CN104474035A - Traditional Chinese medicine preparation capable of effectively treating porcine diarrhea and preparation process thereof - Google Patents
Traditional Chinese medicine preparation capable of effectively treating porcine diarrhea and preparation process thereof Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
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- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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Abstract
The invention discloses a traditional Chinese medicine preparation capable of effectively treating porcine diarrhea. The traditional Chinese medicine preparation disclosed by the invention is composed of the following raw materials in parts by weight: 10-20 parts of honeysuckle, 10-30 parts of polygonum chinense, 15-30 parts of psidium guajave leaves, 10-15 parts of black soya beans and 10-20 parts of common bombax flower. The traditional Chinese medicine preparation exerts great effects of clearing heat and removing toxicity, dehumidifying, astringing to arrest diarrhea, resisting bacteria and diminishing inflammation, and enhancing body immunity after compatibility, and are used for treating the diarrhea of various day-age pigs, the active ingredients are extracted by a traditional Chinese medicine active ingredient extraction technology and an appropriate amount of adjuvants is added to prepare the traditional Chinese medicine powder for treating the diarrhea of various day-age pigs. Clinical test results indicate that the effective rate of treating porcine diarrhea, of the traditional Chinese medicine formula achieves more than 90%, thus the use rate of antibiotics is reduced, and the traditional Chinese medicine formula is safe and non-toxic, free from side effects, and capable of greatly reducing treatment cost while improving the immunity of the whole pig group.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation and the preparation technology that effectively can treat diarrhea of pigs.
Background technology
In recent years, a lot of pig farms occur because many factors causes pig to take watery diarrhea as the disease of cardinal symptom, and sometimes with vomiting, heating paresthesia, inappetence, by hair slightly disorderly, especially common with piglet watery diarrhea, once morbidity, full nest is involved in a few hours, full group is involved in a couple of days, all fall ill in even whole pig farm, morbidity suckling pig rapid dehydration, to become thin death, mortality rate reaches 100%, the larger mortality rate of morbidity age in days has downward trend, but growth promoter is obstructed, fall ill and serious become cad pig more afterwards, large pig watery diarrhea mortality rate is extremely low, even can be not dead, but it is quite serious to lose flesh, need the long period could recover to get fat, application antibiotic therapy effect is undesirable, absolutely void on some pig farm, serious economic loss is brought to the people that raises pigs, have a strong impact on the development of pig industry.
The reason of diarrhea of pigs is extremely complicated, is mainly manifested in following several respects: the reason of (1) pig self.Comprise that digestive system function is complete, digestion power is low inferior, as newborn piglet.(2) factor of environment aspect is had.Comprise temperature, humidity, wind speed etc.(3) factor of feeding and management aspect is had.Mainly contain feed mold, the diarrhoea caused as mycotoxicosis, people are for giving various stress grade.(4) factor of disease aspect is had.Bacteroidal: main escherichia coli, clostridieum welchii, Salmonella, Salmonella paratyphi etc.Viral: mainly contain swine fever, pseudorabies, rotavirus, epidemic diarrhea virus, transmissible gastroenteritis, porcine circovirus, bocavirus etc.Parasitic: coccidiosis, ascarid, pouch ciliate etc.In recent years, porcine diarrhea disease sickness rate had day by day serious trend, and especially winter-spring season morbidity is especially serious, and the suckling pig particularly within 15 ages in days is once morbidity, and almost full nest is dead, brings extremely serious economic loss to China's pig industry.
How to solve ubiquitous diarrhea of pigs in current pig industry, especially the diarrhea of pigs that winter-spring season is multiple is a major issue, once there is pig watery diarrhea in current pig farm, generally make antibiotic treat, effect is undesirable, easily produces drug resistance, toxic and side effects is large, in infringement body, the balance of profitable strain, makes the hypoimmunity of body, accelerates the death of morbidity pig on the contrary.Chinese medicine becomes the active drug preventing and treating livestock and poultry in recent years, has the advantage that it is special: nontoxic, have no side effect, noresidue, not easily produce drug resistance, can immunity of organisms etc. be improved.In order to reach disease preventing and treating, object easy to use, usually relevant Chinese medicine being carried out use in conjunction according to certain principle, mainly containing effective constituent by corresponding method extraction and being prepared into various preparation.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine preparation and the preparation technology that effectively can treat diarrhea of pigs, the oral formulations made is both easy to use, improves drug effect again, greatly reduces antibiotic use amount.
In order to achieve the above object, technical scheme of the present invention is as follows:
Effectively can treat a Chinese medicine preparation for diarrhea of pigs, be made up of the raw material of following weight portion:
Flos Lonicerae 10-20 part, Herb Polygoni Chinensis 10-30 part, Folium Psidii Guajavae 15-30 part, Semen sojae atricolor 10-15 part, Flos Bombacis Malabarici 10-20 part.
The preparation method of described Chinese medicine preparation is as follows:
1st step, is crushed to less than 1 millimeter respectively by above-mentioned Chinese medicine, then mixes and be placed in container, adds 5-10 times of water, at constant temperature 70 DEG C, soaks 4-6 hour;
2nd step, then add 5-10 times of ethanol, under temperature 50 C, keep 4-6 hour;
3rd step, reclaims ethanol, and filter, filtrate adds the acetone of 1 times of volume, leaves standstill 2-3 hour after stirring;
4th step, reclaims acetone, adds medicinal carbon mixing by 1% of medicine liquid volume, filtration after 0.5 hour, and filter vacuum is concentrated, lyophilization obtains Chinese medicine extract;
5th step, makes powder by Zhong medicine Ti Qu Wu ﹕ Wu the mass ratio of Shui Pu Tao Tang ﹕ vitamin C=2 ﹕ 4 ﹕ 0.05, subpackage Chinese medicine preparation.
Described ethanol is dehydrated alcohol, and acetone concentration is 100%, and active carbon is pharmaceutical grade.
The additive capacity of product of the present invention in pig drinking-water is 1000g/ ton.
Below the various Chinese herbal medicine of prescription of the present invention are described in detail.
Flos Lonicerae: cold in nature, sweet in the mouth, enters lung, the heart, stomach warp, has heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery, antiinflammatory, antivirus action, can be used for enteritis, bacillary dysentery, stomachache, tenesmus that epidemic disease poison invasion and attack the intestines and stomach causes.
Herb Polygoni Chinensis: sour in the mouth, puckery, cool in nature.There is heat-clearing and toxic substances removing, dampness removing dysentery relieving, help digestion except the effect such as stagnant, antibacterial.Be used for the treatment of dysentery, enteritis had loose bowels, dyspepsia etc.
Folium Psidii Guajavae: bitter in the mouth; Puckery; Property is put down.There is drying damp and strengthening spleen, heat-clearing and toxic substances removing, astringing to arrest diarrhea effect.Cure mainly have loose bowels, chronic dysentery, stomachache; Dyspeptic abdominal distention etc.
Semen sojae atricolor: sweet in the mouth, cold nature.Can the kidney invigorating tonifying YIN, invigorating spleen to remove dampness, effect except thermal detoxification, tonify deficiency.Compendium of Material Medica is said: " it is many that Semen sojae atricolor enters kidney merit, thus can harness the river, relieving distension, the therapeutic method to keep the adverse QI flowing downwards, controls wind heat and promoting blood circulation and detoxication.”
Flos Bombacis Malabarici: cool in nature, slightly sweet flavor, returns spleen, liver, large intestine channel, has the effects such as heat clearing away, dampness removing, removing toxic substances, hemostasis.Cure mainly and have loose bowels, dysentery, hemorrhage, sore, eczema etc.
After adopting such scheme, the present invention compared with prior art has the following advantages:
(1) the present invention is raw material with compound Chinese medicine, extracts its active ingredient and make oral formulations, and Chinese medicine composition of the present invention is simple, but evident in efficacy.Its extract contains the multiple biological activities such as anthocyanidin, chlorogenic acid, flavone, has antibacterial, antiviral, enhancing human body immunity power, improves the effects such as appetite;
(2) the present invention have that preparation is simple, cost is low, treating both the principal and secondary aspects of a disease, short treating period, have no side effect, have no drug resistance, the feature such as noresidue, the present invention is arranged in pairs or groups by science, the active ingredient of compound Chinese medicine is extracted, its extract is made pharmaceutical preparation efficient, quick-acting, easy to use, greatly reduce antibiotic use amount in diarrhea of pigs treatment, safety non-toxic again, steady quality, effectively diarrhea of pigs is treated for numerous raisers achieve, improve meat quality, strengthen pig immunity, reduce rate of death caused by diarrhoea, improve the object of raise benefit.
The present invention carries out scientific compatibility by using the Chinese medicine with effects such as antibacterial, antiviral, astringing to arrest diarrhea, enhancing human body immunity power, effectively can solve the pig watery diarrhea every year occurred in current pig industry, hypoimmunity, antibiotic dosage is too much, the problems such as meat product Quality Down.Use product of the present invention that pig immunity can be made greatly to improve, antibiotic dosage reduces more than 70%, and treatment pig watery diarrhea effective percentage reaches more than 90%, and meat quality has obvious lifting.
Detailed description of the invention
Composition and the technique of product of the present invention is described below by specific embodiment.
Embodiment 1
A kind of Chinese medicine preparation effectively treating diarrhea of pigs is made up of the raw material of following parts by weight:
Flos Lonicerae 10 parts, Herb Polygoni Chinensis 10 parts, Folium Psidii Guajavae 15 parts, 10 parts, Semen sojae atricolor, Flos Bombacis Malabarici 10 parts.
The preparation method of described Chinese medicine preparation is as follows.
(1) said herbal medicine is crushed to less than 1 millimeter respectively, then mixes and be placed in container, add 5-10 times of water, at constant temperature 70 DEG C, soak 4-6 hour.
(2) add 5-10 times of ethanol again, under temperature 50 C, keep 4-6 hour.
(3) reclaim ethanol, filter, filtrate adds the acetone of 1 times of volume, leaves standstill 2-3 hour after stirring.
(4) reclaim acetone, add medicinal carbon mixing by 1% of medicine liquid volume, filtration after 0.5 hour, filter vacuum is concentrated, lyophilization obtains Chinese medicine extract.
(5) by Chinese medicine extract: anhydrous glucose: the mass ratio of vitamin C=2:4:0.05 makes powder, subpackage.
Described ethanol is dehydrated alcohol, and acetone concentration is 100%, and active carbon is pharmaceutical grade.
The additive capacity of product of the present invention in pig drinking-water is 1000g/ ton.
Embodiment 2
Effectively can treat a Chinese medicine preparation for diarrhea of pigs, be made up of the raw material of Chinese medicine of following weight portion: Flos Lonicerae 15 parts, Herb Polygoni Chinensis 20 parts, Folium Psidii Guajavae 23 parts, 13 parts, Semen sojae atricolor, Flos Bombacis Malabarici 15 parts.
The preparation method of described Chinese medicine preparation is with embodiment 1.
The additive capacity of product of the present invention in pig drinking-water is 1000g/ ton.
Embodiment 3
Effectively can treat a Chinese medicine preparation for diarrhea of pigs, be made up of the raw material of Chinese medicine of following weight portion: Flos Lonicerae 20 parts, Herb Polygoni Chinensis 30 parts, Folium Psidii Guajavae 30 parts, 15 parts, Semen sojae atricolor, Flos Bombacis Malabarici 20 parts.
The preparation method of described Chinese medicine preparation is with embodiment 1.
The additive capacity of product of the present invention in pig drinking-water is 1000g/ ton.
Result of use is tested
The result of use experiment in violent diarrhoea piglet is there is in the embodiment of the present invention 1, embodiment 2, embodiment 3 at 10 ages in days.
Experimental animal selects certain scale pig farm, 100 are selected as test pig in the piglet that the age in days of natural occurrence on a large scale, disease time, coincident with severity degree of condition are close, be divided into 5 groups at random, often organize 20, matched group is for falling ill but not taking any remedy measures, and drug control group is for adopting polygynax treatment.
Administering mode: be dissolved in drinking-water by product of the present invention, gavages 2ml/ head, 2 times/day, connect feed 5 days, record every day disease pig take medicine after symptom variation.
Polygynax soluble powder: commercially available specification is: 100g:6.5g, usage 1L water adds 0.5g, and every gavages 2ml, is used in conjunction 5 days.
Curative effect determinate standard: observe the clinical change such as the spirit of disease pig, appetite, feces after administration every day, and make a record.
Effective: duration of test is sick, and pig spirit takes a turn for the better to some extent, appetite is recovered gradually, feces watery diarrhea is alleviated to some extent.
Effective percentage: in whole process of the test group, the interior test pig sum of sick pig quantity/group taken a turn for the better appears in symptom of diarrhea.
Cure: the sick pig spirit of duration of test takes a turn for the better, appetite is recovered, feces transfers pasty state to gradually.
Dead: the sick pig of duration of test is dead.
Mortality rate: test pig sum in sick pig death toll/group in duration of test group.
Be result of the test of the present invention below table 1:
| Embodiment 1 | Embodiment 2 | Embodiment 3 | Neomycin group | Matched group | |
| Morbidity pig (head) | 20 | 20 | 20 | 20 | 20 |
| Significant figure (head) | 18 | 19 | 19 | 0 | 0 |
| Effective percentage (%) | 85 | 95 | 95 | 0 | 0 |
| Cure number (head) | 17 | 17 | 18 | 0 | 0 |
| Cure rate (%) | 85 | 85 | 90 | 0 | 0 |
| Death toll (%) | 2 | 1 | 1 | 20 | 20 |
| Mortality rate (%) | 10 | 5 | 5 | 100 | 100 |
Shown by table 1 result of the test, when not taking any remedy measures, morbidity piglet mortality rate is 100%, and much larger than the mortality rate adding invention formulation, wherein the drug dose effect of embodiment 3 is optimum.
The present invention chooses one of them embodiment (embodiment 3) and tests further, it is effective compared with antibiotic therapy that above-mentioned test shows that the present invention treats the diarrhoea effect of suckling pig, now alternative selects the natural occurrence pig of 35 age in days nursery pig, choose kind, body weight, age in days, the state of an illness is close, male and female half and half, 120 pigs that feeding environment is identical with feeding manner, be divided at random respectively 3 groups (often organizing male and female half and half), often organize 40 (feeding product of the present invention), polygynax matched group 40 (taking commercial sulfuric acid neomycin soluble powder to treat), matched group (not taking any remedy measures).
Administering mode: medicine is added in drinking water, freely drinks water.
Experimental period: 30 days, all weigh with off-test before test.
Other test method: the same.The results are shown in Table 2
Table 2 product of the present invention is used for the treatment of the result of the test of nursery pig
| Embodiment 3 | Neomycin control group | Matched group | |
| Morbidity pig (head) | 40 | 40 | 40 |
| End of term sum (head) | 40 | 40 | 40 |
| 5th day effective (head) | 40 | 11 | 0 |
| 10th day effective (head) | 40 | 23 | 9 |
| 15th day effective (head) | 40 | 31 | 13 |
| 20th day effective (head) | 40 | 40 | 26 |
| 25th day effective (head) | 40 | 40 | 40 |
| Initial gross weight (kg) | 441.8 | 443.5 | 440.7 |
| End of term gross weight (kg) | 835.3 | 680.7 | 521.3 |
| Total augment weight (kg) | 393.5 | 237.2 | 80.6 |
| Feed-weight ratio | 2.9:1 | 3.9:1 | 4.6:1 |
Found by test, uses product of the present invention to treat diarrhea of pigs, symptom of diarrhea can be suppressed rapidly and to lose flesh phenomenon, effectively reduce and to cause because acutely suffering from diarrhoea body to dewater the death caused.Though matched group is without death, pig becomes abnormal thin and weak.
More than test shows: product of the present invention effectively can treat the diarrhoea of various age in days pig, greatly reduce antibiotic use amount, the immunity of pig can be strengthened simultaneously, the diarrhea of pigs rate that remarkable reduction a variety of causes causes and the phenomenon of seriously losing flesh caused by diarrhoea, improve culture efficiency, effectively improve meat.This prescription composition and preparation is simple, resource is easy to get, low price, easy to use, cause the watery diarrhea disease of heavy losses evident in efficacy to current pig industry, be worthy of popularization.
Claims (7)
1. effectively can treat a Chinese medicine preparation for diarrhea of pigs, it is characterized in that being made up of the raw material of following weight portion:
Flos Lonicerae 10-20 part, Herb Polygoni Chinensis 10-30 part, Folium Psidii Guajavae 15-30 part, Semen sojae atricolor 10-15 part, Flos Bombacis Malabarici 10-20 part.
2. a kind of Chinese medicine preparation effectively treating diarrhea of pigs as claimed in claim 1, is characterized in that being made up of the raw material of following weight portion: Flos Lonicerae 10 parts, Herb Polygoni Chinensis 10 parts, Folium Psidii Guajavae 15 parts, 10 parts, Semen sojae atricolor, Flos Bombacis Malabarici 10 parts.
3. a kind of Chinese medicine preparation effectively treating diarrhea of pigs as claimed in claim 1, is characterized in that being made up of the raw material of following weight portion: Flos Lonicerae 15 parts, Herb Polygoni Chinensis 20 parts, Folium Psidii Guajavae 23 parts, 13 parts, Semen sojae atricolor, Flos Bombacis Malabarici 15 parts.
4. a kind of Chinese medicine preparation effectively treating diarrhea of pigs as claimed in claim 1, is characterized in that being made up of the raw material of following weight portion: Flos Lonicerae 20 parts, Herb Polygoni Chinensis 30 parts, Folium Psidii Guajavae 30 parts, 15 parts, Semen sojae atricolor, Flos Bombacis Malabarici 20 parts.
5. a kind of Chinese medicine preparation effectively treating diarrhea of pigs as claimed in claim 1, is characterized in that preparation method is as follows:
1st step, is crushed to less than 1 millimeter respectively by above-mentioned Chinese medicine, then mixes and be placed in container, adds 5-10 times of water, at constant temperature 70 DEG C, soaks 4-6 hour;
2nd step, then add 5-10 times of ethanol, under temperature 50 C, keep 4-6 hour;
3rd step, reclaims ethanol, and filter, filtrate adds the acetone of 1 times of volume, leaves standstill 2-3 hour after stirring;
4th step, reclaims acetone, adds medicinal carbon mixing by 1% of medicine liquid volume, filtration after 0.5 hour, and filter vacuum is concentrated, lyophilization obtains Chinese medicine extract;
5th step, makes powder by Zhong medicine Ti Qu Wu ﹕ Wu the mass ratio of Shui Pu Tao Tang ﹕ vitamin C=2 ﹕ 4 ﹕ 0.05, subpackage Chinese medicine preparation.
6. a kind of Chinese medicine preparation effectively treating diarrhea of pigs as claimed in claim 5, it is characterized in that: described ethanol is dehydrated alcohol, acetone concentration is 100%, and active carbon is pharmaceutical grade.
7. a kind of additive capacity of Chinese medicine preparation in pig drinking-water effectively treating diarrhea of pigs is 1000g/ ton as claimed in claim 1.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106389937A (en) * | 2016-12-14 | 2017-02-15 | 杨攀 | Chinese herba preparation for preventing and treating swine enterogastritis |
| CN110755572A (en) * | 2019-11-29 | 2020-02-07 | 广东容大生物股份有限公司 | Traditional Chinese medicine compound preparation for preventing and treating porcine diarrhea and preparation method thereof |
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| CN102613412A (en) * | 2012-04-10 | 2012-08-01 | 胡海波 | Feed and traditional Chinese medicine for treating pigling epidemic diarrhea and preparation method thereof |
| CN102894192A (en) * | 2012-09-05 | 2013-01-30 | 河北科技师范学院 | Chinese herbal feed additive for piglet diarrhea prevention and treatment |
| CN103892049A (en) * | 2014-04-02 | 2014-07-02 | 北京康华远景科技有限公司 | Plant feed additive for preventing porcine diarrhea and preparation method |
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| CN106389937A (en) * | 2016-12-14 | 2017-02-15 | 杨攀 | Chinese herba preparation for preventing and treating swine enterogastritis |
| CN110755572A (en) * | 2019-11-29 | 2020-02-07 | 广东容大生物股份有限公司 | Traditional Chinese medicine compound preparation for preventing and treating porcine diarrhea and preparation method thereof |
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