CN101479291B - B-加碳雄甾烷和b-杂雄甾烷的氨基衍生物 - Google Patents

B-加碳雄甾烷和b-杂雄甾烷的氨基衍生物 Download PDF

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Publication number
CN101479291B
CN101479291B CN2007800235240A CN200780023524A CN101479291B CN 101479291 B CN101479291 B CN 101479291B CN 2007800235240 A CN2007800235240 A CN 2007800235240A CN 200780023524 A CN200780023524 A CN 200780023524A CN 101479291 B CN101479291 B CN 101479291B
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CN
China
Prior art keywords
aza
hydrochloride
dione
aminoethoxyimino
oxa
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN2007800235240A
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English (en)
Chinese (zh)
Other versions
CN101479291A (zh
Inventor
A·塞利
B·摩洛
M·多利
G·卡扎纳
G·毕安祺
M·费兰迪
P·费拉里
M·P·扎帕比纳
L·班菲
G·加卡罗内
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sigma Tau Industrie Farmaceutiche Riunite SpA
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Sigma Tau Industrie Farmaceutiche Riunite SpA
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Publication of CN101479291A publication Critical patent/CN101479291A/zh
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Publication of CN101479291B publication Critical patent/CN101479291B/zh
Expired - Fee Related legal-status Critical Current
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
    • C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/004—Expansion of ring B by one atom, e.g. B homo steroids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
    • C07J73/003—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by oxygen as hetero atom

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
CN2007800235240A 2006-06-23 2007-05-31 B-加碳雄甾烷和b-杂雄甾烷的氨基衍生物 Expired - Fee Related CN101479291B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP06116001 2006-06-23
EP06116001.6 2006-06-23
PCT/EP2007/055366 WO2007147713A1 (en) 2006-06-23 2007-05-31 Amino derivatives of b-homoandrostanes and b-heteroandrostanes

Publications (2)

Publication Number Publication Date
CN101479291A CN101479291A (zh) 2009-07-08
CN101479291B true CN101479291B (zh) 2012-09-19

Family

ID=37603055

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2007800235240A Expired - Fee Related CN101479291B (zh) 2006-06-23 2007-05-31 B-加碳雄甾烷和b-杂雄甾烷的氨基衍生物

Country Status (20)

Country Link
US (1) US8022203B2 (https=)
EP (1) EP2032593B1 (https=)
JP (1) JP4664433B2 (https=)
KR (1) KR101446166B1 (https=)
CN (1) CN101479291B (https=)
AR (1) AR061561A1 (https=)
AT (1) ATE497504T1 (https=)
AU (1) AU2007263117B2 (https=)
BR (1) BRPI0713439A2 (https=)
CA (1) CA2654354C (https=)
CY (1) CY1112012T1 (https=)
DE (1) DE602007012348D1 (https=)
DK (1) DK2032593T3 (https=)
EA (1) EA014333B1 (https=)
ES (1) ES2359544T3 (https=)
MX (1) MX2008016425A (https=)
PL (1) PL2032593T3 (https=)
SI (1) SI2032593T1 (https=)
TW (1) TWI372762B (https=)
WO (1) WO2007147713A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2422603T3 (es) 2007-05-31 2013-09-12 Shionogi & Co Compuestos oxiimino y el uso de estos
JP5450387B2 (ja) * 2008-04-02 2014-03-26 株式会社カネカ （ｓ）−３−（１−シアノ−１，１−ジフェニルメチル）−ピロリジンの製造法
US8518934B2 (en) 2008-06-11 2013-08-27 Shonogi & Co., Ltd. Oxycarbamoyl compounds and the use thereof
HUE027408T2 (en) * 2009-03-23 2016-10-28 Sigma Tau Ind Farmaceuti Proteinuria, 5ß, 14β-androstane derivatives for the treatment of glomerulosclerosis and renal failure
GB201104199D0 (en) 2011-03-11 2011-04-27 Syngenta Participations Ag Plant growth regulator compounds

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3328408A (en) * 1964-01-30 1967-06-27 Smith 6-azaestranes, intermediates and process
EP0825197B1 (en) * 1996-08-19 2000-10-04 Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. New 6-hydroxy and 6-oxo-androstane derivatives active on the cardiovascular system and pharmaceutical compositions containing same

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2806029A (en) * 1956-07-16 1957-09-10 Searle & Co 3-oxygenated 12a-aza-c-homopregnane-12, 20-diones and congeners
US3136584A (en) * 1963-01-25 1964-06-09 Whitlock Associates Inc Bulk material hopper unloader
WO2003015715A2 (en) * 2001-08-20 2003-02-27 Bristol-Myers Squibb Company Tetrahydroquinoline derivatives as antithrombotic agents
US7053076B2 (en) * 2001-08-29 2006-05-30 Xenoport, Inc. Bile-acid derived compounds for enhancing oral absorption and systemic bioavailability of drugs
WO2006002381A1 (en) * 2004-06-24 2006-01-05 Wisconsin Alumni Research Foundation Neoglycorandomization and digitoxin analogs

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3328408A (en) * 1964-01-30 1967-06-27 Smith 6-azaestranes, intermediates and process
EP0825197B1 (en) * 1996-08-19 2000-10-04 Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. New 6-hydroxy and 6-oxo-androstane derivatives active on the cardiovascular system and pharmaceutical compositions containing same

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Raj K.R.等.Drugs Derived from Cannabinoids. 6. Synthesis of Cyclic Analogues of Dimethylheptylpyran.<<Journal of Medicinal Chemistry>>.1976,第19卷(第5期),719-721. *
Sergio De M.等.Structure-Based Design and Synthesis of Novel Potent Na+,K+-ATPase Inhibitors Derived from a 5r,14r-Androstane Scaffold as Positive Inotropic Compounds.<<>.2003,第46卷(第17期),3644-3654. *
Sergio De M.等.Structure-Based Design and Synthesis of Novel Potent Na+,K+-ATPase Inhibitors Derived from a 5r,14r-Androstane Scaffold as Positive Inotropic Compounds.<<Journal of Medicinal Chemistry>>.2003,第46卷(第17期),3644-3654.

Also Published As

Publication number Publication date
KR20090023730A (ko) 2009-03-05
DE602007012348D1 (de) 2011-03-17
ES2359544T3 (es) 2011-05-24
US20090209506A1 (en) 2009-08-20
CN101479291A (zh) 2009-07-08
TW200817427A (en) 2008-04-16
JP2009541410A (ja) 2009-11-26
EA014333B1 (ru) 2010-10-29
WO2007147713A1 (en) 2007-12-27
ATE497504T1 (de) 2011-02-15
AR061561A1 (es) 2008-09-03
HK1134097A1 (en) 2010-04-16
CY1112012T1 (el) 2015-11-04
US8022203B2 (en) 2011-09-20
CA2654354A1 (en) 2007-12-27
AU2007263117A1 (en) 2007-12-27
SI2032593T1 (sl) 2011-05-31
BRPI0713439A2 (pt) 2012-03-06
MX2008016425A (es) 2009-01-21
TWI372762B (en) 2012-09-21
AU2007263117A2 (en) 2009-03-12
DK2032593T3 (da) 2011-05-16
CA2654354C (en) 2014-12-23
EA200970046A1 (ru) 2009-06-30
PL2032593T3 (pl) 2011-05-31
JP4664433B2 (ja) 2011-04-06
EP2032593B1 (en) 2011-02-02
KR101446166B1 (ko) 2014-10-01
EP2032593A1 (en) 2009-03-11
AU2007263117B2 (en) 2012-05-24

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