CN101336291A - 用于诱导未成熟单核细胞的树突细胞的激活的组合物和方法 - Google Patents

用于诱导未成熟单核细胞的树突细胞的激活的组合物和方法 Download PDF

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CN101336291A
CN101336291A CNA2006800520283A CN200680052028A CN101336291A CN 101336291 A CN101336291 A CN 101336291A CN A2006800520283 A CNA2006800520283 A CN A2006800520283A CN 200680052028 A CN200680052028 A CN 200680052028A CN 101336291 A CN101336291 A CN 101336291A
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cell
cells
dendritic cell
antigen
tumor
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A·L·博因顿
M·L·博希
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Northwest Biotherapeutics LLC
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CNA2006800520283A 2005-12-08 2006-12-08 用于诱导未成熟单核细胞的树突细胞的激活的组合物和方法 Pending CN101336291A (zh)

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Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102725634A (zh) * 2009-08-24 2012-10-10 纽约市哥伦比亚大学理事会 用于测定cd8+t细胞的健康的测试法
CN103756960A (zh) * 2013-12-04 2014-04-30 深圳市合一康生物科技有限公司 一种高毒性、高增值能力的人d-cik细胞的专用试剂盒
CN103784950A (zh) * 2014-01-22 2014-05-14 北京弘润源生物技术有限公司 乳腺癌特异抗原表位多肽负载的树突状细胞疫苗制备及其试剂盒
CN103800897A (zh) * 2014-03-12 2014-05-21 甘肃中科生物科技有限公司 一种肿瘤特异抗原表位多肽负载的树突状细胞疫苗制备方法及其试剂盒
CN102448485B (zh) * 2009-04-09 2015-01-14 墨尔本大学 免疫原性组合物及其用途
CN104936612A (zh) * 2013-09-05 2015-09-23 奥比思健康解决方案有限责任公司 装载了肿瘤裂解物的微粒
CN105647867A (zh) * 2016-02-28 2016-06-08 深圳爱生再生医学科技有限公司 诱导树突状细胞成熟的方法和树突状细胞
CN105670994A (zh) * 2016-02-28 2016-06-15 深圳爱生再生医学科技有限公司 Dc诱导剂及其应用
WO2016146035A1 (en) * 2015-03-13 2016-09-22 Syz Cell Therapy Co. Methods of cancer treatment using activated t cells
AU2013312135B2 (en) * 2012-09-06 2018-02-22 Orbis Health Solutions Llc Tumor lysate loaded particles
CN110042081A (zh) * 2012-12-18 2019-07-23 伊穆尼肯公司 来自异源供体的单核细胞的共分化
CN110106145A (zh) * 2019-06-12 2019-08-09 兰莲(杭州)生物科技有限公司 一种未成熟树突状细胞培养液及其未成熟树突状细胞的制备方法
US11248208B2 (en) 2018-03-30 2022-02-15 Syz Cell Therapy Co. Multiple antigen specific cell therapy methods

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2464228C (en) 2000-10-27 2017-01-17 Immuno-Rx, Inc. Vaccine immunotherapy for immune suppressed patients
US20070025958A1 (en) 2000-10-27 2007-02-01 Hadden John W Vaccine immunotherapy
JP5647601B2 (ja) * 2008-04-14 2015-01-07 アイ アール エックス セーラピューティクス, インコーポレイテッド Irx−2の改良された作製方法
US8728806B2 (en) * 2008-12-06 2014-05-20 The Board Of Regents, The University Of Texas System Methods and compositions related to Th-1 dendritic cells
JP5797190B2 (ja) 2009-05-15 2015-10-21 アイ アール エックス セーラピューティクス, インコーポレイテッド ワクチン免疫療法
ES2711504T3 (es) * 2009-07-24 2019-05-06 Rhode Island Hospital Vacunas de células dendríticas para tumores que expresan asparaginil-beta-hidroxilasa
AU2010307075B2 (en) 2009-10-12 2014-12-18 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Granulysin in immunotherapy
US9333238B2 (en) 2009-12-08 2016-05-10 Irx Therapeutics, Inc. Method of immunotherapy for treament of human papillomavirus infection
WO2012065156A2 (en) * 2010-11-13 2012-05-18 University Of Florida Research Foundation, Inc. Ex vivo development, expansion and in vivo analysis of a novel lineage of dendritic cells
NL2009102C2 (en) * 2012-07-02 2014-01-06 Dcprime B V Method for dc-loading.
TWI503414B (zh) * 2012-07-05 2015-10-11 Fullhope Biomedical Co Ltd 一種製備專一性t細胞之配方、方法及其配方製備方法
AU2020203845C1 (en) * 2012-09-06 2022-08-11 Orbis Health Solutions, Llc Tumor lysate loaded particles
WO2014093454A1 (en) 2012-12-12 2014-06-19 Orbis Health Solutions, Llc Compositions and methods for tissue regeneration
CN106456532B (zh) 2014-03-05 2020-07-24 奥比思健康解决方案有限责任公司 使用酵母细胞壁颗粒的疫苗递送系统
JP6434139B2 (ja) * 2014-06-23 2018-12-05 ジェイダブリュ クレアジェン インコーポレイテッド 特定遺伝子発現が増加した樹状細胞の製造方法およびこれを利用して製造された樹状細胞を含む自己免疫疾患治療または予防用組成物
EP3350318B1 (en) * 2015-09-15 2022-04-13 NorthWest Biotherapeutics, Inc. Methods relating to activated dendritic cell compositions for subjects with advanced cancers
US11472856B2 (en) 2016-06-13 2022-10-18 Torque Therapeutics, Inc. Methods and compositions for promoting immune cell function
CN109844100A (zh) * 2016-09-01 2019-06-04 株式会社理研免疫再生医学 制备天然杀伤t(nkt)细胞刺激性树突细胞的方法及制备含有nkt细胞刺激性树突细胞和nkt细胞的细胞组合物的方法
WO2018061006A1 (en) * 2016-09-29 2018-04-05 Hadasit Medical Research Services And Development Ltd. Dendritic cell preparations, compositions thereof and methods of using same
KR20210032924A (ko) 2017-09-05 2021-03-25 토크 테라퓨틱스, 인코포레이티드 치료용 단백질 조성물 및 그의 제조 및 사용 방법
CN109957548B (zh) * 2017-12-26 2022-03-18 上海尚泰生物技术有限公司 一种基因修饰的树突状细胞疫苗
JP6881331B2 (ja) * 2018-01-29 2021-06-02 株式会社三洋物産 遊技機
JP6881333B2 (ja) * 2018-01-29 2021-06-02 株式会社三洋物産 遊技機
JP6881332B2 (ja) * 2018-01-29 2021-06-02 株式会社三洋物産 遊技機
KR20210042142A (ko) * 2018-08-10 2021-04-16 주식회사 유틸렉스 암항원 특이적 cd8+ t 세포의 제조 및 동결보존 방법
CN116056716B (zh) * 2020-05-15 2025-10-31 首尔大学校产学协力团 利用从脂肪组织分离出来的基质血管组分的树突状细胞的激活功能的免疫反应增强用组合物
KR102753583B1 (ko) * 2021-11-11 2025-01-10 의료법인 명지의료재단 Kras 특이적 활성화 t 세포 유도용 항원 조성물
KR102818249B1 (ko) * 2021-11-11 2025-06-10 의료법인 명지의료재단 Kras 특이적 활성화 t 세포 유도용 항원 조성물을 이용한 항원 특이적 t 세포 유도방법

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69333433T2 (de) 1992-04-01 2004-12-02 The Rockefeller University Verfahren zur in vitro kultivierung dendritischer vorläuferzellen und deren verwendung zur immunogen herstellung
US5788963A (en) 1995-07-31 1998-08-04 Pacific Northwest Cancer Foundation Isolation and/or preservation of dendritic cells for prostate cancer immunotherapy
US7659119B2 (en) 1996-02-12 2010-02-09 Argos Therapeutics, Inc. Method and compositions for obtaining mature dendritic cells
WO1998046083A1 (en) * 1997-04-17 1998-10-22 The Regents Of The University Of California Use of lentiviral vectors for antigen presentation in dendritic cells
US6558951B1 (en) 1999-02-11 2003-05-06 3M Innovative Properties Company Maturation of dendritic cells with immune response modifying compounds
WO2003010292A2 (en) 2001-07-25 2003-02-06 Northwest Biotherapeutics, Inc. Methods and apparatus for enrichment and culture of monocytic dendritic cell precursors
EP2322603B1 (en) * 2001-09-06 2019-10-16 NorthWest Biotherapeutics, Inc. Compositions and methods for priming monocytic dendritic cells and T cells for Th1 response
AU2003243673B2 (en) 2002-06-19 2010-01-21 Northwest Biotherapeutics, Inc. Tangential flow filtration devices and methods for leukocyte enrichment
AT412145B (de) * 2002-09-13 2004-10-25 Forsch Krebskranke Kinder Verfahren zur herstellung eines zellulären immuntherapeutikums auf basis von il-12-freisetzenden dendritischen zellen
ES2321939T3 (es) * 2003-02-27 2009-06-15 Northwest Biotherapeutics, Inc. Generacion de celulas dendriticas a partir de celulas precursoras dendriticas monociticas con gm-csf en ausencia de citoquinas adicionales.

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
郭建巍等: "人外周血中树突状细胞的诱导及鉴定", 《华西医大学报》 *
陈玉丙等: "小鼠骨髓干细胞体外诱导成熟的树突状细胞对T细胞增殖的影响", 《吉林大学学报(医学版)》 *

Cited By (22)

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CN102725634B (zh) * 2009-08-24 2016-01-20 纽约哥伦比亚大学理事会 用于测定cd8+t细胞的健康的测试法
AU2013312135B2 (en) * 2012-09-06 2018-02-22 Orbis Health Solutions Llc Tumor lysate loaded particles
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CN103756960A (zh) * 2013-12-04 2014-04-30 深圳市合一康生物科技有限公司 一种高毒性、高增值能力的人d-cik细胞的专用试剂盒
CN103784950A (zh) * 2014-01-22 2014-05-14 北京弘润源生物技术有限公司 乳腺癌特异抗原表位多肽负载的树突状细胞疫苗制备及其试剂盒
CN103800897B (zh) * 2014-03-12 2017-03-22 李金珍 一种肿瘤特异抗原表位多肽负载的树突状细胞疫苗制备方法及其试剂盒
CN103800897A (zh) * 2014-03-12 2014-05-21 甘肃中科生物科技有限公司 一种肿瘤特异抗原表位多肽负载的树突状细胞疫苗制备方法及其试剂盒
WO2016146035A1 (en) * 2015-03-13 2016-09-22 Syz Cell Therapy Co. Methods of cancer treatment using activated t cells
CN107735492A (zh) * 2015-03-13 2018-02-23 深圳源正细胞医疗技术有限公司 使用活化t细胞治疗癌的方法
US10967054B2 (en) 2015-03-13 2021-04-06 Syz Cell Therapy Co. Methods of cancer treatment using activated T cells
US11219675B2 (en) 2015-03-13 2022-01-11 Syz Cell Therapy Co. Methods of cancer treatment using activated T cells
US11229689B2 (en) 2015-03-13 2022-01-25 Syz Cell Therapy Co. Methods of cancer treatment using activated T cells
US12312597B2 (en) 2015-03-13 2025-05-27 HRY Z (Shanghai) Biotech Co. Methods of cancer treatment using activated t cells
CN105670994A (zh) * 2016-02-28 2016-06-15 深圳爱生再生医学科技有限公司 Dc诱导剂及其应用
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US11248208B2 (en) 2018-03-30 2022-02-15 Syz Cell Therapy Co. Multiple antigen specific cell therapy methods
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