CN101317966A - Medicine for treating senile dementia and preparation method thereof - Google Patents
Medicine for treating senile dementia and preparation method thereof Download PDFInfo
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- CN101317966A CN101317966A CNA2008101327655A CN200810132765A CN101317966A CN 101317966 A CN101317966 A CN 101317966A CN A2008101327655 A CNA2008101327655 A CN A2008101327655A CN 200810132765 A CN200810132765 A CN 200810132765A CN 101317966 A CN101317966 A CN 101317966A
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- 239000003814 drug Substances 0.000 title claims abstract description 35
- 208000024827 Alzheimer disease Diseases 0.000 title claims abstract description 16
- 206010039966 Senile dementia Diseases 0.000 title claims abstract description 16
- 238000002360 preparation method Methods 0.000 title claims description 7
- 229940079593 drug Drugs 0.000 title description 5
- 239000002775 capsule Substances 0.000 claims abstract description 18
- 239000007788 liquid Substances 0.000 claims abstract description 16
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims abstract description 9
- 235000010234 sodium benzoate Nutrition 0.000 claims abstract description 9
- 239000004299 sodium benzoate Substances 0.000 claims abstract description 9
- 241000489492 Arisaema Species 0.000 claims abstract description 6
- 210000000941 bile Anatomy 0.000 claims abstract description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- 241000208340 Araliaceae Species 0.000 claims description 8
- 241001489978 Eupolyphaga Species 0.000 claims description 8
- 241000237903 Hirudo Species 0.000 claims description 8
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims description 8
- 235000003140 Panax quinquefolius Nutrition 0.000 claims description 8
- 235000008434 ginseng Nutrition 0.000 claims description 8
- 239000009636 Huang Qi Substances 0.000 claims description 5
- 210000000582 semen Anatomy 0.000 claims description 5
- 238000009835 boiling Methods 0.000 claims description 3
- 239000012141 concentrate Substances 0.000 claims description 3
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims description 3
- 238000003756 stirring Methods 0.000 claims description 3
- 239000002671 adjuvant Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 abstract description 8
- 239000008280 blood Substances 0.000 abstract description 8
- 210000004556 brain Anatomy 0.000 abstract description 6
- 206010062717 Increased upper airway secretion Diseases 0.000 abstract description 5
- 208000026435 phlegm Diseases 0.000 abstract description 5
- 230000000694 effects Effects 0.000 abstract description 4
- 230000017531 blood circulation Effects 0.000 abstract description 3
- 230000002490 cerebral effect Effects 0.000 abstract description 3
- 102000015779 HDL Lipoproteins Human genes 0.000 abstract description 2
- 108010010234 HDL Lipoproteins Proteins 0.000 abstract description 2
- 102000019197 Superoxide Dismutase Human genes 0.000 abstract description 2
- 108010012715 Superoxide dismutase Proteins 0.000 abstract description 2
- 230000003727 cerebral blood flow Effects 0.000 abstract description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract description 2
- 150000003254 radicals Chemical class 0.000 abstract description 2
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 abstract description 2
- 241000605447 Anemarrhena Species 0.000 abstract 1
- 241000131329 Carabidae Species 0.000 abstract 1
- 240000007371 Cuscuta campestris Species 0.000 abstract 1
- 241000804384 Cynomorium songaricum Species 0.000 abstract 1
- 241000893536 Epimedium Species 0.000 abstract 1
- 241000305492 Gastrodia Species 0.000 abstract 1
- 244000303040 Glycyrrhiza glabra Species 0.000 abstract 1
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 abstract 1
- 235000017443 Hedysarum boreale Nutrition 0.000 abstract 1
- 235000007858 Hedysarum occidentale Nutrition 0.000 abstract 1
- 241000545744 Hirudinea Species 0.000 abstract 1
- 241000112528 Ligusticum striatum Species 0.000 abstract 1
- 244000241838 Lycium barbarum Species 0.000 abstract 1
- 235000015459 Lycium barbarum Nutrition 0.000 abstract 1
- 235000015468 Lycium chinense Nutrition 0.000 abstract 1
- 235000002789 Panax ginseng Nutrition 0.000 abstract 1
- 244000046146 Pueraria lobata Species 0.000 abstract 1
- 235000010575 Pueraria lobata Nutrition 0.000 abstract 1
- 241000405414 Rehmannia Species 0.000 abstract 1
- 240000001341 Reynoutria japonica Species 0.000 abstract 1
- 235000018167 Reynoutria japonica Nutrition 0.000 abstract 1
- 235000017276 Salvia Nutrition 0.000 abstract 1
- 240000007164 Salvia officinalis Species 0.000 abstract 1
- 229930191283 anemarrhena Natural products 0.000 abstract 1
- 229940107666 astragalus root Drugs 0.000 abstract 1
- 230000000916 dilatatory effect Effects 0.000 abstract 1
- 235000013399 edible fruits Nutrition 0.000 abstract 1
- 235000018905 epimedium Nutrition 0.000 abstract 1
- 239000001947 glycyrrhiza glabra rhizome/root Substances 0.000 abstract 1
- 150000002632 lipids Chemical class 0.000 abstract 1
- 230000001737 promoting effect Effects 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 8
- 201000010099 disease Diseases 0.000 description 7
- 206010012289 Dementia Diseases 0.000 description 5
- 230000007812 deficiency Effects 0.000 description 4
- 210000003734 kidney Anatomy 0.000 description 3
- 230000003213 activating effect Effects 0.000 description 2
- 206010003549 asthenia Diseases 0.000 description 2
- 230000004069 differentiation Effects 0.000 description 2
- 230000010354 integration Effects 0.000 description 2
- 238000012544 monitoring process Methods 0.000 description 2
- 210000000952 spleen Anatomy 0.000 description 2
- 208000011580 syndromic disease Diseases 0.000 description 2
- 206010041954 Starvation Diseases 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 208000026278 immune system disease Diseases 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 238000013507 mapping Methods 0.000 description 1
- 239000002858 neurotransmitter agent Substances 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 210000002381 plasma Anatomy 0.000 description 1
- 231100000572 poisoning Toxicity 0.000 description 1
- 230000000607 poisoning effect Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 210000001202 rhombencephalon Anatomy 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
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- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention relates to a medicament for treating senile dementia, which is prepared from capsule and oral liquid, wherein the capsule comprises red ginseng 16-20 parts, leech 16-20 parts and ground beetle 16-20 parts, the oral liquid comprises prepared fleece flower root 52-60 parts, dodder seed 24-30 parts, cynomorium songaricum 16-20 parts, epimedium 24-30 parts, dried rehmannia root 16-20 parts, anemarrhena rhizome 16-20 parts, wolfberry fruit 24-30 parts, astragalus root 26-32 parts, Ligusticum wallichii 16-20 parts, root of red rooted salvia 24-30 parts, kudzu vine root 16-20 parts, arisaema cum bile 8-10 parts, grassleaf sweelflag rhizome 8-10 parts, licorice root 8-10 parts, gastrodia tuber 18-22 parts and sodium benzoate 0.5-1 part. The medicine has effects of replenishing essence, nourishing marrow, nourishing brain, improving intelligence, invigorating qi, promoting blood circulation, removing blood stasis, and eliminating phlegm, and after administration, serum cholesterol and triglyceride are obviously reduced, high density lipoprotein and superoxide dismutase content is increased, plasma LPO content is reduced, blood lipid is reduced, and free radical is removed; the medicine has the obvious effects of dilating cerebral vessels and increasing cerebral blood flow.
Description
Technical field
The present invention relates to a kind of human brain treatment of diseases medicine that is used for the treatment of, specifically, relate to a kind of Chinese medicine that is used for the treatment of senile dementia.
Background technology
Senile dementia be a kind of be the cerebral retrogressive disease of main performance with the dementia, its cause of disease is still not really clear and definite so far, may be relevant with heredity, neurotransmitter change, poisoning by aluminum, infection, wound immune dysfunction etc.Its patient is artificially many with old age, and the latent onset of attacking is slowly made progress, and the course of disease still be one of difficult and complicated illness of medical circle at present, and medical circle both domestic and external does not still have effective medicine to this disease generally at 5-10.The theory of Chinese medical science of China thinks that this sick basic pathogenesis is deficiency in origin table reality, old Liver and kidney damage of essence, brains inanition, insufficiency of vital energy and blood, lack of preservation of spirit be disease this, the stagnation of phlegm blood stasis, sering is unfavorable is the mark of disease.At the appropriate to the occasion life essence-filling, marrow-benefitting of treatment, brain, benefiting QI for activating blood circulation.
Summary of the invention
The objective of the invention is to deficiency, a kind of novel senile dementia medicine of making according to theory of Chinese medical science is provided at existing treatment senile dementia disease drug.
Technical scheme of the present invention is: a kind of medicine of senile dementia, described medicine is constituted by capsule and oral liquid, wherein capsule is by Radix Ginseng Rubra 16-20 part, Hirudo 16-20 part, and eupolyphaga 16-20 part formation, oral liquid is by Radix Polygoni Multiflori Preparata 52-60 part, Semen Cuscutae 24-30 part, Herba Cynomorii 16-20 part, Herba Epimedii 24-30 part, Radix Rehmanniae 16-20 part, Rhizoma Anemarrhenae 16-20 part, Fructus Lycii 24-30 part, Radix Astragali 26-32 part, Rhizoma Chuanxiong 16-20 part, Radix Salviae Miltiorrhizae 24-30 part, Radix Puerariae 16-20 part, Arisaema Cum Bile 8-10 part, Rhizoma Acori Graminei 8-10 part, Radix Glycyrrhizae 8-10 part, Rhizoma Gastrodiae 18-22 part, and sodium benzoate 0.5-1 part constitutes.
The medicine preparation method of above-mentioned a kind of senile dementia is at first mixed Radix Ginseng Rubra, Hirudo and eupolyphaga and is pulverized according to proportioning, adopt existing pharmaceutical capsules preparation method to make capsule; Remaining medicine mixed by proportioning and with cold water soak 4-5 hour, add water subsequently, with slow fire boiling 1 hour, then with after three layers of filtered through gauze, medicinal residues are added water again and even fry in shallow oil twice, every all over 50 minutes, three times medicinal liquids close and concentrate after juice filters, add sodium benzoate at last and boil and make its dissolving, stir evenly at last, embedding.
Beneficial effect of the present invention is: this medicine has the merit of life essence-filling, marrow-benefitting, brain, benefiting QI for activating blood circulation, change silt clearing away phlegm, after taking, serum cholesterol, triglyceride obviously descend, the content of high density lipoprotein, superoxide dismutase raises, blood plasma LPO content descends, and blood fat reducing and the effect of removing free radical are obvious; And this medicine has expansion of cerebral vascular, the remarkable efficacy of cerebral blood flow increasing amount; In addition, from medication person's HDS integration, the monitoring result of P300 check result and brain electrical activity mapping is taken medicine as can be seen, and hindbrain intelligence is obvious to be improved.
The specific embodiment
First specific embodiment of the present invention, a kind of medicine of senile dementia, described medicine is constituted by capsule and oral liquid, wherein capsule is made of Radix Ginseng Rubra 160 grams, Hirudo 160 grams and eupolyphaga 160 grams, and oral liquid is made of Radix Polygoni Multiflori Preparata 520 grams, Semen Cuscutae 240 grams, Herba Cynomorii 160 grams, Herba Epimedii 240 grams, the Radix Rehmanniae 160 grams, the Rhizoma Anemarrhenae 160 grams, Fructus Lycii 240 grams, the Radix Astragali 260 grams, Rhizoma Chuanxiong 160 grams, Radix Salviae Miltiorrhizae 240 grams, Radix Puerariae 160 grams, Arisaema Cum Bile 80 grams, Rhizoma Acori Graminei 80 grams, Radix Glycyrrhizae 80 grams, Rhizoma Gastrodiae 180 grams and sodium benzoate 6.5 grams.
Second specific embodiment of the present invention, a kind of medicine of senile dementia, described medicine is constituted by capsule and oral liquid, wherein capsule is made of Radix Ginseng Rubra 180 grams, Hirudo 180 grams and eupolyphaga 180 grams, and oral liquid is made of Radix Polygoni Multiflori Preparata 580 grams, Semen Cuscutae 280 grams, Herba Cynomorii 180 grams 0, Herba Epimedii 260 grams, the Radix Rehmanniae 180 grams, the Rhizoma Anemarrhenae 180 grams, Fructus Lycii 160 grams, the Radix Astragali 280 grams, Rhizoma Chuanxiong 180 grams, Radix Salviae Miltiorrhizae 250 grams, Radix Puerariae 180 grams, Arisaema Cum Bile 90 grams, Rhizoma Acori Graminei 90 grams, Radix Glycyrrhizae 90 grams, Rhizoma Gastrodiae 200 grams and sodium benzoate 7 grams.
The 3rd specific embodiment of the present invention, a kind of medicine of senile dementia, described medicine is constituted by capsule and oral liquid, wherein capsule is made of Radix Ginseng Rubra 200 grams, Hirudo 200 grams and eupolyphaga 200 grams, and oral liquid is made of Radix Polygoni Multiflori Preparata 600 grams, Semen Cuscutae 300 grams, Herba Cynomorii 200 grams, Herba Epimedii 300 grams, the Radix Rehmanniae 200 grams, the Rhizoma Anemarrhenae 200 grams, Fructus Lycii 300 grams, the Radix Astragali 320 grams, Rhizoma Chuanxiong 200 grams, Radix Salviae Miltiorrhizae 300 grams, Radix Puerariae 200 grams, Arisaema Cum Bile 100 grams, Rhizoma Acori Graminei 100 grams, Radix Glycyrrhizae 100 grams, Rhizoma Gastrodiae 220 grams and sodium benzoate 7.5 grams.
When said medicine prepares, at first Radix Ginseng Rubra, Hirudo and eupolyphaga are proportionally mixed pulverizing, and make capsule with existing medicament capsule preparation method; Subsequently, remaining medicine mixed by proportioning and with cold water soak 4-5 hour, after adding water and crossing 4 centimetres of powder, with slow fire boiling 1 hour,, again medicinal residues are added water and even fry in shallow oil twice then with after three layers of filtered through gauze, every all over 50 minutes, three times medicinal liquids close juice and filter the back and concentrate, and add sodium benzoate at last and boil and make its dissolving, stir evenly at last, embedding.
During clinical experiment, picked at random suffers from patient's 46 examples of senile dementia as experimental group, wherein male 25 examples, woman's 21 examples, age 58-78 year, 65.12 years old mean age, 8.75 time of on average receiving an education, slight dull-witted 18 examples, moderate dementia 19 examples, severe dementia 9 examples, tcm syndrome differentiation and typing asthenia of both the spleen and kidney 15 examples, deficiency of marrow-reservoir 21 examples, stagnation of phlegm blood stasis 10 examples; Matched group 45 people, wherein male 24 examples, women 21 examples, age 59-77 year, 64.23 years old mean age, on average receive an education 8.35 time slight dull-witted 18 examples, moderate dementia 19 examples, severe dementia 8 examples, tcm syndrome differentiation and typing asthenia of both the spleen and kidney 15 examples, deficiency of marrow-reservoir 21 examples, stagnation of phlegm blood stasis 9 examples; Matched group is taken the outer other drug of this medicine.The every index monitoring result in back of taking medicine is as follows:
1. two groups of treatment front and back HDS integrations relatively
2. P300 rheoencephalogram variation comparison before and after the treatment (* ± S)
The 3. main biochemical indicator comparison of blood before and after the treatment (* ± SD)
Claims (3)
1. the medicine of a senile dementia, it is characterized in that: described medicine is constituted by capsule and oral liquid, wherein capsule is made of Radix Ginseng Rubra 16-20 part, Hirudo 16-20 part and eupolyphaga 16-20 part, and oral liquid comprises Radix Polygoni Multiflori Preparata 52-60 part, Semen Cuscutae 24-30 part, Herba Cynomorii 16-20 part, Herba Epimedii 24-30 part, Radix Rehmanniae 16-20 part, Rhizoma Anemarrhenae 16-20 part, Fructus Lycii 24-30 part, Radix Astragali 26-32 part, Rhizoma Chuanxiong 16-20 part, Radix Salviae Miltiorrhizae 24-30 part, Radix Puerariae 16-20 part, Arisaema Cum Bile 8-10 part, Rhizoma Acori Graminei 8-10 part, Radix Glycyrrhizae 8-10 part and Rhizoma Gastrodiae 18-22 part.
2. the medicine of senile dementia as claimed in claim 1, it is characterized in that: described oral liquid also comprises adjuvant sodium benzoate 0.5-1 part.
3. the medicine preparation method of a senile dementia as claimed in claim 2 is characterized in that: Radix Ginseng Rubra, Hirudo and eupolyphaga are mixed according to proportioning pulverize, adopt existing pharmaceutical capsules preparation method to make capsule; Remaining medicine mixed by proportioning and with cold water soak 4-5 hour, add water subsequently, with slow fire boiling 1 hour, then with after three layers of filtered through gauze, medicinal residues are added water again and even fry in shallow oil twice, every all over 50 minutes, three times medicinal liquids close and concentrate after juice filters, add sodium benzoate at last and boil and make its dissolving, stir evenly at last, embedding.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008101327655A CN101317966B (en) | 2008-07-14 | 2008-07-14 | Medicament for treating senile dementia and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008101327655A CN101317966B (en) | 2008-07-14 | 2008-07-14 | Medicament for treating senile dementia and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101317966A true CN101317966A (en) | 2008-12-10 |
| CN101317966B CN101317966B (en) | 2011-06-22 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2008101327655A Expired - Fee Related CN101317966B (en) | 2008-07-14 | 2008-07-14 | Medicament for treating senile dementia and preparation method thereof |
Country Status (1)
| Country | Link |
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| CN (1) | CN101317966B (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102406850A (en) * | 2011-11-30 | 2012-04-11 | 宋爱民 | Traditional Chinese preparation for treating senile dementia |
| CN103505550A (en) * | 2012-06-28 | 2014-01-15 | 王德生 | Medicine composition for treating senile dementia and preparation method thereof |
| CN104587345A (en) * | 2015-02-10 | 2015-05-06 | 张宏斌 | Traditional Chinese medicine preparation for treating alzheimer disease and preparation method thereof |
| CN104587411A (en) * | 2015-02-11 | 2015-05-06 | 田胜硕 | Traditional Chinese medicine preparation for treating pick disease, and preparation method |
| CN105748851A (en) * | 2016-03-15 | 2016-07-13 | 庄亮 | Medicine for treating Alzheimer disease |
| CN105816803A (en) * | 2016-04-18 | 2016-08-03 | 周振勇 | Drug for treating narcissistic personality disorder |
| CN107361200A (en) * | 2017-07-17 | 2017-11-21 | 山东巧宾农业科技有限公司 | Application of the blattaria in terms of animal tallow ratio is reduced |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1052164C (en) * | 1997-10-13 | 2000-05-10 | 首都医科大学宣武医院 | Traditional Chinese medicine preparation for treating senile dementia |
-
2008
- 2008-07-14 CN CN2008101327655A patent/CN101317966B/en not_active Expired - Fee Related
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102406850A (en) * | 2011-11-30 | 2012-04-11 | 宋爱民 | Traditional Chinese preparation for treating senile dementia |
| CN102406850B (en) * | 2011-11-30 | 2013-12-11 | 宋爱民 | Traditional Chinese preparation for treating senile dementia |
| CN103505550A (en) * | 2012-06-28 | 2014-01-15 | 王德生 | Medicine composition for treating senile dementia and preparation method thereof |
| CN103505550B (en) * | 2012-06-28 | 2015-10-14 | 王德生 | A kind of pharmaceutical composition for the treatment of senile dementia and preparation method thereof |
| CN104587345A (en) * | 2015-02-10 | 2015-05-06 | 张宏斌 | Traditional Chinese medicine preparation for treating alzheimer disease and preparation method thereof |
| CN104587345B (en) * | 2015-02-10 | 2017-12-29 | 张宏斌 | A kind of Chinese medicine preparation for treating Alzheimer disease and preparation method thereof |
| CN104587411A (en) * | 2015-02-11 | 2015-05-06 | 田胜硕 | Traditional Chinese medicine preparation for treating pick disease, and preparation method |
| CN105748851A (en) * | 2016-03-15 | 2016-07-13 | 庄亮 | Medicine for treating Alzheimer disease |
| CN105816803A (en) * | 2016-04-18 | 2016-08-03 | 周振勇 | Drug for treating narcissistic personality disorder |
| CN107361200A (en) * | 2017-07-17 | 2017-11-21 | 山东巧宾农业科技有限公司 | Application of the blattaria in terms of animal tallow ratio is reduced |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101317966B (en) | 2011-06-22 |
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Inventor after: Sun Caihong Inventor after: Wang Xinying Inventor after: Xu Chuanhui Inventor before: Sun Caihong Inventor before: Xu Chuanhui |
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Free format text: CORRECT: INVENTOR; FROM: SUN CAIHONG XU ZHUANHUI TO: SUN CAIHONG WANG XINYING XU ZHUANHUI |
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