CN101305011B - 吡啶衍生物及其在治疗精神障碍中的用途 - Google Patents

吡啶衍生物及其在治疗精神障碍中的用途 Download PDF

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Publication number
CN101305011B
CN101305011B CN2006800418603A CN200680041860A CN101305011B CN 101305011 B CN101305011 B CN 101305011B CN 2006800418603 A CN2006800418603 A CN 2006800418603A CN 200680041860 A CN200680041860 A CN 200680041860A CN 101305011 B CN101305011 B CN 101305011B
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CN101305011A (zh
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吉乌塞普·阿尔瓦罗
丹尼尔·安德里奥蒂
桑德罗·贝尔维德里
罗马诺·迪法比奥
亚历山德罗·法尔奇
里卡多·乔万尼尼
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Kandi Medical Co ltd
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SmithKline Beecham Corp
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Priority claimed from GB0518472A external-priority patent/GB0518472D0/en
Priority claimed from GB0611153A external-priority patent/GB0611153D0/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
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    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Gynecology & Obstetrics (AREA)
  • Rheumatology (AREA)
  • Reproductive Health (AREA)
  • Psychology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CN2006800418603A 2005-09-09 2006-09-07 吡啶衍生物及其在治疗精神障碍中的用途 Active CN101305011B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0518472.6 2005-09-09
GB0518472A GB0518472D0 (en) 2005-09-09 2005-09-09 Novel compounds
GB0611153A GB0611153D0 (en) 2006-06-06 2006-06-06 Novel compounds
GB0611153.8 2006-06-06
PCT/EP2006/008845 WO2007028654A1 (en) 2005-09-09 2006-09-07 Pyridine derivatives and their use in the treatment of psychotic disorders

Publications (2)

Publication Number Publication Date
CN101305011A CN101305011A (zh) 2008-11-12
CN101305011B true CN101305011B (zh) 2011-03-02

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US (3) US7683056B2 (https=)
EP (2) EP1928886B1 (https=)
JP (1) JP5121716B2 (https=)
KR (1) KR101292348B1 (https=)
CN (1) CN101305011B (https=)
AR (1) AR058805A1 (https=)
AT (1) ATE505472T1 (https=)
AU (1) AU2006289281B2 (https=)
BR (1) BRPI0615787B8 (https=)
CA (1) CA2621564C (https=)
CR (1) CR9847A (https=)
CY (1) CY1111907T1 (https=)
DE (1) DE602006021323D1 (https=)
DK (1) DK1928886T3 (https=)
EA (1) EA013909B1 (https=)
HR (1) HRP20110457T1 (https=)
IL (1) IL189578A (https=)
JO (1) JO2722B1 (https=)
MA (1) MA29780B1 (https=)
MY (1) MY145713A (https=)
NO (1) NO340921B1 (https=)
NZ (1) NZ565983A (https=)
PE (1) PE20070614A1 (https=)
PL (1) PL1928886T3 (https=)
PT (1) PT1928886E (https=)
SI (1) SI1928886T1 (https=)
TW (1) TWI378101B (https=)
WO (1) WO2007028654A1 (https=)

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