CN101244258B - Tat-n25多肽在制备治疗银屑病药物的用途 - Google Patents
Tat-n25多肽在制备治疗银屑病药物的用途 Download PDFInfo
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- CN101244258B CN101244258B CN2008100471131A CN200810047113A CN101244258B CN 101244258 B CN101244258 B CN 101244258B CN 2008100471131 A CN2008100471131 A CN 2008100471131A CN 200810047113 A CN200810047113 A CN 200810047113A CN 101244258 B CN101244258 B CN 101244258B
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
G0/G1 | S | G2/M | |
空白对照 | 65.8% | 22.2% | 12.0% |
6M尿素 | 61.1% | 24.5% | 14.3% |
TAT-N25 | 84.2% | 7.6% | 8.2% |
S期细胞数目 | DNA的BrdU的平均掺入强度 | |
空白对照 | 24.9% | 28.5 |
6M尿素 | 27.1% | 31.0 |
TAT-N25 | 5.9% | 24.0 |
实验次数 | 分裂指数 | |
空白对照 | 3 | 16.14±2.16 |
TAT-N25 | 4 | 7.60±2.03 |
实验次数 | 鼠尾细胞颗粒层厚度 | |
空白对照 | 3 | 100% |
TAT-N25 | 4 | 225% |
患者 | 性别 | 年龄 | 银屑病史 | 使用部位 | 使用时间 | 效果 |
BL | 女 | 52 | 32 | 胳膊 | 1个月 | 改善明显 |
CQJ | 男 | 60 | 40 | 腿部 | 10天 | 改善明显 |
CF | 女 | 48 | 30 | 鬓角 | 1个月 | 改善明显 |
DAR | 女 | 35 | 15 | 腿部 | 1个月 | 改善明显 |
DG | 男 | 43 | 20 | 胳膊 | 1个月 | 改善明显 |
HL | 女 | 48 | 30 | 腿部 | 1个月 | 改善明显 |
FYB | 男 | 50 | 31 | 鬓角 | 10天 | 改善明显 |
WP | 男 | 45 | 19 | 颈部 | 10天 | 改善明显 |
YGF | 女 | 38 | 17 | 鬓角 | 1个月 | 改善明显 |
ZQQ | 女 | 46 | 23 | 胳膊 | 1个月 | 改善明显 |
Claims (1)
Priority Applications (2)
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CN2008100471131A CN101244258B (zh) | 2008-03-21 | 2008-03-21 | Tat-n25多肽在制备治疗银屑病药物的用途 |
PCT/CN2009/070653 WO2009115007A1 (zh) | 2008-03-21 | 2009-03-05 | Tat-n25多肽在治疗银屑病等细胞生长异常皮肤病中的用途 |
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CN2008100471131A CN101244258B (zh) | 2008-03-21 | 2008-03-21 | Tat-n25多肽在制备治疗银屑病药物的用途 |
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CN101244258B (zh) * | 2008-03-21 | 2010-10-20 | 夏献民 | Tat-n25多肽在制备治疗银屑病药物的用途 |
CN102321158B (zh) * | 2011-08-23 | 2013-03-27 | 常州德健生物科技有限公司 | 阻止细胞dna合成抑制细胞增殖的多肽及用途 |
CN111956781B (zh) * | 2019-05-20 | 2023-11-17 | 益承康泰(厦门)生物科技有限公司 | 一种多肽在治疗眼部炎症药物中的应用 |
CN110124054B (zh) * | 2019-06-21 | 2022-02-18 | 天津科技大学 | 一种层层自组装的靶向纳米粒子的制备方法和应用 |
CN116466095B (zh) * | 2023-06-15 | 2023-09-01 | 朗肽生物制药股份有限公司 | 一种多肽及其应用 |
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CN101016340A (zh) * | 2007-01-18 | 2007-08-15 | 夏献民 | 融合多肽及其在肿瘤与细胞生长异常相关的疾病治疗中的用途 |
CN101244258B (zh) * | 2008-03-21 | 2010-10-20 | 夏献民 | Tat-n25多肽在制备治疗银屑病药物的用途 |
-
2008
- 2008-03-21 CN CN2008100471131A patent/CN101244258B/zh active Active
-
2009
- 2009-03-05 WO PCT/CN2009/070653 patent/WO2009115007A1/zh active Application Filing
Non-Patent Citations (1)
Title |
---|
张晓艳等.《银屑病患者皮损中磷脂酰肌醇3激酶过表达》.《中华皮肤科杂志》.2002,第35卷(第2期),97-98. * |
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CN101244258A (zh) | 2008-08-20 |
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