CN101396307A - 人工晶状体 - Google Patents

人工晶状体 Download PDF

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Publication number
CN101396307A
CN101396307A CNA2008100917265A CN200810091726A CN101396307A CN 101396307 A CN101396307 A CN 101396307A CN A2008100917265 A CNA2008100917265 A CN A2008100917265A CN 200810091726 A CN200810091726 A CN 200810091726A CN 101396307 A CN101396307 A CN 101396307A
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opticator
iol
intraocular lens
edge
present
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D·摩根
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Alcon Research LLC
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Alcon Manufacturing Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A61F2/16—Intraocular lenses
    • A61F2/1613—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
    • A61F2/1616—Pseudo-accommodative, e.g. multifocal or enabling monovision
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
    • A61F2250/0036—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in thickness

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  • Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Prostheses (AREA)
  • Materials For Medical Uses (AREA)

Abstract

具有降低的内部光学区域和与所述光学部分整体形成的加厚或者升高的外周唇或者缘的IOL。这种设计减小了IOL的质量，使得所述晶状体更易于在非常小的切口中插入，而不损坏光学部分或者具有IOL的稳定性。

Description

人工晶状体
本发明涉及人工晶状体(IOLs)并且更具体地涉及单件IOLs。
发明背景
人眼最简单的基本功能是通过称为角膜的透明外部传送和折射光，并且进一步通过晶状体将像汇聚到眼底的视网膜上而提供视觉。汇聚的像的质量依靠很多因素，包括眼睛的大小、形状和长度，以及角膜和晶状体的形状和透明度。
当外伤、年龄或疾病使得晶状体透明度变差时，因为传送到视网膜上的光减少所以视力下降。眼睛晶状体的这种病症就是医学上公知的白内障。对于该症状的治疗是将晶状体手术摘除并植入人工的晶状体或者IOL。
尽管早期IOLs是由硬质塑料例如聚甲基丙烯酸甲酯(PMMA)制成，，然而由硅树脂、软的丙烯酸树脂和水凝胶制成的软的、可折叠的IOLs因为可以将这些软晶状体折叠或者卷绕并通过较小的切口将其插入所以已经变得越来越受欢迎。有几种卷绕或折叠晶状体的方法供使用。一种受欢迎的方法是将晶状体折叠并提供相对小直径腔的注射盒，晶状体可以从所述腔中通常由软的尖头活塞推入到眼内。最常用的注射盒的设计在美国专利No.4,681,102(Bartell)中说明，并包括一分开的、纵向绞接的盒。类似的设计在美国专利Nos.5,494,484和5,499,987(Feingold)和5,616,148以及5,620,450(Eagles等)中说明。为了美国专利No.4,681,102权利要求中的问题，已经研发了几种固体盒，如参见美国专利No.5,275,604(Rheinish等),5,653,715(Reich等)和美国专利No.5,947,976(Van Noy等)。
这些现有技术的装置打算通过相对大(约3.0mm或更大)的切口将IOL注入到无晶状体眼的后房。已经研发了允许整个外科手术通过更小(2.4mm或更小)的切口来进行的外科技术和IOL。结果是，需要能够卷绕或者折叠得足够小以通过这样小的切口插入的IOL。为了实现该目标，必须将IOL制得更薄，或者不大，然而其仍旧具有30D或者更大的折射能力。将光学部分中心变薄因此需要将光学部分边缘也变薄。具有如此薄横截面的IOL的缺点是，尤其是当由软的、可折叠材料制成时，光学部分边缘非常易碎并且在插入期间容易损坏，尤其是当使用活塞插入装置时。另外，袢/光学部分接合处非常薄弱并且这类晶状体有可能在眼内不稳定。对这类稳定性问题的一种解决方式是在囊袋内植入稳定环并使IOL位于该环内。这类结构在公开号为No.2007/0010881(Soye等)的美国专利中示出。尽管两部分的晶状体系统在提供能够通过非常小的切口植入非常薄的、稳定的IOL时是有效的，然而所述的两个部件比单件式晶状体更难植入。
因此，仍旧需要存在能够通过非常小的切口植入的单件式的、稳定的IOL。
发明内容
本发明通过提供具有降低的内部光学区域和与所述光学部分整体形成的加厚或者升高的外周唇或者缘的IOL来对现有技术进行改进。这种设计减小了IOL的质量，使得所述晶状体更易于在非常小的切口中插入，而不损坏光学部分或者具有IOL的稳定性。
因此本发明的一个目的是提供一种稳定的IOL。
本发明的另一个目的是提供一种更易于通过非常小的切口插入到眼内的稳定的IOL。
本发明的另一个目的是提供具有降低的内部光学区域和与所述光学部分整体形成的加厚或者升高的外周唇或者缘的IOL。
通过参考附图以及下面对附图和权利要求的说明，本发明的其它目的、特征和优点将显而易见。
附图说明
图1是本发明IOL的顶部放大平面图。
图2是沿图1中线A-A获得的本发明IOL的第一实施例的放大横截面视图。
图3是沿图1中线A-A获得的本发明IOL的第二实施例的放大横截面视图。
优选实施例的详细描述
本发明的IOL 10通常包括光学部分12和至少两个袢(haptics)14。IOL 10可以具有任意合适尺寸的总体长度，优选的是处于10.5毫米(mm)和14.0mm之间，最优选的是12.5mm。光学部分12和袢14由相同的材料注塑成单件。用于制造IOL 10的材料可以是任何柔软的可折叠的生物相容材料。合适的材料是水凝胶、硅树脂或软丙烯酸树脂材料，这些材料在美国专利Nos.5,411,553(Gerace等)，5,403,901  (Namdaran  等)，  5,359,021(Weinschenk，  III等)，5,236,970(Christ等)，5,141,507(Parekh)以及4,834,750(Gupta)中有描述。光学部分12具有前侧24和后侧26并且可以为任何合适的尺寸，优选的是处于4.5mm和7.0mm之间并且最优选的是处于5.5mm和6.0mm之间。光学部分12也可以是椭圆形或者卵形。如下表中示出的，光学部分12的最大厚度将依据所需的折射(dioptic)能力和所用材料的折射系数而不同，但是边缘18具有0.1mm的厚度且缘30或30’具有约0.30mm的厚度，对于6D和71D之间的能力范围，光学部分12的中心厚度通常处于0.19mm和1.19mm之间，但是对于人类的真实部分，优选的是中心厚度为0.39mm或更小，最优选的是处于0.37mm和0.39mm之间。
 
能力(D)     光学部分中心厚度(mm)  
71.00       1.19                 
61.25       1.02                 
39.25       0.68                 
24.25       0.45                 
21.75       0.41                 
20.75       0.40                 
19.75       0.39                 
19.00     0.37                 
 
6.25     0.19    
IOL 10最基本的设计标准是对于任何给定直径和能力的光学部分12使光学部分12的厚度最小化以便将需要植入IOL 10所需的外科切口的尺寸最小化。可以改变用于制作光学部分12的材料以吸收紫外线辐射，或者任何其它需要的光波长度，如蓝光或者紫光。
在图2和3中能最清楚地观察到的，光学部分12分别包括周唇或者缘30或者30’，整体形成为光学部分12的一部分并绕光学部分12的周边18基本或者完全延伸。缘30可以被轴向在光学部分12上对中，如图2所示，或者缘30’可以沿轴向设置于光学部分12的前侧。这种结构允许减小光学部分12的厚度同时保持IOL 10在眼内的稳定性。
尽管上面已经描述了本发明的某些实施例，这些描述以示例和说明的目的给出。可以对上述公开的系统和方法进行变化、改变、变更和转变而不脱离本发明的范围或精神。

Claims (4)

1.人工晶状体，包括：
a)具有边缘的光学部分，所述边缘具有约0.1mm的厚度；
b)绕所述光学部分的边缘延伸并与光学部分整体成形的周缘；以及
c)多个从所述周缘延伸并与所述光学部分和周缘整体形成的袢。
2.如权利要求1所述的人工晶状体，其中所述人工晶状体由软丙烯酸材料制成。
3.如权利要求1所述的人工晶状体，其中所述光学部分具有0.19mm到0.39mm之间的最大厚度。
4.如权利要求1所述的人工晶状体，其中所述光学部分具有0.39mm的最大厚度。
CNA2008100917265A 2007-09-27 2008-04-14 人工晶状体 Pending CN101396307A (zh)

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US11/862,244 2007-09-27
US11/862,244 US20090088842A1 (en) 2007-09-27 2007-09-27 Intraocular Lens

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104797215A (zh) * 2012-12-06 2015-07-22 诺华股份有限公司 用于减少眼内透镜中的光效应的边缘设计
CN109069267A (zh) * 2016-05-05 2018-12-21 克拉维斯塔医疗有限公司 用于提高稳定性的人工晶状体设计
CN111629692A (zh) * 2017-09-20 2020-09-04 明视有限责任公司 单件式人工晶状体及其制造方法

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10028824B2 (en) 2012-01-24 2018-07-24 Clarvista Medical, Inc. Modular intraocular lens designs, tools and methods
US9364316B1 (en) 2012-01-24 2016-06-14 Clarvista Medical, Inc. Modular intraocular lens designs, tools and methods
AU2013212271B2 (en) 2012-01-24 2018-01-04 Clarvista Medical, Inc. Modular intraocular lens designs and methods
US10080648B2 (en) 2012-01-24 2018-09-25 Clarvista Medical, Inc. Modular intraocular lens designs, tools and methods
WO2015126604A1 (en) 2014-02-18 2015-08-27 Clarvista Medical, Inc. Modular intraocular lens designs, tools and methods
WO2016058051A1 (en) 2014-10-15 2016-04-21 Minas Theodore Coroneo An improved lens design
AU2015380300B2 (en) 2015-01-30 2020-01-02 Alcon Inc. Modular intraocular lens designs
WO2016159910A1 (en) 2015-04-01 2016-10-06 Karadag Remzi Intraocular lens comprising anchor-winged haptic
WO2016182520A1 (en) 2015-05-12 2016-11-17 Karadag Remzi Anchor-winged haptic tip apparatus for intraocular lenses
WO2017079449A1 (en) 2015-11-04 2017-05-11 Clarvista Medical, Inc. Modular intraocular lens designs, tools and methods
US11382736B2 (en) 2017-06-27 2022-07-12 Alcon Inc. Injector, intraocular lens system, and related methods
CN107601410B (zh) * 2017-09-12 2019-10-18 泉州台商投资区百亚网络科技有限公司 一种多功能的饮料灌装机
JP7389743B2 (ja) * 2017-11-01 2023-11-30 アルコン インコーポレイティド 閉ループ支持部構造体を有する眼内レンズ
JP7095284B2 (ja) * 2018-01-09 2022-07-05 株式会社ニデック 眼内レンズ
US11357620B1 (en) 2021-09-10 2022-06-14 California LASIK & Eye, Inc. Exchangeable optics and therapeutics

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4681102A (en) * 1985-09-11 1987-07-21 Bartell Michael T Apparatus and method for insertion of an intra-ocular lens
US5236970A (en) * 1987-02-05 1993-08-17 Allergan, Inc. Optically clear reinforced silicone elastomers of high optical refractive index and improved mechanical properties for use in intraocular lenses
US4834750A (en) * 1987-09-17 1989-05-30 Ioptex Research, Inc. Deformable-elastic intraocular lens
US5290892A (en) * 1990-11-07 1994-03-01 Nestle S.A. Flexible intraocular lenses made from high refractive index polymers
US5141507A (en) * 1991-12-06 1992-08-25 Iolab Corporation Soft intraocular lens
US5278258A (en) * 1992-05-18 1994-01-11 Allergan, Inc. Cross-linked silicone polymers, fast curing silicone precursor compositions, and injectable intraocular lenses
US5620450A (en) * 1992-09-30 1997-04-15 Staar Surgical Company, Inc. Transverse hinged deformable intraocular lens injecting apparatus
US5616148A (en) * 1992-09-30 1997-04-01 Staar Surgical Company, Inc. Transverse hinged deformable intraocular lens injecting apparatus
US5499987A (en) * 1992-09-30 1996-03-19 Staar Surgical Company Deformable intraocular lens cartridge
JP3664444B2 (ja) * 1992-09-30 2005-06-29 スター・サージカル・カンパニー 眼内レンズ挿入システム
US5331073A (en) * 1992-11-09 1994-07-19 Allergan, Inc. Polymeric compositions and intraocular lenses made from same
US5275604A (en) * 1992-12-03 1994-01-04 Kabi Pharmacia Ophthalmics, Inc. Contoured duct apparatus and method for insertion of flexible intraocular lens
US5653715A (en) * 1993-03-09 1997-08-05 Chiron Vision Corporation Apparatus for preparing an intraocular lens for insertion
US6800091B2 (en) * 1997-08-20 2004-10-05 Thinoptx, Inc. Method of using a small incision lens
US5947976A (en) * 1998-06-02 1999-09-07 Alcon Laboratories, Inc. Asymmetric intraocular lens injection cartridge
US20020022882A1 (en) * 2000-08-17 2002-02-21 Morgan Courtney Flem Rollable intraocular lens having reduced thickness
US6596025B2 (en) * 2001-03-15 2003-07-22 Valdemar Portney Narrow profile intraocular lens
US7204849B2 (en) * 2001-03-15 2007-04-17 Valdemar Portney Narrow profile intraocular lens
US7615073B2 (en) * 2003-12-09 2009-11-10 Advanced Medical Optics, Inc. Foldable intraocular lens and method of making
EP1694252B1 (en) * 2003-12-09 2017-08-09 Abbott Medical Optics Inc. Foldable intraocular lens and method of making
US20050187621A1 (en) * 2004-02-24 2005-08-25 Brady Daniel G. Foldable unitary intraocular lens
US7569073B2 (en) * 2004-12-29 2009-08-04 Bausch & Lomb Incorporated Small incision intraocular lens with anti-PCO feature
US20070010881A1 (en) * 2005-07-11 2007-01-11 Alcon, Inc. Intraocular lens system
US9636213B2 (en) * 2005-09-30 2017-05-02 Abbott Medical Optics Inc. Deformable intraocular lenses and lens systems

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104797215A (zh) * 2012-12-06 2015-07-22 诺华股份有限公司 用于减少眼内透镜中的光效应的边缘设计
US9566150B2 (en) 2012-12-06 2017-02-14 Novartis Ag Edge design for reducing unwanted photic effects in intraocular lenses
CN107157620A (zh) * 2012-12-06 2017-09-15 诺华股份有限公司 用于减少眼内透镜中的光效应的边缘设计
CN107157620B (zh) * 2012-12-06 2019-12-10 诺华股份有限公司 用于减少眼内透镜中的光效应的边缘设计
CN109069267A (zh) * 2016-05-05 2018-12-21 克拉维斯塔医疗有限公司 用于提高稳定性的人工晶状体设计
CN111629692A (zh) * 2017-09-20 2020-09-04 明视有限责任公司 单件式人工晶状体及其制造方法

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TW200913973A (en) 2009-04-01
EP2042124B1 (en) 2010-11-03
MX2008005619A (es) 2009-03-26
EP2042124A1 (en) 2009-04-01
CA2623906C (en) 2011-12-06
DE602008003277D1 (de) 2010-12-16
IL189978A0 (en) 2008-12-29
US20110054603A1 (en) 2011-03-03
RU2008115967A (ru) 2009-10-27
AU2008201271B2 (en) 2010-09-23
KR20120004357A (ko) 2012-01-12
AR067212A1 (es) 2009-10-07

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Application publication date: 20090401