CN101297678A - Chinese medicine antibacterial medicinal composition for curing livestock and poultry intestinal canal diseases and preparation thereof - Google Patents
Chinese medicine antibacterial medicinal composition for curing livestock and poultry intestinal canal diseases and preparation thereof Download PDFInfo
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- CN101297678A CN101297678A CNA200710058421XA CN200710058421A CN101297678A CN 101297678 A CN101297678 A CN 101297678A CN A200710058421X A CNA200710058421X A CN A200710058421XA CN 200710058421 A CN200710058421 A CN 200710058421A CN 101297678 A CN101297678 A CN 101297678A
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/70—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in livestock or poultry
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Abstract
The invention relates to a traditional Chinese medicine antibacterial pharmaceutical composition for treating intestinal tract diseases of livestock and poultry and a preparation method thereof. The pharmaceutical composition is characterized by consisting of the following ingredients according to weight portions: sorrel of 3 to 18 portions and carrier 20 to 60 portions. The preparation method comprises the following steps: the sorrel is crushed into cribble, the sorrel and carrier are respectively and accurately weighed for 3 to 18 portions and 20 to 60 portions according to the weight portions, the sorrel is soaked by boiling water with the weight of above 4 times of that of the sorrel, and the pH value is adjusted to be 7 to 10 by sodium hydroxide or triethanolamine solution, the water temperature in an extraction pot is maintained at 87 to 100 DEG C, the extraction is carried out for 15 to 45 minutes, the filtration is carried out for obtaining supernate, the residue is extracted repeatedly for one time according to the method, the filtrate of the two times is merged and further concentrated to obtain the extraction which is air-dried into powder and evenly mixed with the carrier, and then traditional Chinese medicine antibacterial pharmaceutical composition for treating intestinal tract diseases of livestock and poultry is obtained. The pharmaceutical composition and method of the invention maintain the effective components in the sorrel and combine with the carrier, thus having the advantages of good solubility, quick absorption, and obvious effect.
Description
Technical field
The present invention relates to a kind of Chinese medicine antibacterial combination for the treatment of livestock and poultry intestinal canal diseases and preparation method thereof.
Background technology
At present, the aquaculture of China is raised scattered based on peasant household mostly, and it is uneven that the raiser cultures level, lack relevant feeding and management and epidemic prevention and control knowledge, cause the incidence of disease and the recurrence rate of some diseases to significantly improve, some conditionity pathogenic bacteria such as colibacillosis, salmonellosis, and these diseases bacterium in therapeutic process is easy to generate drug resistance especially, adding spreading unchecked of Western medicine uses and makes a lot of bacterial strains have been produced drug resistance, be easy to generate " anti-milk is arranged " especially for milk cow, therefore there is a lot of veterinary drug producer to be devoted to the research and the production of Chinese medicine, it is little to give full play to herbal toxic effect, be difficult for producing drug resistance, drug residue free, do not influence advantages such as outlet, but the Chinese medicine development so far, be difficult to break away from thick always, greatly, black characteristics, especially powder, effective and the invalid target that has kept Chinese medicine, and diameter of aspirin particle is big, the crude fiber content height, ill domestic animal especially poultry is difficult to digestion and absorbs, active ingredient is difficult to stripping, the result is difficult to the antibiotic or antivirus action of performance, causes its effect average.In the market with national standard in the franzenbach rhubarb root and rhizome end of including be raw material all with the franzenbach rhubarb root and rhizome, on the market and what include in the pharmacopeia mainly is based on the franzenbach rhubarb root and rhizome primary crude drug.
Summary of the invention
The objective of the invention is to overcome the deficiency of above-mentioned technology, Chinese medicine antibacterial combination of a kind of enteritis, diarrhea that can effectively treat the common bacteriosis of livestock and poultry and cause because of feeding and management is improper and preparation method thereof is provided.The present invention carries out essence to franzenbach rhubarb root and rhizome to extract, and discards the dross and selects the essential, and removes impurity wherein, and the active ingredient that keeps wherein makes up, have dissolubility good, absorb fast, outstanding effect advantage.
For achieving the above object, the technical solution adopted in the present invention is as follows:
A kind of Chinese medicine antibacterial combination for the treatment of livestock and poultry intestinal canal diseases is characterized in that consisting of by weight: 3～18 parts of franzenbach rhubarb root and rhizomes, 20～60 parts in carrier.
Described franzenbach rhubarb root and rhizome meets the relevant regulations in " Chinese veterinary drug allusion quotation ".
Described carrier is at least a in DEXTROSE ANHYDROUS, starch, the calcium carbonate, and wherein DEXTROSE ANHYDROUS, starch, calcium carbonate all should meet the relevant regulations in " Chinese veterinary drug allusion quotation ".
A kind of preparation method who treats the Chinese medicine antibacterial combination of livestock and poultry intestinal canal diseases is characterized in that comprising the steps:
(1) franzenbach rhubarb root and rhizome is crushed into meal,
(2) by weight, accurately take by weighing 3～18 parts of franzenbach rhubarb root and rhizomes, 20～60 parts in carrier,
(3) with the boiling water immersion franzenbach rhubarb root and rhizome of above-mentioned franzenbach rhubarb root and rhizome weight more than 4 times, and with NaOH or triethanolamine solution adjust pH is 7-10, keeps water temperature at 87-100 ℃ in extractor, extracts 15-45 minute, crosses the leaching supernatant,
(4) residue repeats to extract once as stated above, merges filtrate twice, further concentrate extract, and dry up into powder, mix with carrier, promptly make a kind of Chinese medicine antibacterial combination for the treatment of livestock and poultry intestinal canal diseases.
Described franzenbach rhubarb root and rhizome meets the relevant regulations in " Chinese veterinary drug allusion quotation ".
Described carrier is at least a in DEXTROSE ANHYDROUS, starch, the calcium carbonate, and wherein DEXTROSE ANHYDROUS, starch, calcium carbonate all should meet the relevant regulations in " Chinese veterinary drug allusion quotation ".
The beneficial effect that the present invention had:
One, the present invention is a pure Chinese medicinal preparation, overcome traditional Chinese medicine powder active ingredient and be difficult to the shortcoming that stripping, spice are wasted time and energy, franzenbach rhubarb root and rhizome is carried out essence to be extracted, discard the dross and select the essential, make in the more effective immersion medicinal material of leaching liquor, fully effective component extracting is removed impurity wherein, the active ingredient that keeps wherein makes up, thereby has dissolubility is good, medicine is better brought into play in absorption soon diseases prevention, resistant effect.
Two, the franzenbach rhubarb root and rhizome in the present invention's prescription has inhibitory action to various bacteria, comprising Escherichia coli, staphylococcus, hemolytic streptococcus, shigella dysenteriae, salmonella, comma bacillus, Pseudomonas aeruginosa etc. are all had good inhibition effect, can be clearing heat and detoxicating, promoting qi circulation and relieving pain and stomach antidiarrheal, stomach strengthening and digestion promoting is to because bacterial diarrhoea, watery diarrhea have better curative effect.
Three, clinical testing shows, the present invention can reach more than 90% to the control rate of the intestines problem that Escherichia coli cause, toxicity of the present invention is little, cost is lower, easy to use, can directly be added in animal drinking-water or the feed, play prevention effect, also strengthen the anti-adversity ability of body simultaneously bacteriosis.
The specific embodiment
Below in conjunction with specific embodiment this explanation is further described.
Embodiment 1:
A kind of Chinese medicine antibacterial combination for the treatment of livestock and poultry intestinal canal diseases is characterized in that consisting of by weight: 7 parts of franzenbach rhubarb root and rhizomes, 20 parts of starch.
Said composition preparation method comprises the steps:
(1) franzenbach rhubarb root and rhizome being crushed to the range estimation granularity is the meal of 7cm,
(2) by weight, accurately take by weighing 7 parts of franzenbach rhubarb root and rhizomes, 20 parts of starch,
(3) with the boiling water immersion franzenbach rhubarb root and rhizome of above-mentioned franzenbach rhubarb root and rhizome weight more than 4 times, and with NaOH or triethanolamine solution adjust pH is 7, keeps water temperature at 95 ℃ in extractor, extracts 30 minutes, crosses the leaching supernatant,
(4) residue repeats to extract once as stated above, merges filtrate twice, further concentrate extract, and dry up into powder, mix with carrier starch, promptly make a kind of Chinese medicine antibacterial combination for the treatment of livestock and poultry intestinal canal diseases.
Embodiment 2:
A kind of Chinese medicine antibacterial combination for the treatment of livestock and poultry intestinal canal diseases is characterized in that consisting of by weight: 7 parts of franzenbach rhubarb root and rhizomes, 34 parts of DEXTROSE ANHYDROUSs.
Said composition preparation method comprises the steps:
(1) franzenbach rhubarb root and rhizome being crushed to the range estimation granularity is the meal of 10cm,
(2) by weight, accurately take by weighing 7 parts of franzenbach rhubarb root and rhizomes, 34 parts of DEXTROSE ANHYDROUSs,
(3) with the boiling water immersion franzenbach rhubarb root and rhizome of above-mentioned franzenbach rhubarb root and rhizome weight more than 4 times, and with NaOH or triethanolamine solution adjust pH is 8, keeps water temperature at 90 ℃ in extractor, extracts 25 minutes, crosses the leaching supernatant,
(4) residue repeats to extract once as stated above, merges filtrate twice, further concentrate extract, and dry up into powder, mix with the carrier DEXTROSE ANHYDROUS, promptly make a kind of Chinese medicine antibacterial combination for the treatment of livestock and poultry intestinal canal diseases.
Embodiment 3:
A kind of Chinese medicine antibacterial combination for the treatment of livestock and poultry intestinal canal diseases is characterized in that consisting of by weight: 18 parts of franzenbach rhubarb root and rhizomes, 60 parts in calcium carbonate.
Said composition preparation method comprises the steps:
(1) franzenbach rhubarb root and rhizome being crushed to the range estimation granularity is the meal of 20cm,
(2) by weight, accurately take by weighing 18 parts of franzenbach rhubarb root and rhizomes, 60 parts in calcium carbonate,
(3) with the boiling water immersion franzenbach rhubarb root and rhizome of above-mentioned franzenbach rhubarb root and rhizome weight more than 4 times, and with NaOH or triethanolamine solution adjust pH is 10, keeps water temperature at 95 ℃ in extractor, extracts 45 minutes, crosses the leaching supernatant,
(4) residue repeats to extract once as stated above, merges filtrate twice, further concentrate extract, and dry up into powder, mix with carrier calcium carbonate, promptly make a kind of Chinese medicine antibacterial combination for the treatment of livestock and poultry intestinal canal diseases.
Embodiment 4:
A kind of Chinese medicine antibacterial combination for the treatment of livestock and poultry intestinal canal diseases is characterized in that consisting of by weight: 15 parts of franzenbach rhubarb root and rhizomes, 57 parts of DEXTROSE ANHYDROUSs.
Said composition preparation method comprises the steps:
(1) franzenbach rhubarb root and rhizome being crushed to the range estimation granularity is the meal of 20cm,
(2) by weight, accurately take by weighing 15 parts of franzenbach rhubarb root and rhizomes, 57 parts of DEXTROSE ANHYDROUSs,
(3) with the boiling water immersion franzenbach rhubarb root and rhizome of above-mentioned franzenbach rhubarb root and rhizome weight more than 4 times, and with NaOH or triethanolamine solution adjust pH is 9, keeps water temperature at 87 ℃ in extractor, extracts 40 minutes, crosses the leaching supernatant,
(4) residue repeats to extract once as stated above, merges filtrate twice, further concentrate extract, and dry up into powder, mix with the carrier DEXTROSE ANHYDROUS, promptly make a kind of Chinese medicine antibacterial combination for the treatment of livestock and poultry intestinal canal diseases.
Embodiment 5:
A kind of Chinese medicine antibacterial combination for the treatment of livestock and poultry intestinal canal diseases is characterized in that consisting of by weight: 12 parts of franzenbach rhubarb root and rhizomes, 30 parts of DEXTROSE ANHYDROUSs.
Said composition preparation method comprises the steps:
(1) franzenbach rhubarb root and rhizome being crushed to the range estimation granularity is the meal of 20cm,
(2) by weight, accurately take by weighing 12 parts of franzenbach rhubarb root and rhizomes, 30 parts of DEXTROSE ANHYDROUSs,
(3) with the boiling water immersion franzenbach rhubarb root and rhizome of above-mentioned franzenbach rhubarb root and rhizome weight more than 4 times, and with NaOH or triethanolamine solution adjust pH is 10, keeps water temperature at 100 ℃ in extractor, extracts 20 minutes, crosses the leaching supernatant,
(4) residue repeats to extract once as stated above, merges filtrate twice, further concentrate extract, and dry up into powder, mix with the carrier DEXTROSE ANHYDROUS, promptly make a kind of Chinese medicine antibacterial combination for the treatment of livestock and poultry intestinal canal diseases.
Embodiment 6:
A kind of Chinese medicine antibacterial combination for the treatment of livestock and poultry intestinal canal diseases is characterized in that consisting of by weight: 10 parts of franzenbach rhubarb root and rhizomes, 50 parts of DEXTROSE ANHYDROUSs.
Said composition preparation method comprises the steps:
(1) franzenbach rhubarb root and rhizome being crushed to the range estimation granularity is the meal of 3cm,
(2) by weight, accurately take by weighing 10 parts of franzenbach rhubarb root and rhizomes, 50 parts of DEXTROSE ANHYDROUSs,
(3) with the boiling water immersion franzenbach rhubarb root and rhizome of above-mentioned franzenbach rhubarb root and rhizome weight more than 4 times, and with NaOH or triethanolamine solution adjust pH is 8, keeps water temperature at 95 ℃ in extractor, extracts 30 minutes, crosses the leaching supernatant,
(4) residue repeats to extract once as stated above, merges filtrate twice, further concentrate extract, and dry up into powder, mix with the carrier DEXTROSE ANHYDROUS, promptly make a kind of Chinese medicine antibacterial combination for the treatment of livestock and poultry intestinal canal diseases.
Embodiment 7:
A kind of Chinese medicine antibacterial combination for the treatment of livestock and poultry intestinal canal diseases is characterized in that consisting of by weight: 3 parts of franzenbach rhubarb root and rhizomes, 20 parts of DEXTROSE ANHYDROUSs.
Said composition preparation method comprises the steps:
(1) franzenbach rhubarb root and rhizome being crushed to the range estimation granularity is the meal of 1cm,
(2) by weight, accurately take by weighing 3 parts of franzenbach rhubarb root and rhizomes, 20 parts of DEXTROSE ANHYDROUSs,
(3) with the boiling water immersion franzenbach rhubarb root and rhizome of above-mentioned franzenbach rhubarb root and rhizome weight more than 4 times, and with NaOH or triethanolamine solution adjust pH is 7, keeps water temperature at 90 ℃ in extractor, extracts 15 minutes, crosses the leaching supernatant,
(4) residue repeats to extract once as stated above, merges filtrate twice, further concentrate extract, and dry up into powder, mix with the carrier DEXTROSE ANHYDROUS, promptly make a kind of Chinese medicine antibacterial combination for the treatment of livestock and poultry intestinal canal diseases.
Clinical testing:
1. to the colibacillary test of calf:
Application example:
Address: Wuqing, Tianjin county Zhang
Incidence: calf spirit is depressed, and is matt by hair, sick calf anorexia, and body temperature is up to 39.5-40 ℃.Diarrhea such as water sample, ight soil are yellow back for canescence, contain ziega, bubble, band blood, and tapinoma-odour is arranged.Take pathological material of disease to diagnose, be judged to Escherichia coli, in feed, add this bactericidal composition in proportion through laboratory, logotype 3 days, feed intake obviously rises, and it is normal that ight soil recovers, and obtains good result.
2. to the test of the white scour of chicken:
Application example
The address: the Lian Yangxian of Liaoning Province hail fort town is in certain
Kind: AA meat chick
Age in days: 7 ages in days
Incidence: because of the brood time feeding and management improper, temperature is lower than normal requirement, causes the chicken group flu of catching cold, and 50% appearance dysentery characterized by white mucous stool and ight soil glue turbid anus phenomenon, and spirit is depressed, the decline of searching for food was used this pharmaceutical composition 3 days, the increase of searching for food, the obvious minimizing of dysentery characterized by white mucous stool, use 2 days again, transference cure, the course of disease is controlled.
Claims (4)
1, a kind of Chinese medicine antibacterial combination for the treatment of livestock and poultry intestinal canal diseases is characterized in that consisting of by weight: 3～18 parts of franzenbach rhubarb root and rhizomes, 20～60 parts in carrier.
2, the Chinese medicine antibacterial combination of treatment livestock and poultry intestinal canal diseases according to claim 1 is characterized in that described carrier is at least a in DEXTROSE ANHYDROUS, starch, the calcium carbonate.
3, a kind of preparation method who treats the Chinese medicine antibacterial combination of livestock and poultry intestinal canal diseases is characterized in that comprising the steps:
(1) franzenbach rhubarb root and rhizome is crushed into meal,
(2) by weight, accurately take by weighing 3～18 parts of franzenbach rhubarb root and rhizomes, 20～60 parts in carrier,
(3) with the boiling water immersion franzenbach rhubarb root and rhizome of above-mentioned franzenbach rhubarb root and rhizome weight more than 4 times, and with NaOH or triethanolamine solution adjust pH is 7-10, keeps water temperature at 87-100 ℃ in extractor, extracts 15-45 minute, crosses the leaching supernatant,
(4) residue repeats to extract once as stated above, merges filtrate twice, further concentrate extract, and dry up into powder, mix with carrier, promptly make a kind of Chinese medicine antibacterial combination for the treatment of livestock and poultry intestinal canal diseases.
4, the preparation method of the Chinese medicine antibacterial combination of treatment livestock and poultry intestinal canal diseases according to claim 3 is characterized in that described carrier is at least a in DEXTROSE ANHYDROUS, starch, the calcium carbonate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA200710058421XA CN101297678A (en) | 2007-07-27 | 2007-07-27 | Chinese medicine antibacterial medicinal composition for curing livestock and poultry intestinal canal diseases and preparation thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA200710058421XA CN101297678A (en) | 2007-07-27 | 2007-07-27 | Chinese medicine antibacterial medicinal composition for curing livestock and poultry intestinal canal diseases and preparation thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101297678A true CN101297678A (en) | 2008-11-05 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA200710058421XA Pending CN101297678A (en) | 2007-07-27 | 2007-07-27 | Chinese medicine antibacterial medicinal composition for curing livestock and poultry intestinal canal diseases and preparation thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102948641A (en) * | 2012-10-24 | 2013-03-06 | 刘向前 | Natural plant feed additive for poultry |
| CN105535387A (en) * | 2014-11-03 | 2016-05-04 | 孙文彬 | Ferment for improving livestock and poultry intestinal diarrhea, and preparation method thereof |
-
2007
- 2007-07-27 CN CNA200710058421XA patent/CN101297678A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102948641A (en) * | 2012-10-24 | 2013-03-06 | 刘向前 | Natural plant feed additive for poultry |
| CN105535387A (en) * | 2014-11-03 | 2016-05-04 | 孙文彬 | Ferment for improving livestock and poultry intestinal diarrhea, and preparation method thereof |
| CN105535387B (en) * | 2014-11-03 | 2018-05-08 | 孙文彬 | Animal and bird intestines diarrhea ferment and preparation method thereof can be improved |
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Open date: 20081105 |