the present invention has good suspension stability, does not have bulky grain after the dispersion, not blocking sprayer.
4. fungicide preparation preparing process of the present invention is simpler, easy to use, is suitable for large scale application.
Specific embodiments
For a better understanding of the present invention, the present invention is described further, but the scope that the present invention requires to protect is not limited to the scope that embodiment representes below in conjunction with embodiment.
Embodiment 1:
Take by weighing Tebuconazole 47.4kg, white carbon black 10kg, phenethyl phenol polyethenoxy sodium sulphate 10kg, ABSNa5kg, wooden sodium 0.2kg, sodium tartrate 0.2kg, kaolin 29.6kg.After mixing, be ground into female powder, female powder is mixed adding a certain proportion of deionized water through micro jet, granulation then, drying, screening is after sample analysis, qualified can the packing.Use 3500 times of liquid of said preparation to carry out field control effectiveness test, the control efficiency of the 8th day and the 15th day behind the sigatoka medicine is respectively 93.7%, 81.5%, the control efficiency of the 8th day and 15 days behind the rice sheath blight disease medicine is respectively 92.5%, 84.5%.
Embodiment 2:
Take by weighing Tebuconazole 84.2kg, white carbon black 5kg, phenethyl phenol polyethenoxy sodium sulphate 8kg, ABSNa 4kg, wooden sodium 0.2kg, sodium tartrate 0.2kg, kaolin 2.6kg.After mixing, be ground into female powder, female powder is mixed adding a certain proportion of deionized water through micro jet, granulation then, drying, screening is after sample analysis, qualified can the packing.Use 2000 times of liquid of said preparation to carry out field control effectiveness test, the control efficiency of the 8th day and the 15th day behind the sigatoka medicine is respectively 95.6%, 84.3%, the control efficiency of the 8th day and 15 days behind the rice sheath blight disease medicine is respectively 93.7%, 81.2%.
The foregoing description shows; Tebuconazole water dispersible granule of the present invention is excellent to sigatoka and rice sheath blight disease effect, and said preparation do not have dust, particle disintegration rate fast, do not have bales stained, to environment, people and animals and other beneficial organism safety;, plant is difficult for producing poisoning.In addition, water-dispersible grain developing agent storage of the present invention and easy to use, product stability is good, can deposit more than 2 years, and its preparation technology is simple, is suitable for large scale application.
Claims (2)
1. a tebuconazole water dispersible granule is characterized in that each content percentage by weight is in the prescription: Tebuconazole 45～80%, disintegrant 1～30%; Dispersant 3～15%, wetting agent 3～5%; Binding agent 0.1～2%; Stabilizing agent 0.1～0.5%; All the other are carrier;
Wherein, described dispersant is a phenethyl phenol polyethenoxy sodium sulphate; Described wetting agent is ABSNa; Described disintegrant is white carbon black; Described adhesive is wooden sodium; Described stabilizing agent is a sodium tartrate; Described carrier is a kaolin.
2. a method for preparing the described tebuconazole water dispersible granule of claim 1 is characterized in that, by weight percentage, and each component in will filling a prescription: Tebuconazole 45～80%, disintegrant 1～30%; Dispersant 3～15%, wetting agent 3～5%; Binding agent 0.1～2%; Stabilizing agent 0.1～0.5%; All the other are carrier, mix, and are ground into female powder through micro jet, female powder is added a certain proportion of deionized water mix, and granulation then, drying makes tebuconazole water dispersible granule after the screening;
Wherein, described dispersant is a phenethyl phenol polyethenoxy sodium sulphate; Described wetting agent is ABSNa; Described disintegrant is white carbon black; Described adhesive is wooden sodium; Described stabilizing agent is a sodium tartrate; Described carrier is a kaolin.
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| CN2008101011351A CN101518241B (en) | 2008-02-28 | 2008-02-28 | Tebuconazole water dispersible granule and preparation method thereof |
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| CN2008101011351A CN101518241B (en) | 2008-02-28 | 2008-02-28 | Tebuconazole water dispersible granule and preparation method thereof |
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| CN101518241A CN101518241A (en) | 2009-09-02 |
| CN101518241B true CN101518241B (en) | 2012-07-25 |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102057902A (en) * | 2010-12-23 | 2011-05-18 | 青岛润生农化有限公司 | Tebuconazole-contained water dispersible granule and preparation method thereof |
| CN102204532B (en) * | 2011-04-04 | 2014-04-16 | 上海禾本药业有限公司 | Tebuconazole water dispersible granule and preparation method thereof |
| CN102919224A (en) * | 2012-11-26 | 2013-02-13 | 上海沪联生物药业（夏邑）股份有限公司 | Water dispersible granules containing tebuconazole and preparation method thereof |
| CN102960355B (en) * | 2012-12-11 | 2015-04-29 | 江苏龙灯化学有限公司 | Improved water dispersive granule |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101015299A (en) * | 2006-11-01 | 2007-08-15 | 张少武 | Water-dispersed granule pesticide composition and making method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101015299A (en) * | 2006-11-01 | 2007-08-15 | 张少武 | Water-dispersed granule pesticide composition and making method thereof |
Non-Patent Citations (3)
| Title |
|---|
| 闫新华等.80%戊唑醇水分散粒剂的研制.《农药》.2004,第43卷(第9期),第404-405页和第408页. * |
| 韩银宝.水分散粒剂在我国的应用.《农药市场信息》.2002,第27和32页. * |
| 马超等.三角坐标图法在农药水分散粒剂配方研制中的应用.《农药学学报》.2006,第8卷(第4期),第379-382页. * |
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