CN101384583A - 氮杂环基-取代的芳基二氢异喹啉酮、它们的制备方法和它们作为药物的用途 - Google Patents

氮杂环基-取代的芳基二氢异喹啉酮、它们的制备方法和它们作为药物的用途 Download PDF

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CN101384583A
CN101384583A CNA2007800057794A CN200780005779A CN101384583A CN 101384583 A CN101384583 A CN 101384583A CN A2007800057794 A CNA2007800057794 A CN A2007800057794A CN 200780005779 A CN200780005779 A CN 200780005779A CN 101384583 A CN101384583 A CN 101384583A
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alkyl
compound
independently
alkoxy
ring
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Chinese (zh)
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L·施温克
S·施滕格林
M·戈塞尔
G·黑斯勒
T·哈克
P·伦宁格
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Sanofi SRL
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
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    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
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    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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CNA2007800057794A 2006-02-15 2007-02-13 氮杂环基-取代的芳基二氢异喹啉酮、它们的制备方法和它们作为药物的用途 Pending CN101384583A (zh)

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DE102006007045 2006-02-15
DE102006007045.3 2006-02-15

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US (1) US8822495B2 (enExample)
EP (1) EP1987020B1 (enExample)
JP (1) JP5175228B2 (enExample)
KR (1) KR20080095877A (enExample)
CN (1) CN101384583A (enExample)
AR (1) AR059458A1 (enExample)
AU (1) AU2007214709A1 (enExample)
BR (1) BRPI0707872A2 (enExample)
CA (1) CA2636873A1 (enExample)
CR (1) CR10160A (enExample)
EC (1) ECSP088680A (enExample)
IL (1) IL193340A0 (enExample)
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NI (1) NI200800217A (enExample)
NZ (1) NZ570503A (enExample)
RU (1) RU2008136898A (enExample)
TN (1) TNSN08326A1 (enExample)
TW (1) TW200800908A (enExample)
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CN102725285A (zh) * 2009-10-29 2012-10-10 Futurechem株式会社 (3-氟-2-羟基)丙基功能性化芳香基衍生物或其药学可接受盐和其制备方法，以及包含该芳香基衍生物作为活性成分用于诊断或治疗脑退化性疾病的药物组合物
CN103086894A (zh) * 2013-02-25 2013-05-08 武汉迪可表面技术有限公司 一种电镀添加剂3-甲基-3-氨基丁炔的合成方法
CN103238060A (zh) * 2010-12-01 2013-08-07 纳尔科公司 用于测定减轻原油蒸馏装置腐蚀的系统参数的方法和装置

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JP5198439B2 (ja) * 2006-06-08 2013-05-15 イーライ リリー アンド カンパニー 新規なｍｃｈ受容体アンタゴニスト
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RU2486187C2 (ru) 2007-09-11 2013-06-27 Эбботт Лэборетриз N-ОКСИДЫ ОКТАГИДРО-ПИРРОЛО[3,4-b]ПИРРОЛА
AR068745A1 (es) * 2007-10-08 2009-12-02 Panacea Biotec Ltd Una composicion en forma de dosificacion farmaceutica oral de unidad de alta dosis de micofenolato sodico, metodo para utilizar dicha composicion y sus usos
SI2212283T1 (sl) * 2007-10-17 2011-12-30 Sanofi Sa Substituirani n-fenil-bipirolidin karboksamidi in njihova terapevtska uporaba
AU2008312636B2 (en) * 2007-10-17 2013-03-14 Sanofi-Aventis Substituted N-phenyl-pyrrolidinylmethylpyrrolidine amides and therapeutic use thereof as histamine H3 receptor modulators
US8034806B2 (en) * 2007-11-02 2011-10-11 Vanderbilt University Bicyclic mGluR5 positive allosteric modulators and methods of making and using same
US8470841B2 (en) 2008-07-09 2013-06-25 Sanofi Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof
CN102137836B (zh) 2008-07-28 2015-08-26 赛丹思科大学 用于治疗代谢疾病的化合物
AR074466A1 (es) * 2008-12-05 2011-01-19 Sanofi Aventis Piperidina espiro pirrolidinona y piperidinona sustituidas y su uso terapeutico en enfermedades mediadas por la modulacion de los receptores h3.
WO2010147234A1 (en) * 2009-06-18 2010-12-23 Banyu Pharmaceutical Co.,Ltd. Diarylamide-spirodiamine derivative
JP5766278B2 (ja) * 2010-05-11 2015-08-19 サノフイ 置換されたｎ−アルキルおよびｎ−アシルテトラヒドロ−イソキノリン誘導体、それらの製造および治療上の使用
TW201206444A (en) 2010-05-11 2012-02-16 Sanofi Aventis Substituted N-heteroaryl tetrahydro-isoquinoline derivatives, preparation and therapeutic use thereof
AR083718A1 (es) 2010-05-11 2013-03-20 Sanofi Aventis Fenil cicloalquil pirrolidina (piperidina) espirolactamas y amidas sustituidas, preparacion y uso terapeutico de las mismas
WO2011143162A1 (en) 2010-05-11 2011-11-17 Sanofi Substituted n-heteroaryl bipyrrolidine carboxamides, preparation and therapeutic use thereof
TW201206910A (en) 2010-05-11 2012-02-16 Sanofi Aventis Substituted N-heterocycloalkyl bipyrrolidinylphenyl amide derivatives, preparation and therapeutic use thereof
JP5833105B2 (ja) * 2010-05-11 2015-12-16 サノフイ 置換ｎ−ヘテロアリールスピロラクタムビピロリジン類、その製造及び治療的使用
AR081976A1 (es) 2010-06-24 2012-10-31 Takeda Pharmaceutical Compuestos heterociclicos fusionados y sus usos como inhibidor de la fosfodiesterasa
TWI570122B (zh) * 2011-06-22 2017-02-11 武田藥品工業股份有限公司 稠合雜環化合物之結晶
WO2015018823A1 (en) 2013-08-08 2015-02-12 Galapagos Nv Thieno[2,3-c]pyrans as cftr modulators
US20210017174A1 (en) 2018-03-07 2021-01-21 Bayer Aktiengesellschaft Identification and use of erk5 inhibitor
CN120923343A (zh) * 2018-10-11 2025-11-11 巴斯夫股份公司 芳族化合物及其医药用途

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CN102725285A (zh) * 2009-10-29 2012-10-10 Futurechem株式会社 (3-氟-2-羟基)丙基功能性化芳香基衍生物或其药学可接受盐和其制备方法，以及包含该芳香基衍生物作为活性成分用于诊断或治疗脑退化性疾病的药物组合物
CN102725285B (zh) * 2009-10-29 2015-05-20 Futurechem株式会社 (3-氟-2-羟基)丙基功能性化芳香基衍生物或其药学可接受盐和其制备方法,以及包含该芳香基衍生物作为活性成分用于诊断或治疗脑退化性疾病的药物组合物
CN103238060A (zh) * 2010-12-01 2013-08-07 纳尔科公司 用于测定减轻原油蒸馏装置腐蚀的系统参数的方法和装置
CN103238060B (zh) * 2010-12-01 2016-04-20 纳尔科公司 用于测定减轻原油蒸馏装置腐蚀的系统参数的方法和装置
CN103086894A (zh) * 2013-02-25 2013-05-08 武汉迪可表面技术有限公司 一种电镀添加剂3-甲基-3-氨基丁炔的合成方法
CN103086894B (zh) * 2013-02-25 2014-10-01 武汉迪可表面技术有限公司 一种电镀添加剂3-甲基-3-氨基丁炔的合成方法

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AR059458A1 (es) 2008-04-09
CA2636873A1 (en) 2007-08-23
US8822495B2 (en) 2014-09-02
IL193340A0 (en) 2009-05-04
MA30221B1 (fr) 2009-02-02
ZA200805939B (en) 2009-12-30
KR20080095877A (ko) 2008-10-29
NI200800217A (es) 2010-02-10
TW200800908A (en) 2008-01-01
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ECSP088680A (es) 2008-09-29
EP1987020A1 (en) 2008-11-05
WO2007093364A1 (en) 2007-08-23
JP5175228B2 (ja) 2013-04-03
EP1987020B1 (en) 2012-10-03
RU2008136898A (ru) 2010-03-20
BRPI0707872A2 (pt) 2011-05-10
CR10160A (es) 2008-10-06
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