CN101495454A - 新型pde4抑制剂 - Google Patents

新型pde4抑制剂 Download PDF

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Publication number
CN101495454A
CN101495454A CNA2007800286628A CN200780028662A CN101495454A CN 101495454 A CN101495454 A CN 101495454A CN A2007800286628 A CNA2007800286628 A CN A2007800286628A CN 200780028662 A CN200780028662 A CN 200780028662A CN 101495454 A CN101495454 A CN 101495454A
Authority
CN
China
Prior art keywords
compound
disease
chronic
pde4
inflammatory
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2007800286628A
Other languages
English (en)
Chinese (zh)
Inventor
K·衡明
G·考尔
王炳和
S·郑
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of North Carolina at Chapel Hill
Georgia State University Research Foundation Inc
Original Assignee
University of North Carolina at Chapel Hill
Georgia State University Research Foundation Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of North Carolina at Chapel Hill, Georgia State University Research Foundation Inc filed Critical University of North Carolina at Chapel Hill
Publication of CN101495454A publication Critical patent/CN101495454A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/20—Oxygen atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CNA2007800286628A 2006-05-31 2007-05-29 新型pde4抑制剂 Pending CN101495454A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US80975106P 2006-05-31 2006-05-31
US60/809,751 2006-05-31

Publications (1)

Publication Number Publication Date
CN101495454A true CN101495454A (zh) 2009-07-29

Family

ID=38801992

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2007800286628A Pending CN101495454A (zh) 2006-05-31 2007-05-29 新型pde4抑制剂

Country Status (2)

Country Link
CN (1) CN101495454A (fr)
WO (1) WO2007142929A2 (fr)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018028560A1 (fr) * 2016-08-10 2018-02-15 广州华真医药科技有限公司 Application de zl-n-91, inhibiteur de phosphodiestérase 4, dans la préparation de médicaments pour le traitement de la prolifération et les métastases des cellules cancéreuses de la prostate
CN109908139A (zh) * 2018-12-28 2019-06-21 南京市儿童医院 西洛司特在制备用于治疗急性肾损伤相关病症的药物中的用途
CN110003102A (zh) * 2019-05-16 2019-07-12 河南师范大学 (R)-2-(α-氘-α-烷基-α-芳香)氮杂芳基化合物及其制备方法和应用
CN110279686A (zh) * 2019-08-01 2019-09-27 汪海涛 一种磷酸二酯酶4抑制剂在预防及治疗帕金森病中的应用
CN112996492A (zh) * 2018-09-05 2021-06-18 阿姆斯特丹大学 Pde11或pde2抑制剂用于治疗帕金森氏疾病的用途

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2836240B1 (fr) 2012-04-10 2019-03-13 Georgia State University Research Foundation, Inc. Compositions et méthodes de traitement d'une otite moyenne et d'autres états par des inhibiteurs de cyld
EP3443001A4 (fr) 2016-04-11 2020-04-29 Obsidian Therapeutics, Inc. Systèmes de biocircuits régulés
SG11201912010XA (en) 2017-06-12 2020-01-30 Obsidian Therapeutics Inc Pde5 compositions and methods for immunotherapy
WO2018237323A1 (fr) * 2017-06-23 2018-12-27 The Board Of Trustees Of The Leland Stanford Junior University Domaines de déstabilisation de pde5a
EP4028413A1 (fr) 2019-09-10 2022-07-20 Obsidian Therapeutics, Inc. Protéines de fusion de ca2-il15 pour une régulation accordable

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3678485D1 (de) * 1985-04-01 1991-05-08 Ciba Geigy Ag 3-fluorpyridyl-2-oxy-phenoxy-derivate mit herbizider wirkung.

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018028560A1 (fr) * 2016-08-10 2018-02-15 广州华真医药科技有限公司 Application de zl-n-91, inhibiteur de phosphodiestérase 4, dans la préparation de médicaments pour le traitement de la prolifération et les métastases des cellules cancéreuses de la prostate
CN107714686A (zh) * 2016-08-10 2018-02-23 赵子建 磷酸二酯酶4抑制剂ZL‑n‑91在制备治疗前列腺癌增生和转移药物中的应用
CN107714686B (zh) * 2016-08-10 2020-01-14 广州华真医药科技有限公司 磷酸二酯酶4抑制剂ZL-n-91在制备治疗前列腺癌增生和转移药物中的应用
CN112996492A (zh) * 2018-09-05 2021-06-18 阿姆斯特丹大学 Pde11或pde2抑制剂用于治疗帕金森氏疾病的用途
CN109908139A (zh) * 2018-12-28 2019-06-21 南京市儿童医院 西洛司特在制备用于治疗急性肾损伤相关病症的药物中的用途
CN109908139B (zh) * 2018-12-28 2022-02-22 南京市儿童医院 西洛司特在制备用于治疗急性肾损伤相关病症的药物中的用途
CN110003102A (zh) * 2019-05-16 2019-07-12 河南师范大学 (R)-2-(α-氘-α-烷基-α-芳香)氮杂芳基化合物及其制备方法和应用
CN110003102B (zh) * 2019-05-16 2022-03-22 河南师范大学 (R)-2-(α-氘-α-烷基-α-芳香)氮杂芳基化合物及其制备方法和应用
CN110279686A (zh) * 2019-08-01 2019-09-27 汪海涛 一种磷酸二酯酶4抑制剂在预防及治疗帕金森病中的应用

Also Published As

Publication number Publication date
WO2007142929A3 (fr) 2008-04-24
WO2007142929A2 (fr) 2007-12-13

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Open date: 20090729