CN105052995B - A kind of complex composition and preparation containing toxic fluoride phosphate and oxazole series bactericidal agent - Google Patents
A kind of complex composition and preparation containing toxic fluoride phosphate and oxazole series bactericidal agent Download PDFInfo
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- CN105052995B CN105052995B CN201510466398.2A CN201510466398A CN105052995B CN 105052995 B CN105052995 B CN 105052995B CN 201510466398 A CN201510466398 A CN 201510466398A CN 105052995 B CN105052995 B CN 105052995B
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Abstract
The present invention provides a kind of complex composition and preparation containing toxic fluoride phosphate and oxazole series bactericidal agent, its disease for being mainly used in preventing and treating various crops.Complex composition of the invention by toxic fluoride phosphate He oxazole series bactericidal agent is constituted, wherein, toxic fluoride phosphate is He the weight ratio of oxazole series bactericidal agent is 60:1 to 1:30.The present invention also provides the pesticidal preparations of the complex composition containing toxic fluoride phosphate and oxazole series bactericidal agent, and wherein complex composition accounts for 0.1% the 80% of the gross weight of the pesticidal preparations.According to demand, the formulation of the pesticidal preparations is the formulations such as wettable powder, water dispersible granules, aqueous emulsion, suspending agent, seed coat agent.The complex composition that the present invention is provided prevents and treats crop disease in certain ratio range has obvious complementation synergistic effect, compared with single dose, expand preventing and treating spectrum; delay drug-fast generation; drug effect is significantly improved, single dose dosage and spraying times are reduced, ecological environment is preferably protected.
Description
Technical field
The present invention relates to technical field of pesticide, more particularly to complex composition and system containing toxic fluoride phosphate and oxazole series bactericidal agent
Agent.
Background technology
With the change of weather and environment, the species survey of plant disease also changes, and single pesticide species are to disease
Harmful prevention effect is undesirable, because disease also gradually strengthens the resistance of single pesticide species, and cannot simultaneously prevent and treat various
Disease.Ru hymexazo, famoxadones, SYP-Z048, Evil frost Ling oxazoles series bactericidal agent are used for a long time, are prevented and treated crop disease and are prevented
Effect declines.Hymexazo, famoxadones, SYP-Z048, Evil frost spirits are known in the art and disclosed pesticide species.
Hymexazo (hymexazo)：CAS 10004-44-1, chemical name is 3- hydroxy-5-methyl base isoxazole , hymexazos
As being a kind of systemic fungicide and soil sterilants, with unique mechanism of action.
Famoxadone (Famoxadone)：CAS 131807-57-3, chemical name is 3- phenylamino -5- methyl -5- (4-
Phenoxyphenyl) -1,3- oxazoline -2,4- diketone, Famoxate is new and effective, broad spectrum pesticide.
The molecular formula of SYP-Z048 is C16H17ClN2O, and chemical name is N- methyl -3- (4- chlorine) phenyl -5- methyl -5-
The oxazoline of pyridine -3- methyl -, is developed by Shenyang Chemical Engineering Inst, and ground leaf can be efficiently controlled not by root application
The generation of disease and harm.Bactericidal activity with wide spectrum, while having protection and therapeutic action and good absorbability.
Evil frosts spirit (oxadixyl anchor) is a kind of bactericide of broad spectrum activity, the plant caused to various disease funguses
Disease has higher prevents and treats result.
Toxic fluoride phosphate is that applicant transfers the possession of the plant virus resistance product (patent No. of new generation for coming by Guizhou University
ZL200510003041.7), it is a kind of novel new Antiphytoviral medicament of fluorine-containing amino phosphonate ester of structure, can be passed through
Activation tobacco bigcatkin willow acid signal conduction path, improves the salicylic content of signaling molecule, so as to promote downstream pathogenesis-related proteins
Expression；Anti-virus ability is obtained by evoking tobacco PAL, POD, SOD Defense Enzyme Activities；Reduced by assembling TMV particles
Invasion of the virus to host.In view of the characteristic such as its structure novelty, mechanism of action uniqueness, toxic fluoride phosphate is for preventing and treating virosis effect
It is prominent, but preventing and treating spectrum is narrow.
Applicant through development test, find toxic fluoride phosphate He oxazole series bactericidal agent mixture prevent and treat multiple diseases have it is more prominent
Prevention effect.The mixture of different pesticide species, is also the common method for preventing and treating agricultural disease at present.Reality can not only be effectively improved
Prevention effect, reduces dosage, and reduces cost can also delay the generation of disease drug resistance, extend the service life of medicament, be disease
The important means of the evil comprehensive regulation.
The content of the invention
The present invention is in view of the shortcomings of the prior art, there is provided a kind of compounded combination containing toxic fluoride phosphate and oxazole series bactericidal agent
Thing and preparation, the complex composition have obvious synergistic effect relative to single dose, can effectively prevent and treat crop disease, reduce agriculture
The dosage of medicine, saves drug cost, delays pathogen to produce and develop the resistance to the action of a drug of toxic fluoride phosphate, is conducive to environmental protection
With the comprehensive regulation of agricultural disease.
To realize above-mentioned purpose, the technical scheme is that：
A kind of complex composition containing toxic fluoride phosphate and oxazole series bactericidal agent, the complex composition is killed by toxic fluoride phosphate and oxazole class
Microbial inoculum is constituted；Wherein, toxic fluoride phosphate is He the weight ratio of oxazole series bactericidal agent is 60：1 to 1：30.
Preferably, on Yi in Suo Shu oxazoles series bactericidal agent Xuan Zi hymexazo, famoxadones, SYP-Z048, Evil frost spirits
Any one.
It is further preferably, above-described toxic in order to ensure that complex composition has preferable preventive effect and synergistic effect
Fluorine Lin is He the weight ratio of oxazole series bactericidal agent is 40:1 to 1:20.
The present invention also provides a kind of pesticidal preparations, and the pesticidal preparations include can on complex composition and agricultural chemicals described above
The auxiliary material of receiving, is then prepared into the pesticidal preparations for preventing and treating agricultural disease.
Above-described pesticidal preparations, preferably, described complex composition accounts for the pesticidal preparations gross weight
0.1%~80%.It is further preferred that described complex composition accounts for the 5%~50% of the pesticidal preparations gross weight.
According to different use demands, the pesticidal preparations that the present invention is provided can be made into various formulations well known in the art.Make
For preferred, in the embodiment that the present invention is provided, the formulation of pesticidal preparations is wettable powder, water dispersible granules, Seed Treatment dry powder
Agent, suspending agent, suspension seed-coating agent, ultra low volume liquids or granule.The formulation of present invention offer is provided.
Acceptable auxiliary material is a kind of mixture with auxiliary agent in filler, solvent on described agricultural chemicals.
Described auxiliary agent includes surfactant, wetting dispersing agent, and antifreezing agent, thickener, stabilization can be also added if necessary
Other conventional functionality auxiliary agents such as agent, defoamer, disintegrant, film forming agent.
Described filler includes white carbon, diatomite, kaolin, precipitated calcium carbonate, soil powder, bentonite, diatomite, corruption
Phytic acid, chitin, urea, ammonium dihydrogen phosphate, middle trace element.
Described solvent includes water, solvent naphtha, cyclohexanone, two wires oil, trimethylbenzene, 1-METHYLPYRROLIDONE, methyl oleate.
Described auxiliary agent includes alkylbenzenesulfonate, lauryl sodium sulfate, dispersing agent MF, lignin
Sulfonate, sodium butylnaphthalenesulfonate, PO-EO block polyethers, REAX-82P, naphthalenesulfonic acid-formaldehyde condensate, DBSA
Calcium, double phenethyl phenol polyethenoxy ethers, Sodium Polyacrylate, phenethyl phenol polyethenoxy ether phosphate, acrylic acid and propionamide are total to
Polymers, AEO, sodium carboxymethylcellulose, condensation compound of alkyl phenol and epoxy ethane, APES,
Negel.
Described disintegrant includes ammonium carbonate, sodium sulphate, ammonium chloride, ammonium sulfate.
Binding agent includes starch, polyvinyl alcohol, ethyl cellulose, sucrose.
Thickener includes xanthans, aluminium-magnesium silicate, pectin, ethyl cellulose.
Antifreezing agent includes propane diols, glycerine, isopropanol, ethylene glycol.
Warning coloration includes pinkish red, acid red.
Pesticidal preparations of the present invention are mainly used in controlling plant diseases.
Complex composition of the present invention can be applied by commonsense method, such as spraying cauline leaf process, it is also possible to root fill apply or
Spread fertilizer over the fields, can also dress seed or seed pelleting is used.
Compared with present technology, complex composition of the invention and pesticidal preparations have the advantages that：
1st, compounded containing toxic fluoride phosphate and oxazole series bactericidal agent, the mechanism of action of two kinds of medicaments is different, and when the two with
When certain weight is than compounding, the co-toxicity coefficient of crop disease is prevented and treated more than 120, show obvious synergistic effect.
2nd, pesticidal preparations of the invention are used for the diseases such as control of plant bacterial wilt, tomato late blight, black streaked dwarf virus of rice
When, preventive effect is higher by more than 20% than the preventive effect of toxic fluoride phosphate single dose Huo oxazole series bactericidal agent single doses, reduces the usage amount of agricultural chemicals, compares single dose
Usage amount reduce 2g/667m2。
3rd, preventive effect is good, and the lasting period is up to 14 days.Oxazole series bactericidal agent and toxic fluoride phosphate compounding are not likely to produce the resistance to the action of a drug, and drug effect is steady
It is fixed, disclosure satisfy that the demand of peasant.
Specific embodiment
The present invention is illustrated with the following example, but is not limited the scope of the invention.Toxic fluoride phosphate used in the present invention
Active compound is provided by Guangxi Tianyuan Biochemical Co., Ltd., and other active compounds for using and preparation are purchased in market.
Preparation prepares embodiment：
The poison Fu Lin hymexazos of embodiment 1 61% wettable powder (60:1)
The , hymexazos 1% of toxic fluoride phosphate 60%, alkylbenzenesulfonate 6%, lauryl sodium sulfate 2%, white carbon 6%, diatom
Soil supplies 100%.By above-mentioned formula rate, each material is mixed into row air-flow crushing, 61% malicious fluorine phosphorus hymexazo is obtained can
Wet powder.
The poison Fu Lin famoxadones of embodiment 2 41% wettable powder (40:1)
The , famoxadones 1% of toxic fluoride phosphate 40%, dispersing agent MF 7%, lauryl sodium sulfate 2%, kaolinite
Soil supplies 100%.By above-mentioned formula rate, each material is carried out into mixed airflow crushing, 41% poison Fu Lin famoxadones are obtained
Wettable powder.
The toxic fluoride phosphate SYP-Z048 wettable powder (30 of embodiment 3 31%:1)
Toxic fluoride phosphate 30%, SYP-Z048 1%, alkylbenzenesulfonate 8%, lignosulfonates 6%, white carbon 10% is high
Ridge soil supplies 100%.By above-mentioned formula rate, each material is carried out into mixed airflow crushing, 31% toxic fluoride phosphate Ding Jun Evil are obtained
Azoles wettable powder.
The poison Fu Lin of embodiment 4 80% Evil frost spirit wettable powders (1:1)
The , Evil of toxic fluoride phosphate 40% frosts spirit 40%, lignosulfonates 5%, lauryl sodium sulfate 2%, precipitated calcium carbonate
2%, white carbon supply 100%.By above-mentioned formula rate, each material is carried out into mixed airflow crushing, 80% toxic fluoride phosphate is obtained
Evil frost spirit wettable powders.
The poison Fu Lin hymexazos of embodiment 5 32.8% water dispersible granules (40:1)
The , hymexazos 0.8% of toxic fluoride phosphate 32%, alkylbenzenesulfonate 5%, di-2-ethylhexylphosphine oxide bitter edible plant sodium sulfonate 3%, ammonium carbonate
10%, starch 2%, kaolin supplies 100%.Above-mentioned raw materials are crushed through airslide disintegrating mill, and are mediated after being uniformly mixed,
Fluidized bed prilling is entered back into, dried, sieved i.e. prepared 32.8% poison Fu Lin hymexazo water dispersible granules.
The poison Fu Lin famoxadones of embodiment 6 49.6% water dispersible granules (1:30)
The , famoxadones 1.6% of toxic fluoride phosphate 48%, naphthalenesulfonic acid-formaldehyde condensate 4%, lauryl sodium sulfate 3%, starch
3%, soil powder supplies 100%.Above-mentioned raw materials are crushed through airslide disintegrating mill, and is mediated after being uniformly mixed, enter back into stream
Granulated in change bed granulating and drying machine, dry, sieve i.e. prepared 49.6% poison Fu Lin famoxadone water dispersible granules.
The toxic fluoride phosphate SYP-Z048 water dispersible granules (1 of embodiment 7 42%:20)
Toxic fluoride phosphate 2%, SYP-Z048 40%, sodium butylnaphthalenesulfonate 5%, PO-EO block polyethers 3%, sodium sulphate 4%, second
Base cellulose 2%, bentonite supplies 100%.Above-mentioned raw materials are crushed through airslide disintegrating mill, and are mediated after being uniformly mixed,
Enter back into and granulated in fluidized-bed granulation dryer, dry, screening is obtained 42% toxic fluoride phosphate SYP-Z048 water-dispersible grain
Agent.
The poison Fu Lin of embodiment 8 41% Evil frost Lingshui Springs dispersible granule (40:1)
The , Evil of toxic fluoride phosphate 40% frost spirit 1%, REAX-82P 4%, naphthalenesulfonic acid-formaldehyde condensate 4%, sodium sulphate 6%, silicon
Diatomaceous earth supplies 100%.Above-mentioned raw materials are crushed through airslide disintegrating mill, and is mediated after being uniformly mixed, entered back into fluid bed and make
Granulated in grain drying machine, dry, sieve and be obtained 41% poison Fu Lin Evil frost Lingshui Spring dispersible granules.
The poison Fu Lin hymexazo Seed Treatments of embodiment 9 12% dry powder doses (1:5)
The , hymexazos 10% of toxic fluoride phosphate 2%, naphthalenesulfonic acid-formaldehyde condensate 4%, calcium dodecyl benzene sulfonate 2.5%, poly- second
Enol 3.2%, pinkish red 1.5%, diatomite 10%, kaolin supplies 100%.Above-mentioned raw materials will be crushed through airslide disintegrating mill,
And be uniformly mixed, 12% poison Fu Lin hymexazo Seed Treatment dry powder doses are obtained.
The poison Fu Lin famoxadone Seed Treatments of embodiment 10 21% dry powder doses (1:20)
The , famoxadones 20% of toxic fluoride phosphate 1%, lignosulfonates 2%, PO-EO block polyethers 2.5%, polyvinyl alcohol
2%, pinkish red 0.5%, bentonite supplies 100%.Above-mentioned raw materials will be crushed through airslide disintegrating mill, and be uniformly mixed, made
Obtain 21% poison Fu Lin famoxadone Seed Treatment dry powder doses.
The toxic fluoride phosphate SYP-Z048 Seed Treatment dry powder doses (60 of embodiment 11 12.2%:1)
Toxic fluoride phosphate 12%, SYP-Z048 0.2%, lauryl sodium sulfate 2%, di-2-ethylhexylphosphine oxide bitter edible plant sodium sulfonate 3%, magnesium silicate
Aluminium 2.5%, acid red 0.5%, kaolin supplies 100%.Above-mentioned raw materials will be crushed through airslide disintegrating mill, and it is equal to stir mixing
It is even, 12.2% toxic fluoride phosphate SYP-Z048 Seed Treatment dry powder doses are obtained.
The poison Fu Lin of embodiment 12 10.2% Evil frost spirit Seed Treatments dry powder doses (50:1)
The , Evil of toxic fluoride phosphate 10% frosts spirit 0.2%, lignosulfonates 1%, di-2-ethylhexylphosphine oxide bitter edible plant sodium sulfonate 3.5%, polyvinyl alcohol
2.5%, acid red 0.5%, bentonite 5%, kaolin supplies 100%.Above-mentioned raw materials will be crushed through airslide disintegrating mill, and stirred
Mix well mixed, 10.2% poison Fu Lin Evil frost spirit Seed Treatment dry powder doses are obtained.
The poison Fu Lin famoxadones of embodiment 13 30.5% suspending agent (60:1)
Toxic fluoride phosphate 30%, famoxadone 0.5%, three phenethyl phenol polyethenoxy ethers 3%, calcium dodecyl benzene sulfonate
1.5%, xanthans 0.2%, propane diols 1.9%, water supplies 100%.By above-mentioned raw materials in ball crusher abrading-ball 2~3 hours, so
After carry out high speed shear to certain particle diameter, that is, 30.5% malicious fluorine phosphorus famoxadone suspending agent is obtained.
The toxic fluoride phosphate SYP-Z048 suspending agent (10 of embodiment 14 11%:1)
Toxic fluoride phosphate 10%, SYP-Z048 1%, double phenethyl phenol polyethenoxy ethers 4%, Sodium Polyacrylate 8%, aluminium-magnesium silicate
1.5%, glycerine 4%, water supplies 100%.By above-mentioned raw materials in ball crusher abrading-ball 2~3 hours, then carry out high speed shear
To certain particle diameter, that is, 11% toxic fluoride phosphate SYP-Z048 suspending agent is obtained.
The poison Fu Lin of embodiment 15 21% Evil frost spirit suspending agents (1:20)
The , Evil of toxic fluoride phosphate 1% frosts spirit 20%, lignosulfonates 3%, di-2-ethylhexylphosphine oxide bitter edible plant sodium sulfonate 4%, pectin 1.5% is different
Propyl alcohol 3%, water supplies 100%.By above-mentioned raw materials in ball crusher abrading-ball 2~3 hours, then carry out high speed shear to certain grain
Footpath, that is, be obtained 21% poison Fu Lin Evil frost spirit suspending agents.
The poison Fu Lin hymexazos of embodiment 16 10% suspension seed-coating agent (1:1)
The , hymexazos 5% of toxic fluoride phosphate 5%, lignosulfonates 3%, phenethyl phenol polyethenoxy ether phosphate 3.5%, second
Base cellulose 2%, ethylene glycol 3%, water supplies 100%.By above-mentioned raw materials in ball crusher abrading-ball 2~3 hours, then carry out height
Speed shearing is coated to certain particle diameter, and 10% poison Fu Lin hymexazo suspension seed-coating agents are obtained.
The poison Fu Lin famoxadones of embodiment 17 11% suspension seed-coating agent (10:1)
The , famoxadones 1% of toxic fluoride phosphate 10%, acrylic acid and propionamide copolymer 2.5%, AEO 3%,
Sodium carboxymethylcellulose 2%, ethylene glycol 3%, water supplies 100%.By above-mentioned raw materials in ball crusher abrading-ball 2~3 hours, then
High speed shear to certain particle diameter is carried out, is coated, 11% poison Fu Lin famoxadone suspension seed-coating agents are obtained.
The toxic fluoride phosphate SYP-Z048 suspension seed-coating agent (1 of embodiment 18 18%:5)
Toxic fluoride phosphate 3%, SYP-Z048 15%, calcium dodecyl benzene sulfonate 2%, condensation compound of alkyl phenol and epoxy ethane 4%,
Ethyl cellulose 2%, glycerine 4%, water supplies 100%.By above-mentioned raw materials in ball crusher abrading-ball 2~3 hours, then carry out
High speed shear is coated to certain particle diameter, and 18% toxic fluoride phosphate SYP-Z048 suspension seed-coating agent is obtained.
The poison Fu Lin famoxadones of embodiment 19 6% ultra low volume liquids (5:1)
The , famoxadones 1% of toxic fluoride phosphate 5%, solvent naphtha 5%, cyclohexanone 20%, APES 6%, dodecane
Base benzene sulfonic acid calcium 2.3%, two wires oil supplies 100%.By above-mentioned raw materials in the mixing kettle after be uniformly mixed after, be obtained 6%
Malicious Fu Lin famoxadone ultra low volume liquids.
The toxic fluoride phosphate SYP-Z048 ultra low volume liquids (1 of embodiment 20 11%:10)
Toxic fluoride phosphate 1%, SYP-Z048 10%, trimethylbenzene 10%, 1-METHYLPYRROLIDONE 10%, AEO
4%, APES 3.5%, methyl oleate supplies 100%.By above-mentioned raw materials, rear stirring mixing is equal in mixing kettle
After even, 11% toxic fluoride phosphate SYP-Z048 ultra low volume liquids are obtained.
The poison Fu Lin of embodiment 21 5.5% hymexazol granules (1:10)
The , hymexazos 5% of toxic fluoride phosphate 0.5%, naphthalenesulfonate formaldehyde condensation compound 2%, lauryl sodium sulfate 1.5%, ethyl
Cellulose 3%, ammonium chloride 5%, humic acid 10%, diatomite supplies 100%.Said components are well mixed, are crushed, add water profit
Stirred after wet, then granulated with screw extruder pelletizer, sieving obtains final product 5.5% poison Fu Lin hymexazo particles after drying
Agent.
The poison Fu Lin famoxadones of embodiment 22 0.5% granule (1:1)
The , famoxadones 0.25% of toxic fluoride phosphate 0.25%, lignosulfonates 2%, sodium butylnaphthalenesulfonate 2%, polyvinyl alcohol
2%, ammonium sulfate 8%, chitin 5%, urea supplies 100%.Said components are well mixed, are crushed, after the wetting that adds water fully
Stir, then granulated with screw extruder pelletizer, sieving obtains final product 0.5% poison Fu Lin famoxadone granules after drying.
The toxic fluoride phosphate SYP-Z048 granule (1 of embodiment 23 0.1%:1)
Toxic fluoride phosphate 0.05%, SYP-Z048 0.05%, Negel 1.5%, naphthalenesulfonate formaldehyde condensation compound 2%,
Polyvinyl alcohol 3%, ammonium sulfate 8%, urea supplies 100%.Said components are well mixed, are crushed, fully stirred after the wetting that adds water
Mix uniform, then granulated with screw extruder pelletizer, sieving obtains final product 0.1% toxic fluoride phosphate SYP-Z048 granule after drying.
The poison Fu Lin of embodiment 24 1.2% Evil frost spirit granules (1:5)
The , Evil of toxic fluoride phosphate 0.2% frosts spirit 1%, Negel 4%, PO-EO block polyethers 1%, sucrose 4%, phosphoric acid
Ammonium dihydrogen 10%, middle micro- 5%, urea supplies 100%.Said components are well mixed, are crushed, after the wetting that adds water fully
Stir, then granulated with screw extruder pelletizer, sieving obtains final product 1.2% poison Fu Lin Evil frost spirit granules after drying.
Toxicity Determination embodiment：
Following indoor biometricses experiment calculates co-toxicity coefficient (CTC) to evaluate mixed effect using the abundant methods of Sun Yun.
Toxicity index TI (B)=(EC of standard agent A50The EC of ÷ B agent50)×100
Actual toxicity index ATI (AB)=(EC of A50The EC of ÷ AB50)×100
Percentage+TI (B) × B percentages in mixture of theoretical toxicity index TTI (AB)=TI (the A) × A in mixture
Number
Actual measurement toxicity index (ATI)=(standard agent EC50÷ reagent agents EC50)×100
Percentage composition+B the medicament toxicity index of A in theoretical toxicity index (TTI)=A medicament toxicity index × mixture × mixed
The percentage composition of B in agent
Co-toxicity coefficient (CTC)=[mixture surveys toxicity index (ATI) ÷ mixtures theoretical toxicity index (TTI)] × 100
Evaluation criterion is：Co-toxicity coefficient >=120 show as synergistic effect；Co-toxicity coefficient≤80 show as antagonism；80<
Co-toxicity coefficient<120 show as summation action.
Toxicity Determination embodiment one
The strains tested that will be stored on test tube slant is transferred on PDA plate, and 3d is cultivated in 28 DEG C of constant incubators, is used
The card punch of diameter 5mm cuts bacterium colony outer rim and is prepared into bacteria cake, standby.
Mycelial growth rate assay method：By toxic fluoride phosphate He 2 kinds of bactericide of hymexazo are respectively prepared the PDA trainings of required concentration
Base flat board is supported, it is control to set not adding medicine, and each concentration is repeated 4 times.Aseptically, bacteria cake is placed in pastille culture medium
Center, is subsequently placed in after cultivating 72h in 28 DEG C of incubators, growth of the observation strains tested under each bactericide different quality concentration
Situation, colony diameter is determined with crossing method, and bacterium colony size is represented with average, calculates relative inhibition.It is soft using Excel
Part is analyzed, and calculates the EC of each medicament50, and co-toxicity coefficient is calculated according to the abundant methods of Sun Yun.Measurement result see the table below 1
The Toxicity Determination result of the control of plant bacterial wilt of table 1
From the result of the test of table 1, toxic fluoride phosphate Yu hymexazos are 60 by weight:1 to 1:Preventing and treating is compounded in the range of 30
The co-toxicity coefficient of bacterial wilt of tomato shows that both are compounded with obvious synergistic function more than 120.Wherein, weight
Than being 40:1~1:In the range of 20, the co-toxicity coefficient of each treatment more than 150, synergy highly significant.
Toxicity Determination embodiment two
Using mycelial growth rate method.After culture medium is melted, be cooled to 45 DEG C or so, be made into respectively content of dispersion for 1,
10th, 100,1000 μ g/ml containing culture medium, poured into after shaking up in the sterilising medium ware of a diameter of 9cm, per ware 10ml.With straight
It is central that footpath is that being beaten for examination strain of will activate of 5mm card punch takes bacteria cake access pastille culture medium flat board, is placed in 28 DEG C of constant temperature and trains
In foster case.After culture 5d, mycelia is just covered with control culture dish, colony diameter is measured with crossing method, calculate Hyphal form
To inhibiting rate.Relative inhibition (%)=(control bacterium colony average diameter-treatment bacterium colony average diameter)/control bacterium colony average diameter
×100.Often treatment is repeated 4 times, and the result for replacing pesticide-treated as control, gained with sterilized water uses Excel software analysis, meter
Calculate the EC of each medicament50, and co-toxicity coefficient is calculated according to the abundant methods of Sun Yun.Measurement result see the table below 2
Table 2 prevents and treats the Toxicity Determination result of tomato late blight
As seen from the data in Table 2, toxic fluoride phosphate Yu famoxadones are 60 by weight:1 to 1:Preventing and treating kind is compounded in the range of 30
The co-toxicity coefficient of eggplant blight shows that both are compounded with synergistic function more than 120.Wherein, toxic fluoride phosphate Yu oxazoles
Bacterium ketone is 40 by weight:1~1:In the range of 20, the co-toxicity coefficient of each treatment more than 150, synergy highly significant.
Table 3 prevents and treats the Toxicity Determination result of tomato late blight
As seen from the data in Table 3, toxic fluoride phosphate Yu Evil frosts spirit is 60 by weight:1 to 1:Preventing and treating tomato is compounded in the range of 30
The co-toxicity coefficient of late blight shows that both are compounded with obvious synergistic function more than 120.Wherein, when weight ratio
It is 40:1~1:In the range of 20, the co-toxicity coefficient of each treatment more than 140, synergy highly significant.
Toxicity Determination embodiment three
Test method：Plant hopper is fed with diseased plant, makes plant hopper band poison, after testing the malicious rate about 35% of band.Potted plant healthy rice strain, uses
In connecing worm.
When rice shoot 1 heart~2 1 heart of leaf to 1 leaf long, inoculated identification is carried out.Per alms bowl cover with translucent cover, the sealing of top gauze,
The worm amount that needs is calculated by 5 small brown rice planthoppers of every seedling, 2~3 age small brown rice planthoppers (the malicious rate about 35% of band) are accessed.Daily expelling parasite 2 times, makes tested rice
Seedling is uniformly by poison.After 48h, the medicament that will prepare various concentrations is uniformly sprayed on for examination seedling, often processes 4 repetitions, everywhere
The seedling of reason grows morbidity under the conditions of natural lighting.Experiment sets the treatment without medicament as blank.Deng blank hair
During disease 50% or so, classification investigation incidence calculates inhibiting rate, uses EC50Value is pressed the abundant methods of Sun Yun and calculates co-toxicity coefficient, determines knot
Fruit is shown in Table 4：
Table 4 prevents and treats the Toxicity Determination result of black streaked dwarf virus of rice
Table 5 prevents and treats the Toxicity Determination result of black streaked dwarf virus of rice
From table 4-5 data, toxic fluoride phosphate is respectively 60 with SYP-Z048, hymexazos by weight:1 to 1:30 scope
The interior co-toxicity coefficient for preventing and treating black streaked dwarf virus of rice that compounds shows that both are compounded with obvious Synergistic more than 120
Effect.Wherein, when weight ratio is 40:1~1:In the range of 20, more than 140, synergy shows the co-toxicity coefficient of each treatment very much
Write.
Crop field test examples
In order to clear and definite toxic fluoride phosphate is various Yu oxazole series bactericidal agent such as hymexazo, famoxadones, SYP-Z048, Evil frost spirit compounding
The prevention effect of crop disease, and compounding use whether synergy and synergy whether substantially, present invention applicant is different at home
Area has carried out substantial amounts of field test.Illustrated with several field embodiments below.Wettable powder is wettable powder.
Comparison medicament 1：30% toxic fluoride phosphate wettable powder, registration card number LS20130359, Guangxi rural area biochemistry share has
Limit company produces.
Comparison medicament 2：70% hymexazo wettable powder, registration card number PD20110451, Shaanxi nation of U.S. limited public affairs of agricultural chemicals
Department；
Comparison medicament 3：30% famoxadone wettable powder, self-control；
Comparison medicament 4：25% SYP-Z048 missible oil, registration card number PD20080774, Shenyang Sciencreat Chemicals Co., Ltd..
Comparison medicament 5：15% Evil frost spirit wettable powders, self-control.
Field test embodiment one：
Test method：According to《The part of NY/T 1464.32-2010 pesticide field efficacy medicine tests criterion the 32nd：Bactericide is prevented
Control bacterial wilt of tomato》, begin to carry out first time pouring root dispenser when seeing diseased plant, it is spaced second dispenser in 7 days.Before dispenser and second medicine
Investigate whole plant respectively per cell within 7 days afterwards, 14 days, record total strain number and diseased plant number, calculate 7 days, 14 days diseases after second medicine
Strain rate and preventive effect, the results are shown in Table 6：
The field test results of the control of plant bacterial wilt of table 6
From result of the test table 6, in the case where usage amount is less, pesticidal preparations control of plant bacterial wilt of the invention
When, preventive effect (the active ingredient dosage 12g/667m of 7d after second medicine2) respectively than single dose toxic fluoride phosphate (active ingredient dosage
15g/667m2) Ji hymexazos (active ingredient dosage 30g/667m2) preventive effect 24.17-34.91%, 35.00- high
45.75%；And the preventive effect up to more than 84% is remained in 14d, the lasting period is long.
Field test embodiment two：
Test method：According to《GB/T 17980.31-2000 pesticide field efficacy medicine tests criterion (one) bactericidal agent for preventing and treating kind
Eggplant early blight and late blight》.First time spray pesticide is carried out when occurring at the beginning of disease, second dispenser in 7 days is spaced.Before dispenser and
7 days after second medicine, carry out within 14 days classification investigation respectively, calculate 7 days after second medicine, 14 days disease indexs and preventive effect, as a result
It is shown in Table 7：
Table 7 prevents and treats the field test results of tomato late blight
From result of the test table 7, in the case where usage amount is less, pesticidal preparations of the invention prevent and treat Phytophthora infestans
Disease, preventive effect (the active ingredient dosage 4g/667m of 7d after second medicine2) respectively than single dose toxic fluoride phosphate (active ingredient dosage
18g/667m2) Ji famoxadones (active ingredient dosage 6g/667m2) preventive effect 38.06%-41.90%, 20.99%- high
24.83%；And the preventive effect up to more than 85% is remained in 14d, the lasting period is long.
Also known by result of the test table 7, in the case that usage amount is less, pesticidal preparations of the invention prevent and treat Phytophthora infestans
Disease, preventive effect (the active ingredient dosage 4g/667m of 7d after second medicine2) respectively than single dose toxic fluoride phosphate (active ingredient dosage
18g/667m2) Ji Evil frost spirits (active ingredient dosage 10g/667m2) preventive effect 39.14%-41.07%, 32.70%- high
34.63%；And the preventive effect up to more than 87% is remained in 14d, the lasting period is long.
Field test embodiment three：
Test method and computational methods：With reference to agricultural technology extension service centre of tourist resources " southern water in 2011
Rice black streak dwarf remedies Chemicals experiment " test method perform, the is carried out when southern rice black-streaked dwarf disease aobvious disease
Spray pesticide, dispenser three times altogether, every mu of water consumption is 60kg later medication every 7 days once.Respectively after third time medicine
Investigated with paddy rice full heading time within 10 days, recorded total strain number and aobvious disease strain number, calculated the incidence of disease and preventive effect, the results are shown in Table 8：
Table 8 prevents and treats the field test results of black streaked dwarf virus of rice
From result of the test table 8, in the case where usage amount is less than single dose, toxic fluoride phosphate and SYP-Z048 compounding prevent harnessing the river
Rice black streak dwarf, prevention effect (the active ingredient dosage 10g/667m of 10d after medicine2) (more effective than single dose toxic fluoride phosphate respectively
Composition dosage 12g/667m2) and SYP-Z048 (active ingredient dosage 30g/667m2) preventive effect 21.43%- high
22.32%th, 34.81%-35.70%；And the preventive effect up to more than 84% is remained in 14d, the lasting period is long.
Claims (8)
1. a kind of complex composition containing toxic fluoride phosphate and oxazole series bactericidal agent, it is characterised in that the complex composition is by malicious fluorine
Lin is He oxazole series bactericidal agent is constituted；Wherein, toxic fluoride phosphate is He the weight ratio of oxazole series bactericidal agent is 60:1 to 1:30；
Suo Shu oxazole series bactericidal agent Wei hymexazo, famoxadones, SYP-Z048, Evil frost spirit in any one.
2. the complex composition containing toxic fluoride phosphate and oxazole series bactericidal agent according to claim 1, it is characterised in that the poison
Fluorine Lin is He the weight ratio of oxazole series bactericidal agent is 40:1 to 1:20.
3. a kind of pesticidal preparations, it is characterised in that the pesticidal preparations include the compounded combination described in any one of claim 1 ~ 2
Acceptable auxiliary material on thing and agricultural chemicals, is then prepared into the pesticidal preparations for preventing and treating agricultural disease.
4. pesticidal preparations according to claim 3, it is characterised in that the complex composition accounts for the pesticidal preparations gross weight
The 0.1% ~ 80% of amount.
5. pesticidal preparations according to claim 4, it is characterised in that the complex composition accounts for the pesticidal preparations gross weight
The 5% ~ 50% of amount.
6. pesticidal preparations according to claim 3, it is characterised in that the formulation of the pesticidal preparations be wettable powder,
Water dispersible granules, Seed Treatment dry powder doses, suspending agent, suspension seed-coating agent, ultra low volume liquids, granule.
7. pesticidal preparations according to claim 3, it is characterised in that acceptable auxiliary material is filler, molten on the agricultural chemicals
A kind of mixture of the and auxiliary agent in agent.
8. the application of the pesticidal preparations as described in claim 3-7 is any, it is characterised in that the pesticidal preparations are used to prevent and treat plants
Thing disease.
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| CN106982844B (en) * | 2017-05-13 | 2018-09-14 | 南京高正农用化工有限公司 | A kind of agricultural bactericidal composition of Bao Han famoxadones and hymexazol |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1687088A (en) * | 2005-04-04 | 2005-10-26 | 贵州大学 | N-substituted benzothiazolyl-1-substituted phenyl-0,0-dialkyl-alpha-amino phosphonate ester derivatives preparation and application |
| CN102715187A (en) * | 2012-06-27 | 2012-10-10 | 广西田园生化股份有限公司 | Sterilization composition containing Dufulin and strobilurins |
| CN102726444A (en) * | 2012-06-27 | 2012-10-17 | 广西田园生化股份有限公司 | Sterilization composition containing Dufulin |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1687088A (en) * | 2005-04-04 | 2005-10-26 | 贵州大学 | N-substituted benzothiazolyl-1-substituted phenyl-0,0-dialkyl-alpha-amino phosphonate ester derivatives preparation and application |
| CN102715187A (en) * | 2012-06-27 | 2012-10-10 | 广西田园生化股份有限公司 | Sterilization composition containing Dufulin and strobilurins |
| CN102726444A (en) * | 2012-06-27 | 2012-10-17 | 广西田园生化股份有限公司 | Sterilization composition containing Dufulin |
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