CN101305011B - 吡啶衍生物及其在治疗精神障碍中的用途 - Google Patents
吡啶衍生物及其在治疗精神障碍中的用途 Download PDFInfo
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- CN101305011B CN101305011B CN2006800418603A CN200680041860A CN101305011B CN 101305011 B CN101305011 B CN 101305011B CN 2006800418603 A CN2006800418603 A CN 2006800418603A CN 200680041860 A CN200680041860 A CN 200680041860A CN 101305011 B CN101305011 B CN 101305011B
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- 0 COC(C[C@]1NCCC1)=*C* Chemical compound COC(C[C@]1NCCC1)=*C* 0.000 description 7
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- CTDIKDIZNAGMFK-UHFFFAOYSA-N CC(C)(C)OC(N(CCSC1)C1C(O)=O)=O Chemical compound CC(C)(C)OC(N(CCSC1)C1C(O)=O)=O CTDIKDIZNAGMFK-UHFFFAOYSA-N 0.000 description 1
- MCFFCQNSBLVXKS-OAHLLOKOSA-N CC(C)(C)OC(N1[C@@H](CNC(OCc2ccccc2)=O)CCC1)=O Chemical compound CC(C)(C)OC(N1[C@@H](CNC(OCc2ccccc2)=O)CCC1)=O MCFFCQNSBLVXKS-OAHLLOKOSA-N 0.000 description 1
- NFRFKIUDOXVXNV-GFCCVEGCSA-N CCOC([C@@H](COC1)N(Cc2ccccc2)C1=O)=O Chemical compound CCOC([C@@H](COC1)N(Cc2ccccc2)C1=O)=O NFRFKIUDOXVXNV-GFCCVEGCSA-N 0.000 description 1
- DOPPZLDDCUSBAF-OEMAIJDKSA-N CCOC([C@H]1COCCCC(Cc2ccccc2)C1)=O Chemical compound CCOC([C@H]1COCCCC(Cc2ccccc2)C1)=O DOPPZLDDCUSBAF-OEMAIJDKSA-N 0.000 description 1
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- ANSUDRATXSJBLY-GSVOUGTGSA-N COC([C@@H](CO)N)=O Chemical compound COC([C@@H](CO)N)=O ANSUDRATXSJBLY-GSVOUGTGSA-N 0.000 description 1
- LTQSJQPTKFNKTH-UHFFFAOYSA-N FCC(CN(CCC1)C1C1)N1P Chemical compound FCC(CN(CCC1)C1C1)N1P LTQSJQPTKFNKTH-UHFFFAOYSA-N 0.000 description 1
- YEJJVVXWENVTAU-UHFFFAOYSA-N FCC1NCC(CCC2)N2C1 Chemical compound FCC1NCC(CCC2)N2C1 YEJJVVXWENVTAU-UHFFFAOYSA-N 0.000 description 1
- DPVSPOJGBBOZGB-UHFFFAOYSA-N O=C(CN1)N(CCNC2)C2C1=O Chemical compound O=C(CN1)N(CCNC2)C2C1=O DPVSPOJGBBOZGB-UHFFFAOYSA-N 0.000 description 1
- QXKAIPFKHPAPLY-ZETCQYMHSA-N O=C1NCCN(CCC2)[C@@H]2C1 Chemical compound O=C1NCCN(CCC2)[C@@H]2C1 QXKAIPFKHPAPLY-ZETCQYMHSA-N 0.000 description 1
- JNTSDSBEAXSUAU-LWOQYNTDSA-N OC[C@H](C(N1C2COCC1)=O)NC2=O Chemical compound OC[C@H](C(N1C2COCC1)=O)NC2=O JNTSDSBEAXSUAU-LWOQYNTDSA-N 0.000 description 1
- OPEBSOKNWMAPLB-JAMMHHFISA-N OC[C@H]1NCC(COCC2)N2C1 Chemical compound OC[C@H]1NCC(COCC2)N2C1 OPEBSOKNWMAPLB-JAMMHHFISA-N 0.000 description 1
Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
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- C07D498/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Child & Adolescent Psychology (AREA)
- Nutrition Science (AREA)
- Gynecology & Obstetrics (AREA)
- Rheumatology (AREA)
- Reproductive Health (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0518472.6 | 2005-09-09 | ||
| GB0518472A GB0518472D0 (en) | 2005-09-09 | 2005-09-09 | Novel compounds |
| GB0611153A GB0611153D0 (en) | 2006-06-06 | 2006-06-06 | Novel compounds |
| GB0611153.8 | 2006-06-06 | ||
| PCT/EP2006/008845 WO2007028654A1 (en) | 2005-09-09 | 2006-09-07 | Pyridine derivatives and their use in the treatment of psychotic disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101305011A CN101305011A (zh) | 2008-11-12 |
| CN101305011B true CN101305011B (zh) | 2011-03-02 |
Family
ID=37546936
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2006800418603A Active CN101305011B (zh) | 2005-09-09 | 2006-09-07 | 吡啶衍生物及其在治疗精神障碍中的用途 |
Country Status (28)
| Country | Link |
|---|---|
| US (3) | US7683056B2 (https=) |
| EP (2) | EP1928886B1 (https=) |
| JP (1) | JP5121716B2 (https=) |
| KR (1) | KR101292348B1 (https=) |
| CN (1) | CN101305011B (https=) |
| AR (1) | AR058805A1 (https=) |
| AT (1) | ATE505472T1 (https=) |
| AU (1) | AU2006289281B2 (https=) |
| BR (1) | BRPI0615787B8 (https=) |
| CA (1) | CA2621564C (https=) |
| CR (1) | CR9847A (https=) |
| CY (1) | CY1111907T1 (https=) |
| DE (1) | DE602006021323D1 (https=) |
| DK (1) | DK1928886T3 (https=) |
| EA (1) | EA013909B1 (https=) |
| HR (1) | HRP20110457T1 (https=) |
| IL (1) | IL189578A (https=) |
| JO (1) | JO2722B1 (https=) |
| MA (1) | MA29780B1 (https=) |
| MY (1) | MY145713A (https=) |
| NO (1) | NO340921B1 (https=) |
| NZ (1) | NZ565983A (https=) |
| PE (1) | PE20070614A1 (https=) |
| PL (1) | PL1928886T3 (https=) |
| PT (1) | PT1928886E (https=) |
| SI (1) | SI1928886T1 (https=) |
| TW (1) | TWI378101B (https=) |
| WO (1) | WO2007028654A1 (https=) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007039123A2 (en) * | 2005-09-22 | 2007-04-12 | Smithkline Beecham Corporation | Combination therapy comprising an nk-3 antagonist and an antipsychotic agent |
| ATE472529T1 (de) * | 2005-10-10 | 2010-07-15 | Glaxo Group Ltd | Prolinamidderivate als natriumkanalmodulatoren |
| TW200730494A (en) * | 2005-10-10 | 2007-08-16 | Glaxo Group Ltd | Novel compounds |
| CN102775396B (zh) | 2005-11-08 | 2014-10-08 | 沃泰克斯药物股份有限公司 | Atp-结合弹夹转运蛋白的杂环调控剂 |
| US7754739B2 (en) | 2007-05-09 | 2010-07-13 | Vertex Pharmaceuticals Incorporated | Modulators of CFTR |
| WO2008090114A1 (en) | 2007-01-24 | 2008-07-31 | Glaxo Group Limited | Pharmaceutical compositions comprising 2-methoxy-5- (5-trifluoromethyl-tetrazol-i-yl-benzyl) - (2s-phenyl-piperidin-3s-yl-) |
| GEP20125379B (en) | 2007-05-03 | 2012-01-10 | Pfizer Ltd | 2 -pyridine carboxamide derivatives as sodium channel modulators |
| CN104447716A (zh) | 2007-05-09 | 2015-03-25 | 沃泰克斯药物股份有限公司 | Cftr调节剂 |
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