CN101204571B - Edible Chinese traditional medicine composite for diabetes mellitus and preparation method thereof - Google Patents
Edible Chinese traditional medicine composite for diabetes mellitus and preparation method thereof Download PDFInfo
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- CN101204571B CN101204571B CN200710115638XA CN200710115638A CN101204571B CN 101204571 B CN101204571 B CN 101204571B CN 200710115638X A CN200710115638X A CN 200710115638XA CN 200710115638 A CN200710115638 A CN 200710115638A CN 101204571 B CN101204571 B CN 101204571B
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Abstract
The invention relates to an edible Chinese medicine combination used for treating diabetes and a preparation method thereof. The components by weight parts are as follows: common yam 20 to 40 parts, ginseng 25 to 50 parts, barbary wolfberry fruit 10 to 30 parts, American ginseng 5 to 25 parts, lotus root 10 to 20 parts and ginger 5 to 10 parts. The Chinese medicine combination of the invention can recover the function of pancreatic beta cells, eliminate insulin resistance, promote function normalization of glucose metabolism, bring blood glucose back to normal level and greatly improve constitution safely and effectively.
Description
Technical field
The present invention relates to a kind of eatable Chinese medicines compositions and preparation method for the treatment of diabetes, belong to the eatable Chinese medicines technical field.
Background technology
Global in recent years diabetes and complication prevalence thereof increase rapidly, and type 2 diabetes mellitus accounts for more than 80% in the diabetics.Type 2 diabetes mellitus is the combined effect of h and E factor and the polygenic inheritance complexity disease that forms.Generally believe that at present insulin resistant and β emiocytosis defective are pathogenetic 2 key links of type 2 diabetes mellitus.The polymorphism of the several genes of each link of insulin resistant and insulin signaling transduction and regulation and control glycolipid metabolism and suddenly change relevant, as 1. insulin signaling albumen genetic abnormalities.2. the insulin signaling protein function changes.3. cytokine is to the depression effect of insulin signaling transduction.4. Developmental and Metabolic Disorder hinders the mechanism such as grade of the transduction of insulin signaling.The reason of β emiocytosis defective comprises: 1. the defective of amount of insulin secretion.2. the undesired and insulinogenic variation of insulin secretion pattern.3. β emiocytosis functional defect etc.Be intended to satisfy clinical demand at present and have research and development of anti-diabetic new drug of novel mechanism of action very active.Many antidiabetic medicines are the fine blood sugar control of energy at first, but continuity along with the medication treatment, then can not keep curative effect, the main cause that antidiabetic medicine lacks long-term effectiveness is that their mechanism of action is to increase target tissue to the sensitivity of insulin action or the activity of raising pancreas generation insulin, but causes the basic reason of diabetes to lack targeting to decay of pancreatic beta cell function and disorderly these of function carbohydrate metabolism.Safety and side effect are two importances that following antidiabetic medicine is demanded urgently improving equally.
Existing antidiabetic medicine, have good efficacy as insulin, metformin, sulfonylureas and the plug (oxazolidinon-5-yl-methyl)-2-thiophene-carboxamides medicine that goes on the market recently, Alpha-glucosidase inhibitor, post-prandial glycemia regulator etc., but still do not have the unsolved many major issues of person in the treating diabetes field.Wherein two the most significant greatly problems be exactly medicine reduce can not keep aspect the hyperglycemia long-term efficacy with can not be at the cause of disease and effective mitigate the disease.Many antidiabetic medicines at first can fine blood sugar control, but along with the continuity of medication treatment, then can not keep curative effect.The present invention has definite curative effect to diabetes; can recover islet function; eliminate insulin resistant; promote body carbohydrate metabolism normalization; make blood sugar recovery to normal level; body constitution is obviously improved, and particularly to blood sugar lowering Western medicine (comprise and use insulin) the bad type 2 diabetes mellitus determined curative effect of control, effective percentage reaches 100%.
Summary of the invention
The present invention is directed to the deficiencies in the prior art; a kind of pancreatic beta cell function of recovering is provided; eliminate insulin resistant; promote body function carbohydrate metabolism normalization; make blood sugar recovery to normal level; body constitution be improved significantly, the eatable Chinese medicines composition and method of making the same of safe and effective treatment diabetes.
The eatable Chinese medicines compositions that the present invention treats diabetes comprises following component, is weight portion: 20～40 parts of Rhizoma Dioscoreaes; 25～50 parts of Radix Ginsengs; 10～30 parts of Fructus Lycii; 5～25 parts of Radix Panacis Quinquefoliis; 10～20 parts of Rhizoma Nelumbiniss; 5～10 parts in Rhizoma Zingiberis Recens.
Further preferred, the eatable Chinese medicines composition component that the present invention treats diabetes is as follows, is weight portion: 25～35 parts of Rhizoma Dioscoreaes; 30～40 parts of Radix Ginsengs; 15～20 parts of Fructus Lycii; 10～20 parts of Radix Panacis Quinquefoliis; 15～18 parts of Rhizoma Nelumbiniss; 5～10 parts in Rhizoma Zingiberis Recens.
It is as follows that the present invention treats the eatable Chinese medicines preparation method of composition of diabetes:
(1) Rhizoma Dioscoreae, Fructus Lycii, Rhizoma Nelumbinis, Rhizoma Zingiberis Recens, Radix Panacis Quinquefolii powder are broken into coarse powder, decoct with water three times, each 0.5-1 hour, collecting decoction, filter, filtrate is condensed into clear paste, is chilled to room temperature, adds ethanol and makes and contain the alcohol amount and reach 70-80%wt, stir, left standstill 20-24 hour, and got supernatant, again supernatant concentration is become clear paste behind the recovery ethanol;
(2) Radix Ginseng is pulverized, sterilization, and oven dry is ground into fine powder again, adds the clear paste that above-mentioned step (1) makes, mixing; Get Chinese medicine composition.
Preferably, the fine powder in the above-mentioned steps (2) is＜75 microns micropowders.
Above Chinese medicine composition can be used for the treatment of diabetes, but is taking convenience, also can be made into different pharmaceutical formulations.
With the Chinese medicine composition that above-mentioned steps (2) makes, make multiple dosage forms such as pill, tablet, granule or capsule by prior art.
Eatable Chinese medicines compositions of the present invention be according to Chinese and western medical science about treatment diabetes basic principle, screening has the Chinese medicine of nourishing, nontoxic medicine-food two-purpose, verifies through prolonged and repeated prescription and makes.Have strengthening the body resistance, supplementing QI and nourishing YIN, treating both the principal and secondary aspects of a disease focuses on the effect of effecting a permanent cure.Be characterized in that 1. promote body function carbohydrate metabolism normalization, make blood sugar recovery, can reach the purpose of curing diabetes to normal level.2. elimination diabetic complication, body constitution be improved significantly.3. particularly to blood sugar lowering Western medicine (comprise and use insulin) the bad type 2 diabetes mellitus determined curative effect of control, effective percentage reaches 100%.The present invention combines eatable Chinese medicines with Western medicine, explore a difficult problem that solves in the treating diabetes, makes great efforts to find out a new road for the radical cure of diabetes.
Preparation clinical observation on the therapeutic effect result of the present invention is as follows:
The type 2 diabetes mellitus patient bad to the control of 97 routine Western medicine (unite to use and reach maximal dose, or insulin consumption every day＞300,000 units, and fasting glucose＞9nmol/L) is used this preparation keeping former adding on the Western medicine basis by the orally-taken blood sugar reducing medicine.
Oral 3 times of Chinese medicine composition of the present invention every day, each 1 gram.
The result shows: produce effects (diabetic complication disappears for blood glucose 3.5～5.5nmol/L, Western medicine decrement or withdraw) 53 examples, effectively (blood glucose 5.6～7.5nmol/L, diabetic complication alleviates) 44 examples; Invalid (blood glucose does not reduce, and complication does not alleviate) 0 example.Have 16 examples to stop using any hypoglycemic medicine more than 1 year in 96 examples, follow up a case by regular visits to blood glucose and still can remain on normal level, 4 years the longest blood glucose do not rebound.This preparation is taken effectively for a long time, the longest taking nearly 8 years, and effect is still remarkable.Find in the observation that this preparation is taken no any untoward reaction for a long time, user's body constitution obviously strengthens, and significantly strong and senile-resistant efficacy is arranged.
The specific embodiment
The present invention will be further described below in conjunction with embodiment, but be not limited thereto.
Embodiment 1: the eatable Chinese medicines compositions of treatment diabetes comprises following component, is weight portion:
20 parts of Rhizoma Dioscoreaes; 25 parts of Radix Ginsengs; 10 parts of Fructus Lycii; 5 parts of Radix Panacis Quinquefoliis; 10 parts of Rhizoma Nelumbiniss; 5 parts in Rhizoma Zingiberis Recens.
Preparation method is as follows:
(1) Rhizoma Dioscoreae, Fructus Lycii, Rhizoma Nelumbinis, Rhizoma Zingiberis Recens, Radix Panacis Quinquefolii powder are broken into coarse powder, decoct with water three times, each 0.5 hour, collecting decoction, filter, filtrate is condensed into clear paste, is chilled to room temperature, adds ethanol and makes and contain the alcohol amount and reach 80%wt, stir, left standstill 22 hours, and got supernatant, again supernatant concentration is become clear paste behind the recovery ethanol;
(2) Radix Ginseng is pulverized, sterilization, and oven dry is ground into micropowders again, adds the clear paste that above-mentioned step (1) makes, mixing; Get Chinese medicine composition.
With the Chinese medicine composition that above-mentioned steps (2) makes, make pill by prior art.
Embodiment 2: the eatable Chinese medicines compositions of treatment diabetes comprises following component, is weight portion:
40 parts of Rhizoma Dioscoreaes; 50 parts of Radix Ginsengs; 30 parts of Fructus Lycii; 25 parts of Radix Panacis Quinquefoliis; 20 parts of Rhizoma Nelumbiniss; 10 parts in Rhizoma Zingiberis Recens.
Preparation method is as follows:
(1) Rhizoma Dioscoreae, Fructus Lycii, Rhizoma Nelumbinis, Rhizoma Zingiberis Recens, Radix Panacis Quinquefolii powder are broken into coarse powder, decoct with water three times, each 1 hour, collecting decoction, filter, filtrate is condensed into clear paste, is chilled to room temperature, adds ethanol and makes and contain the alcohol amount and reach 80%wt, stir, left standstill 24 hours, and got supernatant, again supernatant concentration is become clear paste behind the recovery ethanol;
(2) Radix Ginseng is pulverized, sterilization, and oven dry is ground into micropowders again, adds the clear paste that above-mentioned step (1) makes, mixing; Get Chinese medicine composition.
With the Chinese medicine composition that above-mentioned steps (2) makes, make tablet by prior art.
Embodiment 3: the eatable Chinese medicines compositions of treatment diabetes comprises following component, is weight portion:
30 parts of Rhizoma Dioscoreaes; 35 parts of Radix Ginsengs; 22 parts of Fructus Lycii; 14 parts of Radix Panacis Quinquefoliis; 15 parts of Rhizoma Nelumbiniss; 8 parts in Rhizoma Zingiberis Recens.
Preparation method is as follows:
(1) Rhizoma Dioscoreae, Fructus Lycii, Rhizoma Nelumbinis, Rhizoma Zingiberis Recens, Radix Panacis Quinquefolii powder are broken into coarse powder, decoct with water three times, each 1 hour, collecting decoction, filter, filtrate is condensed into clear paste, is chilled to room temperature, adds ethanol and makes and contain the alcohol amount and reach 80%wt, stir, left standstill 23 hours, and got supernatant, again supernatant concentration is become clear paste behind the recovery ethanol;
(2) Radix Ginseng is pulverized, sterilization, and oven dry is ground into micropowders again, adds the clear paste that above-mentioned step (1) makes, mixing; Get Chinese medicine composition.
With the Chinese medicine composition that above-mentioned steps (2) makes, make granule by prior art.
Claims (3)
1. treat the eatable Chinese medicines compositions of diabetes, it is characterized in that the pharmacodynamic raw materials weight portion is as follows:
20～40 parts of Rhizoma Dioscoreaes; 25～50 parts of Radix Ginsengs; 10～30 parts of Fructus Lycii; 5～25 parts of Radix Panacis Quinquefoliis; 10～20 parts of Rhizoma Nelumbiniss; 5～10 parts in Rhizoma Zingiberis Recens; Make by the following method:
(1) Rhizoma Dioscoreae, Fructus Lycii, Rhizoma Nelumbinis, Rhizoma Zingiberis Recens, Radix Panacis Quinquefolii powder are broken into coarse powder, decoct with water three times, each 0.5-1 hour, collecting decoction, filter, filtrate is condensed into clear paste, is chilled to room temperature, adds ethanol and makes and contain the alcohol amount and reach 70-80%wt, stir, left standstill 20-24 hour, and got supernatant, again supernatant concentration is become clear paste behind the recovery ethanol;
(2) Radix Ginseng is pulverized, sterilization, and oven dry is ground into the micropowders less than 75 microns again, adds the clear paste that above-mentioned step (1) makes, mixing; Get Chinese medicine composition;
Described Chinese medicine composition uses with blood sugar lowering Western medicine insulin.
2. the eatable Chinese medicines compositions of treatment diabetes as claimed in claim 1 is characterized in that ingredients weight parts is as follows:
25～35 parts of Rhizoma Dioscoreaes; 30～40 parts of Radix Ginsengs; 15～20 parts of Fructus Lycii; 10～20 parts of Radix Panacis Quinquefoliis; 15～18 parts of Rhizoma Nelumbiniss; 5～10 parts in Rhizoma Zingiberis Recens.
3. the eatable Chinese medicines compositions of treatment diabetes as claimed in claim 1 is characterized in that the Chinese medicine composition that step (2) makes is made pill, tablet, granule or capsule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200710115638XA CN101204571B (en) | 2007-12-19 | 2007-12-19 | Edible Chinese traditional medicine composite for diabetes mellitus and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200710115638XA CN101204571B (en) | 2007-12-19 | 2007-12-19 | Edible Chinese traditional medicine composite for diabetes mellitus and preparation method thereof |
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| Publication Number | Publication Date |
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| CN101204571A CN101204571A (en) | 2008-06-25 |
| CN101204571B true CN101204571B (en) | 2010-12-01 |
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| CN200710115638XA Expired - Fee Related CN101204571B (en) | 2007-12-19 | 2007-12-19 | Edible Chinese traditional medicine composite for diabetes mellitus and preparation method thereof |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103652916B (en) * | 2013-12-11 | 2015-08-12 | 罗永祺 | A kind of fruit of Chinese wolfberry Chinese yam chewable tablet and preparation method |
| CN103784511B (en) * | 2014-02-26 | 2015-06-03 | 青岛大学 | Magnesium chromium composition |
| CN107865421A (en) * | 2017-11-03 | 2018-04-03 | 安徽生物肽产业研究院有限公司 | A kind of health-oriented products with auxiliary hyperglycemic effect |
| CN110236077A (en) * | 2019-06-04 | 2019-09-17 | 平顶山瑞沣生物科技有限公司 | A kind of nutrient protein stick and preparation method thereof with health-care efficacy |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1211426A (en) * | 1997-09-12 | 1999-03-24 | 张伟 | Medicine for treating diabetes |
| CN1276216A (en) * | 2000-05-25 | 2000-12-13 | 赵国林 | Process for preparing non-decoction Chinese medicine |
| CN1389225A (en) * | 2001-06-06 | 2003-01-08 | 焦更海 | Diabetes treating Chinese medicine prepn. and its prepn. process |
| CN1748574A (en) * | 2005-10-19 | 2006-03-22 | 曲海虎 | Health food for diabetic |
-
2007
- 2007-12-19 CN CN200710115638XA patent/CN101204571B/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1211426A (en) * | 1997-09-12 | 1999-03-24 | 张伟 | Medicine for treating diabetes |
| CN1276216A (en) * | 2000-05-25 | 2000-12-13 | 赵国林 | Process for preparing non-decoction Chinese medicine |
| CN1389225A (en) * | 2001-06-06 | 2003-01-08 | 焦更海 | Diabetes treating Chinese medicine prepn. and its prepn. process |
| CN1748574A (en) * | 2005-10-19 | 2006-03-22 | 曲海虎 | Health food for diabetic |
Non-Patent Citations (2)
| Title |
|---|
| 张克家.微米中药=？纳米中药.动物科学与动物医学20 5.2003,20(5),说明书. |
| 张克家.微米中药=？纳米中药.动物科学与动物医学20 5.2003,20(5),说明书. * |
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| CN101204571A (en) | 2008-06-25 |
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Granted publication date: 20101201 Termination date: 20131219 |