CN101321743A - 作为ptp-酶抑制剂的1,1,3-三氧代-1,2,5-噻二唑烷和它们的用途 - Google Patents
作为ptp-酶抑制剂的1,1,3-三氧代-1,2,5-噻二唑烷和它们的用途 Download PDFInfo
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- CN101321743A CN101321743A CNA2006800455922A CN200680045592A CN101321743A CN 101321743 A CN101321743 A CN 101321743A CN A2006800455922 A CNA2006800455922 A CN A2006800455922A CN 200680045592 A CN200680045592 A CN 200680045592A CN 101321743 A CN101321743 A CN 101321743A
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- Prior art keywords
- thiadiazolidine
- hydroxyl
- dioxo
- ketone
- phenyl
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74849305P | 2005-12-08 | 2005-12-08 | |
| US60/748,493 | 2005-12-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101321743A true CN101321743A (zh) | 2008-12-10 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2006800455922A Pending CN101321743A (zh) | 2005-12-08 | 2006-12-06 | 作为ptp-酶抑制剂的1,1,3-三氧代-1,2,5-噻二唑烷和它们的用途 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20080293782A1 (https=) |
| EP (1) | EP1960377A1 (https=) |
| JP (1) | JP2009518421A (https=) |
| KR (1) | KR20080074966A (https=) |
| CN (1) | CN101321743A (https=) |
| AU (1) | AU2006321904A1 (https=) |
| BR (1) | BRPI0619547A2 (https=) |
| CA (1) | CA2630448A1 (https=) |
| RU (1) | RU2008127253A (https=) |
| WO (1) | WO2007067614A1 (https=) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107337635A (zh) * | 2017-07-21 | 2017-11-10 | 张家港威胜生物医药有限公司 | 一种酰胺类神经再生药物的制备方法 |
| CN117658947A (zh) * | 2022-09-06 | 2024-03-08 | 杭州中美华东制药有限公司 | 蛋白酪氨酸磷酸酶抑制作用的5-(取代芳基)-1,2,5-噻二唑啉-3-酮类化合物 |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA94724C2 (en) * | 2005-12-08 | 2011-06-10 | Новартис Аг | Thiadiazolidinone derivatives as antidiabetic agents |
| CA2629819A1 (en) * | 2005-12-08 | 2007-06-14 | Novartis Ag | 1,2,5-thiazolidine derivatives useful for treating conditions mediated by protein tyrosine phosphatases (ptpase) |
| UA94921C2 (en) | 2005-12-08 | 2011-06-25 | Новартис Аг | 1-orthofluorophenyl substituted 1, 2, 5-thiazolidinedione derivatives as ptp-as inhibitors |
| NZ569329A (en) * | 2006-01-30 | 2011-09-30 | Transtech Pharma Inc | Substituted imidazole derivatives and their use as PTPase inhibitors |
| CA2647472A1 (en) | 2006-03-31 | 2007-10-11 | Novartis Ag | Organic compounds |
| WO2008067527A1 (en) * | 2006-12-01 | 2008-06-05 | Novartis Ag | Inhibitors of protein tyrosine phosphatase for the treatment of muscle atrophy and related disorders |
| JP2011504505A (ja) * | 2007-11-21 | 2011-02-10 | デコード ジェネティクス イーエイチエフ | 肺および心血管障害を治療するためのビアリールｐｄｅ４抑制剤 |
| JP5809157B2 (ja) | 2010-10-08 | 2015-11-10 | 持田製薬株式会社 | 環状アミド誘導体 |
| EP2703393A4 (en) * | 2011-04-28 | 2014-09-24 | Mochida Pharm Co Ltd | CYCLIC AMIDE DERIVATIVE |
| JPWO2012147516A1 (ja) | 2011-04-28 | 2014-07-28 | 持田製薬株式会社 | 環状アミド誘導体 |
| BR112020026086A2 (pt) * | 2018-06-21 | 2021-03-23 | Calico Life Sciences Llc | inibidores da proteína tirosina fosfatase e métodos de uso destes |
| EP4073242A4 (en) | 2019-12-12 | 2024-01-03 | Kumquat Biosciences Inc. | Compositions and methods for potentiating immune activity |
| PE20241474A1 (es) * | 2021-11-23 | 2024-07-17 | Kumquat Biosciences Inc | Compuestos que contienen heteroatomos y usos de estos |
| JP2025513882A (ja) * | 2022-04-14 | 2025-04-30 | ネリオ セラピューティクス，インク． | タンパク質チロシンホスファターゼ阻害剤およびその使用 |
| AR131413A1 (es) * | 2022-12-21 | 2025-03-19 | Bristol Myers Squibb Co | Inhibidores de la proteína tirosina fosfatasa, composiciones y métodos de uso |
| PE20252789A1 (es) | 2023-05-24 | 2025-12-22 | Kumquat Biosciences Inc | Compuestos heterociclicos y usos de estos |
| KR20260040037A (ko) * | 2023-07-14 | 2026-03-23 | 카톨리에케 유니버시테이트 루벤 | 암 및 대사 질병의 치료를 위한 신규 화합물 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2062558A1 (en) * | 1991-03-08 | 1992-09-09 | Prasun K. Chakravarty | Heterocyclic compounds bearing acidic functional groups as angiotensin ii antagonists |
| CA2109524A1 (en) * | 1991-05-10 | 1992-11-11 | Prasun K. Chakravarty | Acidic aralkyl triazole derivatives active as angiotensin ii antagonists |
| US5162340A (en) * | 1991-05-10 | 1992-11-10 | Merck & Co., Inc. | Substituted 1-(2h)-isoquinolinones bearing acidic functional groups as angiotensin ii antagonists |
| US5958957A (en) * | 1996-04-19 | 1999-09-28 | Novo Nordisk A/S | Modulators of molecules with phosphotyrosine recognition units |
| EP1119614B1 (en) * | 1998-07-24 | 2009-12-09 | Merck Frosst Canada Ltd. | Protein tyrosine phosphatase-1b (ptp-1b) deficient mice and uses thereof |
| KR100868587B1 (ko) * | 2002-04-03 | 2008-11-12 | 노파르티스 아게 | Ｐｔｐａｓｅ 1ｂ 억제제로서의 5-치환된1,1-디옥소-1,2,5-티아졸리딘-3-온 유도체 |
| GB0225986D0 (en) * | 2002-11-07 | 2002-12-11 | Astrazeneca Ab | Chemical compounds |
| GB0227813D0 (en) * | 2002-11-29 | 2003-01-08 | Astrazeneca Ab | Chemical compounds |
| EP1594497B1 (en) * | 2002-12-30 | 2009-05-27 | Vertex Pharmaceuticals Incorporated | Sulfhydantoins as phosphate isosteres for use as phosphatase inhibitors in the treatment of cancer and autoimmune disorders |
| US7141596B2 (en) * | 2003-10-08 | 2006-11-28 | Incyte Corporation | Inhibitors of proteins that bind phosphorylated molecules |
| UA94724C2 (en) * | 2005-12-08 | 2011-06-10 | Новартис Аг | Thiadiazolidinone derivatives as antidiabetic agents |
| CA2629819A1 (en) * | 2005-12-08 | 2007-06-14 | Novartis Ag | 1,2,5-thiazolidine derivatives useful for treating conditions mediated by protein tyrosine phosphatases (ptpase) |
| UA94921C2 (en) * | 2005-12-08 | 2011-06-25 | Новартис Аг | 1-orthofluorophenyl substituted 1, 2, 5-thiazolidinedione derivatives as ptp-as inhibitors |
| CA2647472A1 (en) * | 2006-03-31 | 2007-10-11 | Novartis Ag | Organic compounds |
| CA2670491A1 (en) * | 2006-12-01 | 2008-06-12 | Novartis Ag | Inhibitors of protein tyrosine phosphatase for the promotion of physiological cardiac hypertrophy |
| AR066820A1 (es) * | 2007-06-04 | 2009-09-16 | Novartis Ag | Compuestos de tiadiazolidin-3 ona |
-
2006
- 2006-12-06 CA CA002630448A patent/CA2630448A1/en not_active Abandoned
- 2006-12-06 CN CNA2006800455922A patent/CN101321743A/zh active Pending
- 2006-12-06 JP JP2008544466A patent/JP2009518421A/ja active Pending
- 2006-12-06 KR KR1020087013698A patent/KR20080074966A/ko not_active Withdrawn
- 2006-12-06 AU AU2006321904A patent/AU2006321904A1/en not_active Abandoned
- 2006-12-06 US US12/096,421 patent/US20080293782A1/en not_active Abandoned
- 2006-12-06 WO PCT/US2006/046544 patent/WO2007067614A1/en not_active Ceased
- 2006-12-06 RU RU2008127253/04A patent/RU2008127253A/ru not_active Application Discontinuation
- 2006-12-06 BR BRPI0619547-4A patent/BRPI0619547A2/pt not_active IP Right Cessation
- 2006-12-06 EP EP06839093A patent/EP1960377A1/en not_active Withdrawn
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107337635A (zh) * | 2017-07-21 | 2017-11-10 | 张家港威胜生物医药有限公司 | 一种酰胺类神经再生药物的制备方法 |
| CN117658947A (zh) * | 2022-09-06 | 2024-03-08 | 杭州中美华东制药有限公司 | 蛋白酪氨酸磷酸酶抑制作用的5-(取代芳基)-1,2,5-噻二唑啉-3-酮类化合物 |
| CN117658947B (zh) * | 2022-09-06 | 2026-03-06 | 杭州中美华东制药有限公司 | 蛋白酪氨酸磷酸酶抑制作用的5-(取代芳基)-1,2,5-噻二唑啉-3-酮类化合物 |
Also Published As
| Publication number | Publication date |
|---|---|
| US20080293782A1 (en) | 2008-11-27 |
| AU2006321904A8 (en) | 2008-07-17 |
| BRPI0619547A2 (pt) | 2011-10-04 |
| JP2009518421A (ja) | 2009-05-07 |
| AU2006321904A1 (en) | 2007-06-14 |
| WO2007067614A1 (en) | 2007-06-14 |
| KR20080074966A (ko) | 2008-08-13 |
| CA2630448A1 (en) | 2007-06-14 |
| RU2008127253A (ru) | 2010-01-20 |
| EP1960377A1 (en) | 2008-08-27 |
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