CN101407538B - 一种zp120的固相合成方法 - Google Patents
一种zp120的固相合成方法 Download PDFInfo
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- CN101407538B CN101407538B CN2007101645850A CN200710164585A CN101407538B CN 101407538 B CN101407538 B CN 101407538B CN 2007101645850 A CN2007101645850 A CN 2007101645850A CN 200710164585 A CN200710164585 A CN 200710164585A CN 101407538 B CN101407538 B CN 101407538B
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Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Peptides Or Proteins (AREA)
Abstract
Description
步骤 | 溶剂(或试剂) | 用量(ml/g) | 次数 | 时间(分钟/次) | 备注 |
1 | 二氯甲烷 | 5~7 | 2 | 2 | 1,2交替洗 |
2 | 乙醇 | 5~7 | 2 | 2 | |
3 | 20%哌啶/DMF | 10 | 2 | 20 | |
4 | 二氯甲烷 | 5~7 | 3 | 2 | 4,5交替洗 |
5 | 乙醇 | 5~7 | 3 | 2 | |
6 | 加入1~5当量Fmoc-保护氨基酸,1~5当量的HOBt,所述HOBt用二氯甲烷或二氯甲烷与N,N-二甲基甲酰胺溶解,而后加入1~5当量的N,N-二异丙基碳二亚胺,搅拌,室温 | 1 | 2~5小时 | ||
7 | 二氯甲烷 | 5~7 | 3 | 2 | 7,8交替洗 |
8 | 乙醇 | 5~7 | 3 | 2 |
峰 | 保留时间(min) | 峰高(mAU) | 峰面积(mAU*min) | 峰面积百分比(%) |
1 | 5.152 | 2.1765 | 0.2329 | 0.04 |
2 | 10.667 | 0.7092 | 0.2324 | 0.04 |
3 | 11.267 | 156.3432 | 29.3202 | 4.88 |
4 | 11.894 | 42.5172 | 14.6909 | 2.45 |
5 | 12.393 | 17.2760 | 5.3031 | 0.88 |
6 | 14.261 | 1352.8342 | 509.5120 | 84.88 |
7 | 15.418 | 75.2133 | 34.3250 | 5.72 |
8 | 16.129 | 1.2559 | 0.3822 | 0.06 |
9 | 16.826 | 12.2855 | 4.2735 | 0.71 |
10 | 17.720 | 0.7645 | 0.2333 | 0.04 |
11 | 18.406 | 13762 | 0.4506 | 0.08 |
12 | 28.580 | 1.4037 | 0.1972 | 0.03 |
13 | 29.414 | 3.5739 | 0.6193 | 0.10 |
14 | 29.917 | 3.9723 | 0.5339 | 0.09 |
Total: | 1671.702 | 600.307 | 100 |
Claims (1)
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CN2007101645850A CN101407538B (zh) | 2007-12-11 | 2007-12-11 | 一种zp120的固相合成方法 |
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CN2007101645850A CN101407538B (zh) | 2007-12-11 | 2007-12-11 | 一种zp120的固相合成方法 |
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CN101407538A CN101407538A (zh) | 2009-04-15 |
CN101407538B true CN101407538B (zh) | 2011-09-14 |
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Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN103102387A (zh) * | 2013-01-25 | 2013-05-15 | 苏州昊帆生物科技有限公司 | 载有多肽缩合剂的多孔材料,及其制备方法和用途 |
CN105461800A (zh) * | 2015-12-22 | 2016-04-06 | 何润泽 | 一种kpv肽及其类似物的多肽的制备方法 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001098214A1 (en) * | 2000-06-19 | 2001-12-27 | Novozymes Biotech, Inc. | Methods for eliminating the formation of biofilm |
US7244701B2 (en) * | 2000-06-16 | 2007-07-17 | Zealand Phama A/S | Diuretic peptide conjugate |
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2007
- 2007-12-11 CN CN2007101645850A patent/CN101407538B/zh not_active Expired - Fee Related
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7244701B2 (en) * | 2000-06-16 | 2007-07-17 | Zealand Phama A/S | Diuretic peptide conjugate |
WO2001098214A1 (en) * | 2000-06-19 | 2001-12-27 | Novozymes Biotech, Inc. | Methods for eliminating the formation of biofilm |
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Owner name: HANGZHOU ADELAI NUOTAI PHARMACEUTICAL TECHNOLOGY C Free format text: FORMER NAME: HANGZHOU SINOPEP PHARMACEUTICAL INC. |
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Address after: Hangzhou City, Zhejiang province 310018 Hangzhou economic and Technological Development Zone No. 6 Street No. 452 Hangzhou City high-tech incubator incubator building No. 1 room 3B01-3B04 Patentee after: HANGZHOU ADLAI NORTYE PHARMACEUTICAL TECHNOLOGY CO., LTD. Address before: Hangzhou City, Zhejiang province 310018 Hangzhou economic and Technological Development Zone No. 6 Street No. 452 Hangzhou City high-tech incubator incubator building No. 1 room 3B01-3B04 Patentee before: Hangzhou Sinopep Pharmaceutical Inc. |
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Denomination of invention: Solid phase synthesis method of ZP120 Effective date of registration: 20150116 Granted publication date: 20110914 Pledgee: Bank of Hangzhou Limited by Share Ltd Binjiang branch Pledgor: HANGZHOU ADLAI NORTYE PHARMACEUTICAL TECHNOLOGY CO., LTD. Registration number: 2015990000044 |
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Address after: Hangzhou City, Zhejiang province 310018 Hangzhou economic and Technological Development Zone No. 6 Street No. 452 Hangzhou City high-tech incubator incubator building No. 1 room 3B01-3B04 Patentee after: HANGZHOU ANUO BIOLOGICAL MEDICINE TECHNOLOGY CO., LTD. Address before: Hangzhou City, Zhejiang province 310018 Hangzhou economic and Technological Development Zone No. 6 Street No. 452 Hangzhou City high-tech incubator incubator building No. 1 room 3B01-3B04 Patentee before: HANGZHOU ADLAI NORTYE PHARMACEUTICAL TECHNOLOGY CO., LTD. |
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Granted publication date: 20110914 Termination date: 20191211 |