CN101375161A - 靶定金黄色葡萄球菌ORF0657n的抗原结合蛋白 - Google Patents

靶定金黄色葡萄球菌ORF0657n的抗原结合蛋白 Download PDF

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Publication number
CN101375161A
CN101375161A CNA2007800036232A CN200780003623A CN101375161A CN 101375161 A CN101375161 A CN 101375161A CN A2007800036232 A CNA2007800036232 A CN A2007800036232A CN 200780003623 A CN200780003623 A CN 200780003623A CN 101375161 A CN101375161 A CN 101375161A
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CN
China
Prior art keywords
seq
region
mab
amino acids
amino acid
Prior art date
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Pending
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CNA2007800036232A
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English (en)
Chinese (zh)
Inventor
M·J·布朗
A·S·安德森
L·D·科普
K·U·延森
T·麦尼利
B·哈维
E·杜尔
R·埃恩斯特
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Merck and Co Inc
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Merck and Co Inc
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Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of CN101375161A publication Critical patent/CN101375161A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
    • C07K16/1271—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Micrococcaceae (F), e.g. Staphylococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/72—Increased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CNA2007800036232A 2006-01-27 2007-01-23 靶定金黄色葡萄球菌ORF0657n的抗原结合蛋白 Pending CN101375161A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US76302306P 2006-01-27 2006-01-27
US60/763,023 2006-01-27

Publications (1)

Publication Number Publication Date
CN101375161A true CN101375161A (zh) 2009-02-25

Family

ID=38327867

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2007800036232A Pending CN101375161A (zh) 2006-01-27 2007-01-23 靶定金黄色葡萄球菌ORF0657n的抗原结合蛋白

Country Status (7)

Country Link
US (1) US20110091480A1 (enExample)
EP (1) EP1982185A4 (enExample)
JP (1) JP2009524428A (enExample)
CN (1) CN101375161A (enExample)
AU (1) AU2007210170A1 (enExample)
CA (1) CA2637152A1 (enExample)
WO (1) WO2007089470A2 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100166772A1 (en) * 2007-05-31 2010-07-01 Anderson Annaliesa S ANTIGEN-BINDING PROTEINS TARGETING S. AUREUS ORF0657n
US9181329B2 (en) 2007-08-31 2015-11-10 The University Of Chicago Methods and compositions related to immunizing against Staphylococcal lung diseases and conditions
CA2697538C (en) 2007-08-31 2019-02-12 University Of Chicago Methods and compositions related to immunizing against staphylococcal lung diseases and conditions
US8758765B2 (en) 2008-07-29 2014-06-24 The University Of Chicago Compositions and methods related to Staphylococcal bacterium proteins
SMT202000246T1 (it) 2009-04-03 2020-07-08 Univ Chicago Composizioni e metodi relativi a varianti della proteina a (spa)
BR112013000097B1 (pt) 2010-07-02 2022-02-01 The University Of Chicago Polipeptídeo imunogênico isolado, composição imunogênica e seu uso
US8945588B2 (en) 2011-05-06 2015-02-03 The University Of Chicago Methods and compositions involving protective staphylococcal antigens, such as EBH polypeptides

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6916605B1 (en) * 1990-07-10 2005-07-12 Medical Research Council Methods for producing members of specific binding pairs
BR0207068A (pt) * 2001-01-26 2004-12-21 Inhibitex Inc Anticorpo monoclonal para a protéina clfa, anti-soro isolado, anticorpo isolado e anticorpo humanizado contendo o referido anticorpo, kit diagnóstico compreendendo o referido anticorpo, método para diagnóstico de uma infecção por s.aureus, composição farmacêutica para o tratamento ou prevenção da referida infecção, método para indução de de uma resposta imunológica, método para identificação de anticorpos monoclonais para a protéina clfa e fragmento ativo isolado a partir do domìnio a da protéina clfa do s.aureus
US20070275460A1 (en) * 2003-03-03 2007-11-29 Xencor.Inc. Fc Variants With Optimized Fc Receptor Binding Properties
NZ544542A (en) * 2003-07-24 2009-01-31 Merck & Co Inc Polypeptides for inducing a protective immune response against staphylococcus aureus
US20060188515A1 (en) * 2003-07-24 2006-08-24 Anderson Annaliesa S Polypeptides for inducing a protective immune response against staphylococcus aureus
ES2589927T3 (es) * 2005-01-21 2016-11-17 Merck Sharp & Dohme Corp. Polipéptidos para inducir una respuesta inmunitaria protectora contra Staphylococcus aureus
WO2008140632A2 (en) * 2007-01-24 2008-11-20 Merck & Co., Inc. Polypeptides for inducing a protective immune response against staphylococcus epidermidis
WO2008115415A2 (en) * 2007-03-19 2008-09-25 Merck & Co., Inc Polypeptides for inducing a protective immune response against staphylococcus epidermidis
US20100166772A1 (en) * 2007-05-31 2010-07-01 Anderson Annaliesa S ANTIGEN-BINDING PROTEINS TARGETING S. AUREUS ORF0657n

Also Published As

Publication number Publication date
WO2007089470A3 (en) 2008-01-24
WO2007089470A2 (en) 2007-08-09
AU2007210170A1 (en) 2007-08-09
EP1982185A2 (en) 2008-10-22
WO2007089470A9 (en) 2007-11-01
EP1982185A4 (en) 2010-04-28
JP2009524428A (ja) 2009-07-02
CA2637152A1 (en) 2007-08-09
US20110091480A1 (en) 2011-04-21

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Application publication date: 20090225