CN101312948B - 用于治疗炎症的lta4h的二芳基取代杂环抑制剂 - Google Patents

用于治疗炎症的lta4h的二芳基取代杂环抑制剂 Download PDF

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CN101312948B
CN101312948B CN200680043305.4A CN200680043305A CN101312948B CN 101312948 B CN101312948 B CN 101312948B CN 200680043305 A CN200680043305 A CN 200680043305A CN 101312948 B CN101312948 B CN 101312948B
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mmol
pyrrolidine
phenoxymethyl
compound
alkyl
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CN101312948A (zh
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J·辛格
V·桑达纳亚卡
M·格尼
P·于
L·比德尔
B·马马特
赵镭
R·K·米什拉
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Decode Genetics ehf
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN200680043305.4A 2005-09-21 2006-06-23 用于治疗炎症的lta4h的二芳基取代杂环抑制剂 Expired - Fee Related CN101312948B (zh)

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US71901605P 2005-09-21 2005-09-21
US60/719,016 2005-09-21
PCT/US2006/024393 WO2007040682A1 (en) 2005-09-21 2006-06-23 Biaryl substituted heterocycle inhibitors of lta4h for treating inflammation

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CN101312948A CN101312948A (zh) 2008-11-26
CN101312948B true CN101312948B (zh) 2015-01-14

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EP (1) EP1926708B1 (cg-RX-API-DMAC7.html)
JP (1) JP5133889B2 (cg-RX-API-DMAC7.html)
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CN (1) CN101312948B (cg-RX-API-DMAC7.html)
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US7737145B2 (en) * 2005-12-29 2010-06-15 Estrellita Pharmaceuticals, Llc Diamine derivatives as inhibitors of leukotriene A4 hydrolase
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WO2011011598A1 (en) 2009-07-24 2011-01-27 Decode Genetics Ehf Process for preparing 4- { (s) -2- (4-(4-chlorophenoxy) phenoxymethyl) pyrrolidin-1-yl) } butyric acid and salts thereof
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US9617197B2 (en) 2010-08-04 2017-04-11 University Of Virginia Patent Foundation Compositions and methods for treating inflammatory diseases
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