CN101361789A - Traditional Chinese medicine formulation for treating and preventing lung impairment after tumor controlling radiotherapy - Google Patents
Traditional Chinese medicine formulation for treating and preventing lung impairment after tumor controlling radiotherapy Download PDFInfo
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Abstract
The invention relates to a traditional Chinese traditional medicine preparation for preventing and curing lung injury after radiation therapy of tumor, which is prepared by the following raw medicine materials with weight ratios and by the following technique: 5 portions to 30 portions of angelica, 5 portions to 10 portions of rhizoma ligustici wallichii, 5 portions to 30 portions of astragalus roots, 5 portions to 15 portions of fructus ligustri lucidi, 5 portions to 15 portions of herba celiptae and 5 portions to 15 portions of sophora alopecuroides; according to the weight ratios, the angelica, the rhizoma ligustici wallichii, the astragalus roots, the fructus ligustri lucidi, the herba celiptae and the sophora alopecuroides are selected, added with 10 times to 15 times of water, soaked for 24 hours to 36 hours and decocted for 3 times; decocting liquids of the tree times are combined and filtered; filter liquid is collected and concentrated into a thick paste with a relative density of 1:1.25 to 1.35 for standby purpose; the thick paste is roasted at low temperature for 10 hours, thus obtaining a dry paste powder; according to a weight ratio of 1 to 0.5 of the dry paste powder to dextrin, an auxiliary material is added; subpackaging is carried out after granulation. The prescription can protect patients with tumors from lung injury after radiation therapy, increase the tolerance of the patients with tumors, improve the life quality of the patients and enhance the resisting capability of the whole body.
Description
Affiliated technical field
The invention belongs to Chinese medicine and preparation field thereof, specifically is a kind of Chinese medicine preparation of preventing and treating injury of lung behind the tumor radiotherapy.This compound medicine consists of: Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Astragali, Fructus Ligustri Lucidi, Herba Ecliptae, Herba Sophorae alopecuroidis.Clinical use for many years, curative effect is good.
Background technology
Induced lung injury (Irradiation-induced pulmonary damage) is a main complication after breast tumor radiotherapy, the bone marrow transplantation pretreatment, comprises the pulmonary fibrosis (pulmonary fibrosis) in early stage acute pneumonia (acute pneumonitis) and later stage.Its sickness rate is reported as 19%-37.2% abroad, domesticly is reported as 8.25%.(radiation pulmonaryfibrosis, RPF) more thorny, severe patient often jeopardizes patient's life to the radiation fibrosis of lung of its middle and late stage, is to cause these patient treatments and poor prognosis even one of non-protopathy main causes of death take place.In addition, because lungs are radiation medium sensitivity sexual organs, radioprotective in wartime or accidental at ordinary times nuclear accident damage also usually can be involved lungs, the induced radioactivity injury of lung.Therefore, the research of induced lung injury more is subject to people's attention, has become the important subject in current bone marrow transplantation and the radiological medicine field.Its pathogenesis and further prophylactic treatment still are in the exploratory stage at present.
Interstitial pulmonary fibrosis belongs to one of listed difficult disease of WHO, case fatality rate height, 5 years survival rates only 50%, and the western medical treatment interstitial pulmonary fibrosis does not have special method, the main principle of putting prevention first that adopts.Now Chang Yong Western medicine such as cytokine inhibitor, antioxidant, selenium preparation, glucocorticoid etc.Cytokine inhibitor treatment injury of lung is a kind of promising Therapeutic Method, but only is in the trial stage at present.Although the traditional Chinese medical science, doctor trained in Western medicine are many in the research in this field of control induced lung injury, still there is not breakthrough at present.Comparatively speaking, the traditional Chinese medical science is occupied certain advantage in this field.The tcm syndrome differentiation and treatment interstitial pulmonary fibrosis has certain advantage.According to the clinical manifestation of interstitial pulmonary fibrosis, the traditional Chinese medical science is classified as it in categories such as " cough ", " consumptive lung disease ", " pulmonary distension ", " lung-QI stagnation syndrome ".Think that interstitial pulmonary fibrosis is chronic, a gradual pathological changes, cause the deficiency in origin and excess in superficiality of expectorant blood stasis resistance lung network for remaining of pathogens due to deficiency of vital QI and demonstrate,prove that expectorant blood resistance network is the domination of pathogen, is the main root that produces pulmonary fibrosis, the resistance of expectorant blood stasis damages gas the moon with the passing of time again, causes deficiency of both QI and YIN.Vital QI being weakened and pathogen being violent reciprocal causation, formation deficiency in origin and excess in superficiality are the card that the touching difficulty of characteristics heals.So many in treatment is the basic rule of treatment with blood circulation and promoting silt, is aided with supplementing QI and nourishing YIN.
The present invention is made up of six medicaments such as Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Astragali, Fructus Ligustri Lucidi, Herba Ecliptae and Herba Sophorae alopecuroidiss.Purpose is the Chinese medicine that a kind of treatment tumor radiotherapy injury of lung of the effect with supplementing QI and nourishing YIN, promoting flow of QI and blood, lung moistening collateral dredging is provided for people.Said preparation has good prospects for application to the treatment of radiation fibrosis of lung.
The objective of the invention is to realize by following technical proposals.
Summary of the invention:
The present invention treats the Chinese medicine of tumor radiotherapy injury of lung, and it is mainly by the raw material of following formulation by weight: 30 parts of Radix Angelicae Sinensis, 5 parts of Rhizoma Chuanxiongs, 30 parts of the Radixs Astragali, 5 parts of Fructus Ligustri Lucidi, 5 parts of Herba Ecliptaes, 5 parts of Herba Sophorae alopecuroidiss become granule through conventional processes.
The traditional Chinese medical science is thought lung being a delicate viscus, likes clear and rich and cold-resistant heat.The burning hot malicious heresy of the lonizing radiation lung yin of burning, consumption impairing the lung gas very easily causes deficiency of both QI and YIN, the card that stops in the blood stasis.Follow the common etiology and pathogenesis that the patient has, the combination principle of utilization traditional Chinese medical science monarch is selected the natural Chinese medicines side of being combined into " supplementing QI and nourishing YIN, promoting flow of QI and blood, lung moistening collateral dredging ".Demonstrating fully the present invention is under the prerequisite of the traditional Chinese medical science " organic conception ", closely the pathogeny side of sending of radiation damage disease ubiquity " deficiency of both QI and YIN; stop in the blood stasis " makes medicine behind the tumor radiotherapy, has strengthened accuracy and the high efficiency of the present invention to this treatment of diseases undoubtedly.Of the present inventionly form by medicines such as Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Astragali, Fructus Ligustri Lucidi, Herba Ecliptae and Herba Sophorae alopecuroidiss.Six medicines share has removing pathogenic heat from blood and toxic substance from the body, nourshing blood and promoting blood circulation, the effect of regulating qi to disperse stagnation.Wherein ought be classified as " panacea in the blood is also ", sweet, hot, temperature.Return liver, the heart, spleen channel.Enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation; The Radix Astragali is sweet, temperature.Return lung, spleen channel.Invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Two health preserving with drugs blood QI invigorating, the poison holding of invigorating blood circulation.So in the side, do monarch drug; Fructus Ligustri Lucidi is sweet, bitter, cold.Return liver, kidney channel, the tonifying liver kidney yin, crow must make eye bright.Herba Ecliptae sweet in the mouth, acid, cool in nature; Return kidney, Liver Channel; Go into cloudy blood, kind holding back admittedly; Has nourishing the liver and kidney, crow palpus teeth consolidating, the effect of cooling blood for hemostasis.Close and be the ERZHI WAN liver and kidney tonifying, nourishing yin and stopping bleeding, principal drug assistance YIN nourishing removing heat from blood is to be ministerial drug; The hot temperature of " the gas medicine in the blood " Rhizoma Chuanxiong is returned liver, gallbladder, pericardium channel, and its property is hot fragrant, warm promoting blood circulation, can blood circulation promoting and blood stasis dispelling with regulating menstruation, again can activating QI to alleviate the depression with pain relieving; Can strengthen the power that the monarch drug Radix Angelicae Sinensis is invigorated blood circulation, make Radix Astragali tonify without causing stagnation, be to be adjuvant drug.Herba Sophorae alopecuroidis SophoraalopecuroidesL. has another name called Radix Sophorae Alopecuroidis, loud, high-pitched sound suitable-Bao Riqige (mongolian medicine name) is a cassia leguminous plant, and hardship is cold.Poisonous.Effects such as heat-clearing and toxic substances removing, pain relieving parasite killing are arranged.Invigorating middle warmer is attacked, and directly lets out evil poison, is to be messenger drug.Full side nourishes blood and unlikely blood stasis, and QI invigorating is not forgotten promoting the circulation of blood.So row and poly-, mend and oiliness, reinforcement and elimination in combination, giving consideration to both the incidental and fundamental is to put pearls and jade together, and brings out the best in each other.This shows, the present invention's square medicine, dialectical legislation is original, and prescription is sent YAOJING and is worked as, and compatibility is ingenious and rigorous, and the pathogenesis that hits again, is the good medicine that tumor radiotherapy subtracts disease in fact.
Modern pharmacology studies show that: just can the Antiradiation injury bibliographical information relevant for Radix Angelicae Sinensis, sodium ferulate as far back as the seventies; Radix Angelicae Sinensis need can prevent from disease (leukemia, tumor etc.) the irradiation caused chromosomal aberration in back and the ill effect at a specified future date of radiation therapy.Radix Angelicae Sinensis polysaccharide has effects such as antitumor, radioprotective; Other there are some researches show: Rhizoma Chuanxiong, Radix Angelicae Sinensis have a better role to induced lung injury, and Radix Angelicae Sinensis, Rhizoma Chuanxiong can both be expanded on every side little blood vessel, microcirculation improvement or blood flow state to some extent.Radix Astragali pharmacological action is enhancing human body immunity function, enhancing hemopoietic function.Improve substance metabolism, strengthen effects such as gonad function, anti-stress, slow down aging.Effects such as the Radix Astragali also has heart tonifying, blood pressure regulation, antiviral property myocarditis, protects the liver, antiulcer.Astragalus polysaccharides and Radix Astragali saponin are its main effective ingredient.Fructus Ligustri Lucidi has antiinflammatory, antibacterial, blood sugar lowering, blood fat reducing, protects the liver, antithrombotic formation, defying age and antifatigue effect, can regulate immunity, improves immunological function of cancer patients; Herba Sophorae alopecuroidis is rich in alkaloid, and Herba Sophorae alopecuroidis total alkali has protective action to the radiation damage of 60Co radiation gamma mice; Herba Ecliptae is through modern pharmacological research, have bacteriostasis, hepatoprotective effect, energy obviously enhancing non-specific immunity and cellular immune function, antimutagenesis can make Cavia porcellus human body heart coronary flow increase significant prolongation life or the raising survival rate anastalsis esophageal carcinoma-109 cell that moderate lethal effect is arranged to the influence of cardiovascular system, and mice is had obvious calmness, analgesic activity.
The specific embodiment:
The prescription of injury of lung after the treatment tumor chest radiotherapy, its composition and content are 30 parts of Radix Angelicae Sinensis, 5 parts of Rhizoma Chuanxiongs, 30 parts of the Radixs Astragali, 5 parts of Fructus Ligustri Lucidi, 5 parts of Herba Ecliptaes, 5 parts of Herba Sophorae alopecuroidiss, every part is 1 gram; Each 100 kilograms of medical materials add about 1000L distilled water, decoct 3 times, and with slow fire boiling 1.5-2.5 hours, it was stand-by to leach medicinal liquid for the first time; Add the water of 7.5-10.5 times of amounts the 2nd time, decocted 1.5 hours, it is stand-by to leach medicinal liquid; Add the water of 5-7.5 times of amounts the 3rd time, decocted 1 hour, it is stand-by to leach medicinal liquid; Merge three times decocting liquid, filter; Be concentrated into relative density and be 1.15 thick paste, stand-by; Low-temperature bake 10 hours, the powder that gets dry extract, by dried cream powder: dextrin is that the weight ratio of 1:0.5 adds adjuvant, granulates granulate; Use Co after the pack (every bag of 12g) behind the granule
60Irradiation sterilization.The present invention is through clinical checking for many years.
Now 62 complete routine medical records (getting 60 routine matched groups in addition) are summed up and are reported as follows:
Chinese medical discrimination
One, cloudy impairing the lung is dry: be more common in after the radiotherapy 1～3 month, main performance has zest dry cough, no expectorant or few expectorant, and pharyngalgia, the xerostomia desire for cold drinks, uncomfortable in chest vexed, or companion's low grade fever, poor appetite, the scarce Tianjin of the few tongue of red tongue, thready and rapid pulse.
Two, the asthenia of pulmonosplenic qi blood stasis of holding concurrently: the plain body of patient is insufficiency of the spleen, radiation-induced damage in addition, course of disease delay, cough is outbreak repeatedly, the sticky or stiff in bulk of expectorant, Se Bai or band Lycoperdon polymorphum Vitt, morning, expectoration was more, often accompanied the gastral cavilty feeling of fullness, the poor appetite vomiting and nausea, weak lazyness is moving, loose stool, frequent micturition, the body of the tongue purple is dim, tongue is greasy in vain or yellow greasy, and soft pulse is sliding or sliding thin.
Three, excessive noxious heat, expectorant heat stagnation lung: vascular permeability strengthens after the radiotherapy, and the alveolar interstitial edema easily merges pulmonary infection, and makes in pyretic toxicity and the phlegm-fire strongly fragrant.Show as fever with aversion to cold more, cough with copious phlegm, expectorant glues thick or thick Huang, coughs up to tell not wellly, coughs very chest pain or hemoptysis, xerostomia desire drink, red tongue, yellow and thin fur or yellow greasy, slippery and rapid pulse.
Therapeutic Method: accept radiocurable patient, treatment by Chinese herbs group 62 examples, carry and begin to take the present invention the last week and finish to radiotherapy, radiation period is not found acute radiation pneumonia patient, radiation pneumonia 3 examples take place in 1～3 week after the radiotherapy, cooperate and use antibiotic therapy, 6 months generation pulmonary fibrosis 1 examples after the radiotherapy.
Other observes the no treatment by Chinese herbs matched group of 60 examples, 38 examples of not falling ill, radiation pneumonia 9 examples, radioactive fibrosis 1 example.(seeing table 1 for details).
The incidence of table 1 Chinese herb prevention induced lung injury
As can be seen from Table 1, in the patient of 62 routine clinical observations, normal control group pulmonary fibrosis sickness rate 16.67%, and Chinese herb prevention group pulmonary fibrosis sickness rate only 6.45%.Take that radiation pneumonia, radiation fibrosis of lung take place patient of the present invention and to be forced to interrupt the incidence rate of radiotherapy all lower because of serious radiotherapy side effect, prove that it really can alleviate the side effect of radiotherapy, helps the patient to finish radiotherapy smoothly.
Claims (3)
1. Chinese medicine preparation of preventing and treating injury of lung behind the tumor radiotherapy, this drug prescription is made up of the Six-element Chinese crude drug, whole flavour of a drug in it is characterized in that writing out a prescription all belong to version " the standard medical material that one one of Chinese pharmacopoeia is recorded in 2005, prescription drug is as follows: Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Astragali, Fructus Ligustri Lucidi, Herba Ecliptae, Herba Sophorae alopecuroidis.
2. the Chinese medicine preparation of injury of lung is prepared into granule with it behind the control tumor radiotherapy as claimed in claim 1, it is characterized in that taking by weighing respectively according to prescription drug and specific proportioning, and through extracting, concentrate and prepared such as granulation, the prescription of its medicine is as follows:
5 parts-10 parts of 5 parts of-20 parts of Rhizoma Chuanxiongs of Radix Angelicae Sinensis
10 parts-15 parts of 5 parts of-15 parts of Fructus Ligustri Lucidi of the Radix Astragali
10 parts-15 parts of 10 portions of-15 portions of Herba Sophorae alopecuroidiss of Herba Ecliptae.
Behind the preparation right 2 described control tumor radiotherapies injury of lung Chinese medicine preparation, its formulation and technology and method feature are:
(1) chooses Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Astragali, Fructus Ligustri Lucidi, Herba Ecliptae, Herba Sophorae alopecuroidis according to weight proportion and add 10-15 times of amounts of water, soaked 24-36 hours;
(2) decoct 3 times, with slow fire boiling 1.5-2.5 hours, it was stand-by to leach medicinal liquid for the first time; Add the water of 7.5-10.5 times of amounts the 2nd time, decocted 1.5 hours, it is stand-by to leach medicinal liquid; Add the water of 5-7.5 times of amounts the 3rd time, decocted 1 hour, it is stand-by to leach medicinal liquid;
(3) merge three decocting liquids, filter; Collect filtrate;
(4) filtrate is concentrated into the thick paste that relative density is 1:1.25-1.35, and is standby;
(5) low-temperature bake is 10 hours, the powder that gets dry extract, and by dried cream powder: dextrin is that the weight ratio of 1:0.5 adds adjuvant;
(6) granulate, packing behind the granulate is used
60Co irradiation bomb irradiation sterilization.
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| CN2008101511687A CN101361789B (en) | 2008-09-28 | 2008-09-28 | Traditional Chinese medicine formulation for treating and preventing lung impairment after tumor controlling radiotherapy |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102688260A (en) * | 2012-05-17 | 2012-09-26 | 广州军区广州总医院 | Medicinal composition for treating vaginal dryness |
| CN103768117A (en) * | 2014-01-28 | 2014-05-07 | 中国药科大学 | Application of Eclipta prostrate extract in preparation of anti-pulmonary fibrosis drugs |
| CN106177251A (en) * | 2016-08-30 | 2016-12-07 | 郭英华 | A kind of prevent and treat Chinese medicine preparation of injury of lung and preparation method thereof after tumor radiotherapy |
| CN106389546A (en) * | 2016-10-18 | 2017-02-15 | 漯河医学高等专科学校 | Traditional Chinese medicine for postoperative treatment of colorectal cancer and preparation method of traditional Chinese medicine |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1093411C (en) * | 1999-08-17 | 2002-10-30 | 石家庄阳光药业有限公司 | Anti-cancer medicinal composition and its preparing method |
| CN1226041C (en) * | 2001-11-22 | 2005-11-09 | 栾保义 | Anti-cancer Chinese medicine formula |
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2008
- 2008-09-28 CN CN2008101511687A patent/CN101361789B/en not_active Expired - Fee Related
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102688260A (en) * | 2012-05-17 | 2012-09-26 | 广州军区广州总医院 | Medicinal composition for treating vaginal dryness |
| CN102688260B (en) * | 2012-05-17 | 2013-04-17 | 广州军区广州总医院 | Medicinal composition for treating vaginal dryness |
| CN103768117A (en) * | 2014-01-28 | 2014-05-07 | 中国药科大学 | Application of Eclipta prostrate extract in preparation of anti-pulmonary fibrosis drugs |
| CN103768117B (en) * | 2014-01-28 | 2016-04-13 | 中国药科大学 | Herba Ecliptae extract is preparing the application in anti-fibrosis drug |
| CN106177251A (en) * | 2016-08-30 | 2016-12-07 | 郭英华 | A kind of prevent and treat Chinese medicine preparation of injury of lung and preparation method thereof after tumor radiotherapy |
| CN106389546A (en) * | 2016-10-18 | 2017-02-15 | 漯河医学高等专科学校 | Traditional Chinese medicine for postoperative treatment of colorectal cancer and preparation method of traditional Chinese medicine |
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| CN101361789B (en) | 2011-07-27 |
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