CN101238222B - 作为2型糖尿病风险诊断标记物的tcf7l2基因的遗传变异体 - Google Patents
作为2型糖尿病风险诊断标记物的tcf7l2基因的遗传变异体 Download PDFInfo
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- CN101238222B CN101238222B CN2006800221296A CN200680022129A CN101238222B CN 101238222 B CN101238222 B CN 101238222B CN 2006800221296 A CN2006800221296 A CN 2006800221296A CN 200680022129 A CN200680022129 A CN 200680022129A CN 101238222 B CN101238222 B CN 101238222B
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- tcf7l2
- diabetes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
- C12N15/1006—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/136—Screening for pharmacological compounds
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/172—Haplotypes
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Obesity (AREA)
- Pharmacology & Pharmacy (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Emergency Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Oncology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Plant Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69217405P | 2005-06-20 | 2005-06-20 | |
| US60/692,174 | 2005-06-20 | ||
| US75715506P | 2006-01-06 | 2006-01-06 | |
| US60/757,155 | 2006-01-06 | ||
| PCT/IS2006/000014 WO2006137085A1 (en) | 2005-06-20 | 2006-06-16 | Genetic variants in the tcf7l2 gene as diagnostic markers for risk of type 2 diabetes mellitus |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101238222A CN101238222A (zh) | 2008-08-06 |
| CN101238222B true CN101238222B (zh) | 2013-04-10 |
Family
ID=37036993
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2006800221296A Expired - Fee Related CN101238222B (zh) | 2005-06-20 | 2006-06-16 | 作为2型糖尿病风险诊断标记物的tcf7l2基因的遗传变异体 |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US7585630B2 (https=) |
| EP (1) | EP1907569B1 (https=) |
| JP (1) | JP5301987B2 (https=) |
| KR (1) | KR101374304B1 (https=) |
| CN (1) | CN101238222B (https=) |
| AU (1) | AU2006260477B2 (https=) |
| BR (1) | BRPI0612301A2 (https=) |
| CA (1) | CA2612475C (https=) |
| EA (1) | EA016397B1 (https=) |
| IL (1) | IL188147A (https=) |
| MX (1) | MX2007015848A (https=) |
| NO (1) | NO341910B1 (https=) |
| NZ (1) | NZ564285A (https=) |
| WO (1) | WO2006137085A1 (https=) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7407955B2 (en) | 2002-08-21 | 2008-08-05 | Boehringer Ingelheim Pharma Gmbh & Co., Kg | 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions |
| US7501426B2 (en) | 2004-02-18 | 2009-03-10 | Boehringer Ingelheim International Gmbh | 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions |
| DE102004054054A1 (de) | 2004-11-05 | 2006-05-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine |
| JP5301987B2 (ja) * | 2005-06-20 | 2013-09-25 | デコード・ジェネティクス・イーエイチエフ | 2型糖尿病のリスクの診断マーカーとしてのtcf7l2遺伝子中の遺伝子変異体 |
| DE102005035891A1 (de) | 2005-07-30 | 2007-02-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel |
| EP1852108A1 (en) | 2006-05-04 | 2007-11-07 | Boehringer Ingelheim Pharma GmbH & Co.KG | DPP IV inhibitor formulations |
| PE20080251A1 (es) | 2006-05-04 | 2008-04-25 | Boehringer Ingelheim Int | Usos de inhibidores de dpp iv |
| EP2540725A1 (de) | 2006-05-04 | 2013-01-02 | Boehringer Ingelheim International GmbH | Polymorphe von 1-((4-Methyl-chinazolin-2-yl)methyl)-3-methyl-7-(2-butin-1-yl)-8-(3-(R)-amino-piperidin-1-yl)xanthin |
| SG177148A1 (en) * | 2006-11-30 | 2012-01-30 | Decode Genetics Ehf | Genetic susceptibility variants of type 2 diabetes mellitus |
| WO2008109079A2 (en) * | 2007-03-01 | 2008-09-12 | Novetide, Ltd. | High purity peptides |
| CA2685816A1 (en) * | 2007-04-30 | 2008-11-06 | Compugen Ltd. | Allelic polymorphism associated with diabetes |
| PE20091730A1 (es) | 2008-04-03 | 2009-12-10 | Boehringer Ingelheim Int | Formulaciones que comprenden un inhibidor de dpp4 |
| BRPI0916997A2 (pt) | 2008-08-06 | 2020-12-15 | Boehringer Ingelheim International Gmbh | Inibidor de dpp-4 e seu uso |
| UY32030A (es) | 2008-08-06 | 2010-03-26 | Boehringer Ingelheim Int | "tratamiento para diabetes en pacientes inapropiados para terapia con metformina" |
| CN102149407A (zh) | 2008-09-10 | 2011-08-10 | 贝林格尔.英格海姆国际有限公司 | 治疗糖尿病和相关病症的组合疗法 |
| US20200155558A1 (en) | 2018-11-20 | 2020-05-21 | Boehringer Ingelheim International Gmbh | Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug |
| CN102256976A (zh) | 2008-12-23 | 2011-11-23 | 贝林格尔.英格海姆国际有限公司 | 有机化合物的盐形式 |
| AR074990A1 (es) | 2009-01-07 | 2011-03-02 | Boehringer Ingelheim Int | Tratamiento de diabetes en pacientes con un control glucemico inadecuado a pesar de la terapia con metformina |
| AU2010269841A1 (en) | 2009-07-10 | 2012-02-23 | Decode Genetics Ehf | Genetic markers associated with risk of diabetes mellitus |
| KR20240090632A (ko) * | 2009-11-27 | 2024-06-21 | 베링거 인겔하임 인터내셔날 게엠베하 | 리나글립틴과 같은 dpp-iv 억제제를 사용한 유전자형 검사된 당뇨병 환자의 치료 |
| CN102946875A (zh) | 2010-05-05 | 2013-02-27 | 贝林格尔.英格海姆国际有限公司 | 组合疗法 |
| WO2011161161A1 (en) | 2010-06-24 | 2011-12-29 | Boehringer Ingelheim International Gmbh | Diabetes therapy |
| AR083878A1 (es) | 2010-11-15 | 2013-03-27 | Boehringer Ingelheim Int | Terapia antidiabetica vasoprotectora y cardioprotectora, linagliptina, metodo de tratamiento |
| US8883800B2 (en) | 2011-07-15 | 2014-11-11 | Boehringer Ingelheim International Gmbh | Substituted quinazolines, the preparation thereof and the use thereof in pharmaceutical compositions |
| US9555001B2 (en) | 2012-03-07 | 2017-01-31 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition and uses thereof |
| JP6218811B2 (ja) | 2012-05-14 | 2017-10-25 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Sirs及び/又は敗血症の治療に用いるdpp−4阻害薬としてのキサンチン誘導体 |
| JP6224084B2 (ja) | 2012-05-14 | 2017-11-01 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 糸球体上皮細胞関連障害及び/又はネフローゼ症候群の治療に用いるdpp−4阻害薬としてのキサンチン誘導体 |
| WO2013174767A1 (en) | 2012-05-24 | 2013-11-28 | Boehringer Ingelheim International Gmbh | A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference |
| US20160077079A1 (en) * | 2013-03-14 | 2016-03-17 | The Children's Hospital Of Philadelphia | The children's hospital of philadelphia |
| RU2521202C1 (ru) * | 2013-04-12 | 2014-06-27 | Федеральное государственное автономное образовательное учреждение высшего профессионального образования "Белгородский государственный национальный исследовательский университет" | Способ прогнозирования риска развития сахарного диабета второго типа у больных гипертонической болезнью |
| EP3110449B1 (en) | 2014-02-28 | 2023-06-28 | Boehringer Ingelheim International GmbH | Medical use of a dpp-4 inhibitor |
| CN103882127B (zh) * | 2014-03-13 | 2016-03-16 | 河北联合大学 | 用于预测患2型糖尿病肾病发生风险的试剂盒 |
| WO2016201438A1 (en) * | 2015-06-11 | 2016-12-15 | The Children's Hospital Of Philadelphia | New targets modulated by a casual variant of type 2 diabetes (t2d) embedded within the tcf7l2 gene and methods of use thereof for identifying agents having efficacy for the treatment of type 2 diabetes and other metabolic disorders |
| CN109310697A (zh) | 2016-06-10 | 2019-02-05 | 勃林格殷格翰国际有限公司 | 利格列汀和二甲双胍的组合 |
| CN109182508A (zh) * | 2018-10-22 | 2019-01-11 | 北京华夏时代生物工程有限公司 | Tcf7l2基因单核苷酸多态性的荧光原位杂交测序方法 |
| TWI702292B (zh) * | 2018-12-28 | 2020-08-21 | 薩摩亞商康多富國際有限公司 | 個人化新陳代謝疾病保健食品組合的決定方法及非暫態電腦可讀取儲存媒體 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1548553A (zh) * | 2003-05-21 | 2004-11-24 | 中国医学科学院基础医学研究所 | 用于预测2型糖尿病易感性的试剂盒及引物 |
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| JP2003516974A (ja) | 1999-12-17 | 2003-05-20 | カイロン コーポレイション | グリコーゲンシンターゼキナーゼ3のピラジンベースインヒビター |
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| JP5301987B2 (ja) * | 2005-06-20 | 2013-09-25 | デコード・ジェネティクス・イーエイチエフ | 2型糖尿病のリスクの診断マーカーとしてのtcf7l2遺伝子中の遺伝子変異体 |
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2006
- 2006-06-16 JP JP2008517701A patent/JP5301987B2/ja not_active Expired - Fee Related
- 2006-06-16 EP EP06745230.0A patent/EP1907569B1/en active Active
- 2006-06-16 CN CN2006800221296A patent/CN101238222B/zh not_active Expired - Fee Related
- 2006-06-16 CA CA2612475A patent/CA2612475C/en active Active
- 2006-06-16 AU AU2006260477A patent/AU2006260477B2/en not_active Ceased
- 2006-06-16 US US11/454,296 patent/US7585630B2/en active Active
- 2006-06-16 KR KR1020087001376A patent/KR101374304B1/ko not_active Expired - Fee Related
- 2006-06-16 EA EA200800087A patent/EA016397B1/ru not_active IP Right Cessation
- 2006-06-16 NZ NZ564285A patent/NZ564285A/en not_active IP Right Cessation
- 2006-06-16 WO PCT/IS2006/000014 patent/WO2006137085A1/en not_active Ceased
- 2006-06-16 BR BRPI0612301-5A patent/BRPI0612301A2/pt not_active Application Discontinuation
- 2006-06-16 MX MX2007015848A patent/MX2007015848A/es active IP Right Grant
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2007
- 2007-12-13 IL IL188147A patent/IL188147A/en active IP Right Grant
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2008
- 2008-01-21 NO NO20080389A patent/NO341910B1/no not_active IP Right Cessation
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2009
- 2009-06-15 US US12/456,381 patent/US20090275043A1/en not_active Abandoned
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2011
- 2011-11-11 US US13/294,802 patent/US20120149016A1/en not_active Abandoned
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1548553A (zh) * | 2003-05-21 | 2004-11-24 | 中国医学科学院基础医学研究所 | 用于预测2型糖尿病易感性的试剂盒及引物 |
Non-Patent Citations (1)
| Title |
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| Struan F A Grant et al.Variant of transcription factor 7-like 2(TCF7L2)gene confers risk of type 2 diabetes.《Nature Genetics》.2006,第38卷(第3期),320-323. * |
Also Published As
| Publication number | Publication date |
|---|---|
| NZ564285A (en) | 2010-03-26 |
| KR20080051128A (ko) | 2008-06-10 |
| CN101238222A (zh) | 2008-08-06 |
| US20090275043A1 (en) | 2009-11-05 |
| NO20080389L (no) | 2008-01-21 |
| EP1907569A1 (en) | 2008-04-09 |
| KR101374304B1 (ko) | 2014-03-14 |
| BRPI0612301A2 (pt) | 2009-01-27 |
| AU2006260477B2 (en) | 2012-02-23 |
| JP2008546403A (ja) | 2008-12-25 |
| CA2612475A1 (en) | 2006-12-28 |
| HK1117569A1 (en) | 2009-01-16 |
| NO341910B1 (no) | 2018-02-19 |
| EA016397B1 (ru) | 2012-04-30 |
| CA2612475C (en) | 2015-07-28 |
| EA200800087A1 (ru) | 2008-06-30 |
| WO2006137085A1 (en) | 2006-12-28 |
| MX2007015848A (es) | 2008-04-22 |
| US7585630B2 (en) | 2009-09-08 |
| EP1907569B1 (en) | 2013-04-10 |
| US20120149016A1 (en) | 2012-06-14 |
| US20060286588A1 (en) | 2006-12-21 |
| IL188147A0 (en) | 2008-03-20 |
| AU2006260477A8 (en) | 2006-12-28 |
| AU2006260477A1 (en) | 2006-12-28 |
| IL188147A (en) | 2013-02-28 |
| JP5301987B2 (ja) | 2013-09-25 |
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