CN101431894A - 螺环化合物和应用方法 - Google Patents
螺环化合物和应用方法 Download PDFInfo
- Publication number
- CN101431894A CN101431894A CNA2007800017195A CN200780001719A CN101431894A CN 101431894 A CN101431894 A CN 101431894A CN A2007800017195 A CNA2007800017195 A CN A2007800017195A CN 200780001719 A CN200780001719 A CN 200780001719A CN 101431894 A CN101431894 A CN 101431894A
- Authority
- CN
- China
- Prior art keywords
- hydroxyl
- quinazoline
- azepine
- azaspiro
- low
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/96—Spiro-condensed ring systems
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
- A01N43/36—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom five-membered rings
- A01N43/38—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom five-membered rings condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/20—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D497/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D497/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/20—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dentistry (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Pain & Pain Management (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Description
Claims (9)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US75960106P | 2006-01-17 | 2006-01-17 | |
US60/759,601 | 2006-01-17 | ||
US11/647,823 US7977346B2 (en) | 2006-01-17 | 2006-12-30 | Spiro compounds and methods of use |
US11/647,823 | 2006-12-30 | ||
PCT/US2007/060537 WO2007084875A2 (en) | 2006-01-17 | 2007-01-14 | Spiro compounds and methods of use |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101431894A true CN101431894A (zh) | 2009-05-13 |
CN101431894B CN101431894B (zh) | 2013-05-22 |
Family
ID=38264002
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2007800017195A Active CN101431894B (zh) | 2006-01-17 | 2007-01-14 | 螺环化合物和应用方法 |
Country Status (10)
Country | Link |
---|---|
US (2) | US7977346B2 (zh) |
EP (1) | EP1973407B1 (zh) |
JP (1) | JP5522341B2 (zh) |
KR (1) | KR101441694B1 (zh) |
CN (1) | CN101431894B (zh) |
AT (1) | ATE534292T1 (zh) |
AU (1) | AU2007205962B2 (zh) |
CA (1) | CA2638107A1 (zh) |
ES (1) | ES2375660T3 (zh) |
WO (1) | WO2007084875A2 (zh) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102452988A (zh) * | 2010-10-27 | 2012-05-16 | 中国科学院化学研究所 | 一种喹唑啉衍生物及其制备方法 |
CN103529160A (zh) * | 2013-10-10 | 2014-01-22 | 中国医学科学院肿瘤医院 | Uplc-ms/ms法测定人血浆中西莫替尼的浓度 |
CN106279192A (zh) * | 2015-05-26 | 2017-01-04 | 江苏先声药业有限公司 | 一种喹唑啉衍生物盐酸盐的结晶多晶型物 |
CN113072480A (zh) * | 2021-04-13 | 2021-07-06 | 常州佳德医药科技有限公司 | 一种手性(-)-5-氮杂螺[2.4]庚烷-7-醇、制备方法及应用 |
CN113292479A (zh) * | 2021-05-27 | 2021-08-24 | 南京合巨药业有限公司 | 一种5-氮杂螺[2.4]庚烷及其盐的制备方法 |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2220055A2 (en) * | 2007-07-19 | 2010-08-25 | F. Hoffmann-La Roche AG | Novel heterocyclyl compounds and their use as chemokine antagonists |
CN101245070B (zh) * | 2008-03-26 | 2010-09-15 | 江苏先声药物研究有限公司 | 一种螺环喹唑啉蛋白酪氨酸激酶抑制剂的合成新工艺 |
US8211911B2 (en) * | 2008-08-19 | 2012-07-03 | Guoqing Paul Chen | Compounds as kinase inhibitors |
AU2009303602B2 (en) * | 2008-10-14 | 2012-06-14 | Sunshine Lake Pharma Co., Ltd. | Compounds and methods of use |
CN102382106A (zh) * | 2010-08-30 | 2012-03-21 | 黄振华 | 苯胺取代的喹唑啉衍生物 |
CN102796109B (zh) * | 2011-05-23 | 2015-10-07 | 复旦大学 | 4-氨基喹唑啉化合物及其制备方法和用途 |
EP2796451B1 (en) * | 2011-12-20 | 2018-08-01 | Wei Qian | Heterocycle amido alkyloxy substituted quinazoline derivative and use thereof |
CN102863373B (zh) * | 2012-09-07 | 2014-03-12 | 苏州康润医药有限公司 | 5-苄基氮杂螺[2,4]庚烷的合成方法 |
US9353123B2 (en) | 2013-02-20 | 2016-05-31 | Kala Pharmaceuticals, Inc. | Therapeutic compounds and uses thereof |
CN107108597B (zh) | 2014-10-31 | 2020-04-17 | 英立维尔英国有限公司 | 多巴胺d3受体拮抗剂化合物 |
Family Cites Families (31)
Publication number | Priority date | Publication date | Assignee | Title |
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US3344145A (en) * | 1963-10-21 | 1967-09-26 | Geschickter Fund Med Res | N-substituted phenoxyalkyl or phenylthioalkyl-mono azaspiroalkanes |
MY105136A (en) | 1988-04-27 | 1994-08-30 | Daiichi Seiyaku Co | Optically active pyridonecarboxylic acid derivatives. |
CA1336090C (en) | 1988-08-31 | 1995-06-27 | Isao Hayakawa | Spiro-substituted cyclic amines of quinolone derivatives |
JP2769058B2 (ja) | 1990-10-25 | 1998-06-25 | 第一製薬株式会社 | シクロプロパン誘導体の製法 |
US5137892A (en) | 1990-12-12 | 1992-08-11 | Abbott Laboratories | Quinoline, naphthyridine and pyridobenzoxazine derivatives |
JP3045574B2 (ja) | 1991-05-17 | 2000-05-29 | 第一製薬株式会社 | アミノ化合物の製造法 |
AU661999B2 (en) | 1991-05-28 | 1995-08-17 | Daiichi Pharmaceutical Co., Ltd. | Pyridonecarboxylic acid derivative |
US5591748A (en) | 1991-06-07 | 1997-01-07 | Smithkline Beecham Corporation | Immunomodulatory azaspiranes |
JPH06145167A (ja) | 1992-11-06 | 1994-05-24 | Hokuriku Seiyaku Co Ltd | 8−メトキシ−5−メチルキノリン−3−カルボン酸誘導体 |
CA2115025A1 (en) | 1993-02-08 | 1994-08-09 | Atsushi Furutani | Process for producing amines |
CA2115024A1 (en) | 1993-04-27 | 1994-10-28 | Atsushi Furutani | Process for producing amines |
DE69430581D1 (de) | 1993-10-14 | 2002-06-13 | Abbott Lab | Verbindungen des chinolizinon-typs |
GB9508538D0 (en) | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quinazoline derivatives |
IL122296A0 (en) | 1995-06-06 | 1998-04-05 | Abbott Lab | Quinolizinone type compounds |
EP0895989B1 (en) * | 1997-08-07 | 2005-05-18 | Eli Lilly And Company | 1-[4-(Substituted alkoxy)benzyl] naphthalene compounds having estrogen inhibitory activity |
US6387928B1 (en) | 1997-09-15 | 2002-05-14 | The Procter & Gamble Co. | Antimicrobial quinolones, their compositions and uses |
US6197974B1 (en) | 1998-10-26 | 2001-03-06 | Abbott Laboratories | Enantioselective synthesis of 3-aminopyrrolidines |
EA005585B1 (ru) | 2000-01-24 | 2005-04-28 | Уорнер-Ламберт Компани | 3-аминохиназолин-2,4-дионовые антибактериальные агенты |
JP2002053536A (ja) | 2000-08-08 | 2002-02-19 | Dai Ichi Seiyaku Co Ltd | スピロアミノピロリジン誘導体およびその製造法 |
JP2002069072A (ja) | 2000-08-25 | 2002-03-08 | Dai Ichi Seiyaku Co Ltd | スピロピロリドン誘導体およびその製法 |
DE10042059A1 (de) * | 2000-08-26 | 2002-03-07 | Boehringer Ingelheim Pharma | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
JP2002201191A (ja) | 2000-09-28 | 2002-07-16 | Dai Ichi Seiyaku Co Ltd | キノロンカルボン酸誘導体の製造方法およびその製造中間体 |
TWI239942B (en) * | 2001-06-11 | 2005-09-21 | Dainippon Pharmaceutical Co | N-arylphenylacetamide derivative and pharmaceutical composition containing the same |
CN1184221C (zh) | 2001-08-08 | 2005-01-12 | 中国医学科学院医药生物技术研究所 | 有7-(7-氨甲基-5-氮杂螺[2,4]庚烷)取代基的新喹啉羧酸衍生物及其制备方法 |
JP2004099609A (ja) | 2002-08-23 | 2004-04-02 | Dai Ichi Seiyaku Co Ltd | 光学活性7−アミノ−5−アザスピロ[2.4]ヘプタンの製造法 |
WO2005026165A1 (en) | 2003-09-12 | 2005-03-24 | Warner-Lambert Company Llc | Quinolone antibacterial agents |
DE10360745A1 (de) * | 2003-12-23 | 2005-07-28 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Amid-Verbindungen mit MCH-antagonistischer Wirkung und diese Verbindungen enthaltende Arzneimittel |
WO2006073167A1 (ja) | 2005-01-07 | 2006-07-13 | Ono Pharmaceutical Co., Ltd. | ピロリジン誘導体 |
US7563805B2 (en) | 2005-05-19 | 2009-07-21 | Daiichi Pharmaceutical Co., Ltd. | Tri-, tetra-substituted-3-aminopyrrolidine derivative |
US7928232B2 (en) | 2005-05-20 | 2011-04-19 | Daiichi Sankyo Company, Limited | Method for producing asymmetric tetrasubstituted carbon atom-containing compound |
JPWO2007037330A1 (ja) | 2005-09-28 | 2009-04-09 | 第一三共株式会社 | キノロン含有凍結乾燥製剤の製造方法 |
-
2006
- 2006-12-30 US US11/647,823 patent/US7977346B2/en not_active Expired - Fee Related
-
2007
- 2007-01-14 ES ES07717289T patent/ES2375660T3/es active Active
- 2007-01-14 EP EP07717289A patent/EP1973407B1/en not_active Not-in-force
- 2007-01-14 KR KR1020087013862A patent/KR101441694B1/ko active IP Right Grant
- 2007-01-14 JP JP2008550552A patent/JP5522341B2/ja not_active Expired - Fee Related
- 2007-01-14 CN CN2007800017195A patent/CN101431894B/zh active Active
- 2007-01-14 AU AU2007205962A patent/AU2007205962B2/en not_active Ceased
- 2007-01-14 CA CA002638107A patent/CA2638107A1/en not_active Abandoned
- 2007-01-14 WO PCT/US2007/060537 patent/WO2007084875A2/en active Application Filing
- 2007-01-14 AT AT07717289T patent/ATE534292T1/de active
-
2011
- 2011-06-01 US US13/151,251 patent/US20110237794A1/en not_active Abandoned
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102452988A (zh) * | 2010-10-27 | 2012-05-16 | 中国科学院化学研究所 | 一种喹唑啉衍生物及其制备方法 |
US9233995B2 (en) | 2010-10-27 | 2016-01-12 | Institute Of Chemistry, Chinese Academy Of Sciences | Quinazoline derivatives and quinazoline complex protein kinase inhibitor for inhibiting multiplication of tumor cells and preparation method thereof |
CN102452988B (zh) * | 2010-10-27 | 2016-01-27 | 中国科学院化学研究所 | 一种喹唑啉衍生物及其制备方法 |
CN103529160A (zh) * | 2013-10-10 | 2014-01-22 | 中国医学科学院肿瘤医院 | Uplc-ms/ms法测定人血浆中西莫替尼的浓度 |
CN103529160B (zh) * | 2013-10-10 | 2015-10-21 | 中国医学科学院肿瘤医院 | Uplc-ms/ms法测定人血浆中西莫替尼的浓度 |
CN106279192A (zh) * | 2015-05-26 | 2017-01-04 | 江苏先声药业有限公司 | 一种喹唑啉衍生物盐酸盐的结晶多晶型物 |
CN106279192B (zh) * | 2015-05-26 | 2020-06-23 | 江苏先声药业有限公司 | 一种喹唑啉衍生物盐酸盐的结晶多晶型物 |
CN113072480A (zh) * | 2021-04-13 | 2021-07-06 | 常州佳德医药科技有限公司 | 一种手性(-)-5-氮杂螺[2.4]庚烷-7-醇、制备方法及应用 |
CN113072480B (zh) * | 2021-04-13 | 2022-09-30 | 常州佳德医药科技有限公司 | 一种手性(-)-5-氮杂螺[2.4]庚烷-7-醇、制备方法及应用 |
CN113292479A (zh) * | 2021-05-27 | 2021-08-24 | 南京合巨药业有限公司 | 一种5-氮杂螺[2.4]庚烷及其盐的制备方法 |
Also Published As
Publication number | Publication date |
---|---|
US20110237794A1 (en) | 2011-09-29 |
CA2638107A1 (en) | 2007-07-26 |
WO2007084875A2 (en) | 2007-07-26 |
ATE534292T1 (de) | 2011-12-15 |
ES2375660T3 (es) | 2012-03-05 |
JP5522341B2 (ja) | 2014-06-18 |
WO2007084875A3 (en) | 2007-11-29 |
JP2009523737A (ja) | 2009-06-25 |
AU2007205962A1 (en) | 2007-07-26 |
US7977346B2 (en) | 2011-07-12 |
CN101431894B (zh) | 2013-05-22 |
EP1973407B1 (en) | 2011-11-23 |
AU2007205962B2 (en) | 2012-06-07 |
US20070167470A1 (en) | 2007-07-19 |
EP1973407A4 (en) | 2010-09-15 |
KR101441694B1 (ko) | 2014-09-19 |
EP1973407A2 (en) | 2008-10-01 |
KR20080098581A (ko) | 2008-11-11 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C41 | Transfer of patent application or patent right or utility model | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20091127 Address after: California, USA Applicant after: National Day Chen Co-applicant after: Advenchen Laboratories, LLC Co-applicant after: Jiangsu Simcere Pharmaceutical Research Company Limited Address before: California, USA Applicant before: National Day Chen Co-applicant before: Advenchen Laboratories, LLC |
|
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
C41 | Transfer of patent application or patent right or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20170224 Address after: California Patentee after: Chen Guoqing Patentee after: Advenchen Laboratories, LLC Patentee after: Jiangsu Simcere Pharmaceutical Co., Ltd. Address before: American California Patentee before: Chen Guoqing Patentee before: Advenchen Laboratories, LLC Patentee before: Jiangsu Simcere Pharmaceutical Research Company Limited |