CN101365715B - 基质金属蛋白酶11疫苗 - Google Patents

基质金属蛋白酶11疫苗 Download PDF

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Publication number
CN101365715B
CN101365715B CN2006800370642A CN200680037064A CN101365715B CN 101365715 B CN101365715 B CN 101365715B CN 2006800370642 A CN2006800370642 A CN 2006800370642A CN 200680037064 A CN200680037064 A CN 200680037064A CN 101365715 B CN101365715 B CN 101365715B
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CN
China
Prior art keywords
mmp
encoding
polypeptide
ltb
vaccine
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Expired - Fee Related
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CN2006800370642A
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English (en)
Chinese (zh)
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CN101365715A (zh
Inventor
真纳罗·奇利贝托
多马尼科·拉扎罗
费德里卡·莫里
达尼埃洛·佩鲁齐
L·奥里西焦
N·拉莫尼卡
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MSD Italia SRL
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Istituto di Ricerche di Biologia Molecolare P Angeletti SpA
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6402—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals
    • C12N9/6405—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals not being snakes
    • C12N9/6416—Metalloendopeptidases (3.4.24)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CN2006800370642A 2005-10-07 2006-10-03 基质金属蛋白酶11疫苗 Expired - Fee Related CN101365715B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US72449805P 2005-10-07 2005-10-07
US60/724,498 2005-10-07
PCT/EP2006/009536 WO2007042169A2 (en) 2005-10-07 2006-10-03 Matrix metalloproteinase 11 vaccine

Publications (2)

Publication Number Publication Date
CN101365715A CN101365715A (zh) 2009-02-11
CN101365715B true CN101365715B (zh) 2013-03-27

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ID=37451271

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CN2006800370642A Expired - Fee Related CN101365715B (zh) 2005-10-07 2006-10-03 基质金属蛋白酶11疫苗

Country Status (9)

Country Link
US (2) US8106176B2 (https=)
EP (1) EP1934246B8 (https=)
JP (1) JP5361386B2 (https=)
CN (1) CN101365715B (https=)
AT (1) ATE521629T1 (https=)
AU (1) AU2006301582B2 (https=)
CA (1) CA2623531C (https=)
ES (1) ES2370040T3 (https=)
WO (1) WO2007042169A2 (https=)

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Publication number Priority date Publication date Assignee Title
US8216997B2 (en) 2008-08-14 2012-07-10 Acceleron Pharma, Inc. Methods for increasing red blood cell levels and treating anemia using a combination of GDF traps and erythropoietin receptor activators
TW201803586A (zh) 2008-08-14 2018-02-01 艾瑟勒朗法瑪公司 使用ｇｄｆ阱以增加紅血球水平
EP2568044B1 (en) * 2008-09-29 2015-04-08 The Trustees of The University of Pennsylvania Tumor vascular marker-targeted vaccines
KR20120049214A (ko) 2009-06-08 2012-05-16 악셀레론 파마 인코포레이티드 발열성 지방세포를 증가시키는 방법
AU2010282361B2 (en) * 2009-08-13 2015-03-19 Acceleron Pharma Inc. Combined use of GDF traps and erythropoietin receptor activators to increase red blood cell levels
CN107028886A (zh) 2009-11-04 2017-08-11 不列颠哥伦比亚大学 含有核酸的脂质粒子及相关的方法
WO2013059922A1 (en) 2011-10-25 2013-05-02 The University Of British Columbia Limit size lipid nanoparticles and related methods
CN105143456A (zh) 2013-03-15 2015-12-09 不列颠哥伦比亚大学 用于转染的脂质纳米粒子和相关方法
LT3388075T (lt) 2015-03-27 2023-11-10 Immatics Biotechnologies Gmbh Nauji peptidai ir peptidų deriniai, skirti naudoti imunoterapijai prieš įvairius navikus (seq id 25 - mrax5-003)
GB201505305D0 (en) 2015-03-27 2015-05-13 Immatics Biotechnologies Gmbh Novel Peptides and combination of peptides for use in immunotherapy against various tumors
CN110418648B (zh) * 2017-02-22 2023-09-08 丁恩雨 一种编码人GM-CSF与多串连表位融合的mRNA癌症疫苗
US20220362402A1 (en) * 2019-10-08 2022-11-17 Exhaura, Ltd. Compositions and methods for ocular therapy
US20240199725A1 (en) 2021-04-16 2024-06-20 Korea University Research And Business Foundation Human antibody targeting covid-19 virus
GB202117583D0 (en) * 2021-12-06 2022-01-19 Cambridge Entpr Ltd Protein expression
CN116590263A (zh) * 2023-07-02 2023-08-15 广州庆毅生物医药科技有限公司 一种重组蛋白、单克隆抗体及其检测试剂盒和应用

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IL78775A (en) * 1985-05-15 1992-06-21 Biotech Australia Pty Ltd Oral vaccines
GB9112553D0 (en) 1991-06-11 1991-07-31 Wellcome Found Fusion proteins
US5786464C1 (en) 1994-09-19 2012-04-24 Gen Hospital Corp Overexpression of mammalian and viral proteins
NZ332954A (en) * 1996-05-23 2000-07-28 Xoma Corp Use of BPI protein products to treat humans with hemorrhage due to trauma
US6114148C1 (en) * 1996-09-20 2012-05-01 Gen Hospital Corp High level expression of proteins
BR0010077A (pt) 1999-04-26 2002-01-15 K U Leuven Res & Dev Universit Gene sintético para expressão de uma proteìna retroviral ativa em eucariotas
CA2385172A1 (en) * 1999-10-08 2001-04-19 Active Biotech Ab Ab5 toxin b subunit mutants with altered chemical conjugation characteristics
GB9930768D0 (en) * 1999-12-29 2000-02-16 Pfizer Ltd Composition
JP2004508064A (ja) 2000-09-15 2004-03-18 メルク　エンド　カムパニー　インコーポレーテッド コドン最適化ｈｉｖ１−ｇａｇ、ｐｏｌ、ｎｅｆおよび修飾体を発現する増強された第１世代アデノウイルスワクチン
US20040110152A1 (en) 2002-12-10 2004-06-10 Isis Pharmaceuticals Inc. Modulation of matrix metalloproteinase 11 expression
GB0321615D0 (en) * 2003-09-15 2003-10-15 Glaxo Group Ltd Improvements in vaccination
EA012066B1 (ru) * 2003-10-10 2009-08-28 Паудерджект Вэксинс, Инк. Способ, вызывающий т-клеточный ответ
CA2555013C (en) * 2004-02-11 2013-10-15 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. Carcinoembryonic antigen fusions and uses thereof

Non-Patent Citations (5)

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Title
A Noel et al.Demonstration in vivo that stromelysin-3 functions through its proteolytic activity.《Oncogene》.2000,第19卷1605-1612. *
Erxi Wu et al.Stromelysin-3 Suppresses Tumor Cell Apoptosis in a Murine Model.《Journal of Cellular Biochemistry》.2001,第82卷549-555. *
Liezhen Fu et al.A Causative Role of Stromelysin-3 in Extracellular Matrix Remodeling and Epithelial Apoptosis during Intestinal Metamorphosis in Xenopus laevis.《THE JOURNAL OF BIOLOGICAL CHEMISTRY》.2005,第280卷(第30期),27856-27865. *
Olivia FROMIGUE et al.ACTIVE STROMELYSIN-3 (MMP-11) INCREASES MCF-7 SURVIVAL IN THREE-DIMENSIONAL MATRIGEL CULTURE VIA ACTIVATION OF p42/p44 MAP-KINASE.《Int. J. Cancer》.2003,第106卷355-363. *
SASHKO DAMJANOVSKI et al.Overexpression of Matrix Metalloproteinases Leads to Lethality in Transgenic Xenopus laevis: Implications for Tissue-Dependent Functions of Matrix Metalloproteinases During Late Embryonic Development.《DEVELOPMENTAL DYNAMICS》.2001,第221卷37-47. *

Also Published As

Publication number Publication date
ATE521629T1 (de) 2011-09-15
ES2370040T3 (es) 2011-12-12
EP1934246A2 (en) 2008-06-25
JP5361386B2 (ja) 2013-12-04
AU2006301582B2 (en) 2011-10-13
WO2007042169A3 (en) 2007-05-31
US8106176B2 (en) 2012-01-31
US20120177679A1 (en) 2012-07-12
US8492522B2 (en) 2013-07-23
CA2623531C (en) 2013-12-10
CA2623531A1 (en) 2007-04-19
JP2009509553A (ja) 2009-03-12
CN101365715A (zh) 2009-02-11
EP1934246B8 (en) 2012-02-08
US20090155298A1 (en) 2009-06-18
EP1934246B1 (en) 2011-08-24
WO2007042169A2 (en) 2007-04-19
AU2006301582A1 (en) 2007-04-19

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Free format text: FORMER OWNER: ISTITUTO DI RICERCHE DI BIOLOGYIA MOLECOLARE P.ANGELETTI S.P.A

Effective date: 20140619

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Patentee before: Angeletti P. Ist Richerche Bio

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CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20130327

Termination date: 20181003