CN101474356A - 一种治疗脊髓及相关疾病的中药颗粒剂 - Google Patents
一种治疗脊髓及相关疾病的中药颗粒剂 Download PDFInfo
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- CN101474356A CN101474356A CNA2009100210028A CN200910021002A CN101474356A CN 101474356 A CN101474356 A CN 101474356A CN A2009100210028 A CNA2009100210028 A CN A2009100210028A CN 200910021002 A CN200910021002 A CN 200910021002A CN 101474356 A CN101474356 A CN 101474356A
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Abstract
本发明涉及一种治疗脊髓疾病的中成药，尤其是涉及骨髓及相关疾病引起的腰酸腿软，肌肉痿缩疼痛，冷热感迟钝，目眩耳鸣等症的治疗及其制备方法。它是由熟地黄、枸杞子、丹参、巴戟天、山茱萸、牡丹皮、黄芪、紫梢花、马钱子粉、冬虫夏草、当归、川芎、鹿茸、黄精、山药、鸡血藤、人参、牛脊髓(鲜)等十八味中药材组成，全方具有益精填髓，补肾壮阳的作用，在对骨髓及相关疾病引起的腰酸腿软，肌肉痿缩疼痛，冷热感迟钝，目眩耳鸣等症的治疗和预防方面均具有极好的效果，可显著降低此类病症对广大患者身心健康的威胁。
Description
技术领域
本发明涉及一种治疗脊髓疾病的中成药，尤其是涉及一种治疗脊髓及相关疾病的中药颗粒剂及其制备方法。
背景技术
脊髓及相关疾病的病因及发病机制至今尚无统一的认识，其所引起的腰膝酸软、肌肉痿缩疼痛、冷热感迟钝、目眩耳鸣等症状呈慢性、进行性加重，严重危害着人类的健康。其实为一难治性疾病，目前尚无特效治疗，从中医方面寻求有效方药，有重要的现实意义。
发明内容
本发明目的是提供一种疗效好，无毒副作用的治疗脊髓及相关疾病的中药颗粒剂，以克服现有治疗药物的不足。
本发明是这样实现的：先取熟地44～66份、枸杞子44～66份、丹参35～53份、巴戟天44～66份、山茱萸35～53份、牡丹皮26～40份、黄芪35～53份、紫梢花35～53份、当归44～66份、川芎26～44份、黄精44～66份、山药35～53份、鸡血藤35～53份，加水煎煮2～4次，第一次2～4小时，第二次1～3小时，第三次0.5～1.5小时，合并煎液，滤过，滤液浓缩成稠膏，备用。将人参44～66份、鹿茸9～13份、冬虫夏草9～13份粉碎成细粉，与马钱子粉22～33份配研，过筛，备用。将牛脊髓44～66份除去杂质切成碎块，60～100℃以下干燥，粉碎成细粉。将上述稠膏与人参等细粉、牛脊髓细粉混匀，干燥粉碎成细粉，过筛，加入蔗糖粉264～396份，糊精，混匀，制成颗粒，分装成100袋，即得产品。
由于采用了上述技术方案，本发明与现有治疗由脊髓及相关疾病引起的腰酸腿软，肌肉痿缩疼痛，冷热感迟钝，目眩耳鸣等症的药物相比，本发明采用地道中药材为原料，组方合理，疗效确切且无毒副作用。
本发明配方中熟地为生地黄的加工炮制品，含梓醇(Catalpol)等。可滋阴补血，益精填髓。用于肝肾阴虚，腰膝酸软，骨蒸潮热，盗汗遗精，内热消渴，血虚萎黄，心悸怔忡，月经不调，崩漏下血，眩晕，耳鸣，须发早白。枸杞子为茄科植物宁夏枸杞Lycium barbarum L.的干燥成熟果实，含枸杞子多糖(MedlarPolysaccharides)、甜菜碱(Betaine)等。可滋补肝肾，益精明目。用于虚劳精亏，腰膝酸痛，眩晕耳鸣，内热消渴，血虚萎黄，目昏不明。丹参为唇形科植物丹参Salvia miltiorrhiza Bge.的干燥根及根茎，含丹参酮IIA(Tanshinone IIA)、丹酚酸B(Lithospermate B)等。可祛瘀止痛，活血通经，清心除烦。用于月经不调，经闭痛经，癥瘕积聚，胸腹刺痛，热痹疼痛，疮疡肿痛，心烦不眠；肝脾肿大，心绞痛。巴戟天为茜草科植物巴戟天Morinda officinalis How的干燥根，含蒽醌(Anthraquinone)、黄酮(Flavone)类化合物。可补肾阳，强筋骨，祛风湿。用于阳痿遗精，宫冷不孕，月经不调，少腹冷痛，风湿痹痛，筋骨痿软。山茱萸为山茱萸科植物Cornus officinalis Sieb.et Zucc.的干燥成熟果肉，含马钱苷(Loganin)等。可补益肝肾，涩精固脱。用于眩晕耳鸣，腰膝酸痛，阳痿遗精，遗尿尿频，崩漏带下，大汗虚脱，内热消渴。牡丹皮为毛茛科植物牡丹Paeonia suffruticosa Andr.的干燥根皮，含丹皮酚(Paeonol)。可清热凉血，活血化瘀。用于温毒发斑，吐血衄血，夜热早凉，无汗骨蒸，经闭痛经，痈肿疮毒，跌扑伤痛。黄芪为豆科植物蒙古黄芪Astragalusmembranaceus(Fisch.)Beg.var.mongholicus(Bge.)Hsiao或膜荚黄芪Astragalus membranaceus(Fisch.)Beg.的干燥根，含黄芪甲苷(Astragaloside)等。可补气固表，利尿托毒，排脓，敛疮生肌。用于气虚乏力，食少便溏，中气下陷，久泄脱肛，便血崩漏，表虚自汗，气虚水肿，痈疽难溃，久溃不敛，血虚痿黄，内热消渴；慢性肾炎蛋白尿，糖尿病。紫梢花为淡水海绵科动物脆针海绵Brittle sponge-pin的干燥群体，含海绵硬蛋白(Hardprotein sponge)、海绵异硬蛋白(Sponge different hardware protein)、磷酸盐(Phosphate)、碳酸盐(Carbonate)等。可益阳涩精，用于治疗阳痿，遗精，白浊，带下，小便不禁，阴囊湿疹等。马钱子为马前科植物马钱Strychnosnux-vomica L.的干燥成熟种子，含士的宁(Strychnine)、马钱子碱(Strychnine)。可通络止痛，散结消肿。用于风湿顽痹，麻木瘫痪，跌扑损伤，痈疽肿痛；小儿麻痹后遗症，类风湿性关节痛。冬虫夏草是麦角菌科真菌冬虫夏草Cordycrps sinensis(Berk.)Sacc.寄生在幼虫蛾科昆虫幼虫上的子座及幼虫尸体的复合体，含腺苷(Adenosine)等。可补肺益肾，止血，化痰。用于痰热咳嗽，胸闷胁痛。当归为伞形科植物当归Angelica Sinensis(Oliv.)Diels.的干燥根，含蒿本内脂(Ligustilide)、正丁烯酰内酯(n-butylidenephthalide)、阿魏酸(Ferulic acid)等。可补血活血，调经止痛，润肠通便。用于血虚萎黄，眩晕心悸，月经不调，经闭痛经，虚寒腹痛，肠燥便秘，风湿痹痛，跌扑损伤，痈疽疮疡。川芎为伞形科植物川芎Ligusticumchuanxiong Hort.的干燥根茎，含含挥发油、阿魏酸(ferulic acid)，以及4-羟基-3-丁基酽内酯(4—hydroxy-3-butylphthalide)、川芎酽内酯(senkyunolide)、藁本内酯(Ligustilide)、川芎嗪(tetramethylpyrazine)、川芎酚(chuanxiongol)、瑟丹酸(sedanic acid)等。可活血行气，祛风止痛。用于月经不调，经闭痛经，癥瘕腹痛，胸胁刺痛，跌扑肿痛，头痛，风湿痹痛。鹿茸为鹿科动物梅花鹿Cervus nippon Temminck或马鹿Cervus elaphusLinnaeus的雄鹿未骨化密生茸毛的幼角，含骨质(Osteoporosis)，胶质(Glial)及蛋白质(Protein)，灰分中含钙(Calcium)、磷(Phosphorus)、锰(Manganese)等。可壮肾阳，益精血，强筋骨，调冲任，托疮毒。用于阳痿滑精，宫冷不孕，羸瘦，神疲，畏寒，眩晕耳鸣耳聋，腰脊冷痛，筋骨痿软，崩漏带下，阴疽不敛。黄精为百合科植物滇黄精(Polygonatum kingianum Coll.et Hemsl.)、黄精(Polygonatum sibiricum Red.)或多花黄精(Polygonatumcyrtonema Hua.)的干燥根茎，含黄精多糖(Polygonatum polysaccharide)等。可补气养阴，健脾，润肺，益肾。用于脾胃虚弱，体倦乏力，口干食少，肺虚燥咳，精血不足，内热消渴。山药为薯蓣科植物薯蓣Dioscorea oppositaThunb.的干燥根茎，含淀粉酶(Amylase)、多酚氧化酶(Polyphenol oxidase)等物质。可补脾养胃，生津益肺，补肾涩精。用于脾虚食少，久泄不止，肺虚喘咳，肾虚遗精，带下，尿频，虚热消渴。鸡血藤为豆科植物密花豆Spatholobus suberectus Dunn的干燥藤茎，含表无羁萜醇(friedelan-3β-ol)，胡萝卜甙(daucosterol)，β-谷甾醇(β-sitosterol)等。可活血，补血，通络。用于月经不调，血虚萎黄，麻木瘫痪，风湿痹痛。人参为五加科植物人参Panax ginseng C.A.Mey.的干燥根及根茎，含10多种人参皂甙(Ginsenosides)等。可大补元气，复脉固脱，补脾益肺，生津，安神。用于体虚欲脱，肢冷脉微，脾虚食少，肺虚喘咳，津伤口渴，内热消渴，久病虚羸，惊悸失眠，阳痿宫冷；心力衰竭，心源性休克。牛骨髓富含蛋白质，对脊髓及其相关疾病患者极为有益。
本发明对症用药施治，组方科学合理，药材来源广泛易得，成本低，安全无毒副作用，药效快，使用方便，是临床治疗脊髓及相关疾病引起的腰酸腿软，肌肉痿缩疼痛，冷热感迟钝，目眩耳鸣等症状的优选用药。
具体实施方式：
本发明实施例1：先取熟地44克、枸杞子44克、丹参35克、巴戟天44克、山茱萸35克、牡丹皮26克、黄芪35克、紫梢花35克、当归44克、川芎26克、黄精44克、山药35克、鸡血藤35克，加水煎煮2次，第一次2小时，第二次1小时，第三次0.5小时，合并煎液，滤过，滤液浓缩成稠膏，备用。将人参44克、鹿茸9克、冬虫夏草9克粉碎成细粉，与马钱子粉22克配研，过筛，备用。将牛脊髓44克除去杂质切成碎块，60℃以下干燥，粉碎成细粉。将上述稠膏与人参等细粉、牛脊髓细粉混匀，干燥粉碎成细粉，过筛，加入蔗糖粉264克，糊精，混匀，制成颗粒，分装成100袋，即得产品。
本发明实施例2：先取熟地55克、枸杞子55克、丹参44克、巴戟天55克、山茱萸44克、牡丹皮33克、黄芪44克、紫梢花44克、当归55克、川芎33克、黄精55克、山药44克、鸡血藤44克加水煎煮3次，第一次3小时，第二次2小时，第三次1小时，合并煎液，滤过，滤液浓缩成稠膏，备用。将人参55克、鹿茸11克、冬虫夏草11克粉碎成细粉，与马钱子粉27.5克配研，过筛，备用。将牛脊髓55克除去杂质切成碎块，80℃以下干燥，粉碎成细粉。将上述稠膏与人参等细粉、牛脊髓细粉混匀，干燥粉碎成细粉，过筛，加入蔗糖粉330克，糊精适量，混匀，制成颗粒，分装成100袋，即得产品。
本发明实施例3：先取熟地66克、枸杞子66克、丹参53克、巴戟天66克、山茱萸53克、牡丹皮40克、黄芪53克、紫梢花53克、当归66克、川芎44克、黄精66克、山药53克、鸡血藤35～53克加水煎煮4次，第一次4小时，第二次3小时，第三次1.5小时，合并煎液，滤过，滤液浓缩成稠膏，备用。将人参66克、鹿茸13克、冬虫夏草13克粉碎成细粉，与马钱子粉33克配研，过筛，备用。将牛脊髓66克除去杂质切成碎块，100℃以下干燥，粉碎成细粉。将上述稠膏与人参等细粉、牛脊髓细粉混匀，干燥粉碎成细粉，过筛，加入蔗糖粉396克，糊精，混匀，制成颗粒，分装成100袋，即得产品。
其成品药的用法用量为：开水冲服，一次7.5g，一日2次。
Claims (6)
1、一种治疗脊髓及相关疾病的中药颗粒剂，其特征在于：它由熟地等十八味中草药制成，各味中草药按重量份的配比分别为：
熟地 44～66份 枸杞子 44～66份 丹参 35～53份
巴戟天 44～66份 山茱萸 35～53份 牡丹皮 26～40份
黄芪 35～53份 紫梢花 35～53份 马钱子粉 22～33份
冬虫夏草 9～13份 当归 44～66份 川芎 26～44份
鹿茸 9～13份 黄精 44～66份 山药 35～53份
鸡血藤 35～53份 人参 44～66份 牛脊髓(鲜) 44～66份
2、一种治疗脊髓及相关疾病的中药颗粒剂，其特征在于：它由熟地等十八味中草药制成，各味中草药按重量份的配比分别为：
熟地 55份 枸杞子 55份 丹参 44份
巴戟天 55份 山茱萸 44份 牡丹皮 33份
黄芪 44份 紫梢花 44份 马钱子粉 27.5份
冬虫夏草 11份 当归 55份 川芎 33份
鹿茸 11份 黄精 55份 山药 44份
鸡血藤 44份 人参 55份 牛脊髓(鲜) 55份
3、根据权力要求1所述的一种治疗脊髓及相关疾病的中药颗粒剂，其特征在于：主配方还可以加入下列组份及重量份：
蔗糖粉 264～396份
4、根据权力要求2所述的一种治疗脊髓及相关疾病的中药颗粒剂，其特征在于：主配方还可以加入下列组份及重量份：
蔗糖粉 330份
5、根据权力要求1、3所述的一种治疗脊髓及相关疾病的中药颗粒剂，其特征在于：它的制备工艺为：先取熟地、枸杞子、丹参、巴戟天、山茱萸、牡丹皮、黄芪、紫梢花、当归、川芎、黄精、山药、鸡血藤加水煎煮2-4次，第一次2-4小时，第二次1-3小时，第三次0.5-1.5小时，合并煎液，滤过，滤液浓缩成稠膏，备用。将人参、鹿茸、冬虫夏草粉碎成细粉，与马钱子粉配研，过筛，备用。将牛脊髓除去杂质切成碎块，60～100℃以下干燥，粉碎成细粉。将上述稠膏与人参等细粉、牛脊髓细粉混匀，干燥粉碎成细粉，过筛，加入蔗糖粉、糊精，混匀，制成颗粒，分装成100袋，即得产品。
6、根据权力要求2、4所述的一种治疗脊髓及相关疾病的中药颗粒剂，其特征在于：它的制备工艺为：先取熟地、枸杞子、丹参、巴戟天、山茱萸、牡丹皮、黄芪、紫梢花、当归、川芎、黄精、山药、鸡血藤加水煎煮3次，第一次3小时，第二次2小时，第三次1小时，合并煎液，滤过，滤液浓缩成稠膏，备用。将人参、鹿茸、冬虫夏草粉碎成细粉，与马钱子粉配研，过筛，备用。将牛脊髓除去杂质切成碎块，80℃以下干燥，粉碎成细粉。将上述稠膏与人参等细粉、牛脊髓细粉混匀，干燥粉碎成细粉，过筛，加入蔗糖粉、糊精，混匀，制成颗粒，分装成100袋，即得产品。
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101828720B (zh) * | 2010-05-13 | 2012-07-04 | 山东森健生物科技发展有限公司 | 一种用于增强骨密度的保健食品 |
| CN104306813A (zh) * | 2013-11-12 | 2015-01-28 | 魏钰 | 一种治疗肌肉酸痛的药剂 |
| CN104324282A (zh) * | 2013-11-12 | 2015-02-04 | 魏钰 | 一种治疗肌肉酸痛的药剂的制备方法 |
| CN105796876A (zh) * | 2016-03-15 | 2016-07-27 | 甘保明 | 一种补精益血的复方牛髓口服液及制备方法 |
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2009
- 2009-01-21 CN CNA2009100210028A patent/CN101474356A/zh active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101828720B (zh) * | 2010-05-13 | 2012-07-04 | 山东森健生物科技发展有限公司 | 一种用于增强骨密度的保健食品 |
| CN104306813A (zh) * | 2013-11-12 | 2015-01-28 | 魏钰 | 一种治疗肌肉酸痛的药剂 |
| CN104324282A (zh) * | 2013-11-12 | 2015-02-04 | 魏钰 | 一种治疗肌肉酸痛的药剂的制备方法 |
| CN105796876A (zh) * | 2016-03-15 | 2016-07-27 | 甘保明 | 一种补精益血的复方牛髓口服液及制备方法 |
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