CA2637152A1 - Antigen-binding proteins targeting s. aureus orf0657n - Google Patents

Antigen-binding proteins targeting s. aureus orf0657n Download PDF

Info

Publication number
CA2637152A1
CA2637152A1 CA002637152A CA2637152A CA2637152A1 CA 2637152 A1 CA2637152 A1 CA 2637152A1 CA 002637152 A CA002637152 A CA 002637152A CA 2637152 A CA2637152 A CA 2637152A CA 2637152 A1 CA2637152 A1 CA 2637152A1
Authority
CA
Canada
Prior art keywords
seq
mab
amino acids
region
binding protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002637152A
Other languages
English (en)
French (fr)
Inventor
Martha J. Brown
Annaliesa S. Anderson
Leslie D. Cope
Kathrin Ute Jansen
Tessie Mcneely
Barrett R. Harvey
Eberhard Durr
Robin Ernst
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp & Dohme LLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2637152A1 publication Critical patent/CA2637152A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267—Gram-positive bacteria
    • C07K16/1271—Micrococcaceae (F); Staphylococcaceae (F), e.g. Staphylococcus (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/72—Increased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CA002637152A 2006-01-27 2007-01-23 Antigen-binding proteins targeting s. aureus orf0657n Abandoned CA2637152A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US76302306P 2006-01-27 2006-01-27
US60/763,023 2006-01-27
PCT/US2007/001687 WO2007089470A2 (en) 2006-01-27 2007-01-23 Antigen-binding proteins targeting s. aureus orf0657n

Publications (1)

Publication Number Publication Date
CA2637152A1 true CA2637152A1 (en) 2007-08-09

Family

ID=38327867

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002637152A Abandoned CA2637152A1 (en) 2006-01-27 2007-01-23 Antigen-binding proteins targeting s. aureus orf0657n

Country Status (7)

Country Link
US (1) US20110091480A1 (enExample)
EP (1) EP1982185A4 (enExample)
JP (1) JP2009524428A (enExample)
CN (1) CN101375161A (enExample)
AU (1) AU2007210170A1 (enExample)
CA (1) CA2637152A1 (enExample)
WO (1) WO2007089470A2 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20100021577A (ko) * 2007-05-31 2010-02-25 머크 앤드 캄파니 인코포레이티드 에스.아우레우스 ＯＲＦ0657ｎ을 표적화하는 항원 결합 단백질
KR20100072228A (ko) 2007-08-31 2010-06-30 유니버시티 오브 시카고 스타필로코커스 폐 질환 및 상태에 대한 면역화와 관련된 방법 및 조성물
US9181329B2 (en) 2007-08-31 2015-11-10 The University Of Chicago Methods and compositions related to immunizing against Staphylococcal lung diseases and conditions
US8758765B2 (en) 2008-07-29 2014-06-24 The University Of Chicago Compositions and methods related to Staphylococcal bacterium proteins
HRP20160274T1 (hr) 2009-04-03 2016-04-08 University Of Chicago Pripravci i metode vezane za varijante proteina a (spa)
AU2011274367B2 (en) 2010-07-02 2015-04-23 The University Of Chicago Compositions and methods related to protein A (SpA) variants
US8945588B2 (en) 2011-05-06 2015-02-03 The University Of Chicago Methods and compositions involving protective staphylococcal antigens, such as EBH polypeptides
CA3139981A1 (en) 2019-05-14 2020-11-19 The University Of Chicago Methods and compositions comprising staphylococcus protein a (spa) variants
US12528882B2 (en) 2019-09-13 2026-01-20 The University Of Chicago Methods and compositions for treating staphylococcal infections
CN116234814A (zh) * 2020-08-28 2023-06-06 江苏恒瑞医药股份有限公司 用于降低异源多肽末端异质性的信号肽

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6916605B1 (en) * 1990-07-10 2005-07-12 Medical Research Council Methods for producing members of specific binding pairs
WO2002072600A2 (en) * 2001-01-26 2002-09-19 Inhibitex, Inc. Monoclonal antibodies to the clfa protein and method of use in treating or preventing infections
US20070275460A1 (en) * 2003-03-03 2007-11-29 Xencor.Inc. Fc Variants With Optimized Fc Receptor Binding Properties
NZ544542A (en) * 2003-07-24 2009-01-31 Merck & Co Inc Polypeptides for inducing a protective immune response against staphylococcus aureus
WO2005009378A2 (en) * 2003-07-24 2005-02-03 Merck & Co., Inc. Polypeptides for inducing a protective immune response against staphylococcus aureus
WO2006078680A2 (en) * 2005-01-21 2006-07-27 Merck & Co., Inc. Polypeptides for inducing a protective immune response against staphylococcus aureus
CN101610781A (zh) * 2007-01-24 2009-12-23 默克公司 用于诱导针对表皮葡萄球菌的保护性免疫应答的多肽
WO2008115415A2 (en) * 2007-03-19 2008-09-25 Merck & Co., Inc Polypeptides for inducing a protective immune response against staphylococcus epidermidis
KR20100021577A (ko) * 2007-05-31 2010-02-25 머크 앤드 캄파니 인코포레이티드 에스.아우레우스 ＯＲＦ0657ｎ을 표적화하는 항원 결합 단백질

Also Published As

Publication number Publication date
EP1982185A4 (en) 2010-04-28
US20110091480A1 (en) 2011-04-21
AU2007210170A1 (en) 2007-08-09
CN101375161A (zh) 2009-02-25
WO2007089470A3 (en) 2008-01-24
WO2007089470A2 (en) 2007-08-09
JP2009524428A (ja) 2009-07-02
EP1982185A2 (en) 2008-10-22
WO2007089470A9 (en) 2007-11-01

Similar Documents

Publication Publication Date Title
US8653242B2 (en) Therapeutic antibodies against flagellated Pseudomonas aeruginosa
CN101679516B (zh) 靶向金黄色葡萄球菌ORF0657n的抗原结合蛋白
JP5981347B2 (ja) Ｐｃｓｋ９アンタゴニスト
US8877191B2 (en) Antibodies to the PcrV antigen of Pseudomonas aeruginosa
US20110091480A1 (en) Antigen-Binding Proteins Targeting S. Aureus Orf0657n
WO2014028748A1 (en) Interleukin 2 antibodies and antibody complexes
CN106132988A (zh) 抗金黄色葡萄球菌lukgh(lukab)毒素的抗体和抗体序列
EP2999713A2 (en) Generation of highly potent antibodies neutralizing the lukgh (lukab) toxin of staphylococcus aureus
CN113416249B (zh) 针对破伤风毒素的组合物
US20240059764A1 (en) ANTIGEN-BINDING PROTEIN TARGETING STAPHYLOCOCCUS AUREUS a-HEMOLYSIS AND APPLICATION THEREOF
CN114957460A (zh) 交叉中和金黄色葡萄球菌毒素的抗原结合蛋白及其用途
RU2815280C1 (ru) Антитело против столбнячного токсина и его применение
US20240174736A1 (en) Antigen-binding protein targeting pneumolysin and use thereof
TW202506731A (zh) 治療多重抗藥性細菌感染之方法
NZ618266B2 (en) Anti-pseudomonas psl binding molecules and uses thereof

Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued

Effective date: 20130123