CN101321736B - 对m1受体具有活性的化合物及其在医药中的用途 - Google Patents

对m1受体具有活性的化合物及其在医药中的用途 Download PDF

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Publication number
CN101321736B
CN101321736B CN2006800451692A CN200680045169A CN101321736B CN 101321736 B CN101321736 B CN 101321736B CN 2006800451692 A CN2006800451692 A CN 2006800451692A CN 200680045169 A CN200680045169 A CN 200680045169A CN 101321736 B CN101321736 B CN 101321736B
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CN
China
Prior art keywords
compound according
compound
methyl
hydrogen
formula
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Expired - Fee Related
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CN2006800451692A
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English (en)
Chinese (zh)
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CN101321736A (zh
Inventor
布赖恩·布德齐克
戴维·G·库珀
伊恩·T·福布斯
文森佐·加齐亚
金坚
史东川
保罗·W·史密斯
格雷厄姆·沃克
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Glaxo Group Ltd
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Glaxo Group Ltd
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Priority claimed from GBGB0519950.0A external-priority patent/GB0519950D0/en
Priority claimed from GB0602040A external-priority patent/GB0602040D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of CN101321736A publication Critical patent/CN101321736A/zh
Application granted granted Critical
Publication of CN101321736B publication Critical patent/CN101321736B/zh
Expired - Fee Related legal-status Critical Current
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/26—Oxygen atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CN2006800451692A 2005-09-30 2006-09-27 对m1受体具有活性的化合物及其在医药中的用途 Expired - Fee Related CN101321736B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB0519950.0A GB0519950D0 (en) 2005-09-30 2005-09-30 Compounds
GB0519950.0 2005-09-30
GB0602040A GB0602040D0 (en) 2006-02-01 2006-02-01 Compounds
GB0602040.8 2006-02-01
PCT/GB2006/003590 WO2007036715A2 (en) 2005-09-30 2006-09-27 Compounds which have activity at m1 receptor and their uses in medicine

Publications (2)

Publication Number Publication Date
CN101321736A CN101321736A (zh) 2008-12-10
CN101321736B true CN101321736B (zh) 2012-04-04

Family

ID=37598231

Family Applications (1)

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CN2006800451692A Expired - Fee Related CN101321736B (zh) 2005-09-30 2006-09-27 对m1受体具有活性的化合物及其在医药中的用途

Country Status (24)

Country Link
US (2) US8283364B2 (https=)
EP (1) EP1943230B1 (https=)
JP (1) JP5209480B2 (https=)
KR (2) KR101374458B1 (https=)
CN (1) CN101321736B (https=)
AR (1) AR056103A1 (https=)
AT (1) ATE492537T1 (https=)
AU (1) AU2006296369B2 (https=)
BR (1) BRPI0616609A2 (https=)
CA (1) CA2624504C (https=)
CR (1) CR9904A (https=)
DE (1) DE602006019119D1 (https=)
EA (1) EA016286B1 (https=)
IL (1) IL190219A (https=)
JO (1) JO2634B1 (https=)
MA (1) MA29849B1 (https=)
MY (1) MY148504A (https=)
NO (1) NO20081945L (https=)
NZ (1) NZ566508A (https=)
PE (1) PE20070490A1 (https=)
TW (1) TWI389905B (https=)
UA (1) UA101299C2 (https=)
WO (1) WO2007036715A2 (https=)
ZA (1) ZA200802167B (https=)

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WO2007036718A2 (en) 2005-09-30 2007-04-05 Glaxo Group Limited Compounds which have activity at m1 receptor and their uses in medicine
US8283364B2 (en) 2005-09-30 2012-10-09 Glaxo Group Limited Compounds which have activity at M1 receptor and their uses in medicine
US7766829B2 (en) * 2005-11-04 2010-08-03 Abbott Diabetes Care Inc. Method and system for providing basal profile modification in analyte monitoring and management systems
GB0605785D0 (en) * 2006-03-22 2006-05-03 Glaxo Group Ltd Compounds
GB0706165D0 (en) * 2007-03-29 2007-05-09 Glaxo Group Ltd Compounds
GB0706170D0 (en) * 2007-03-29 2007-05-09 Glaxo Group Ltd Compounds
GB0706164D0 (en) * 2007-03-29 2007-05-09 Glaxo Group Ltd Compounds
GB0706174D0 (en) * 2007-03-29 2007-05-09 Glaxo Group Ltd Compounds
GB0718415D0 (en) * 2007-09-20 2007-10-31 Glaxo Group Ltd Compounds
WO2009124882A1 (en) * 2008-04-09 2009-10-15 H. Lundbeck A/S Novel piperidinyl-1,3-dihydro-benzoimidazol-2-ones as m1 agonists
GB0817982D0 (en) 2008-10-01 2008-11-05 Glaxo Group Ltd Compounds
WO2016073294A1 (en) * 2014-11-03 2016-05-12 William Beaumont Hospital Method for treating underactive bladder syndrome
KR20170141769A (ko) * 2015-04-29 2017-12-26 얀센 파마슈티카 엔.브이. 인돌론 화합물 및 ampa 수용체 조절제로서의 이의 용도
ES2865330T3 (es) 2015-04-29 2021-10-15 Janssen Pharmaceutica Nv Azabenzimidazoles y su uso como moduladores del receptor AMPA
CA2996717A1 (en) 2015-09-11 2017-03-16 Chase Pharmaceuticals Corporation Muscarinic combination and its use for combating hypocholinergic disorders of the central nervous system
CN107673994A (zh) * 2017-04-27 2018-02-09 联化科技股份有限公司 一种芳基甲烷类化合物的制备方法
CN107739342B (zh) * 2017-11-29 2020-01-10 华南理工大学 一种一步合成5-二芳氨基苯并咪唑酮衍生物的方法
CN117049938B (zh) * 2023-06-20 2024-06-14 山东轩德医药科技有限公司 一种6-溴-2,3-二氟甲苯的制备方法

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Also Published As

Publication number Publication date
ZA200802167B (en) 2009-08-26
DE602006019119D1 (de) 2011-02-03
US8283364B2 (en) 2012-10-09
US8481566B2 (en) 2013-07-09
AR056103A1 (es) 2007-09-19
CR9904A (es) 2008-07-29
JP5209480B2 (ja) 2013-06-12
KR20130091791A (ko) 2013-08-19
WO2007036715A2 (en) 2007-04-05
AU2006296369B2 (en) 2012-12-20
NZ566508A (en) 2011-07-29
TW200806657A (en) 2008-02-01
KR20080049090A (ko) 2008-06-03
EP1943230A2 (en) 2008-07-16
NO20081945L (no) 2008-06-04
EA016286B1 (ru) 2012-03-30
IL190219A0 (en) 2008-11-03
IL190219A (en) 2012-10-31
US20080058378A1 (en) 2008-03-06
CA2624504C (en) 2014-07-08
JO2634B1 (en) 2012-06-17
MY148504A (en) 2013-04-30
US20080255195A1 (en) 2008-10-16
AU2006296369A1 (en) 2007-04-05
JP2009512635A (ja) 2009-03-26
EA200801001A1 (ru) 2008-08-29
ATE492537T1 (de) 2011-01-15
MA29849B1 (fr) 2008-10-03
BRPI0616609A2 (pt) 2011-06-28
CA2624504A1 (en) 2007-04-05
PE20070490A1 (es) 2007-05-30
CN101321736A (zh) 2008-12-10
UA101299C2 (uk) 2013-03-25
EP1943230B1 (en) 2010-12-22
TWI389905B (zh) 2013-03-21
KR101374458B1 (ko) 2014-03-17
WO2007036715A3 (en) 2007-05-18

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Granted publication date: 20120404

Termination date: 20170927