CN101252845B - 胶囊化活性成分、制备方法及其用途 - Google Patents

胶囊化活性成分、制备方法及其用途 Download PDF

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Publication number
CN101252845B
CN101252845B CN2006800319167A CN200680031916A CN101252845B CN 101252845 B CN101252845 B CN 101252845B CN 2006800319167 A CN2006800319167 A CN 2006800319167A CN 200680031916 A CN200680031916 A CN 200680031916A CN 101252845 B CN101252845 B CN 101252845B
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CN
China
Prior art keywords
starch
active ingredient
particle
capsules
glassy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN2006800319167A
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English (en)
Chinese (zh)
Other versions
CN101252845A (zh
Inventor
皮埃尔-艾蒂安·布克朗
格雷戈里·达尔代勒
塞巴斯蒂安·古安
比吉特·施莱芬鲍姆
吉尔·特罗法迪
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Firmenich SA
Original Assignee
Firmenich SA
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Filing date
Publication date
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Application filed by Firmenich SA filed Critical Firmenich SA
Publication of CN101252845A publication Critical patent/CN101252845A/zh
Application granted granted Critical
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Expired - Fee Related legal-status Critical Current
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/70—Fixation, conservation, or encapsulation of flavouring agents
    • A23L27/72—Encapsulation
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115—Fatty acids or derivatives thereof; Fats or oils
    • A23L33/12—Fatty acids or derivatives thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
    • A23P10/00—Shaping or working of foodstuffs characterised by the products
    • A23P10/30—Encapsulation of particles, e.g. foodstuff additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5052—Proteins, e.g. albumin
    • A61K9/5057—Gelatin

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nutrition Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Mycology (AREA)
  • Medicinal Preparation (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Cosmetics (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN2006800319167A 2005-08-30 2006-08-29 胶囊化活性成分、制备方法及其用途 Expired - Fee Related CN101252845B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP05107932 2005-08-30
EP05107932.5 2005-08-30
US71490905P 2005-09-06 2005-09-06
US60/714,909 2005-09-06
PCT/IB2006/052995 WO2007026307A2 (en) 2005-08-30 2006-08-29 Encapsulated active ingredients, methods of preparation and their use

Publications (2)

Publication Number Publication Date
CN101252845A CN101252845A (zh) 2008-08-27
CN101252845B true CN101252845B (zh) 2012-03-28

Family

ID=37809262

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2006800319167A Expired - Fee Related CN101252845B (zh) 2005-08-30 2006-08-29 胶囊化活性成分、制备方法及其用途

Country Status (10)

Country Link
US (1) US20080206325A1 (https=)
EP (1) EP1924156B1 (https=)
JP (1) JP5322643B2 (https=)
CN (1) CN101252845B (https=)
AT (1) ATE430488T1 (https=)
CA (1) CA2620507C (https=)
DE (1) DE602006006695D1 (https=)
ES (1) ES2325039T3 (https=)
RU (1) RU2008112212A (https=)
WO (1) WO2007026307A2 (https=)

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JP2010530293A (ja) * 2007-05-21 2010-09-09 フイルメニツヒ ソシエテ アノニム 大きいコアセルベート化カプセル
US20100272859A1 (en) * 2007-08-28 2010-10-28 Pepsico, Inc. Delivery and controlled release of encapsulated water-insoluble flavorants
US9186640B2 (en) 2007-08-28 2015-11-17 Pepsico, Inc. Delivery and controlled release of encapsulated lipophilic nutrients
MX342002B (es) * 2008-11-10 2016-09-09 Colgate Palmolive Co Capsulas no perecederas.
WO2010143141A1 (en) * 2009-06-10 2010-12-16 Firmenich Sa Spray-dried delivery system
MX2012013337A (es) * 2010-05-17 2013-04-05 Abbott Lab Metodo para hacer emulsiones nutricionales que contienen aceites encapsulados.
WO2012012359A1 (en) * 2010-07-19 2012-01-26 Actamax Surgical Materials, Llc Method for making a polysaccharide dialdehyde having high purity
EP2673050B1 (en) 2011-02-10 2016-03-30 Alfa Biogene International B.V. Plant hsp70 for use in the treatment of food allergy
PT2672837T (pt) 2011-02-11 2019-07-12 Clover Corporation Ltd Composições nutricionais e suas utilizações
US20130004617A1 (en) * 2011-07-01 2013-01-03 Pepsico, Inc. Coacervate complexes, methods and food products
US9687010B2 (en) 2012-03-14 2017-06-27 Mccormick & Company, Incorporated Extrusion encapsulation of actives at an increased load, using surface active plant extracts
GB201206859D0 (en) * 2012-04-19 2012-05-30 Givaudan Sa Method and composition
FR2996418B1 (fr) * 2012-10-09 2015-05-29 Seppic Sa Compositions alimentaires comprenant des capsules obtenues par coacervation ne mettant pas en œuvre de reticulant toxique
CN103876103A (zh) * 2014-01-21 2014-06-25 四川亿生元科技有限公司 益生元食用盐及其制备方法
CN103876104A (zh) * 2014-01-21 2014-06-25 四川亿生元科技有限公司 益生元低钠盐和益生元低钠盐复合调味料及其制备方法
JP6605508B2 (ja) * 2014-02-27 2019-11-13 ビー‐オーガニック フィルムス コーポレイション 一重らせんｖ構造を有する官能化デンプン中に含まれる生物活性剤
CA2985332C (en) 2015-05-18 2023-01-03 5071, Inc. Homogenous cannabis compositions and methods of making the same
CN108602040A (zh) * 2016-02-02 2018-09-28 弗门尼舍有限公司 在室温下干燥悬浮液的方法
US10508185B2 (en) 2016-06-21 2019-12-17 Baker Hughes, A Ge Company, Llc Controlled release of activation chemicals for the deployment of shape memory polymers
US20210093578A1 (en) * 2017-04-27 2021-04-01 Clover Corporation Limited Encapsulated nutritional and pharmaceutical compositions
EP3651738B1 (en) * 2017-07-14 2024-04-03 5071, Inc. Cannabinoid compositions and methods of preparation thereof
JP7263262B2 (ja) * 2017-07-27 2023-04-24 フイルメニツヒ ソシエテ アノニム ヒドロゲルマイクロカプセルの懸濁液を乾燥させるための方法
JP7004968B2 (ja) * 2017-10-06 2022-01-21 青葉化成株式会社 食用の徐放性機能材の製造方法
TW201943410A (zh) * 2018-04-10 2019-11-16 荷蘭商帝斯曼知識產權資產管理有限公司 具有彈性結構之多顆粒固體劑型
AU2019258327B2 (en) * 2018-04-27 2024-03-07 Dsm Ip Assets B.V. Powderous composition comprising carotenoid and/or derivative thereof, D-glycose oligomers and modified polysaccharide as well as food, feed or personal care formulation comprising the composition
MX2020009660A (es) 2018-06-21 2020-10-08 Firmenich & Cie Compuestos para proporcionar un olor a fresa de larga duracion.
TR201810669A2 (tr) * 2018-07-25 2018-08-27 Bursa Teknik Ueniversitesi Enkapsüle edi̇lmi̇ş bi̇r ari sütü ve i̇lgi̇li̇ üreti̇m yöntemi̇
WO2020182792A1 (en) * 2019-03-12 2020-09-17 Dsm Ip Assets B.V. Coated coacervate capsules
US12350367B2 (en) * 2019-09-12 2025-07-08 Nulixir Inc. Particles for administration of active ingredients and methods of making the same
US12291689B2 (en) 2019-12-19 2025-05-06 Firmenich Sa Compounds for providing a long-lasting floral and fruity odor
JP2021115287A (ja) * 2020-01-28 2021-08-10 青葉化成株式会社 液状医療材料
JP2021115285A (ja) * 2020-01-28 2021-08-10 青葉化成株式会社 液状高分子化合物組成物
US12030680B2 (en) * 2020-05-22 2024-07-09 Protocol Lab, LLC Systems and methods for oxygen free packaging
CN112494453B (zh) * 2020-12-30 2022-03-04 山东农业大学 一种琼脂/麦芽糊精缓释胶囊及其制备方法
CN118076235A (zh) * 2021-10-21 2024-05-24 菲仕兰坎皮纳荷兰公司 含有食用油的粉末状组合物及其在食物产品中的用途
US12378950B2 (en) 2023-07-11 2025-08-05 Baker Hughes Oilfield Operations Llc Controlled deployment of shape-memory articles
KR20260038287A (ko) * 2023-07-13 2026-03-18 디에스엠 아이피 어셋츠 비.브이. 쉘 및 중심부 충전물을 포함하는 pufa 함유 식용 제품

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WO1997013416A1 (en) * 1995-10-12 1997-04-17 Mccormick & Company, Inc. Double encapsulation process and flavorant compositions prepared thereby
US20020044968A1 (en) * 1996-10-28 2002-04-18 General Mills, Inc. Embedding and encapsulation of sensitive components into a matrix to obtain discrete controlled release particles
US20040017017A1 (en) * 2002-07-24 2004-01-29 Van Lengerich Bernhard H. Encapsulation of sensitive components using pre-emulsification
US20040037890A1 (en) * 2000-12-15 2004-02-26 Jack Burger Moisture and oxygen stable composition and a process for obtaining said composition

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WO1997013416A1 (en) * 1995-10-12 1997-04-17 Mccormick & Company, Inc. Double encapsulation process and flavorant compositions prepared thereby
US20020044968A1 (en) * 1996-10-28 2002-04-18 General Mills, Inc. Embedding and encapsulation of sensitive components into a matrix to obtain discrete controlled release particles
US20040037890A1 (en) * 2000-12-15 2004-02-26 Jack Burger Moisture and oxygen stable composition and a process for obtaining said composition
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Also Published As

Publication number Publication date
CA2620507A1 (en) 2007-03-08
EP1924156B1 (en) 2009-05-06
ES2325039T3 (es) 2009-08-24
RU2008112212A (ru) 2009-10-10
JP2009506106A (ja) 2009-02-12
WO2007026307A3 (en) 2007-07-12
JP5322643B2 (ja) 2013-10-23
US20080206325A1 (en) 2008-08-28
EP1924156A2 (en) 2008-05-28
CN101252845A (zh) 2008-08-27
CA2620507C (en) 2011-07-19
ATE430488T1 (de) 2009-05-15
WO2007026307A2 (en) 2007-03-08
DE602006006695D1 (de) 2009-06-18

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