CN101507829A - Sanitary moisture paper tissue capable of cleaning vaginal and preparation method thereof - Google Patents
Sanitary moisture paper tissue capable of cleaning vaginal and preparation method thereof Download PDFInfo
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- CN101507829A CN101507829A CNA2009100107667A CN200910010766A CN101507829A CN 101507829 A CN101507829 A CN 101507829A CN A2009100107667 A CNA2009100107667 A CN A2009100107667A CN 200910010766 A CN200910010766 A CN 200910010766A CN 101507829 A CN101507829 A CN 101507829A
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- cleaning
- pudendum
- sanitary
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- disinfection sanitizer
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- YKRGDOXKVOZESV-UHFFFAOYSA-N paeoniflorin Natural products O1C(C)(C2(CC34)OC5C(C(O)C(O)C(CO)O5)O)CC3(O)OC1C24COC(=O)C1=CC=CC=C1 YKRGDOXKVOZESV-UHFFFAOYSA-N 0.000 description 3
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- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
- FRXSZNDVFUDTIR-UHFFFAOYSA-N 6-methoxy-1,2,3,4-tetrahydroquinoline Chemical compound N1CCCC2=CC(OC)=CC=C21 FRXSZNDVFUDTIR-UHFFFAOYSA-N 0.000 description 1
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- Agricultural Chemicals And Associated Chemicals (AREA)
- Absorbent Articles And Supports Therefor (AREA)
Abstract
The invention provides a pudendum-cleaning sanitary wet tissue, which comprises a pudendum-cleaning germicidal disinfectant and a spun-laced non-woven fabric. The pudendum-cleaning germicidal disinfectant comprises the following composition in percentage by weight: 0.149 to 0.15 percent of hydrochloride polyhexamethylene guanide, 0.199 to 0.2 percent of glycerol, 0.099 to 0.1 percent of peony extract, 0.029 to 0.03 percent of rosemary essential oil, and the balance being purified water. The spun-laced non-woven fabric is cut into a slice or a sanitary napkin, and the spun-laced non-woven fabric slice or the sanitary napkin is sprayed with a prepared pudendum-cleaning germicidal disinfectant aqueous solution and then is packed as the pudendum-cleaning sanitary wet tissue under aseptic conditions by use of PVC membrane. The pudendum-cleaning sanitary wet tissue has the advantages that the wet tissue is strong in sterilizing capability, fast to act, good in stability, free from irritating skin, applicable to men and women for cleaning pudendum, hermetic in package, easy to carry and convenient to use, does not need additional avoidance place, and can achieve the aim of cleaning pudendum only by using the wet tissue to wipe pudendum in a toilet.
Description
Technical field
The present invention relates to the daily life wet sanitary napkins, the sanitary moisture paper tissue capable of cleaning vaginal that particularly relates to a kind of clean cloudy disinfection sanitizer and make with it.
Background technology
Unavoidable contact antibacterial, fungus and viral micro-organisms in people's the routine work.When skin injury or Abwehrkraft des Koepers were low, pathogenic microorganism then can be taken advantage of a weak point, and causes part or systemic infection disease.At present at each types of populations market of men and women, old and young multiple different sterilizing preparation and wet tissue have appearred, to skin, the antibacterial of mucosal sites, fungus, virus is killed certain effect, but to adult men and women urinary system skin, the mucosal infections antibacterial, fungus, the disinfectant preparation of virus precaution treatment and the wet tissue kind of making of disinfectant preparation are seldom, town and country are not popularized, and cause bacillary, mycotic, commonly encountered diseases such as trichomonal vaginitis, frequently-occurring disease, its cause of disease be pudendum unclean due to, so keep the male and female pudendum cleaning extremely important to ensureing urinary system health.There is following problem under the current situation that does not obtain broad-spectrum at the pudendum-cleaning hygienic articles for use: the one, wash clean no sterilizing and itch-relieving treatment preventive effect with clear water.The 2nd, clean with soap and disinfectant, though certain bactericidal action is arranged, life-time service has zest to skin, mucosa, simultaneously family is used the concentration that is difficult to grasp disinfectant.The 3rd, though special-purpose liquid for cleaning private part has no adverse reaction, need certain avoidance place when using, also to have special-purpose sanitary equipment, real is inconvenience.The 4th, pasteurization towelette in the market mostly is before the meal, hand disinfection after an action of the bowels, prevents that mainly illness finds its way in by the mouth, is not suitable for the pudendum cleaning.
Summary of the invention
The technical problem to be solved in the present invention is that development is a kind of to be used for the clean cloudy disinfection sanitizer of pudendum cleaning and to utilize clean cloudy disinfection sanitizer to make sanitary moisture paper tissue capable of cleaning vaginal, and its preparation method is provided.
The technical scheme that adopts is:
Sanitary moisture paper tissue capable of cleaning vaginal comprises clean cloudy disinfection sanitizer and spun-laced nonwoven fabric.The prescription of clean cloudy disinfection sanitizer is:
Polyhaxemethylenguanidine Hydrochloride 0.149-0.15wt%
Glycerol 0.199-0.2wt%
Radix Paeoniae Alba extract 0.099-0.1wt%
Rosemary ethereal oil 0.029-0.03wt%
The pure water surplus
Be hybridly prepared into clean cloudy disinfection sanitizer by above-mentioned component.In actual production, can enlarge at double according to producing needs.
Pharmacology in the above-mentioned component:
Polyhaxemethylenguanidine Hydrochloride (Polyhexamethelenneguanidine Hydrochloride PHMG).PHMG is the wide spectrum disinfectant, characteristics are that sterilizing power is strong, effect fast, good stability, actual nontoxic level .0.3%PHMG effect 2min get final product 100% and kill escherichia coli, staphylococcus aureus, Candida albicans, Hemolytic streptococcus; 0.1%PHMG effect 5min can kill HIV (human immunodeficiency virus); 0.5%PHMG effect 1min can kill HIV (human immunodeficiency virus).The skin irritation test is 0 grade, and is non-stimulated.Acute toxicity test: 1%PHMG LD50 is greater than the nontoxic level in the true border of 5000mg/kgBW.The sterilization mechanism of PHMG: it belongs to polyguanidine family macromolecule polymer, in aqueous solution, can produce ionization, its hydrophilic group partly contains intensive electropositive, absorption is electronegative all kinds of bacterial virus usually, thereby antibacterial, virus breeding have been suppressed, add that the thin film of polymer formation has stopped up the ion channel of this part microorganism, make its rapid death by suffocation, reach best bactericidal effect.Studying data at home and abroad shows that PHMG is the desirable disinfectant of safe and effective kill bacteria, fungus, virus.
Glycerol is humidizer
Radix Paeoniae Alba extract Paronia pall Extract
The source: this product is the dry root from ranunculaceae plant Radix Paeoniae (paeoBia lactiflora Pall), extracts with new and high technology is refining.Its English Paeoniflorin by name;
Molecular formula: C2 3H28011; Molecular weight: 480.45.
Character: there is strong Radix Paeoniae abnormal smells from the patient at pale brown toner end.
Product specification: contain active ingredient paeoniflorin 10%-50% HPLC and detect.
Effect and purposes: paeoniflorin has nourishing blood for regulating menstruation, astringing YIN to stop sweating, suppressing the hyperactive liver analgesic function.Be used for diseases such as dysmenorrhea, amenorrhea, pain in chest and hypochondrium, stomachache, limb pain twin, headache are dizzy, haematemesis.
Rosemary ethereal oil, the essential oil that from natural flower of Herba Rosmarini Officinalis, extracts, its fragrance is suitable, clinical practice cephalocathartic relieving fatigue, diuresis helps gets rid of moisture retention symptom in the female menstrual period, and the menstrual cramps of releiving changes very few through blood flow, for the natural antibacterial agent that skin is itched, can eliminate skin turgor and edema.
Described spun-laced nonwoven fabric cuts into pieces, folds or be made into commercially available sanitary towel shape, with clean cloudy disinfection sanitizer aqueous solution shower water prick nonwoven cloth section of the present invention or sanitary towel, is packaged into sanitary moisture paper tissue capable of cleaning vaginal with the PVC film phonograph seal under aseptic condition then.
The present invention adopts the essence of Polyhaxemethylenguanidine Hydrochloride wide spectrum disinfectant and extracted form natural plant, and sterilizing power is strong, effect is quick, good stability, and is non-stimulated to skin, is applicable to clean cloudy use of men and women.Pudendum-cleaning hygienic towel of the present invention packs, and is easy to carry about with one, and is easy to use, need not the avoidance place, need not individual special-purpose sanitary equipment, only needs a towel to go into the lavatory spy at hands and wipe away the purpose that can reach clean the moon.
The preparation method of sanitary moisture paper tissue capable of cleaning vaginal comprises the steps:
Step 1
Prepare clean cloudy disinfection sanitizer, take by weighing Polyhaxemethylenguanidine Hydrochloride, glycerol, Radix Paeoniae Alba extract, rosemary ethereal oil and pure water by clean cloudy disinfection sanitizer component and be mixed into aqueous solution;
Step 2
To shear, fold and spray clean cloudy disinfection sanitizer absorption as the spun-laced nonwoven fabric of sterilizing agent carrier;
Step 3
The spun-laced nonwoven fabric of the clean cloudy disinfection sanitizer of absorption is packed envelope with the PVC film, and carry out quality inspection;
Step 4
Coding;
Step 5
Intermediate package or pack two kinds of specifications greatly, inspection declaration keeps sample;
Step 6
The inspection declaration warehousing after passing.
Sanitary moisture paper tissue capable of cleaning vaginal detects
Detect through disease prevention and control center, Liaoning Province, it is as follows that it detects conclusion:
1, nertralizer qualification test (support methods)
Test repeats 3 times, and test temperature is 20 ℃ ± 1 ℃.When sanitary moisture paper tissue capable of cleaning vaginal is prototype, contain 3.0g/L lecithin, volume fraction is the 0.03mol/L phosphate buffer of 3.0% Tween 80, effectively in the neutralization solution and thalline remained on surface disinfectant to the effect of test organisms, and nertralizer and neutralized reaction product thereof have no adverse effects to test organisms and culture medium.
2, microorganism detection
The microorganism detection of sanitary moisture paper tissue capable of cleaning vaginal meets the regulation of State Standard of the People's Republic of China's " disposable use hygienic article sanitary standard " GB 15979-2002.
3, Candida albicans bactericidal assay (support methods).
According to State Standard of the People's Republic of China's " disposable use hygienic article sanitary standard " GB15979-2002, test temperature is 20 ℃ ± 1 ℃, and test repeats 3 times.Sanitary moisture paper tissue capable of cleaning vaginal is a prototype, and be 2min action time, is 98.80% to the oidiomycetic average bactericidal rate of white.Bactericidal action is arranged.
4, staphylococcus aureus bactericidal assay (support methods)
According to State Standard of the People's Republic of China's " disposable use hygienic article sanitary standard " GB 15979-2002, test temperature is 20 ℃ ± 1 ℃, and test repeats 3 times.Sanitary moisture paper tissue capable of cleaning vaginal is a prototype, and be 2min action time, is 100% to the average bactericidal rate of staphylococcus aureus.Bactericidal action is arranged.
5, stability test (bactericidal property, support methods)
According to State Standard of the People's Republic of China's " disposable use hygienic article sanitary standard " GB15979-2002, test temperature is 20 ℃ ± 1 ℃, and test repeats 3 times.Deposit back (accelerated test: 54 ℃ ± 1 ℃ of laying temperature, relative humidity 75% ± 1%, 14 days standing times), sanitary moisture paper tissue capable of cleaning vaginal is a prototype, and be 2min action time, is 98.60% to the oidiomycetic average bactericidal rate of white.Bactericidal action is arranged.
Sanitary hydrojet for cleaning vagina is tested skin irritation
Use large ear rabbit as animal subject during test, its method:
24h removes the hair of rabbit back both sides skin before the test, and the unhairing scope is 3 * 3cm
2, the left side is contrast (blank), the right is the trial zone, gets next day to be tried thing and be cut into 2.5 * 2.5cm
2Size contains the about 0.5ml of wet tissue liquid and directly sticks on trial zone skin, covers with two-layer gauze and the non-stimulated plastic foil of one deck then, and reuse nonirritant adhesive plaster is fixed, sealing 4h.Check that in 1h, the 24h, the 48h that remove after being tried thing the rabbit skin reacts, and the record result, the second portion sterile products inspection technology standard invading the exterior 2-11 that presses " disinfection technology standard " (2002) carries out skin irritation reaction scoring.
Result of the test shows:
The rabbit skin is no abnormal in test, and skin irritation reaction top average (stimulation index) is 0, and the result shows that being tried thing belongs to nonirritant to rabbit skin irritant test.
The specific embodiment
Raw material
The spun-laced nonwoven fabric that adopts Dalian auspicious smooth nonwoven fabric Group Co.,Ltd to produce;
The Polyhaxemethylenguanidine Hydrochloride that adopts the big gram of Qingdao gram biochemical technology company limited to produce;
The Radix Paeoniae extracting solution that adopts Shanghai Xiang Hui bio tech ltd to produce;
Adopt the rosemary ethereal oil of the rich trade Co., Ltd of Guangzhou Australia supply;
Production equipment
The Lufeng board RF series wet tissue manufacturing machine and the automated packaging equipment that adopt Ru Fong machinery (Zhengzhou) Co., Ltd. to produce, collection automatic cutting folding, quantitatively humidification, automatically counting, automatically the perforate decals, be packaged as the automatic production line of one automatically, solved in the wet tissue production process because of manually contacting a difficult problem that causes the product bad hidden danger.
Embodiment one
1, the clean cloudy disinfection sanitizer of preparation 10000g
Take by weighing:
Polyhaxemethylenguanidine Hydrochloride 15g
Glycerol 20g
Radix Paeoniae Alba extract 10g
Rosemary ethereal oil 3g
Pure water 9952g
Said medicine and pure water are hybridly prepared into clean cloudy disinfectant aqueous solution.
2, spun-laced nonwoven fabric is cut into lamellar, folding and spray clean cloudy disinfection sanitizer and fully adsorb.
3, the spun-laced nonwoven fabric that will adsorb clean cloudy disinfection sanitizer is packed envelope with the PVC film, and carries out quality inspection, and quality inspection comprises sense organ requirement, physical and chemical index, microbiological indicator, bactericidal effect, stabilizing effect and sanitary toxicology.
Sense organ requires to meet table 1 regulation
The requirement of table 1 sense organ
| Project | Requirement |
| Color and luster | Colourless |
| Abnormal smells from the patient | Tasteless |
| Character | Liquid |
| Impurity | Visible impurity of no naked eyes and foreign body |
Physical and chemical index should meet table 2 regulation
Table 2 physical and chemical index
| Project | Index |
| Active substance content | 0.146—0.15％ |
| PH value | 5.5-6.5 |
Microbiological indicator should meet table 3 regulation
Table 3 microbiological indicator
| Detect index | Standard value | Measured value |
| The antibacterial Seedling sum (cfu/ml) that falls | ≤20 | 0 |
| The fungus qualitative detection | Must not detect | Do not detect |
| Coliform | Must not detect | Do not detect |
| Candida albicans | Must not detect | Do not detect |
| Bacillus pyocyaneus | Must not detect | Do not detect |
| Hemolytic streptococcus | Must not detect | Do not detect |
Bactericidal effect should meet table 4 regulation
Table 4 bactericidal effect
| Project | Time | Sterilizing rate |
| Candida albicans | 2min | 98.8% sterilization |
| Staphylococcus aureus | 2min | 100% sterilization |
Stabilizing effect should meet table 5 regulation
Table 5 stabilizing effect
| Project | Time | Sterilizing rate |
| Candida albicans | 2min | 98.6% sterilization |
Sanitary toxicology should meet table 5 regulation
Table 6 sanitary toxicology
| Project | Stimulation index | Index |
| A skin irritation test | 0 | Non-stimulated |
4, coding
5, packing, packing can be divided fractional pack, intermediate package, big packing, and 1 or 10 PVC are packed for fractional pack; Intermediate package is cover box, every box-packed 50 bags of finished products; Big packing places big carton with intermediate package, should meet the corrugated case standard.The bag label has name of product, factory's name, factory site, lot number, net content, date of manufacture, shelf-life and has description.It is a collection of to produce having a daily output of of ad eundem, Packing Sound product with same materials, therefrom randomly draws 24 bags and stays and do sample survey.
6, warehouse-in, finished product warehouse-in is stored, and must not contact or near goods moist, that be corrosive or be easy to become damp, must not put together with deleterious chemicals and harmful substance.
Embodiment two
The clean cloudy disinfection sanitizer of preparation 10000ml
Take by weighing:
Polyhaxemethylenguanidine Hydrochloride 15g
Glycerol 20g
Radix Paeoniae Alba extract 10g
Rosemary ethereal oil 3g
Place mixer, add pure water to 10000ml, be mixed with hydrochloric polyhexamethylene guanidine 0.149wt%, glycerol 0.199wt%, the clean cloudy disinfection sanitizer aqueous solution of Radix Paeoniae Alba extract 0.099wt%, rosemary ethereal oil 0.029wt%, clean cloudy disinfection solution with preparation sprays in the sanitary towel that spun-laced nonwoven fabric is made, and aseptic sealed packages becomes product.
Preparation method is identical with embodiment one.
Claims (2)
1, sanitary moisture paper tissue capable of cleaning vaginal comprises clean cloudy disinfection sanitizer and spun-laced nonwoven fabric, it is characterized in that the prescription of described clean cloudy disinfection sanitizer is:
Polyhaxemethylenguanidine Hydrochloride 0.149-0.15wt%
Glycerol 0.199-0.2wt%
Radix Paeoniae Alba extract 0.099-0.1wt%
Rosemary ethereal oil 0.029-0.03wt%
The pure water surplus
Be hybridly prepared into clean cloudy disinfection sanitizer aqueous solution by above-mentioned component; Described spun-laced nonwoven fabric cuts into pieces, folds or be made into commercially available sanitary towel shape, with clean cloudy disinfection sanitizer aqueous solution shower water prick nonwoven cloth section of the present invention or sanitary towel, is packaged into sanitary moisture paper tissue capable of cleaning vaginal with the PVC film phonograph seal under aseptic condition then.
2, the preparation method of sanitary moisture paper tissue capable of cleaning vaginal according to claim 1, its feature comprises the steps:
Step 1
Prepare clean cloudy disinfection sanitizer, take by weighing Polyhaxemethylenguanidine Hydrochloride, glycerol, Radix Paeoniae Alba extract, rosemary ethereal oil and pure water by clean cloudy disinfection sanitizer component and be mixed into aqueous solution;
Step 2
To shear, fold and spray clean cloudy disinfection sanitizer absorption as the spun-laced nonwoven fabric of sterilizing agent carrier;
Step 3
The spun-laced nonwoven fabric of the clean cloudy disinfection sanitizer of absorption is packed envelope with the PVC film, the sampling quality inspection.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2009100107667A CN101507829A (en) | 2009-03-20 | 2009-03-20 | Sanitary moisture paper tissue capable of cleaning vaginal and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2009100107667A CN101507829A (en) | 2009-03-20 | 2009-03-20 | Sanitary moisture paper tissue capable of cleaning vaginal and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101507829A true CN101507829A (en) | 2009-08-19 |
Family
ID=41000464
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2009100107667A Pending CN101507829A (en) | 2009-03-20 | 2009-03-20 | Sanitary moisture paper tissue capable of cleaning vaginal and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101507829A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104288087A (en) * | 2014-09-30 | 2015-01-21 | 江苏奇力康皮肤药业有限公司 | Vagina-cleaning wet wipe and preparation method thereof |
-
2009
- 2009-03-20 CN CNA2009100107667A patent/CN101507829A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104288087A (en) * | 2014-09-30 | 2015-01-21 | 江苏奇力康皮肤药业有限公司 | Vagina-cleaning wet wipe and preparation method thereof |
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Application publication date: 20090819 |