CN101426773A - 治疗精神疾病和神经疾病的代谢型谷氨酸受体增效剂5-苯基-3-苄基-唑烷-2-酮衍生物和相关化合物 - Google Patents

治疗精神疾病和神经疾病的代谢型谷氨酸受体增效剂5-苯基-3-苄基-唑烷-2-酮衍生物和相关化合物 Download PDF

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Publication number
CN101426773A
CN101426773A CNA200680051938XA CN200680051938A CN101426773A CN 101426773 A CN101426773 A CN 101426773A CN A200680051938X A CNA200680051938X A CN A200680051938XA CN 200680051938 A CN200680051938 A CN 200680051938A CN 101426773 A CN101426773 A CN 101426773A
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Prior art keywords
oxazolidines
ketone
phenyl
alkylidene group
ylmethyl
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Chinese (zh)
Inventor
A·斯拉西
B·约瑟夫
F·马
I·埃格尔
J·克莱顿
M·伊萨克
K·斯维尔策克
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AstraZeneca AB
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AstraZeneca AB
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    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing alicyclic rings
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Health & Medical Sciences (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
CNA200680051938XA 2005-12-15 2006-12-06 治疗精神疾病和神经疾病的代谢型谷氨酸受体增效剂5-苯基-3-苄基-唑烷-2-酮衍生物和相关化合物 Pending CN101426773A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US75034705P 2005-12-15 2005-12-15
US60/750,347 2005-12-15

Publications (1)

Publication Number Publication Date
CN101426773A true CN101426773A (zh) 2009-05-06

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CNA200680051938XA Pending CN101426773A (zh) 2005-12-15 2006-12-06 治疗精神疾病和神经疾病的代谢型谷氨酸受体增效剂5-苯基-3-苄基-唑烷-2-酮衍生物和相关化合物

Country Status (8)

Country Link
US (2) US7816354B2 (fr)
EP (1) EP1994016A2 (fr)
JP (1) JP2009519929A (fr)
CN (1) CN101426773A (fr)
AR (1) AR057218A1 (fr)
TW (1) TW200732313A (fr)
UY (1) UY29988A1 (fr)
WO (1) WO2007078523A2 (fr)

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EP1994016A2 (fr) 2008-11-26
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