CN105796876A - 一种补精益血的复方牛髓口服液及制备方法 - Google Patents

一种补精益血的复方牛髓口服液及制备方法 Download PDF

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CN105796876A
CN105796876A CN201610148222.7A CN201610148222A CN105796876A CN 105796876 A CN105796876 A CN 105796876A CN 201610148222 A CN201610148222 A CN 201610148222A CN 105796876 A CN105796876 A CN 105796876A
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Abstract

一种补精益血的复方牛髓口服液，由以下重量的组分制成：牛髓制剂150‑160份、黄精1‑3份、当归2‑4份、芍药3‑5份、地黄2‑4份、阿胶2‑4份、灵芝3‑5份、黑木耳5‑7份、黑豆3‑5份、黑芝麻6‑8份、枸杞子8‑10份、桑葚5‑7份、巴戟天3‑5份、生地6‑8份、熟地2‑4份。本发明的有益效果是：本发明以牛髓为原料，作为液相制剂，可以保证所有原料的药性的综合，保证口服液的综合疗效，吸收快、奏效迅速，服用方便，口感好，各组份间无配伍禁忌，功效确切，用量安全无副作用，适宜长期服用，具有较好的补精益血效果。

Description

一种补精益血的复方牛髓口服液及制备方法
技术领域
本发明涉及保健药品技术领域，具体涉及一种补精益血的复方牛髓口服液及制备方法。
背景技术
从古至今健康长寿，延续生命，青春永驻一直都是人类从不放弃的追求，随着人类社会的物质文明不断发展，科技水平不断提高，更激发了人们享受生活，探索生命奇迹的欲望。随之延缓衰老、增强体质、美容养颜的功能性食品应运而生，并且具有非常可观的经济价值。
我国是一个畜牧业大国，每年都有牛骨头产生，而牛骨中含有大量的牛髓，然而大部分牛髓没有得以充分的开发利用，造成了极大的资源浪费，从一只牛髓中提取出的生物活性物质的价值远远大于一只牛本身的价值，如对牛髓进行综合开发利用，不但能改善当地农牧民的收入，增加地方财政税收，还可提高我国国民整体健康素质，这将会产生巨大的经济效益和社会效益。
牛髓具有补精润肺，壮阳助胃的功效，主治疗虚痨羸瘦，精血亏损传统的牛髓加工只是进行普通的粉碎，煎煮，餐食，工艺较为简陋，牛髓的有效成份难以得到充分提取，不仅造成资源浪费，而且得不到有效的药性发挥。
发明内容
本发明所要解决的技术问题在于提供一种补精益血的复方牛髓口服液及制备方法，该方法简单，制备的产品有效成分好，应用效果明显，保健效果好。
本发明所要解决的技术问题采用以下技术方案来实现：
一种补精益血的复方牛髓口服液，由以下重量的组分制成：牛髓制剂150-160份、黄精1-3份、当归2-4份、芍药3-5份、地黄2-4份、阿胶2-4份、灵芝3-5份、黑木耳5-7份、黑豆3-5份、黑芝麻6-8份、枸杞子8-10份、桑葚5-7份、巴戟天3-5份、生地6-8份、熟地2-4份。
各原料的优选组分为：牛髓制剂155份、黄精2份、当归3份、芍药4份、地黄3份、阿胶3份、灵芝4份、黑木耳6份、黑豆4份、黑芝麻7份、枸杞子9份、桑葚6份、巴戟天4份、生地7份、熟地3份。
所述的牛髓制剂制备方法为：
(1)将新鲜的牛髓分拣后去除杂物，放入清洗液或纯净水中进行浸泡35-40分钟，控制温度为20-30℃，然后捞出冷却后，迅速投入冷库中，降温至0℃以下，保存至少4h；
所述的清洗液为：水60-80g、大蒜2-4g、双氧水10-20g、碳酸氢钠3-5g复配而成；
(2)将步骤(1)冷库中的牛髓取出，放入温水中浸泡10分钟解冻，放入绞肉机，绞制后，过800-1000目的网筛，得到牛髓碎末；
(3)将上述牛髓碎末放入蒸笼上层，下层加入牛髓碎末3倍的清水，然后开启蒸制，收集蒸制产生的蒸汽，冷却收集液体，即可得到。
上述补精益血的复方牛髓口服液的制备方法如下：
(1)将黄精、当归、芍药、地黄、阿胶、灵芝、黑木耳、黑豆、黑芝麻、枸杞子、桑葚、巴戟天、生地和熟地使用温水洗净；
(2)将清洗后的药物晾干后，切碎，放入煎锅中，兑以药物总量10倍的清水，分3次进行煎煮，合并3次得到的煎液；
(3)将上述煎液与原料中的牛髓制剂进行混合后，搅拌均匀，先加热至沸腾，然后再自然冷却至室温，然后放入冷库中，控制温度为1-2℃，静置3-5h，取出；
(4)将滤液在温度为30-40℃，真空度为0.07-0.08Mpa下进行减压浓缩，浓缩至相对密度为1.10-1.15kg/m3，得到浓缩液，将浓缩液冷藏，静置24小时，上清液离心、过滤得到离心液，即可。
本发明的有益效果是：本发明以牛髓为原料，作为液相制剂，可以保证所有原料的药性的综合，保证口服液的综合疗效，吸收快、奏效迅速，服用方便，口感好，各组份间无配伍禁忌，功效确切，用量安全无副作用，适宜长期服用，具有较好的补精益血效果。
具体实施方式
为了使本发明实现的技术手段、创作特征、达成目的与功效易于明白了解，下面结合具体实施例，进一步阐述本发明。
实施例1
称取：牛髓制剂150kg、黄精1kg、当归2kg、芍药3kg、地黄2kg、阿胶2kg、灵芝3kg、黑木耳5kg、黑豆3kg、黑芝麻6kg、枸杞子8kg、桑葚5kg、巴戟天3kg、生地6kg、熟地2kg。
实施例2
称取：牛髓制剂160kg、黄精3kg、当归4kg、芍药5kg、地黄4kg、阿胶4kg、灵芝5kg、黑木耳7kg、黑豆5kg、黑芝麻8kg、枸杞子10kg、桑葚7kg、巴戟天5kg、生地8kg、熟地4kg。
实施例3
称取：牛髓制剂155kg、黄精2kg、当归3kg、芍药4kg、地黄3kg、阿胶3kg、灵芝4kg、黑木耳6kg、黑豆4kg、黑芝麻7kg、枸杞子9份kg、桑葚6kg、巴戟天4kg、生地7kg、熟地3kg。
制备上述实施例1、2或3的方法，包括以下步骤：
(1)将黄精、当归、芍药、地黄、阿胶、灵芝、黑木耳、黑豆、黑芝麻、枸杞子、桑葚、巴戟天、生地和熟地使用温水洗净；
(2)将清洗后的药物晾干后，切碎，放入煎锅中，兑以药物总量10倍的清水，分3次进行煎煮，合并3次得到的煎液；
(3)将上述煎液与原料中的牛髓制剂进行混合后，搅拌均匀，先加热至沸腾，然后再自然冷却至室温，然后放入冷库中，控制温度为1-2℃，静置3-5h，取出；
(4)将滤液在温度为30-40℃，真空度为0.07-0.08Mpa下进行减压浓缩，浓缩至相对密度为1.10-1.15kg/m3，得到浓缩液，将浓缩液冷藏，静置24小时，上清液离心、过滤得到离心液，即可。
本发明实施例1制得得一种补精益血的复方牛髓口服液，在某医院的门诊亚健康患者病人使用，用药人员650人，男性340人，女性310人，年龄在30-65岁，平均年龄41岁。用药人员每日2次，每次服用10mL，坚持服药90天。观察用药人员对药物的耐受情况、有无过敏反应、用药前后肝肾功能及血象变化，病情变化情况。所有用药人员均有较好的耐受性，用药后肝肾功能指标无异常，血象无明显变化，无皮疹等过敏反应，用药期间未出现胃肠不适、腹泻等症状。经使用本口服液后治愈病例590例，好转病例60例，无无效病例。治愈是指治疗后有效缓解亚健康症状；好转是指治疗后初步缓解亚健康症状。无效是指对本药方无反应。
由上述情况说明，本发明所述的药物，相关患者使用后，能够有效缓解亚健康症状，且无明显副作用。
上述过程中典型病例如下：
季某某，男性，52岁，河南郑州人。经常感觉疲劳、失眠、头晕耳鸣、腰腿酸软、诊断为亚健康患者。服用本发明实施例口服液，每日3次，每次服用10mL，坚持服药90天。用药人员均有较好的耐受性，用药后肝肾功能指标无异常，血象无明显变化，无皮疹等过敏反应，服药期间未出现胃肠不适、腹泻等症状。服药90天后，经检查头晕耳鸣、腰腿酸软、疲劳症状消失，睡眠质量高，达到治愈标准。
以上显示和描述了本发明的基本原理和主要特征和本发明的优点。本行业的技术人员应该了解，本发明不受上述实施例的限制，上述实施例和说明书中描述的只是说明本发明的原理，在不脱离本发明精神和范围的前提下，本发明还会有各种变化和改进，这些变化和改进都落入要求保护的本发明范围内。本发明要求保护范围由所附的权利要求书及其等效物界定。

Claims (4)

1.一种补精益血的复方牛髓口服液，由以下重量的组分制成：牛髓制剂150-160份、黄精1-3份、当归2-4份、芍药3-5份、地黄2-4份、阿胶2-4份、灵芝3-5份、黑木耳5-7份、黑豆3-5份、黑芝麻6-8份、枸杞子8-10份、桑葚5-7份、巴戟天3-5份、生地6-8份、熟地2-4份。
2.根据权利要求1所述的一种补精益血的复方牛髓口服液，其特征在于：各原料的优选组分为：牛髓制剂155份、黄精2份、当归3份、芍药4份、地黄3份、阿胶3份、灵芝4份、黑木耳6份、黑豆4份、黑芝麻7份、枸杞子9份、桑葚6份、巴戟天4份、生地7份、熟地3份。
3.根据权利要求1所述的一种补精益血的复方牛髓口服液，其特征在于：所述的牛髓制剂制备方法为：
(1)将新鲜的牛髓分拣后去除杂物，放入清洗液或纯净水中进行浸泡35-40分钟，控制温度为20-30℃，然后捞出冷却后，迅速投入冷库中，降温至0℃以下，保存至少4h；
所述的清洗液为：水60-80g、大蒜2-4g、双氧水10-20g、碳酸氢钠3-5g复配而成；
(2)将步骤(1)冷库中的牛髓取出，放入温水中浸泡10分钟解冻，放入绞肉机，绞制后，过800-1000目的网筛，得到牛髓碎末；
(3)将上述牛髓碎末放入蒸笼上层，下层加入牛髓碎末3倍的清水，然后开启蒸制，收集蒸制产生的蒸汽，冷却收集液体，即可得到。
4.一种制备权利要求1或2中所述一种补精益血的复方牛髓口服液的方法，其特征在于，步骤如下：
(1)将黄精、当归、芍药、地黄、阿胶、灵芝、黑木耳、黑豆、黑芝麻、枸杞子、桑葚、巴戟天、生地和熟地使用温水洗净；
(2)将清洗后的药物晾干后，切碎，放入煎锅中，兑以药物总量10倍的清水，分3次进行煎煮，合并3次得到的煎液；
(3)将上述煎液与原料中的牛髓制剂进行混合后，搅拌均匀，先加热至沸腾，然后再自然冷却至室温，然后放入冷库中，控制温度为1-2℃，静置3-5h，取出；
(4)将滤液在温度为30-40℃，真空度为0.07-0.08Mpa下进行减压浓缩，浓缩至相对密度为1.10-1.15kg/m3，得到浓缩液，将浓缩液冷藏，静置24小时，上清液离心、过滤得到离心液，即可。
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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101474356A (zh) * 2009-01-21 2009-07-08 西安仁仁药业有限公司 一种治疗脊髓及相关疾病的中药颗粒剂
CN102284001A (zh) * 2011-07-19 2011-12-21 南通大学 复方黄精口服液及其制备方法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101474356A (zh) * 2009-01-21 2009-07-08 西安仁仁药业有限公司 一种治疗脊髓及相关疾病的中药颗粒剂
CN102284001A (zh) * 2011-07-19 2011-12-21 南通大学 复方黄精口服液及其制备方法

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