CN101384545A - 氘化的儿茶酚胺衍生物及包含所述化合物的药物 - Google Patents
氘化的儿茶酚胺衍生物及包含所述化合物的药物 Download PDFInfo
- Publication number
- CN101384545A CN101384545A CNA2007800059126A CN200780005912A CN101384545A CN 101384545 A CN101384545 A CN 101384545A CN A2007800059126 A CNA2007800059126 A CN A2007800059126A CN 200780005912 A CN200780005912 A CN 200780005912A CN 101384545 A CN101384545 A CN 101384545A
- Authority
- CN
- China
- Prior art keywords
- deuteriums
- amino
- dihydroxy phenyl
- physiology
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/001—Acyclic or carbocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/26—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Psychology (AREA)
- Psychiatry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
化合物 | AUC0-t[fmol/min*min] |
L-2-氨基-3-(3,4-二羟基苯基)丙酸 | 228 |
L-2-氨基-2,3,3-三氘-3-(3,4-二羟基苯基)丙酸 | 533 |
L-2-氨基-2,3-二氘-3-(3,4-二羟基苯基)丙酸(实施例6) | 685 |
Claims (41)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102006008316 | 2006-02-17 | ||
DE102006008316.4 | 2006-02-17 | ||
PCT/EP2007/001555 WO2007093450A2 (en) | 2006-02-17 | 2007-02-16 | Deuterated catecholamine derivatives and medicaments comprising said compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101384545A true CN101384545A (zh) | 2009-03-11 |
CN101384545B CN101384545B (zh) | 2014-09-03 |
Family
ID=38236462
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN200780005912.6A Expired - Fee Related CN101384545B (zh) | 2006-02-17 | 2007-02-16 | 氘化的儿茶酚胺衍生物及包含所述化合物的药物 |
Country Status (24)
Country | Link |
---|---|
US (2) | US8247603B2 (zh) |
EP (2) | EP3101001B1 (zh) |
JP (1) | JP5248331B2 (zh) |
KR (1) | KR101411422B1 (zh) |
CN (1) | CN101384545B (zh) |
AU (1) | AU2007214622B2 (zh) |
BR (1) | BRPI0708071A8 (zh) |
CA (1) | CA2642593C (zh) |
CY (1) | CY1117995T1 (zh) |
DK (1) | DK1991522T3 (zh) |
EA (1) | EA017983B1 (zh) |
ES (1) | ES2587368T3 (zh) |
HR (1) | HRP20161039T1 (zh) |
HU (1) | HUE028777T2 (zh) |
IL (1) | IL193102A (zh) |
LT (1) | LT1991522T (zh) |
ME (1) | ME02508B (zh) |
PL (1) | PL1991522T3 (zh) |
PT (1) | PT1991522T (zh) |
RS (1) | RS55142B1 (zh) |
SI (1) | SI1991522T1 (zh) |
UA (1) | UA97795C2 (zh) |
WO (1) | WO2007093450A2 (zh) |
ZA (1) | ZA200806568B (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104968643A (zh) * | 2013-02-05 | 2015-10-07 | 伊莫菲尔股份公司 | 位置特异性的非对称氘富集儿茶酚胺衍生物和包含所述化合物的药物 |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7776314B2 (en) | 2002-06-17 | 2010-08-17 | Grunenthal Gmbh | Abuse-proofed dosage system |
US20070048228A1 (en) | 2003-08-06 | 2007-03-01 | Elisabeth Arkenau-Maric | Abuse-proofed dosage form |
US8969417B2 (en) | 2008-06-06 | 2015-03-03 | Pharmatwob Ltd. | Pharmaceutical compositions for treatment of Parkinsons disease |
MX2011000637A (es) | 2008-07-15 | 2011-05-02 | Theracos Inc | Derivados deuretados de bencilbenceno y metodos de uso. |
US20130225697A1 (en) | 2012-02-28 | 2013-08-29 | Grunenthal Gmbh | Tamper-resistant dosage form comprising pharmacologically active compound and anionic polymer |
CN116768882A (zh) | 2012-09-18 | 2023-09-19 | 奥斯拜客斯制药有限公司 | 化合物、及其药物组合物及治疗方法 |
US9550780B2 (en) | 2012-09-18 | 2017-01-24 | Auspex Pharmaceuticals, Inc. | Formulations pharmacokinetics of deuterated benzoquinoline inhibitors of vesicular monoamine transporter 2 |
US9763904B2 (en) | 2013-02-05 | 2017-09-19 | Teva Pharmaceuticals International Gmbh | Position-specific asymmetric deuterium enriched catecholamine derivatives and medicaments comprising said compounds |
WO2014174425A2 (en) * | 2013-04-24 | 2014-10-30 | Mahesh Kandula | Compositions and methods for the treatment of orthostasis and neurological diseases |
KR20160041912A (ko) * | 2013-07-08 | 2016-04-18 | 오스펙스 파마슈티칼스, 인코포레이티드 | 디히드록시페닐 신경전달물질 화합물, 조성물 및 방법 |
US20160303110A1 (en) * | 2013-11-22 | 2016-10-20 | Auspex Pharmaceuticals, Inc. | Methods of treating abnormal muscular activity |
EA032920B1 (ru) | 2013-12-03 | 2019-08-30 | Оспекс Фармасьютикалз, Инк. | Способы получения соединений бензохинолина |
EP3102190A4 (en) | 2014-02-07 | 2017-09-06 | Auspex Pharmaceuticals, Inc. | Novel pharmaceutical formulations |
EP2918266A1 (en) | 2014-03-11 | 2015-09-16 | CDRD Berolina AB | Composition comprising a dopamine agonist and an L-DOPA derivative for treating Parkinson's disease |
GB201420341D0 (en) * | 2014-11-17 | 2014-12-31 | Evolution Valves Ltd | Valve arrangement |
CN114796209A (zh) | 2015-03-06 | 2022-07-29 | 奥斯拜客斯制药有限公司 | 氘代丁苯那嗪或包含氘代丁苯那嗪的组合物 |
CN106343013A (zh) * | 2015-07-19 | 2017-01-25 | 中国科学院上海有机化学研究所 | 一种粮食储存方法 |
MX2018004339A (es) | 2015-10-09 | 2019-04-15 | Teva Pharmaceuticals Int Gmbh | Combinación de levodopa deuterado con carbidopa y opicapona para el tratamiento del mal de parkinson. |
CN105360267B (zh) * | 2015-10-09 | 2017-11-10 | 青岛振坤食品机械有限公司 | 一种全自动穿串机 |
CN105862897B (zh) * | 2016-04-11 | 2018-01-16 | 江苏省华建建设股份有限公司 | 砂质泥岩地基浅基础原槽浇筑施工工法 |
JP2022510424A (ja) * | 2018-12-06 | 2022-01-26 | センダ バイオサイエンシーズ, インコーポレイテッド | トリメチルアミン産生の阻害剤としての第四級アンモニウム塩 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3699158A (en) | 1969-08-25 | 1972-10-17 | Merck & Co Inc | Selective deuteration of tyrosine, aspartic and glutamic acids |
DE2049807A1 (en) | 1970-10-10 | 1972-04-13 | Hartmeyer H | Conversion of closed cell plastics foam to - open cell structure |
DE2049115C3 (de) | 1970-10-06 | 1981-07-30 | Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai, Tokyo | Verwendung von Calcium-5-butylpicolinat und/oder Calcium-5-pentylpicolinat bei der Bekämpfung des Parkinsonismus mit 3-(3,4-Dihydroxyphenyl)-L-alanin (L-Dopa) |
DE3779500T2 (de) * | 1986-06-10 | 1993-01-21 | Chiesi Farma Spa | Levodopa-methyl-ester enthaltende pharmazeutische zusammensetzungen, ihre herstellung und therapeutische verwendungen. |
IT1226902B (it) | 1988-07-12 | 1991-02-21 | Mini Ricerca Scient Tecnolog | Processo per la sintesi del levodopa |
US5354885A (en) * | 1992-12-24 | 1994-10-11 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Process for preparing ethyl ester of L-DOPA |
US6221335B1 (en) * | 1994-03-25 | 2001-04-24 | Isotechnika, Inc. | Method of using deuterated calcium channel blockers |
US6440710B1 (en) * | 1998-12-10 | 2002-08-27 | The Scripps Research Institute | Antibody-catalyzed deuteration, tritiation, dedeuteration or detritiation of carbonyl compounds |
ATE234299T1 (de) * | 1999-12-03 | 2003-03-15 | Pfizer Prod Inc | Sulfamoylheteroarylpyrazolverbindungen zur verwendung als analgetisches/entzündungshemmendes mittel |
DE10261808A1 (de) | 2002-12-19 | 2004-07-08 | Turicum Drug Development Ag | Verwendung von L-DOPA, seiner Derivate und diese Verbindungen enthaltender Arzneimittel zur Prophylaxe psychotischer Erkrankungen |
DE10261807A1 (de) * | 2002-12-19 | 2004-07-01 | Turicum Drug Development Ag | Deuterierte Catecholaminderivate sowie diese Verbindungen enthaltende Arzneimittel |
-
2007
- 2007-02-16 ME MEP-2016-167A patent/ME02508B/me unknown
- 2007-02-16 HU HUE07703542A patent/HUE028777T2/en unknown
- 2007-02-16 UA UAA200811184A patent/UA97795C2/uk unknown
- 2007-02-16 LT LTEP07703542.6T patent/LT1991522T/lt unknown
- 2007-02-16 DK DK07703542.6T patent/DK1991522T3/en active
- 2007-02-16 PT PT77035426T patent/PT1991522T/pt unknown
- 2007-02-16 RS RS20160674A patent/RS55142B1/sr unknown
- 2007-02-16 CN CN200780005912.6A patent/CN101384545B/zh not_active Expired - Fee Related
- 2007-02-16 US US12/224,120 patent/US8247603B2/en not_active Ceased
- 2007-02-16 BR BRPI0708071A patent/BRPI0708071A8/pt not_active Application Discontinuation
- 2007-02-16 JP JP2008554702A patent/JP5248331B2/ja not_active Expired - Fee Related
- 2007-02-16 WO PCT/EP2007/001555 patent/WO2007093450A2/en active Application Filing
- 2007-02-16 PL PL07703542T patent/PL1991522T3/pl unknown
- 2007-02-16 US US14/464,568 patent/USRE46555E1/en active Active
- 2007-02-16 EP EP16170031.5A patent/EP3101001B1/en active Active
- 2007-02-16 EP EP07703542.6A patent/EP1991522B1/en active Active
- 2007-02-16 AU AU2007214622A patent/AU2007214622B2/en not_active Ceased
- 2007-02-16 EA EA200801826A patent/EA017983B1/ru not_active IP Right Cessation
- 2007-02-16 KR KR1020087022011A patent/KR101411422B1/ko active IP Right Grant
- 2007-02-16 ES ES07703542.6T patent/ES2587368T3/es active Active
- 2007-02-16 CA CA2642593A patent/CA2642593C/en active Active
- 2007-02-16 SI SI200731819A patent/SI1991522T1/sl unknown
-
2008
- 2008-07-28 ZA ZA200806568A patent/ZA200806568B/xx unknown
- 2008-07-29 IL IL193102A patent/IL193102A/en active IP Right Grant
-
2016
- 2016-08-17 HR HRP20161039TT patent/HRP20161039T1/hr unknown
- 2016-08-17 CY CY20161100808T patent/CY1117995T1/el unknown
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104968643A (zh) * | 2013-02-05 | 2015-10-07 | 伊莫菲尔股份公司 | 位置特异性的非对称氘富集儿茶酚胺衍生物和包含所述化合物的药物 |
CN104968643B (zh) * | 2013-02-05 | 2020-03-03 | 梯瓦制药国际有限责任公司 | 位置特异性的非对称氘富集儿茶酚胺衍生物和包含所述化合物的药物 |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN101384545B (zh) | 氘化的儿茶酚胺衍生物及包含所述化合物的药物 | |
US5525631A (en) | Compositions of the ethyl ester of L-DOPA | |
JP2018193356A (ja) | 重水素化カテコールアミン誘導体ならびにそれらの化合物を含有する医薬品 | |
WO2019038638A1 (en) | PROCESS FOR PREPARING AMIDE OF PURIFIED LEVODOPA | |
EP3432874B1 (en) | Methods and compositions for treatment of prader-willi syndrome | |
WO2020035853A1 (en) | Process for preparing purified levodopamide free base | |
US20190224184A1 (en) | Preparation of (-)-cocaine hydrochloride |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
C41 | Transfer of patent application or patent right or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20160304 Address after: Berlin Patentee after: Imoffel AG Address before: Berlin Patentee before: BIRDS PHARMA GMBH BEROLINA INNOVATIVE RESEARCH & DEVELOPMENT SERVICES |
|
TR01 | Transfer of patent right |
Effective date of registration: 20170527 Address after: Switzerland Jonathan Patentee after: Teva Pharmaceuticals International GmbH Address before: Ulm Patentee before: Weisuo Fan Co.,Ltd. Effective date of registration: 20170527 Address after: Ulm Patentee after: Weisuo Fan Co.,Ltd. Address before: Berlin Patentee before: Imoffel AG |
|
CF01 | Termination of patent right due to non-payment of annual fee | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20140903 Termination date: 20210216 |