CN101502566A - Chinese medicament preparation for preventing and treating fowl respiratory disease and preparation method thereof - Google Patents
Chinese medicament preparation for preventing and treating fowl respiratory disease and preparation method thereof Download PDFInfo
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- CN101502566A CN101502566A CNA2008101543989A CN200810154398A CN101502566A CN 101502566 A CN101502566 A CN 101502566A CN A2008101543989 A CNA2008101543989 A CN A2008101543989A CN 200810154398 A CN200810154398 A CN 200810154398A CN 101502566 A CN101502566 A CN 101502566A
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Abstract
The invention relates to a traditional Chinese medicine preparation for preventing and treating respiratory tract diseases of poultry and a preparation method thereof. The traditional Chinese medicine preparation consists of honeysuckle flower, weeping forsythiae capsule, ephedra herb, cassia twig, gypsum and liquoric root, the formula is reasonable and has no toxic side effects, raw materials are easy to obtain, and the cost is low, thereby having the advantages of wide range of applications, high bioavailability and good therapeutic effect.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition for the treatment of poultry respiratory tract diseases and preparation method thereof.
Background technology
The respiratory tract disease of poultry often shows as and sheds tears, flows nose liquid, cough, ataxia, breathing rale, hole swelling under visible the facial area swelling, particularly socket of the eye when serious.Mainly show as airsacculitis, perihepatitis and pericarditis on the pathology, if mix coli-infection, situation may be more serious.Poultry respiratory tract diseases is mainly caused by Frustrate blood and mycoplasma, escherichia coli, haemophilus paragallinarum, infectious bronchitis virus, laryngotracheitis virus, Avian pneumo-encephalitis virus, bird flu virus, avian pneumovirus etc.The indirect cause of disease comprises environmental factors (air quality of temperature, hen house and humidity), stress (vaccination, commentaries on classics group, stocking density, hydropenia etc.), nutrition (as malnutrition, vitamin A deficiency) etc., all can bring out or promote the generation and the development of poultry respiratory tract diseases.Except above factor, some mycotoxins that can cause that the immunosuppressant disease comprises that the mycotoxin too high levels causes in Marek, infectious bursal disease, the infection of the anemia factor, reovirus infection, avian leukosis, reticuloendotheliosis disease and the feedstuff are poisoned and can be reduced the immunity of chicken, promote the generation of respiratory tract disease.
The respiratory tract disease of poultry all has generation throughout the year, is more common in the season that the Winter-Spring weather is cold and variation is more violent especially.This disease causes that chicken group's death increases, growth slows down, the price of deed descends and the discarded rate of the trunk course of processing raises, and the expenditure of a large amount of medicines, vaccine and labour cost etc., bring quite serious loss to poultry husbandry.Document announcement is arranged, and the respiratory tract disease of poultry can cause that growth of meat chicken speed significantly reduces, and feedstuff-meat ratio obviously improves; The laying rate of laying hen and kind chicken reduces, abnormal-shape egg increases, the hatching of breeding eggs rate reduces, strong young rate descends.Respiratory tract disease taking place easily in the growth of meat chicken process, or when immune respiratory tract live-virus vaccine, be very easy to serious vaccine reaction takes place, causes the increase and the production loss of medicine expense.Because Frustrate blood and mycoplasma and colibacillary mixed infection, cause around serious airsacculitis, the pericarditis regulating liver-QI inflammation etc., cause significantly improving of mortality rate and mortality.According to statistics, after the kind chicken infected Frustrate blood and mycoplasma, feed conversion rate reduced 10-20%, death rate rising 10-20%; Open and produce that age in days postponed for 2 weeks, 5-10% falls in peak phase laying rate; The laying rate decline 10-20% of laying hen; Weak young increase by 10%, the body weight reduction by 38% of broiler, the marketing time that the hatching of breeding eggs rate reduces 5-10%, chickling prolongs, the treatment cost rises.
The respiratory tract disease cause of disease complexity of poultry easily causes the secondary infection of multiple disease, and at present, the medicine of treatment poultry respiratory tract diseases though obtained certain curative effect, does not have effect to the disease that virus causes based on the Western medicine of antibacterial action.In recent years, the Chinese medicine that is used for the treatment of respiratory tract disease of report also has a lot, as Flos Lonicerae, Fructus Forsythiae, Radix Bupleuri or the like and some compound preparations.No matter be Western medicine or Chinese medicine, administering mode is by injection, drinking-water administration mostly.Injecting drug use, medication bother, lose time, stress be greatly, the growth, pulmonary's absorbance that influence animal are less than 20% and easily produce drug resistance; And the drinking-water administration, the easy but curative effect of medication not as drug administration by injection, pulmonary's absorbance less than 10%, dosage is big, cost is high.
Summary of the invention
The objective of the invention is to be to provide a kind of instant effect, the medicine of treatment poultry respiratory tract diseases easy to use.
The objective of the invention is to realize in the following way: a kind of spray for the treatment of respiratory tract disease, its component thing and percentage by weight are: 1～10 part of Flos Lonicerae, 2～8 parts of Fructus Forsythiaes, 2～5 parts in Herba Ephedrae, 2～4 parts of Ramulus Cinnamomi, 1～6 part in Gypsum Fibrosum, 1～3 part in Radix Glycyrrhizae.Flos Lonicerae, Fructus Forsythiae are principal agent in the side, have fragrance and evacuate, the effect of loose lung meridian pathogenic heat, heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation; Herba Ephedrae is dispelled at the wind and cold of table, and depressed lung-energy dispersing opens and closes strongly fragrant lung qi, and the Ramulus Cinnamomi expelling pathogenic factors from muscles is delivered, promoting the flow of QI-blood by warming the meridian, and saturating battalion reaches and defends, and the two is ministerial drug altogether; Gypsum Fibrosum rushes down the hot and suffocating adjuvant drug that is clearly; Radix Glycyrrhizae is for making, and all medicine mediation compatibilities, combined effect make prescription have heat-clearing and toxic substances removing, anti-inflammation, hot cool relieving the exterior syndrome, the effect of clearing lung, relieving asthma.
The preparation method of spray: earlier Chinese medicine composition is taken by weighing by formula ratio, added 10 times of water logging bubbles 12 hours, decoct twice, decocted 1 hour for the first time, decocted 45 minutes for the second time, after twice medicinal liquid merges filtration, adding ethanol (95%) makes the alcohol amount of containing reach 65% (volume ratio), behind the mixing, 4 ℃ leave standstill centrifugal concentrate after 12 hours, and then add ethanol (95%) and make and contain the alcohol amount and reach 80% (volume ratio), after 4 ℃ of mixings leave standstill 12 hours, use filter paper filtering, filtrate adds distilled water diluting after being concentrated into alcohol volatilization totally, filtering with microporous membrane with 0.45 μ m, be concentrated into relative density 1.10～1.15 (60 ℃), add proper auxiliary materials, fill promptly.
Beneficial effect of the present invention and advantage:
1, compositions of the present invention is a pure Chinese medicinal preparation, and reasonable recipe has no side effect, raw material be easy to get and cost low.
2, this product indication is wide, and various respiratory tract diseases such as infectious bronchitis, infectious laryngotracheitis, infective rhinitis, chronic respiratory tract disease are all had preventive and therapeutic effect.
3, with the spray pattern administration, drug absorption is fast, can be directly to reach site of action, and drug effect occurs rapidly.Oral administration, most need being absorbed through gastrointestinal mucosa with diffusion way of medicine enters blood circulation, is distributed to corresponding site with blood flow and plays a role.This not only needs a process, and medicine is subject to the influence of interior plurality of enzymes of gastrointestinal tract and acid-base value.Medicine is also incomplete in little intestinal absorption in addition, and not only drug effect is slow, even reduces drug effect.Intramuscular administration is comparatively fast wasted time and energy though absorb, and can cause the human damage body sometimes.In addition, it is not enough to arrive the respiratory mucosa dose by blood, affects the treatment.Inhalation can make medicine directly arrive lung, air bag and play a role, and can avoid medicine to the gastrointestinal pessimal stimulation, avoids the metabolic degradation effect to medicine of liver, gastrointestinal tract.Big owing to alveolar area in addition, and abundant blood capillary is arranged, so medicine is absorbed rapidly, some drug bioavailability is near 100%, and the bioavailability of oral administration has only 20%.
4, medicine directly contacts with pulmonary, can promote the synthetic of lung surface active substance, strengthens fibre swing, increases the removing ability of mucociliary transportation system, prevents repeated infection.Medicine directly acts on mucous membrane surface, can repair the mucosa system rapidly, promotes immunity of organisms, prevents repeated infection.
5, have the unexistent air bag of mammal in the respiratory system of chicken, can increase the gas exchange of pulmonary ventilation volume and enhancing lung.Simultaneously, the lung of chicken is expanded and is shunk unlike the mammal lung, but gas is through the lung operation and with lung interior conduit turnover air bag.This respiratory system construction features can enlarge the drug diffusion area, increases drug absorption.In addition, inhalation can make medicine directly in large quantities attached to balloon surface, thoroughly kills the pathogen on the air bag.
6, time saving and energy saving, it is certain, even that medicine sucks, and therapeutic effect is good.Inhalation can alleviate spice, drinks water or catch the labor intensity of chicken, reduces chicken group's stress.For the chicken that can not search for food or drink water, can make medicine arrive positions such as trachea, bronchus rapidly through respiratory tract, suppress effectively or kill pathogenic organisms, play therapeutical effect.
7, other medicine is with the form ejection of aerosol, make it to be dispersed into microgranule, allow poultry by the respiratory tract suction and in respiratory tract performance local action, or medicine is absorbed through alveolar enter blood and bring into play the whole body therapeutic effect, so systemic infection that causes for escherichia coli etc. and septicemia etc. also have good therapeutical effect.
8, detect according to laboratory in addition and clinical example shows that spray delivery is very high at the tissue concentration of pulmonary, but the tissue concentration of liver and kidney but than oral, injection is much lower, when spray delivery is described to the injury minimum of kidney and liver; For the chicken group of disease later stage liver and kidney major injury, spray delivery also is to select preferably.
The specific embodiment
Following examples are in order to embodiment preferred of the present invention to be described, to it will be appreciated by those skilled in the art that following description shall not be applied to restriction protection scope of the present invention.
Embodiment 1
1. prescription is formed: 9 parts of Flos Loniceraes (90g), 7 parts of Fructus Forsythiaes (70g), 3 parts in Herba Ephedrae (30g), 2 parts of Ramulus Cinnamomi (20g), 2 parts in Gypsum Fibrosum (20g), 1.5 parts in Radix Glycyrrhizae (15g).
2. preparation method: earlier Chinese medicine composition is taken by weighing by formula ratio, added 1000ml water logging bubble 12 hours, decoct twice, decocted 1 hour for the first time, decocted 45 minutes for the second time, after twice medicinal liquid merges filtration, adding ethanol (95%) makes the alcohol amount of containing reach 65% (volume ratio), behind the mixing, 4 ℃ leave standstill centrifugal concentrate after 12 hours, and then add ethanol (95%) and make and contain the alcohol amount and reach 80% (volume ratio), after 4 ℃ of mixings leave standstill 12 hours, use filter paper filtering, filtrate adds distilled water diluting after being concentrated into alcohol volatilization totally, filtering with microporous membrane with 0.45 μ m, be concentrated into relative density 1.10～1.15 (60 ℃), after the cooling, fill promptly.
Embodiment 2
1. prescription is formed: 8 parts of Flos Loniceraes (80g), 8 parts of Fructus Forsythiaes (80g), 3 parts in Herba Ephedrae (30g), 3 parts of Ramulus Cinnamomi (30g), 5 parts in Gypsum Fibrosum (50g), 2 parts in Radix Glycyrrhizae (20g).
2. preparation method: earlier Chinese medicine composition is taken by weighing by formula ratio, added 1000ml water logging bubble 12 hours, decoct twice, decocted 1 hour for the first time, decocted 45 minutes for the second time, after twice medicinal liquid merges filtration, adding ethanol (95%) makes the alcohol amount of containing reach 65% (volume ratio), behind the mixing, 4 ℃ leave standstill centrifugal concentrate after 12 hours, and then add ethanol (95%) and make and contain the alcohol amount and reach 80% (volume ratio), after 4 ℃ of mixings leave standstill 12 hours, use filter paper filtering, filtrate adds distilled water diluting after being concentrated into alcohol volatilization totally, filtering with microporous membrane with 0.45 μ m, be concentrated into relative density 1.10～1.15 (60 ℃), after the cooling, fill promptly.
Embodiment 3
The clinical efficacy experiment
1.1 material
Embodiment 1 (Chinese medicine spray): Flos Lonicerae 90g, Fructus Forsythiae 70g, Herba Ephedrae 30g, Ramulus Cinnamomi 20g, Gypsum Fibrosum 20g, Radix Glycyrrhizae 15g.
Chinese medicine oral liquid: Flos Lonicerae 90g, Fructus Forsythiae 70g, Herba Ephedrae 30g, Ramulus Cinnamomi 20g, Gypsum Fibrosum 20g, Radix Glycyrrhizae 15g, the method preparation of pressing embodiment 1 is filled in the oral liquid bottle.
Chemicals: erythromycin thiocyanate soluble powder: erythromycin thiocyanate 2,500 ten thousand units, anhydrous glucose adds to 500g, mixing, promptly.
2 methods
Choose the chicken group who suffers from respiratory tract disease and be divided into 3 groups, the 1st group is used the Chinese medicine spray to treat, and the 2nd group is used Chinese medicine oral liquid to treat, and the 3rd group is used chemicals-erythromycin thiocyanate soluble powder to treat.The using method of 3 kinds of medicines sees Table 1.
The using method of 3 kinds of medicines of table 1
3. experimental result
3 kinds of medicines see Table 2. to the therapeutic outcome of respiratory disease of chicken
3 kinds of medicines of table 2 are to the therapeutic outcome of respiratory disease of chicken
As seen from the table, the cure rate of Chinese medicine spray is apparently higher than Chinese medicine oral liquid and erythromycin thiocyanate soluble powder.
Claims (3)
1, a kind of Chinese medicine composition of preventing and treating poultry respiratory tract diseases is made by following parts by weight proportion raw material medicine: 1～10 part of Flos Lonicerae, 2～8 parts of Fructus Forsythiaes, 2～5 parts in Herba Ephedrae, 2～4 parts of Ramulus Cinnamomi, 1～6 part in Gypsum Fibrosum, 1～3 part in Radix Glycyrrhizae.
2,, it is characterized in that compositions made by following parts by weight proportion raw material medicine: 9 parts of Flos Loniceraes, 7 parts of Fructus Forsythiaes, 3 parts in Herba Ephedrae, 2 parts of Ramulus Cinnamomi, 2 parts in Gypsum Fibrosum, 1.5 parts in Radix Glycyrrhizae according to the Chinese medicine composition of the described control poultry respiratory tract diseases of claim 1.
3, a kind of dosage form of being made by the Chinese medicine composition of claim 1 or 2 described control poultry respiratory tract diseases is a spray.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008101543989A CN101502566A (en) | 2008-12-24 | 2008-12-24 | Chinese medicament preparation for preventing and treating fowl respiratory disease and preparation method thereof |
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| CNA2008101543989A CN101502566A (en) | 2008-12-24 | 2008-12-24 | Chinese medicament preparation for preventing and treating fowl respiratory disease and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103070945A (en) * | 2013-02-18 | 2013-05-01 | 李承平 | Ephedra forsythia tablet |
| CN112138045A (en) * | 2020-10-13 | 2020-12-29 | 遵义医科大学附属医院 | Pharmaceutical composition for preventing or treating sepsis, preparation method thereof and traditional Chinese medicine processing equipment |
-
2008
- 2008-12-24 CN CNA2008101543989A patent/CN101502566A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103070945A (en) * | 2013-02-18 | 2013-05-01 | 李承平 | Ephedra forsythia tablet |
| CN112138045A (en) * | 2020-10-13 | 2020-12-29 | 遵义医科大学附属医院 | Pharmaceutical composition for preventing or treating sepsis, preparation method thereof and traditional Chinese medicine processing equipment |
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Open date: 20090812 |